Elevated expression of endoglin, a component of the TGF-β-receptor complex, correlates with proliferation of tumor endothelial cells

International Journal of Cancer

Volumn 81, Issue 4, 1999, Pages 568-572

  Miller, Daniel W ^a   Graulich, Wolff ^a   Karges, Bernadett ^a   Stahl, Sabine ^a   Ernst, Michael ^a   Ramaswamy, Annette ^a   Sedlacek, H Harald ^b   Müller, Rolf ^a   Adamkiewicz, Jürgen ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN A; ENDOGLIN; KI 67 ANTIGEN; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LUNG TUMOR; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR VASCULARIZATION;

ANTIGENS, CD; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; HUMANS; LUNG; LUNG NEOPLASMS; RECEPTORS, CELL SURFACE; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION, GENETIC; UMBILICAL VEINS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0032908133     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19990517)81:4<568::AID-IJC11>3.0.CO;2-X     Document Type: Article

References (23)

1. ARCARI, P., MARTINELLI, R. and SALVATORE, F., The complete sequence of a full length cDNA for human liver glyceraldehyde-3-phosphate dehydrogenase: evidence for multiple mRNA species. Nucleic Acids Res., 12, 9179-9189 (1984).
2. BRAVO, R. and MACDONALD-BRAVO, H., Induction of the nuclear protein "cyclin" in quiescent mouse 3T3 cells stimulated by serum and growth factors. Correlation with DNA synthesis. EMBO J., 3, 3177-3181 (1984).
3. BURROWS, F.J. and THORPE, P.E., Vascular targeting - a new approach to the therapy of solid tumors. Pharmacol. Ther., 64, 155-74 (1994).
4. DERYNCK, R. and FENG, X.H., TGF-beta receptor signaling. Biochim. biophys. Acta, 1333, F105-F150 (1997).
5. DUTTA, A., CHANDRA, R., LEITER, L.M. and LESTER, S., Cyclins as markers of tumor proliferation: immunocytochemical studies in breast cancer. Proc. nat. Acad Sci. (Wash.), 92, 5386-5390 (1995).
6. FIDLER, I.J. and ELLIS, L.M., The implications of angiogenesis for the biology and therapy of cancer metastasis [comment]. Cell, 79, 185-188 (1994).
7. GOUGOS, A. and LETARTE, M., Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells. J. biol. Chem., 265, 8361-8364 (1990).
8. GRIFFIOEN, A.W., DAMEN, C.A., BLIJHAM, G.H. and GROENEWEGEN, G., Endoglin/CD105 may not be an optimal tumor endothelial treatment target. Breast Cancer Res. Treat., 39, 239-240 (1996).
9. HUGHES, J.H., ROKHLIN, O.W. and COHEN, M.B., Endoglin (CD105) expression in non-neoplastic and neoplastic human tissues and human cancer cell lines. Oncol. Rep., 3, 379-383 (1996).
10. KARKAVELAS, G., MAVROPOULOU, S., FOUNTZILAS, G., CHRISTOFORIDOU, V., KARAVELIS, A., FOROGLOU, G. and PAPADIMITRIOU, C., Correlation of proliferating cell nuclear antigen assessment, histologic parameters and age with survival in patients with glioblastoma multiforme. Anticancer Res., 15, 531-536 (1995).
11. LETARTE, M., GREAVES, A. and VERA, S., CD105 (endoglin). In: S.F. Schlossman, L. Baumsell, and W. Gilks (eds.), Leukocyte typing, V, pp. 1756-1759, Oxford University Press, Oxford (1995).
12. MAIER, J.A., DELIA, D., THORPE, P.E. and GASPARINI, G., In vitro inhibition of endothelial cell growth by the antiangiogenic drug AGM-1470 (TNP-470) and the anti-endoglin antibody TEC-11. Anticancer Drugs, 8, 238-244 (1997).
13. MCALLISTER, K.A. and 19 OTHERS, Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nature Genet., 8, 345-351 (1994).
14. SCHLÜTER, C., DUCHROW, M., WOHLENBERG, C., BECKER, M.H.G., KEY, G., FLAD, H.-D. and GERDES, J., The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle maintaining protein. J. Cell Biol., 123, 513-522 (1993).
15. SEON, B.K., MATSUNO, F., HARUTA, Y., KONDO, M. and BARCOS, M., Long lasting complete inhibition of human solid tumors in SCID mice by targeting endothelial cells of tumor vasculature with antihuman endoglin immunotoxin. Clin. Cancer Res. 3, 1031-1044 (1997).
16. SEWING, A., BÜRGER, C., BRÜSSELBACH, S., SCHALK, C., LUCIBELLO, F.C. and MüLLER, R., Human cyclin Dl encodes a labile nuclear protein whose synthesis is directly induced by growth factors and suppressed by cyclic AMP. J. Cell Sci., 104, 545-555 (1993).
17. THORNTON, S.C., MUELLER, S.N. and LEVINE, E.M., Human endothelial cells: use of heparin in cloning and long-term serial cultivation. Science, 222, 623-625 (1983).
18. THORPE, P.E. and BURROWS, F.J., Antibody-directed targeting of the vasculature of solid tumors. Breast Cancer Res. Treat., 36, 237-251 (1995).
19. VARTANIAN, R.K. and WEIDNER, N., Correlation of intratumoral endothelial cell proliferation with microvessel density (tumor angiogenesis) and tumor cell proliferation in breast carcinoma. Amer. J. Pathol., 144, 1188-1194 (1994).
20. WEIDNER, N., SEMPLE, J.P., WELCH, W.R. and FOLKMAN, J., Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. New Engl. J. Med., 324, 1-8 (1991).
21. WRANA, J.L., ATTISANO, L., WIESER, R., VENTURA, F. and MASSAGUÉ, J., Mechanism of activation of the TGF-β receptor. Nature (Lond.), 370, 341-347 (1994).
22. YANG, E.Y. and MOSES, H.L., Changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane. J. Cell Biol., 111, 732-741 (1990).
23. YINGLING, J.M., WANG, X.-F. and BASSING, C.H., Signaling by the transforming growth factor-β receptors. Biochim. biophys. Acta, 1242, 115-136 (1995).