Balanced macrophage activation hypothesis: A biological model for development of drugs targeted at macrophage functional states

Pathobiology

Volumn 67, Issue 5-6, 1999, Pages 277-281

  McGrath, Michael S ^a   Kodelja, Vitam ^b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b OXO Chemie   (Switzerland)

^c OXO Chemie   (Germany)

Author keywords

AIDS; Autoimmune disease; Immune activation; Inflammation; Macrophage; WF10

Indexed keywords

ANTIRETROVIRUS AGENT; TETRACHLORODECAOXIDE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; CONFERENCE PAPER; DRUG TARGETING; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; MACROPHAGE ACTIVATION; PRIORITY JOURNAL;

EID: 0343340411     PISSN: 10152008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000028079     Document Type: Conference Paper

References (9)

1. Kühne FW: Die erwünschte Sauerstoffaktivierung, dokumentiert am Beispiel der Wundheilung: der Weg zur Oxoferin-Therapie; in Elsmer EF, Bors W, Wilmanns W (eds): Reaktive Sauerstoffspezies in der Medizin, Berlin, Springer, 1986, pp 5-15.
2. Raffanti SP, Schaffner W, Federspiel CF, Blackwell RB, Ching OA, Kühne FW: Randomized, double-blind, placebo-controlled trial of the immune modulator WF10 in patients with advanced AIDS. Infection 1998;26: 201-206.
3. Hinz H, Hautzinger H, Stahl KW: Rationale for and results from a randomized double-blind trial of tctrachlorodecaoxygen anion complex in wound healing. Lancet 1986;1: 825-828.
4. Goerdt S, Orfanos CE: Other functions, other genes: Alternative activation of antigen-presenting cells. Immunity 1999;10:137-142.
5. Kodelja V, Müller C, Politz O, Hakij N, Orfanos CE, Goerdt S: Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1α with a Th2-associated expression pattern. J Immunol 1998;160:1411-1418.
6. McGrath MS, Benike C, Kuehne FW, Engleman E: Effect of WF10 (TCDO) on antigen presentation. Transplant Proc 1998;30:4200-4204.
7. McGrath MS, Gascon R, Kahn J, Ah Ching O. Kühne F, Pulliam L, Herndier B: Blood macrophage TNF-α expression, elevated in AIDS dementia, is down-regulated by in vitro WF10 exposure (abstract 2046). Keystone Symposia on Molecular and Cellular Biology, Park City, 1998.
8. Uttaravichien T, et al: A prospective study to evaluate the use of WF10 in the treatment of post-radiation cystitis. Submitted.
9. Herndier B, Lull R, Ah Ching O, Broz M, Kuehne FW, Kahn J: Immunological parameters modified in HIV disease by the macrophage activity immunomodulator WF10 (a phase II pathogenesis study) (abstract 22417). 12th World AIDS Conference, Geneva, 1998.