From naive to effector - Alterations with aging

Immunological Reviews

Volumn 160, Issue , 1997, Pages 9-18

  Linton, Phyllis Jean ^a   Haynes, Laura ^b   Tsui, Lisa ^b   Zhang, Xiaohong ^c   Swain, Susan ^b  

^a SIDNEY KIMMEL CANCER CENTER   (United States)

^b TRUDEAU INSTITUTE   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GLYCOPROTEIN P; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 3; T LYMPHOCYTE RECEPTOR;

AGING; ANIMAL CELL; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; IMMUNE RESPONSE; IMMUNOSTIMULATION; MEMORY CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; TRANSGENIC MOUSE;

AGING; ANIMALS; ANTIGENS; CD4-POSITIVE T-LYMPHOCYTES; HUMANS; IMMUNOLOGIC MEMORY; INTERLEUKIN-2; MICE; MICE, TRANSGENIC; MODELS, IMMUNOLOGICAL; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA;

EID: 0031451795     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-065X.1997.tb01023.x     Document Type: Review

References (62)

1. Ernst DN, et al. Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice. J Immunol 1990;145:1295-1302.
2. hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin A. Eur J Immunol 1989;19:977-982.
3. hi CD4+ T cells. Eur J Immunol 1991;21:273-281.
4. Ernst DN, Weigle WO, Noonan DJ, McQuitty DN, Hobbs MY The age-associated increase in IFN-gamma synthesis by mouse CD8+ T cells correlates with shifts in the frequencies of cell subsets defined by membrane CD44, CD45RB, 3G11, and MEL-14 expression. J Immunol 1993;151:575-587.
5. Utsuyama M, et al. Differential age-change in the numbers of CD4+CA45RA+ and CD4+CD29+ T cell subsets in human peripheral blood. Mech Ageing Dev 1992;63:S7-68.
6. Flurkey K, Stadecker M, Miller RA. Memory T lymphocyte hyporesponsiveness to noncognate stimuli: a key factor in age-related immunodeficiency. Eur J Immunol 1992;22:931-935.
7. Shi J, Miller RA. Differential tyrosine-specific protein phosphorylation in mouse T lymphocyte subsets: effect of age. J Immunol 1993;151:730-739.
8. Whisler RL, Grants LS. Age-related alterations in the activation and expression of phosphotyrosine kinase and protein kinase C (PKC) among human B cells. Mech Ageing Dev 1993;71:31-46.
9. Utsuyama M, Varga Z, Fukami K, Homma Y, Takenawa T, Hirokawa K. Influence of age on the signal transduction of T cells in mice. Int Immunol 1993;5:1177-1182.
10. Kirschman DA, Murasko DM. Splenic and inguinal lymph node T cells of aged mice respond differently to polyclonal and antigen-specific stimuli. Cell Immunol 1992;139:426-437.
11. Weksler ME, Hutteroth TH. Impaired lymphocyte function in aged humans. J Clin Invest 1974;53:99-104.
12. Kishimoto S, Tomino S, Mitsuya H, Fujiwara H, Tsuda H. Age-related decline in the in vitro and in vivo syntheses of anti-tetanus toxoid antibody in humans. J Immunol 1980;125:2347-2352.
13. Burns EA, Lum LG, L'Hommedieu G, Goodwin JS. Specific humoral immunity in the elderly: in vivo and in vitro response to vaccination. J Gerontol 1993;48: B231-B236.
14. Tanchot C, Rocha B. The peripheral T cell repertoire: independent homeostatic regulation of virgin and activated CD8+ T cell pools. Eur J Immunol 1995;25:2127-2136.
15. Nordin AA, Collins GD. Limiting dilution analysis of alloreactive cytotoxic precursor cells in aging mice. J Immunol 1983;131:2215-2218.
16. Negoro S, et al. Mechanisms of age-related decline in antigen-specific T cell proliferative response: IL-2 receptor expression and recombinant IL-2 induced proliferative response of purified TAC-positive T cells. Mech Ageing Dev 1986;36:223-241.
17. + cells and cell subsets from young and old mice. Cell Immunol 1994;154:264-272.
18. Kubo M, Cinader B. Polymorphism of age-related changes in interleukin (IL) production: differential changes of T helper subpopulations, synthesizing IL-2, IL-3, and IL-4. Eur J Immunol 1990;20:1289-1296.
19. Chang MP, Utsuyama M, Hirokawa K, Makinodan T. Decline in the production of interleukin-3 with age in mice. Cell Immunol 1988;115:1-12.
20. Engwerda CR, Handwerger BS, Fox BS. Aged T cells are hyporesponsive to co-stimulation mediated by CD28. J Immunol 1994;152:3740-3747.
21. Kirman I, et al. Treatment of old mice with IL-2 corrects dysregulated IL-2 and IL-4 production. Int Immunol 1996;8:1009-1015.
22. Unutzmaz D, Pileri P, Abrignani S. Antigen-independent activation of naive and memory resting T cells by a cytokine combination. J Exp Med 1994;180:1159-1164.
23. Swain SL, et al. From naive to memory T cells. Immunol Rev 1996;150:143-167.
24. Croft M, Dubey C. Accessory molecule and co-stimulation requirements for CD4 T cell response. Crit Rev Immunol 1997;17:89-118.
25. Zhang H, et al. Unequal death in T helper cell (Th) 1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid fas/fasL-mediated apoptosis. J Exp Med 1997;185:1837-1849.
26. Zhang X, Giangreco L, Broome HE, Dargan CM, Swain SL Control of CD4 effector fate: transforming growth factor b1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion. J Exp Med 1995;182:699-709.
27. Tough D, Borrow P, Sprent J. Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science 1996;272:1947-1950.
28. Kramer S, Schimpl A, Hunig T. Immunopathology of interleukin (IL) 2-deficient mice: thymus dependence and suppression by thymus-dependent cells with an intact IL-2 gene. J Exp Med 1995;182:1769-1776.
29. Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 1995;3:521-530.
30. Murasko DM, Goonewardene IM. T cell function in aging: mechanisms of decline. Annu Rev Gerontol Geriatr 1990;10:71-96.
31. Kaye J, Hsu M-L, Sauron M-E, Jameson SC, Gascoigne NRJ, Hedrick SM. Selective development of CD4+ T cells in Tg mice expressing a class II MHC-restricted antigen receptor. Nature 1989;341:746-749.
32. Croft M, Duncan DD, Swain SL. Response of naive antigen-specific CD4+ T cells in vitro: characteristics and antigen-presenting requirements. J Exp Med 1992;176:1431-1437.
33. Dubey C, Croft M, Swain SL. Co-stimulatory requirements of naive CD4+ T cells. ICAM-1 or B7-1 can costimulate naive CD4 T cell activation but both are required for optimum response. J Immunol 1995;155:45-57.
34. Jemmerson R, Morrow PR, Klinman NR, Patterson Y. Analysis of an evolutionary conserved antigenic site on mammalian cytochrome c using synthetic peptides. Proc Natl Acad Sci USA 1985;82:1508-1512.
35. McHeyzer-Williams MG, Davis MM. Antigen-specific development of primary and memory T cells in vivo. Science 1995;268:106-111.
36. Hedrick SM, Engel I, Fink PJ, Hsu M-L, Hansburg D, Matis LA. Selection of amino acid sequences in the beta chain of the T cell antigen receptor. Science 1988;239:1541-1544.
37. Balomenos D, Balderas RS, Mulvany KP, Kaye J, Kono DH. Theofilopoulos AN. Incomplete T cell receptor Vβ allelic exclusion and dual Vβ-expressing cells. J Immunol 1995;155:3308-3312.
38. Linton P-J, Haynes L, Klinman NR, Swain SL. Antigen independent changes in CD4 T cells with aging. J Exp Med 1996;184:1891-1900.
39. Swain SL. Generation and in vivo persistence of polarized Th1 and Th2 memory cells. Immunity 1994;1:543-552.
40. Luqman M, Bottomly K. Activation requirements for CD4+ T cells differing in CD45R expression. J Immunol 1992;149:2300-2306.
41. Haynes L, Linton P-J, Swain SL. Age-related changes in CD4 T cells of T cell receptor Tg mice. Mech Ageing Dev 1997;93:95-105.
42. Hirokawa K. Understanding the mechanism of the age-related decline in immune function. Nutr Rev 1992;50:361-366.
43. Swain SL, et al. Helper T-cell subsets: phenotype function and the role of lymphokines in regulating their development. Immunol Rev 1991;123:115-144.
44. Witkowski JM, Miller RA. Increased function of P-glycoprotein in T lymphocytes of aging mice. J Immunol 1993;150:1296-1306.
45. Bommhardt U, Cerottini JC, MacDonald HR. Heterogeneity in P-glycoprotein (multridrug resistance) activity among murine peripheral T cell: correlation with surface phenotype and effector function. Eur J Immunol 1994;24:2974-2981.
46. Gottesman MM, Pastan I. Biochemistry of multidrug resistance and a superfamily of membrane-associated transport proteins. Annu Rev Biochem 1993;62:385-427.
47. Juranka PF, Zastawny RL, Ling V. P-glycoprotein: multidrug-resistance and a superfamily of membrane-associated transport proteins. FASEB J 1989;3:2583-2592.
48. Witkowski JM, Li SP, Gorgas G, Miller RA. Extrusion of the P-glycoprotein substrate rhodamine-123 distinguishes CD4 memory T cell subsets that differ in IL-2-driven-IL-4 production. J Immunol 1994;153:658-665.
49. Pahlavani MA, Richardson A. The effect of age on the expression of interleukin-2. Mech Ageing Dev 1996;89:125-154.
50. Trebilcock GU, Ponnappan U. Evidence for lowered induction of nuclear factor kappa B in activated human T lymphocytes during aging. Gerontology 1996;42:137-146.
51. Trebilcock GU, Ponnappan U. Induction and regulation of NFKB during aging: role of protein kinases. Clin Immunol Immunopathol 1996;79:87-91.
52. Effros RB, Walford RL. The effect of age on the antigen-presenting mechanism in limiting dilution precursor cell frequency analysis. Cell Immunol 1984;88:531-539.
53. Shearer GM. Th1/Th2 changes in aging. Mech Ageing Dev 1997;94:1-5.
54. Swain SL. Lymphokines and the immune response: the central role of interleukin-2. Curr Opin Immunol 1991;3:304-310.
55. Van Parijs L, Biuckians A, Ibragimov A, Alt FW, Willerford DM, Abbas AK. Functional responses and apoptosis of CD25 (IL-2R alpha)-deficient T cells expressing a Tg antigen receptor. J Immunol 1997;158:3738-3745.
56. Lenardo MJ. Interleukin-2 programs mouse α/β T lymphocytes for apoptosis. Nature 1991;353:858-861.
57. Wang R, Rogers AM, Rush BJ, Russell JH. Induction of sensitivity to activation-induced death in primary CD4+ cells: a role for interleukin-2 in the negative regulation of responses by mature CD4+ T cells. Eur J Immunol 1996;26:2263-2270.
58. Kneitz B, Herrmann T, Yonehara S, Schimpl A. Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice. Eur J Immunol 1995;25:2572-2577.
59. Kramer S, Mamalaki C, Horak I, Schimpl A, Kioussis D, Hung T. Thymic selection and peptide-induced activation of T cell receptor-Tg CD8 T cells in interleukin-2-deficient mice. Eur J Immunol 1994;24:2317-2322.
60. Nakajima H, Shores EW, Noguchi M, Leonard WJ. The common cytokine receptor gamma chain plays an essential role in regulating lymphoid homeostasis. J Exp Med 1997;185:189-195.
61. Jenkins MK, Miller RA. Memory and anergy: challenges to traditional models of T lymphocyte differentiation. FASEB J 1992;6:2428-2433.
62. Dutton RW Bradley LM, Swain SL. T cell memory. Annu Rev Immunol (In press).