Point substitution in the central hydrophobic cluster of a human β- amyloid congener disrupts peptide folding and abolishes plaque competence

Biochemistry

Volumn 35, Issue 44, 1996, Pages 13914-13921

  Esler, William P ^a   Stimson, Evelyn R ^a   Ghilardi, Joseph R ^b   Lu, Yi An ^c   Felix, Arthur M ^c   Vinters, Harry V ^d   Mantyh, Patrick W ^b   Lee, Jonathan P ^e   Maggio, John E ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c HOFFMANN LA ROCHE INC   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e Boston University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; AMYLOID BETA PROTEIN; PEPTIDE;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; AUTORADIOGRAPHY; BRAIN; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; HYDROPHOBICITY; IMMUNOHISTOCHEMISTRY; MALE; MASS SPECTROMETRY; MEMBRANE BINDING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN FOLDING; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SENILE PLAQUE; SILVER STAINING;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; NEUROFIBRILLARY TANGLES; PEPTIDE FRAGMENTS; POINT MUTATION; PROTEIN FOLDING; SOLUBILITY;

EID: 0029854533     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi961302+     Document Type: Article

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