Dysregulation of IL-10 production with aging: Possible linkage to the age-associated decline in DHEA and its sulfated derivative

Experimental Gerontology

Volumn 31, Issue 3, 1996, Pages 393-408

  Spencer, Nina F L ^a   Norton, Steven D ^b   Harrison, Lisa Lyn ^b   Li, Gang Zhou ^a   Daynes, Raymond A ^a,c  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b Paradigm Biosciences Inc   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Aging; Autoantibodies; B1 cells; Cytokines; DHEA(S); Immunosenescence; Interleukin 10; Interleukin 6

Indexed keywords

ANIMALIA;

AUTOANTIBODY; CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 6; PRASTERONE;

AGING; ANIMAL CELL; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ANTIBODY TITER; ARTICLE; B LYMPHOCYTE ACTIVATION; GENETIC LINKAGE; IMMUNOCOMPETENCE; LYMPHOID CELL; MOUSE; NONHUMAN; PERITONEAL CAVITY; PRIORITY JOURNAL; SULFATION;

AGING; ANIMALS; AUTOANTIBODIES; B-LYMPHOCYTES; DEHYDROEPIANDROSTERONE; DEHYDROEPIANDROSTERONE SULFATE; FEMALE; INTERLEUKIN-10; MICE; MICE, INBRED CBA;

EID: 0029998281     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/0531-5565(95)02033-0     Document Type: Article

References (57)

1. ALLISON, A.C. and NAWATA, Y. Cytokines mediating the proliferation and differentiation of B-1 lymphocytes and their role in ontogeny and phylogeny. Ann. NY Acad. Sci. 651, 200-219, 1992.
2. ARANEO, B.A., DOWELL, T., TERUI, T., DEIGEL, M., and DAYNES, R.A. Dihydrotestosterone exerts a depressive influence on the production of interleukin-4 (IL-4), IL-5, and gamma-interferon, but not IL-2 by activated murine T cells. Blood 78(3), 688-699, 1991.
3. BARNES, P.F., LU, S., ABRAMS, J.S., WANG, E., YAMAMURA, M., and MODLIN, R.L. Cytokine production at the site of disease in human tuberculosis. Infect. Immunol. 61(8), 3482-3489, 1993.
4. BENJAMIN, D., KNOBLOCH, T., and DAYTON, M.A. Human B-cell interleukin-10: B-Cell lines derived from patients with acquired immunodeficiency syndrome and Burkitt's lymphoma constitutively secrete large quantities of interleukin-10. Blood 80(5), 1289-1298, 1992.
5. + B-cell clone through surface Ig and MHC class II molecules. Ann. NY Acad. Sci. 651, 228-240, 1992.
6. bp/Wts Mice. Ann. NY Acad. Sci. 651, 494-497, 1992.
7. + double positive lymphocytes with ageing and cytotoxic chemotherapy. Mech. Ageing Dev. 58(2-3), 127-138, 1991.
8. BUCKLER, A.J., VIE, H., SONENSHEIN, G.E., and MILLER, R.A. Defective T lymphocytes in old mice. Diminished production of mature c-myc RNA after mitogen exposure not attributable to alterations in transcription or RNA stability. J. Immunol. 140(7), 2442-2446, 1988.
9. CHEN, Q., DANIEL, V., MAHER, D.W., and HERSEY, P. Production of IL-10 by melanoma cells: Examination of its role in immunosuppression mediated by melanoma. Int. J. Cancer 56, 755-760, 1994.
10. CHIRGWIN, J.M., PRYZBYLA, G., MCDONALD, P.J., and RUTTER, W.J. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18(24), 5294-5299, 1979.
11. CILLARI, E., MILANO, S., DIELI, M., ARCOLEO, F., PEREGO, R., LEONI, F., GROMO, G., and SEVERN, A. Thymopentin reduces the susceptibility of aged mice to cutaneous leishmaniasis by modulating CD4 T-cell subsets. Immunology 76, 362-366, 1992.
12. CLERICI, M., WYNN, T.A., BERZOFSKY, J.A., BLATT, S.P., HENDRIX, C.W., SHER, A., COFFMAN, R.L., and SHEARER, G.M. Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus. J. Clin. Invest. 93, 768-775, 1994.
13. DAYNES, R.A. and ARANEO, B.A. Prevention and reversal of some age-associated changes in immunologic responses by supplemental dehydroepiandrosterone sulfate therapy. Aging Immunol. Infect. Dis. 3(3), 135-154, 1992.
14. DAYNES, R.A., ARANEO, B.A., ERSHLER, W.B., MALONEY. C., LI, G.-Z., and RYU, S.-Y. Altered regulation of IL-6 production with normal aging: Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative. J. Immunol. 150(12), 5219-5230, 1993.
15. DAYNES, R.A., DOWELL, T., and ARANEO, B.A. Platelet derived growth factor is a potent biologic response modifier of T cells. J. Exp. Med. 174, 1323-1334, 1991.
16. DE WAAL MALEFYT, R., HAANEN, J., SPITS. H., ROCAROLO, M.G., TE VELDE, A., FIGDOR, C., JOHNSON, K., KASTELEIN, R., YSSEL, H., and DE VRIES, J.E. Human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J. Exp. Med. 174(4), 915-924, 1991.
17. DIGHIERO, G., TRAVADE, P., CHEVRET, S., FENAUX, P., CHASTANG, C., BINET, J.L., and CLL, T.F.C.G.O. B-Cell chronic lymphocytic leukemia: Present status and future directions. Blood 78(8), 1901-1914, 1991.
18. DING, L., LINSLEY, P.S., HUANG, L.Y., GERMAIN. R., and SHEVACH, E.M. IL-10 inhibits macrophages costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J. Immunol. 151(3), 1224-1234, 1993.
19. + T cells from young and aged mice. J. Immunol. 145(5), 1295-12302, 1990.
20. ERNST, D.N., WEIGLE, W.O., MCQUITTY, D.N., ROTHERMEL, A.L., and HOBBS, M.V. Stimulation of murine T cell subsets with anti-CD3 antibody. Age-related defects in the expression of early activation molecules. J. Immunol. 142(5), 1413-1421, 1989.
21. FINKE, J., TERNES, P., MERTELSMANN, R., and DOLKEN, G. Expression of interleukin 10 in B lymphocytes of different origin. Leukemia 7(11), 1852-1857, 1993.
22. FIORENTINO, D.F., BOND. M.W., and MOSMANN. T.R. Two types of mouse T helper cell. IV. TH2 clones secrete a factor that inhibits cytokine production by TH1 clones. J. Exp. Med. 170, 2081-2095, 1989.
23. FIORENTINO, D.F., ZLOTNIK. A., MOSMANN. T.R., HOWARD, M., and O'GARRA, A. IL-10 inhibits cytokine production by activated macrophages. J. Immunol. 147(11), 3815-3822, 1991.
24. FRANCESCHI, C., MONTI, D., SANSONI, P., and CASSARIZZA, A. The immunology of exceptional individuals: The lesson of centenarians. Immunol. Today 16, 12-16, 1995.
25. GILLIS, S., KOZAK, R., DURANTE, M., and WEKSLER, M.E. Immunological studies of aging. J. Clin. Invest. 67(4), 937-942, 1981.
26. GOIDL, E.A., STASHAK, P.N., MARTIN-MCEVOY, S.J., and HIERNAUX, J.R. Age related changes in serum immunoglobulin isotypes and isotype subclass levels among standard long-lived and autoimmune and immunodeficient strains of mice. Aging Immunol. Infect. Dis. 1, 227-236, 1988.
27. GOTTESMAN, R.S., EDINGTON, J., TSIAGBE, V.K., and THORBECKE, G.J. Influence of cytokines and the effect of aging on colony formation by B-cell subsets. Aging Immunol. Infect. Dis. 4(3), 197-211, 1993.
28. HAYAKAWA, K., HARDY, R.R., HERZENBERG, L.A., and HERZENBERG, L.A. Progenitors for Ly-1 B cells are distinct from progenitors for other B cells. J. Exp. Med. 161, 1554-1468, 1985.
29. HEINE, J.W. and ADLER, W.H. The quantitative production of interferon by mitogen-stimulated mouse lymphocytes as a function of age and its effect on the lymphocytes proliferative response. J. Immunol. 118(4), 1136-1139, 1977.
30. + cells and cell subsets from young and old mice. Cell Immunol. 154, 264-272, 1994.
31. INAMIZU, T., CHANG, M.-P., and MAKINODAN. T. Influence of age on the production and regulation of interleukin-1 in mice. Immunology 55, 447-455, 1985.
32. KATO, K. and HIROKAWA, K. Qualitative and quantitative analysis of autoantibody production in aging mice. Aging Immunol. Infect. Dis. 1(3), 177-190, 1993.
33. LEVY, Y. and BROUET, J.C. Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the bcl-2 protein. J. Clin. Invest. 93, 424-428, 1994.
34. LLORENTE, L., RICHAUD-PATIN, Y., FIOR, R., ALCOCER-VARELA, J., WIJDENES, J., FOURRIER, B.M., GALANAUD, P., and EMILIE, D. In vivo production of interleukin-10 by non-T cells in rheumatoid arthritis, Sjögrens syndrome, and systemic lupus erythematosus. Arthritis Rheum. 37(11), 1647-1655, 1994.
35. LYNGBYE, J. and KROLL, J. Quantitative immunoelectrophoresis of proteins in serum from a normal population: season-, age-, and sex-related variations. Clin. Chem. 17(6), 495-500, 1971.
36. MARIOTTI, S., SANSONI, P., BARBESINO, G., CATUREGLI, P., MONTI, D., COSSARIZZA, A., GIACOMELLI, T.. PASSERI, G., FAGIOLO, U., PINCHERA, A., and FRANCESCHI, C. Thyroid and other organ-specific autoantibodies in healthy centenarians. Lancet 339, 1506-1508, 1992.
37. MILLER, R.A. Accumulation of hyporesponsive, calcium extruding memory T cells as a key feature of age-dependent immune dysfunction. Clin. Immunol. Immunopathol. 58(3), 302-317, 1991a.
38. MILLER, R.A. Aging and immune function. Int. Rev. Cytol. 124, 187-214, 1991b.
39. MOORE, K.W., O'GARRA, A., DE WAAL MALEFYT, R., VIEIRA, P., and MOSMANN, T. Interleukin-10. Annu. Rev. Immunol. 11, 165-190, 1993.
40. NAGEL, J.E., CHOPRA, R.K., CHREST, F.J., MCCOY, M.T., SCHNEIDER, E.L., HOLBROOK, N.J., and ADLER, W.H. Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors. J. Clin. Invest. 81(4), 1096-1102, 1988.
41. NAGELKERKEN, L., HERTOGH-HUIJBREGTS, A., DOBBER, R., and DRAGER, A. Age-related changes in lymphokinc production related to a decreased number of CD45RBhi T cells. Eur. J. Immunol. 21(2), 273-281, 1991.
42. O'GARRA, A., CHANG, R., GO, N., HASTINGS, R., HAUGHTON, G., and HOWARD. M. Ly-1 B (B-1) cells are the main source of B cell derived interleukin 10. Eur. J. Immunol. 22, 711-717, 1992.
43. ORENTREICH, N., BRIND, J.L., RIZER, R.L., and VOGELMAN, J.H. Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulhood. J. Clin. Endocrinol. Metab. 59(3), 551-555, 1984.
44. PECANHA, L.M., SNAPPER, C.M., LEES, A., and MOND, J.J. Lymphokine control of type 2 antigen response. IL-10 inhibits IL-5-but not IL-2-induced Ig secretion by T cell-independent antigens. J. Immunol. 148(11), 3427-3432, 1992.
45. PHILOSOPHE, B. and MILLER, R.A. Diminished calcium signal generation in subsets of T lymphocytes that predominate in old mice. J. Gerontol. 45, B87-B93, 1990.
46. +B in rheumatoid arthritis. Ann. NY Acad. Sci. 651, 540-550, 1992.
47. + B cells in the production of autoantibodies in murine systemic lupus erythematosus. Ann. NY Acad. Sci. 651, 588-590, 1992.
48. SCHUMACHER, J.H., O'GARRA, A., SHRADER, B., VAN KIMMENADE, A., BOND, M.W., MOSMANN, T.R., and COFFMAN, R. L. The characterization of four monoclonal antibodies specific for mouse IL-5 and development of mouse and human IL-5 enzyme-linked immunosorbent. J. Immunol. 141, 1576-1581, 1988.
49. STALL, A.M., ADAMS, S., HERZENBERG, L.A., and KANTOR, A.B. Characteristics and Development of the murine B-1b (Ly-1 B Sister) cell population. Ann. NY Acad. Sci. 651, 33-43, 1992.
50. + B cells and naturally occurring autoantibodies in cancer patients. Clin. Exp. Immunol. 85, 418-423, 1991.
51. TAGA, K. and TASOTO, G. IL-10 inhibits human T cell proliferation and IL-2 production. J. Immunol. 148, 1143-1148, 1992.
52. THOMAN, M.L. and WEIGLE, W.O. The cellular and subcellular bases of immunosenescence. Adv. Immunol. 46, 221-261, 1989.
53. VIE, H. and MILLER, R.A. Decline with age, in the proportion of mouse T cells that express IL-2 receptors after mitogen stimulation. Mech. Ageing Dev. 33(3), 313-322, 1986.
54. WEKSLER, M. and HUTTEROTH, T.H. Impaired lymphocyte function in aged humans. J. Clin. Invest. 53(1), 99-104, 1974.
55. XU, H.J., ROBERTS-THOMSON, P.J., AHERN, M.J., and AOLA, H. Comparative Evaluation of CD5 B cells in patients with rheumatoid arthritis and essential mixed cryoimmunoglobulinemia using FACS analyzer and FACSCAN flow cytometer. Ann. NY Acad. Sci. 651, 594-598, 1992.
56. YAMAJI, J. and IBAYASHI, H. Plasma dehydroepiandrosterone sulfate in normal and pathologic conditions. J. Clin. Endocrinol. Metab. 29, 273-278, 1969.
57. ZHOU, T., EDWARDS, C.K., III, and MOUNTZ, J.D. Prevention of age-related T cell apoptosis defect in CD2-fastransgenic mice. J. Exp. Med. 182, 129-137, 1995.