Cu/Zn superoxide dismutase mutants associated with amyotrophic lateral sclerosis show enhanced formation of aggregates in vitro

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 12, 2003, Pages 7021-7026

  Stathopulos, P B ^a   Rumfeldt, J A O ^a   Scholz, G A ^a   Irani, R A ^a   Frey, H E ^a   Hallewell, R A ^c   Lepock, J R ^b   Meiering, E M ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER; RECOMBINANT ENZYME; SUPEROXIDE DISMUTASE; ZINC;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CORRELATION ANALYSIS; CYTOTOXICITY; DIFFERENTIAL SCANNING CALORIMETRY; DISEASE ASSOCIATION; GENE MUTATION; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN FOLDING; PROTEIN STABILITY; STRUCTURE ACTIVITY RELATION; THERMOSTABILITY;

AMYOTROPHIC LATERAL SCLEROSIS; APOENZYMES; ENZYME STABILITY; HEAT; HOLOENZYMES; HUMANS; MACROMOLECULAR SUBSTANCES; MICROSCOPY, ELECTRON; MUTATION; PROTEIN FOLDING; RECOMBINANT PROTEINS; SUPEROXIDE DISMUTASE; TRIFLUOROETHANOL;

EID: 0037795635     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.1237797100     Document Type: Article

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