메뉴 건너뛰기




Volumn 16, Issue 2, 2004, Pages 151-156

Aging, immunity and cancer

Author keywords

FDC; Follicular dendritic cell; IFN; IL; Interferon; Interleukin; Leukemia inhibitory factor; LIF; M CSF; Macrophage colony stimulating factor; Natural killer; NK; Oncostatin M; OSM; SCF; Stem cell factor; T cell receptor; TCR; TEC; Thymic epithelial cell; TNF

Indexed keywords

AGING; B LYMPHOCYTE; CANCER SUSCEPTIBILITY; CANCER THERAPY; CELL ACTIVITY; CELL COUNT; CELL FUNCTION; CELL INTERACTION; CELL POPULATION; CELL RENEWAL; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DOWN REGULATION; EFFECTOR CELL; GENE EXPRESSION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMORAL IMMUNITY; IMMUNE DEFICIENCY; IMMUNE SYSTEM; IMMUNITY; IMMUNOSURVEILLANCE; MEMORY CELL; METASTASIS; MOLECULAR DYNAMICS; NATURAL KILLER CELL; NONHUMAN; PROGNOSIS; PROTEIN EXPRESSION; REVIEW; T LYMPHOCYTE; THYMUS FUNCTION;

EID: 1542321222     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2004.01.009     Document Type: Review
Times cited : (141)

References (58)
  • 3
    • 0036584494 scopus 로고    scopus 로고
    • T cells and aging, January 2002 update
    • This exhaustive review covers both epidemiological characteristics and cellular mechanisms of T-cell immunosenescence, with particular attention to the growing body of studies under the SENIEUR protocol.
    • Pawelec G., Barnett Y., Forsey R., Frasca D., Globerson A., McLeod J., Caruso C., Franceschi C., Fulop T., Gupta S.et al. T cells and aging, January 2002 update. Front Biosci. 7:2002;d1056-d1183 This exhaustive review covers both epidemiological characteristics and cellular mechanisms of T-cell immunosenescence, with particular attention to the growing body of studies under the SENIEUR protocol.
    • (2002) Front Biosci , vol.7 , pp. 1056-d1183
    • Pawelec, G.1    Barnett, Y.2    Forsey, R.3    Frasca, D.4    Globerson, A.5    McLeod, J.6    Caruso, C.7    Franceschi, C.8    Fulop, T.9    Gupta, S.10
  • 4
    • 0035137939 scopus 로고    scopus 로고
    • The SENIEUR protocol after 16 years: The next step is to study the interaction of ageing and disease
    • Ligthart G.H. The SENIEUR protocol after 16 years: the next step is to study the interaction of ageing and disease. Mech Ageing Dev. 122:2001;136-140.
    • (2001) Mech Ageing Dev , vol.122 , pp. 136-140
    • Ligthart, G.H.1
  • 5
    • 0036644685 scopus 로고    scopus 로고
    • Is human immunosenescence clinically relevant? Looking for 'immunological risk phenotypes'
    • Pawelec G., Ouyang Q., Colonna-Romano G., Candore G., Lio D., Caruso C. Is human immunosenescence clinically relevant? Looking for 'immunological risk phenotypes'. Trends Immunol. 23:2002;330-332.
    • (2002) Trends Immunol , vol.23 , pp. 330-332
    • Pawelec, G.1    Ouyang, Q.2    Colonna-Romano, G.3    Candore, G.4    Lio, D.5    Caruso, C.6
  • 6
    • 0037398104 scopus 로고    scopus 로고
    • Survival in a population sample is predicted by proportions of lymphocyte subsets
    • Huppert F.A., Pinto E.M., Morgan K., Brayne C. Survival in a population sample is predicted by proportions of lymphocyte subsets. Mech Ageing Dev. 124:2003;449-451.
    • (2003) Mech Ageing Dev , vol.124 , pp. 449-451
    • Huppert, F.A.1    Pinto, E.M.2    Morgan, K.3    Brayne, C.4
  • 7
    • 0028606349 scopus 로고
    • Age-related decline in proliferative potential of purified stem cell candidates
    • Lansdorp P.M., Dragowska W., Thomas T.E., Little M.T., Mayani H. Age-related decline in proliferative potential of purified stem cell candidates. Blood Cells. 20:1994;376-380.
    • (1994) Blood Cells , vol.20 , pp. 376-380
    • Lansdorp, P.M.1    Dragowska, W.2    Thomas, T.E.3    Little, M.T.4    Mayani, H.5
  • 8
    • 0029035273 scopus 로고
    • Bone marrow progenitor cell growth and karyotype changes in healthy 88-year-old subjects
    • Nilsson-Ehle H., Swolin B., Westin J. Bone marrow progenitor cell growth and karyotype changes in healthy 88-year-old subjects. Eur J Haematol. 55:1995;14-18.
    • (1995) Eur J Haematol , vol.55 , pp. 14-18
    • Nilsson-Ehle, H.1    Swolin, B.2    Westin, J.3
  • 9
    • 0034663420 scopus 로고    scopus 로고
    • Age-related changes of human bone marrow: A histometric estimation of proliferative cells, apoptotic cells, T cells, B cells and macrophages
    • Ogawa T., Kitagawa M., Hirokawa K. Age-related changes of human bone marrow: a histometric estimation of proliferative cells, apoptotic cells, T cells, B cells and macrophages. Mech Ageing Dev. 117:2000;57-68.
    • (2000) Mech Ageing Dev , vol.117 , pp. 57-68
    • Ogawa, T.1    Kitagawa, M.2    Hirokawa, K.3
  • 11
    • 0025688052 scopus 로고
    • In vitro analysis of age-related changes in the developmental potential of bone marrow thymocyte progenitors
    • Sharp A., Kukulansky T., Globerson A. In vitro analysis of age-related changes in the developmental potential of bone marrow thymocyte progenitors. Eur J Immunol. 20:1990;2541-2546.
    • (1990) Eur J Immunol , vol.20 , pp. 2541-2546
    • Sharp, A.1    Kukulansky, T.2    Globerson, A.3
  • 12
    • 0031985281 scopus 로고    scopus 로고
    • Impaired ability of bone marrow stromal cells to support B-lymphopoiesis with age
    • Stephan R.P., Reilly C.R., Witte P.L. Impaired ability of bone marrow stromal cells to support B-lymphopoiesis with age. Blood. 91:1998;75-88.
    • (1998) Blood , vol.91 , pp. 75-88
    • Stephan, R.P.1    Reilly, C.R.2    Witte, P.L.3
  • 13
    • 0034715948 scopus 로고    scopus 로고
    • Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: An 11-year follow-up study of a general population
    • Imai K., Matsuyama S., Miyake S., Suga K., Nakachi K. Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population. Lancet. 356:2000;1795-1799.
    • (2000) Lancet , vol.356 , pp. 1795-1799
    • Imai, K.1    Matsuyama, S.2    Miyake, S.3    Suga, K.4    Nakachi, K.5
  • 14
    • 0035123548 scopus 로고    scopus 로고
    • Prognostic significance of natural killer cell activity in patients with gastric carcinoma: A multivariate analysis
    • Takeuchi H., Maehara Y., Tokunaga E., Koga T., Kakeji Y., Sugimachi K. Prognostic significance of natural killer cell activity in patients with gastric carcinoma: a multivariate analysis. Am J Gastroenterol. 96:2001;574-578.
    • (2001) Am J Gastroenterol , vol.96 , pp. 574-578
    • Takeuchi, H.1    Maehara, Y.2    Tokunaga, E.3    Koga, T.4    Kakeji, Y.5    Sugimachi, K.6
  • 16
    • 0033788507 scopus 로고    scopus 로고
    • Functional alteration of granulocytes, NK cells, and natural killer T cells in centenarians
    • Miyaji C., Watanabe H., Toma H., Akisaka M., Tomiyama K., Sato Y., Abo T. Functional alteration of granulocytes, NK cells, and natural killer T cells in centenarians. Hum Immunol. 61:2000;908-916.
    • (2000) Hum Immunol , vol.61 , pp. 908-916
    • Miyaji, C.1    Watanabe, H.2    Toma, H.3    Akisaka, M.4    Tomiyama, K.5    Sato, Y.6    Abo, T.7
  • 17
    • 0034907247 scopus 로고    scopus 로고
    • The unexpected contribution of immunosenescence to the leveling off of cancer incidence and mortality in the oldest old
    • Bonafe M., Valensin S., Gianni W., Marigliano V., Franceschi C. The unexpected contribution of immunosenescence to the leveling off of cancer incidence and mortality in the oldest old. Crit Rev Oncol Hematol. 39:2001;227-233.
    • (2001) Crit Rev Oncol Hematol , vol.39 , pp. 227-233
    • Bonafe, M.1    Valensin, S.2    Gianni, W.3    Marigliano, V.4    Franceschi, C.5
  • 18
    • 0033854211 scopus 로고    scopus 로고
    • The effect of age on the B-cell repertoire
    • Weksler M.E., Szabo P. The effect of age on the B-cell repertoire. J Clin Immunol. 20:2000;240-249.
    • (2000) J Clin Immunol , vol.20 , pp. 240-249
    • Weksler, M.E.1    Szabo, P.2
  • 19
    • 0036901212 scopus 로고    scopus 로고
    • The effect of age on immunologic response to recombinant hepatitis B vaccine: A meta-analysis
    • Fisman D.N., Agrawal D., Leder K. The effect of age on immunologic response to recombinant hepatitis B vaccine: a meta-analysis. Clin Infect Dis. 35:2002;1368-1375.
    • (2002) Clin Infect Dis , vol.35 , pp. 1368-1375
    • Fisman, D.N.1    Agrawal, D.2    Leder, K.3
  • 20
  • 21
    • 0031464890 scopus 로고    scopus 로고
    • Immunosenescence and germinal center reaction
    • Zheng B., Han S., Takahashi Y., Kelsoe G. Immunosenescence and germinal center reaction. Immunol Rev. 160:1997;63-77.
    • (1997) Immunol Rev , vol.160 , pp. 63-77
    • Zheng, B.1    Han, S.2    Takahashi, Y.3    Kelsoe, G.4
  • 22
    • 0036772765 scopus 로고    scopus 로고
    • Age-related depression of FDC accessory functions and CD21 ligand-mediated repair of co-stimulation
    • This paper examines the potential role of follicular dendritic cells (FDCs) in the changes of B-cell function in aging. Young and old FDCs were combined with young B and T cells in an in vitro germinal center, demonstrating a loss in ovalbumin -specific antibody response with older FDCs.
    • Aydar Y., Balogh P., Tew J.G., Szakal A.K. Age-related depression of FDC accessory functions and CD21 ligand-mediated repair of co-stimulation. Eur J Immunol. 32:2002;2817-2826 This paper examines the potential role of follicular dendritic cells (FDCs) in the changes of B-cell function in aging. Young and old FDCs were combined with young B and T cells in an in vitro germinal center, demonstrating a loss in ovalbumin -specific antibody response with older FDCs.
    • (2002) Eur J Immunol , vol.32 , pp. 2817-2826
    • Aydar, Y.1    Balogh, P.2    Tew, J.G.3    Szakal, A.K.4
  • 26
    • 0034124915 scopus 로고    scopus 로고
    • The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection
    • Haynes B.F., Markert M.L., Sempowski G.D., Patel D.D., Hale L.P. The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Annu Rev Immunol. 18:2000;529-560.
    • (2000) Annu Rev Immunol , vol.18 , pp. 529-560
    • Haynes, B.F.1    Markert, M.L.2    Sempowski, G.D.3    Patel, D.D.4    Hale, L.P.5
  • 27
    • 0035126095 scopus 로고    scopus 로고
    • 11-color, 13-parameter flow cytometry: Identification of human naive T cells by phenotype, function, and T-cell receptor diversity
    • De Rosa S.C., Herzenberg L.A., Roederer M. 11-color, 13-parameter flow cytometry: identification of human naive T cells by phenotype, function, and T-cell receptor diversity. Nat Med. 7:2001;245-248.
    • (2001) Nat Med , vol.7 , pp. 245-248
    • De Rosa, S.C.1    Herzenberg, L.A.2    Roederer, M.3
  • 30
    • 0036311982 scopus 로고    scopus 로고
    • Molecular characterization of the mouse involuted thymus: Aberrations in expression of transcription regulators in thymocyte and epithelial compartments
    • This paper analyzes the timecourse of molecular changes characterizing thymic involution, separately analyzing changes in the epithelial and thymocyte populations. The authors demonstrate that thymic involution results from an array of molecular changes in both thymocytes and TECs.
    • Ortman C.L., Dittmar K.A., Witte P.L., Le P.T. Molecular characterization of the mouse involuted thymus: aberrations in expression of transcription regulators in thymocyte and epithelial compartments. Int Immunol. 14:2002;813-822 This paper analyzes the timecourse of molecular changes characterizing thymic involution, separately analyzing changes in the epithelial and thymocyte populations. The authors demonstrate that thymic involution results from an array of molecular changes in both thymocytes and TECs.
    • (2002) Int Immunol , vol.14 , pp. 813-822
    • Ortman, C.L.1    Dittmar, K.A.2    Witte, P.L.3    Le P., T.4
  • 31
    • 0344043443 scopus 로고    scopus 로고
    • Checkpoints in thymocytopoiesis in aging: Expression of the recombination activating genes RAG-1 and RAG-2
    • Yehuda A.B., Friedman G., Wirtheim E., Abel L., Globerson A. Checkpoints in thymocytopoiesis in aging: expression of the recombination activating genes RAG-1 and RAG-2. Mech Ageing Dev. 102:1998;239-247.
    • (1998) Mech Ageing Dev , vol.102 , pp. 239-247
    • Yehuda, A.B.1    Friedman, G.2    Wirtheim, E.3    Abel, L.4    Globerson, A.5
  • 32
    • 0037012030 scopus 로고    scopus 로고
    • Age-associated thymic atrophy is linked to a decline in IL-7 production
    • Andrew D., Aspinall R. Age-associated thymic atrophy is linked to a decline in IL-7 production. Exp Gerontol. 37:2002;455-463.
    • (2002) Exp Gerontol , vol.37 , pp. 455-463
    • Andrew, D.1    Aspinall, R.2
  • 33
    • 0035253734 scopus 로고    scopus 로고
    • Il-7 and not stem cell factor reverses both the increase in apoptosis and the decline in thymopoiesis seen in aged mice
    • Andrew D., Aspinall R. Il-7 and not stem cell factor reverses both the increase in apoptosis and the decline in thymopoiesis seen in aged mice. J Immunol. 166:2001;1524-1530.
    • (2001) J Immunol , vol.166 , pp. 1524-1530
    • Andrew, D.1    Aspinall, R.2
  • 34
    • 0034651657 scopus 로고    scopus 로고
    • Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy
    • Sempowski G.D., Hale L.P., Sundy J.S., Massey J.M., Koup R.A., Douek D.C., Patel D.D., Haynes B.F. Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy. J Immunol. 164:2000;2180-2187.
    • (2000) J Immunol , vol.164 , pp. 2180-2187
    • Sempowski, G.D.1    Hale, L.P.2    Sundy, J.S.3    Massey, J.M.4    Koup, R.A.5    Douek, D.C.6    Patel, D.D.7    Haynes, B.F.8
  • 35
    • 0036856473 scopus 로고    scopus 로고
    • Leukemia inhibitory factor is a mediator of Escherichia coli lipopolysaccharide-induced acute thymic atrophy
    • Sempowski G.D., Rhein M.E., Scearce R.M., Haynes B.F. Leukemia inhibitory factor is a mediator of Escherichia coli lipopolysaccharide-induced acute thymic atrophy. Eur J Immunol. 32:2002;3066-3070.
    • (2002) Eur J Immunol , vol.32 , pp. 3066-3070
    • Sempowski, G.D.1    Rhein, M.E.2    Scearce, R.M.3    Haynes, B.F.4
  • 36
    • 0037396220 scopus 로고    scopus 로고
    • Plasma cytokine profiles in elderly humans
    • This paper describes the significant increase in IL-6 levels observed even in the healthy aged.
    • Forsey R.J., Thompson J.M., Ernerudh J., Hurst T.L., Strindhall J., Johansson B., Nilsson B.O., Wikby A. Plasma cytokine profiles in elderly humans. Mech Ageing Dev. 124:2003;487-493 This paper describes the significant increase in IL-6 levels observed even in the healthy aged.
    • (2003) Mech Ageing Dev , vol.124 , pp. 487-493
    • Forsey, R.J.1    Thompson, J.M.2    Ernerudh, J.3    Hurst, T.L.4    Strindhall, J.5    Johansson, B.6    Nilsson, B.O.7    Wikby, A.8
  • 41
    • 0036867423 scopus 로고    scopus 로고
    • Divergent telomerase and CD28 expression patterns in human CD4 and CD8 T cells following repeated encounters with the same antigenic stimulus
    • Valenzuela H.F., Effros R.B. Divergent telomerase and CD28 expression patterns in human CD4 and CD8 T cells following repeated encounters with the same antigenic stimulus. Clin Immunol. 105:2002;117-125.
    • (2002) Clin Immunol , vol.105 , pp. 117-125
    • Valenzuela, H.F.1    Effros, R.B.2
  • 44
    • 0030833497 scopus 로고    scopus 로고
    • Constraints on CD4 recovery postchemotherapy in adults: Thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells
    • Hakim F.T., Cepeda R., Kaimei S., Mackall C.L., McAtee N., Zujewski J., Cowan K., Gress R.E. Constraints on CD4 recovery postchemotherapy in adults: thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells. Blood. 90:1997;3789-3798.
    • (1997) Blood , vol.90 , pp. 3789-3798
    • Hakim, F.T.1    Cepeda, R.2    Kaimei, S.3    MacKall, C.L.4    McAtee, N.5    Zujewski, J.6    Cowan, K.7    Gress, R.E.8
  • 46
    • 0031466825 scopus 로고    scopus 로고
    • Thymic aging and T-cell regeneration
    • Mackall C.L., Gress R.E. Thymic aging and T-cell regeneration. Immunol Rev. 160:1997;91-102.
    • (1997) Immunol Rev , vol.160 , pp. 91-102
    • MacKall, C.L.1    Gress, R.E.2
  • 48
    • 0034720664 scopus 로고    scopus 로고
    • Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution
    • Douek D.C., Vescio R.A., Betts M.R., Brenchley J.M., Hill B.J., Zhang L., Berenson J.R., Collins R.H., Koup R.A. Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution. Lancet. 355:2000;1875-1881.
    • (2000) Lancet , vol.355 , pp. 1875-1881
    • Douek, D.C.1    Vescio, R.A.2    Betts, M.R.3    Brenchley, J.M.4    Hill, B.J.5    Zhang, L.6    Berenson, J.R.7    Collins, R.H.8    Koup, R.A.9
  • 49
    • 0031869628 scopus 로고    scopus 로고
    • Thymic function in young/old chimeras: Substantial thymic T cell regenerative capacity despite irreversible age-associated thymic involution
    • Mackall C.L., Punt J.A., Morgan P., Farr A.G., Gress R.E. Thymic function in young/old chimeras: substantial thymic T cell regenerative capacity despite irreversible age-associated thymic involution. Eur J Immunol. 28:1998;1886-1893.
    • (1998) Eur J Immunol , vol.28 , pp. 1886-1893
    • MacKall, C.L.1    Punt, J.A.2    Morgan, P.3    Farr, A.G.4    Gress, R.E.5
  • 51
    • 0032402158 scopus 로고    scopus 로고
    • Reconstitution of the T-cell compartment after bone marrow transplantation: Restoration of the repertoire by thymic emigrants
    • Dumont-Girard F., Roux E., van Lier R.A., Hale G., Helg C., Chapuis B., Starobinski M., Roosnek E. Reconstitution of the T-cell compartment after bone marrow transplantation: restoration of the repertoire by thymic emigrants. Blood. 92:1998;4464-4471.
    • (1998) Blood , vol.92 , pp. 4464-4471
    • Dumont-Girard, F.1    Roux, E.2    Van Lier, R.A.3    Hale, G.4    Helg, C.5    Chapuis, B.6    Starobinski, M.7    Roosnek, E.8
  • 52
    • 0036645530 scopus 로고    scopus 로고
    • Suppression of lymphoma and epithelial malignancies effected by interferon gamma
    • -/- mice spontaneously develop cancers at high frequency in the second year of life.
    • -/- mice spontaneously develop cancers at high frequency in the second year of life.
    • (2002) J Exp Med , vol.196 , pp. 129-134
    • Street, S.E.1    Trapani, J.A.2    MacGregor, D.3    Smyth, M.J.4
  • 53
  • 54
    • 0034626769 scopus 로고    scopus 로고
    • The age of cancer
    • DePinho R.A. The age of cancer. Nature. 408:2000;248-254.
    • (2000) Nature , vol.408 , pp. 248-254
    • Depinho, R.A.1
  • 55
    • 0031051427 scopus 로고    scopus 로고
    • Cancer of the oldest old. What we have learned from autopsy studies
    • Stanta G., Campagner L., Cavallieri F., Giarelli L. Cancer of the oldest old. What we have learned from autopsy studies. Clin Geriatr Med. 13:1997;55-68.
    • (1997) Clin Geriatr Med , vol.13 , pp. 55-68
    • Stanta, G.1    Campagner, L.2    Cavallieri, F.3    Giarelli, L.4
  • 56
    • 0030854406 scopus 로고    scopus 로고
    • Aging and cancer: Issues of basic and clinical science
    • Ershler W.B., Longo D.L. Aging and cancer: issues of basic and clinical science. J Natl Cancer Inst. 89:1997;1489-1497.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1489-1497
    • Ershler, W.B.1    Longo, D.L.2
  • 58
    • 0037097583 scopus 로고    scopus 로고
    • Protection from thymic epithelial cell injury by keratinocyte growth factor: A new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation
    • Min D., Taylor P.A., Panoskaltsis-Mortari A., Chung B., Danilenko D.M., Farrell C., Lacey D.L., Blazar B.R., Weinberg K.I. Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation. Blood. 99:2002;4592-4600.
    • (2002) Blood , vol.99 , pp. 4592-4600
    • Min, D.1    Taylor, P.A.2    Panoskaltsis-Mortari, A.3    Chung, B.4    Danilenko, D.M.5    Farrell, C.6    Lacey, D.L.7    Blazar, B.R.8    Weinberg, K.I.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.