Presenilin Modulates Pen-2 Levels Posttranslationally by Protecting It from Proteasomal Degradation

Biochemistry

Volumn 43, Issue 12, 2004, Pages 3555-3563

  Crystal, Adam S ^a   Morais, Vanessa A ^a,b,c   Fortna, Ryan R ^a   Carlin, Dan ^a   Pierson, Theodore C ^a   Wilson, Christina A ^d   Lee, Virginia M Y ^d   Doms, Robert W ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^c INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLÓGICA   (Portugal)

^d Center for Neurodegenerative Disease Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; DEGRADATION; DISEASES; GENES; PATHOLOGY; RNA;

STEADY-STATE LEVELS; TRANSGENIC MOUSE MODELS;

PROTEINS;

AMYLOID PRECURSOR PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; GAMMA SECRETASE; MEMBRANE PROTEIN; MESSENGER RNA; NERVE CELL ADHESION MOLECULE; NICASTRIN; NOTCH RECEPTOR; PRESENILIN 1; PRESENILIN 2; PROTEIN PEN2; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL CULTURE; COMPLEX FORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DEGRADATION KINETICS; GENETIC DISORDER; HALF LIFE TIME; HUMAN; HUMAN CELL; MEMBRANE BINDING; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DEFECT; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REGULATORY MECHANISM; STEADY STATE; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CELL LINE; CYSTEINE ENDOPEPTIDASES; ENDOPEPTIDASES; ENDOPLASMIC RETICULUM; HALF-LIFE; HUMANS; MEMBRANE PROTEINS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, TRANSGENIC; MULTIENZYME COMPLEXES; PRESENILIN-1; PRESENILIN-2; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; QUAIL; TRANSCRIPTION, GENETIC;

ANIMALIA; MUS MUSCULUS;

EID: 1642267052     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0361214     Document Type: Article

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