Deletion of Fcγ receptor IIB renders H-2b mice susceptible to collagen-induced arthritis

Journal of Experimental Medicine

Volumn 189, Issue 1, 1999, Pages 187-194

  Yuasa, Takae ^a,b   Kubo, Satoshi ^a   Yoshino, Tadashi ^c   Ujike, Azusa ^a,b   Matsumura, Kimio ^a   Ono, Masao ^a,b   Ravetch, Jeffrey V ^d   Takai, Toshiyuki ^a,b  

^a TOHOKU UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

^d ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Autoimmunity; Collagen induced arthritis; Fc receptor; Gene targeting; Macrophage

Indexed keywords

ANTIBODY; COLLAGEN; CYTOKINE; FC RECEPTOR; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; FC GAMMA RECEPTOR IIB; H2 ANTIGEN; INTERLEUKIN 1; LEUKOCYTE ANTIGEN;

ANIMAL CELL; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIGEN ANTIBODY COMPLEX; ARTICLE; AUTOIMMUNITY; CYTOKINE PRODUCTION; GENE TARGETING; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; ANIMAL; BLOOD; CARTILAGE; CATTLE; DISEASE MODEL; IMMUNOLOGY; LIMB; METABOLISM; MOUSE MUTANT; PATHOLOGY; PERITONEUM MACROPHAGE; SECRETION;

ANIMALS; ANTIBODIES; ANTIGENS, CD; ARTHRITIS, RHEUMATOID; AUTOIMMUNITY; CARTILAGE; CATTLE; COLLAGEN; DISEASE MODELS, ANIMAL; EXTREMITIES; H-2 ANTIGENS; INTERLEUKIN-1; MACROPHAGES, PERITONEAL; MICE; MICE, KNOCKOUT; RECEPTORS, IGG;

EID: 0033521239     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.189.1.187     Document Type: Article

References (49)

1. Ravetch, J.V., and J.-P. Kinet. 1991. Fc receptors. Annu. Rev. Immunol. 9:457-492.
2. Metzger, H. 1992. The receptor with high affinity for IgE. Immunol. Rev. 125:37-48.
3. Fridman, W.H., C. Bonnerot, M. Daëron, S. Amigorena, J.L. Teillaud, and C. Sautes. 1992. Structural bases of Fcγ receptor functions. Immunol. Rev. 125:49-76.
4. van de Winkel, J.G.J., and P.J.A. Capel. 1993. Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications. Immunol. Today. 14:215-221.
5. Ravetch, J.V. 1994. Fc receptors: rubor redux. Cell. 78:553-560.
6. Takai, T., and J.V. Ravetch. 1999. Fc receptor genetics and the manipulation of genes in the study of FcR biology. In Immunoglobulin Receptors and Their Physiological and Pathological Roles in Immunity. J.G.J. van de Winkel and P.M. Hogarth, editors. Kluwer Academic Publishers Group, Netherlands. In press.
7. Greenberg, S., P. Chang, and S.C. Silverstein. 1993. Tyrosine phosphorylation is required for Fc receptor-mediated phagocytosis in mouse macrophages. J. Exp. Med. 177:529-534.
8. Crowley, M.T., P.S. Costello, C.J. Fitzer-Attas, M. Turner, F. Meng, C. Lowell, V.L.J. Tybulewicz, and A.L. DeFranco. 1997. A critical role for Syk in signal transduction and phagocytosis mediated by Fcγ receptors on macrophages. J. Exp. Med. 186:1027-1039.
9. Gavin, A.L., N. Bames, H.M. Dijstelbloem, and P.M. Hogarth. 1998. Identification of the mouse IgG3 receptor: implications for antibody effector function at the interface between innate and adaptive immunity. J. Immunol. 160:20-23.
10. Fanger, N.A., D. Voigtlaender, C. Liu, S. Swink, K. Wardwell, J. Fisher, R.F. Graziano, L.C. Pfefferkorn, and P.M. Guyre. 1997. Characterization of expression, cytokine regulation, and effector function of the high affinity IgG receptor Fc gamma RI (CD64) expressed on human blood dendritic cells J. Immunol. 158:3090-3098.
11. Hazenbos, W.L.W., J.E. Gessner, F.M.A. Hofhuis, H. Kuipers, D. Meyer, I.A.F.M. Heijnen, R.E. Schmidt, M. Sandor, P.J.A. Capel, M. Däeron, et al. 1996. Impaired IgG-dependent anaphylaxis and Arthus reaction in FcγRIII (CD16) deficient mice. Immunity. 5:181-188.
12. Takai, T., M. Li, D. Sylvestre, R. Clynes, and J.V. Ravetch. 1994. FcR γ chain deletion results in pleiotrophic effector cell defects. Cell. 76:519-529.
13. Clynes, R., and J.V. Ravetch. 1995. Cytotoxic antibodies trigger inflammation through Fc receptors. Immunity. 3:21-26.
14. Dombrowicz, D., V. Flamand, K.K. Brigman, B.H. Koller, and J.-P. Kinet. 1993. Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor a chain gene. Cell. 75:969-976.
15. Miyajima, I., D. Dombrowicz, T.R. Martin, J.V. Ravetch, J.P. Kinet, and S.J. Galli. 1997. Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and FcγRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis. J. Clin. Invest. 99:901-914.
16. Dombrowicz, D., V. Flamand, I. Miyajima, J.V. Ravetch, S.J. Galli, and J.-P. Kinet. 1997. Absence of Fc∈RI α chain results in upregulation of FcγRIII-dependent mast cell degranulation and anaphylaxis. Evidence of competition between Fc∈RI and FcγRIII for limiting amounts of FcR β and γ chain. J. Clin. Invest. 99:915-925.
17. Sylvestre, D.L., and J.V. Ravetch. 1994. Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade. Science. 265:1095-1098.
18. Sylvestre, D.L., and J.V. Ravetch. 1996. A dominant role for mast cell Fc receptors in the Arthus reaction. Immunity. 5:387-390.
19. Sylvestre, D., R. Clynes, M. Ma, H. Warren, M.C. Carroll, and J.V. Ravetch. 1996. Immunoglobulin G-mediated inflammatory responses develop normally in complement-deficient mice. J. Exp. Med. 184:2385-2392.
20. Clynes, R., C. Dumitru, and J.V. Ravetch. 1998. Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis. Science. 279:1052-1054.
21. Clynes, R., Y. Takechi, Y. Moroi, A. Houghton, and J.V. Ravetch. 1998. Fc receptors are required in passive and active immunity to melanoma. Proc. Natl. Acad. Sci. USA. 95: 652-656.
22. Daëron, M., S. Latour, O. Malbec, E. Espinosa, P. Pina, S. Pasmans, and W.H. Fridman. 1995. The same tyrosine-based inhibition motif, in the intracytoplasmic domain of FcγRIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation. Immunity. 3:635-646.
23. Muta, T., T. Kurosaki, Z. Misulovin, M. Sanchez, M.C. Nussenzweig, and J.V. Ravetch. 1994. A 13-amino-acid motif in the cytoplasmic domain of FcγRIIB modulates B-cell receptor signalling. Nature. 368:70-73.
24. Ono, M., S. Bolland, P. Tempst, and J.V. Ravetch. 1996. Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FcγRIIB. Nature. 383: 263-266.
25. Clynes, R., J.S. Maizes, R. Guinamard, M. Ono, T. Takai, and J.V. Ravetch. 1999. Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors. J. Exp. Med. 189: 179-185.
26. Takai, T., M. Ono, M. Hikida, H. Ohmori, and J.V. Ravetch. 1996. Augmented humoral and anaphylactic responses in FcγRII-deficient mice. Nature. 379:346-349.
27. Courtenay, J.S., M.J. Dallman, A.D. Dayan, A. Marten, and B. Mosedale. 1980. Immunization against heterologous type II collagen induces arthritis in mice. Nature. 283:666-668.
28. Holmdahl, R., L. Jansson, D. Gullberg, K. Rubin, P.O. Forsberg, and L. Klareskog. 1985. Incidence of arthritis and autoreactivity of anti-collagen antibodies after immunization of DBA/1 mice with heterologous and autologous collagen II. Clin. Exp. Immunol. 62:639-646.
29. Trentham, D.E., A.S. Townes, and A.H. Kang. 1977. Autoimmunity to type II collagen: an experimental model of arthritis J. Exp. Med. 146:857-868.
30. Trentham, D.E., A.S. Townes, A.H. Kang, and J.R. David. 1978. Humoral and cellular sensitivity to collagen in type II collagen-induced arthritis in rats. J. Clin. Invest. 61:89-96.
31. Feldmann, M., F.M. Brennan, and R.N. Maini. 1996. Rheumatoid arthritis. Cell. 85:307-310.
32. Nabozny, G.H., J.M. Baisch, S. Cheng, D. Cosgrove, M.M. Griffiths, H.S. Luthra, and C.S. David. 1996. HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: a novel model for human polyarthritis. J. Exp. Med. 183:27-37.
33. Wooley, P.H., H.S. Luthra, J.M. Stuart, and S.C. David. 1981. Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I-region) linkage and antibody correlates. J. Exp. Med. 154:688-700.
34. Wooley, P.H., H.S. Luthra, M.M. Griffiths, J.M. Stuart, A. Huse, and C.S. David. 1985. Type II collagen-induced arthritis in mice. IV. Variations in immunogenetic regulation provide evidence for multiple arthritogenic epitopes on the collagen molecule. J. Immunol. 135:2443-2451.
35. Brunsberg, U., K. Gustafson, L. Jansson, E. Michaëlsson, L. Ährlund-Richter, S. Pettersson, R. Mattsson, and R. Holmdahl. 1994. Expression of transgenic class II Ab gene confers susceptibility to collagen-induced arthritis. Eur. J. Immunol. 24:1698-1702.
36. Ranges, G.E., S. Sriram, and S.M. Cooper. 1985. Prevention of type II collagen-induced arthritis by in vivo treatment with anti-L3T4J. Exp. Med. 162:1105-1110.
37. Chiocchia, G., M.C. Boissier, and C. Fournier. 1991. Therapy against murine collagen-induced arthritis with T cell receptor Vβ-specific antibodies. Eur. J. Immunol. 21:2899-2905.
38. Mo, J., A. Scheynius, and R. Holmdahl. 1994. Antibody recognition of mouse cartilage in vivo; epitope- and idiotype-specific binding and inhibition. Scand. J. Immunol. 39:122-130.
39. Stuart, J.M., and F.J. Dixon. 1983. Serum transfers of collagen-induced arthritis in mice. J. Exp. Med. 158:378-392.
40. Holmdahl, R., M. Andersson, T.J. Goldshmidt, K. Gustafsson, L. Jansson, and J.A. Mo. 1990. Type II collagen autoimmunity in animals and provocations leading to arthritis. Immunol. Rev. 118:193-232.
41. Holmdahl, R., C. Vingsbo, V. Malmström, L. Jansson, and M. Holmdahl. 1994. Chronicity of arthritis induced with homologous type II collagen (CII) in rats is dependent on anti-CII B-cell activation. J. Autoimmun. 7:739-752.
42. Seki, N., Y. Sudo, T. Yoshioka, S. Sugihara, T. Fujitsu, S. Sakuma, T. Ogawa, T. Hamaoka, H. Senoh, and H. Fujiwara. 1988. Type II collagen-induced murine arthritis. Induction and perpetuation of arthritis require synergy between humoral and cell-mediated immunity. J. Immunol. 140:1477- 1484.
43. Svensson, L., J. Jirholt, R. Holmdahl, and L. Jansson. 1998. B cell-deficient mice do not develop type II collagen-induced arthritis (CIA). Clin. Exp. Immunol. 111:521-526.
44. Ohmori, H., N. Hase, M. Hikida, T. Takai, and N. Endo. 1992. Enhancement of antigen-induced interleukin 4 and IgE production by specific IgG1 in murine lymphocytes. Cell. Immunol. 145:299-310.
45. Brennan, F.M., D. Chantry, A. Jackson, R. Maini, and M. Feldmann. 1989. Inhibitory effect of TNFα antibodies on synovial cell interleukin-1 production in rheumatoid arthritis. Lancet. 2:244-247.
46. Thorbecke, G.J., R. Shah, C.H. Leu, A.P. Kuruvilla, A.M. Hardison, and M.A. Palladino. 1992. Involvement of endogenous tumour necrosis factor α and transforming growth factor β during induction of collagen type arthritis in mice. Proc. Natl. Acad. Sci. USA. 89:7375-7379.
47. Williams, R.O., L.J. Mason, M. Feldmann, and R.N. Maini. 1994. Synergy between anti-CD4 and anti-TNF in the amelioration of established collagen-induced arthritis. Proc. Natl. Acad. Sci. USA. 91:2762-2766.
48. Mulherin, D., O. Fitzgerald, and B. Bresnihan. 1996. Synovial tissue macrophage populations and articular damage in rheumatoid arthritis. Arthritis Rheum. 39:115-124.
49. van Lent, P.L., A.E. Holthuysen, L. van den Bresselaar, N. van Rooijen, L.B. van de Putte, and W.B. van den Berg. 1995. Role of macrophage-like synovial lining cells in localization and expression of experimental arthritis. Scand. J. Rheumatol. 24(Suppl. 101):83-89.