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Volumn 145, Issue 1, 2004, Pages 184-193

The Anorexigenic Fatty Acid Synthase Inhibitor, C75, Is a Nonspecific Neuronal Activator

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN; ANOREXIGENIC AGENT; C 75; CERULENIN; FATTY ACID SYNTHASE; GREEN FLUORESCENT PROTEIN; MELANOCORTIN 4 RECEPTOR; NEUROPEPTIDE Y; PROOPIOMELANOCORTIN; UNCLASSIFIED DRUG;

EID: 0347719519     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-0337     Document Type: Article
Times cited : (40)

References (78)
  • 1
    • 0037048669 scopus 로고    scopus 로고
    • Prevalence and trends in obesity among US adults, 1999-2000
    • Flegal KM, Carroll MD, Ogden CL, Johnson CL 2002 Prevalence and trends in obesity among US adults, 1999-2000. JAMA 288:1723-1727
    • (2002) JAMA , vol.288 , pp. 1723-1727
    • Flegal, K.M.1    Carroll, M.D.2    Ogden, C.L.3    Johnson, C.L.4
  • 2
    • 0032010796 scopus 로고    scopus 로고
    • Current estimates of the economic cost of obesity in the United States
    • Wolf AM, Colditz GA 1998 Current estimates of the economic cost of obesity in the United States. Obese Res 6:97-106
    • (1998) Obese Res , vol.6 , pp. 97-106
    • Wolf, A.M.1    Colditz, G.A.2
  • 3
    • 0027437262 scopus 로고
    • Medical hazards of obesity
    • Pi-Sunyer FX 1993 Medical hazards of obesity. Ann Intern Med 119:655-660
    • (1993) Ann Intern Med , vol.119 , pp. 655-660
    • Pi-Sunyer, F.X.1
  • 4
    • 0035112424 scopus 로고    scopus 로고
    • Current status of medical and surgical therapy for obesity
    • Mun EC, Blackburn GL, Matthews JB 2001 Current status of medical and surgical therapy for obesity. Gastroenterology 120:669-681
    • (2001) Gastroenterology , vol.120 , pp. 669-681
    • Mun, E.C.1    Blackburn, G.L.2    Matthews, J.B.3
  • 5
    • 0031886359 scopus 로고    scopus 로고
    • The physiology of body weight regulation: Relevance to the etiology of obesity in children
    • Rosenbaum M, Leibel RL 1998 The physiology of body weight regulation: relevance to the etiology of obesity in children. Pediatrics 101:525-539
    • (1998) Pediatrics , vol.101 , pp. 525-539
    • Rosenbaum, M.1    Leibel, R.L.2
  • 6
    • 0036093071 scopus 로고    scopus 로고
    • Low-dose leptin administration reverses effects of sustained weight reduction on energy expenditure and circulating concentrations of thyroid hormones
    • Rosenbaum M, Murphy EM, Heymsfield SB, Matthews DE, Leibel RL 2002 Low-dose leptin administration reverses effects of sustained weight reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab 87:2391-2394
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2391-2394
    • Rosenbaum, M.1    Murphy, E.M.2    Heymsfield, S.B.3    Matthews, D.E.4    Leibel, R.L.5
  • 9
    • 0037047112 scopus 로고    scopus 로고
    • C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity
    • Thupari JN, Landree LE, Ronnett GV, Kuhajda FP 2002 C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci USA 99:9498-9502
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 9498-9502
    • Thupari, J.N.1    Landree, L.E.2    Ronnett, G.V.3    Kuhajda, F.P.4
  • 10
    • 0037133185 scopus 로고    scopus 로고
    • Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice
    • Kumar MV, Shimokawa T, Nagy TR, Lane MD 2002 Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice. Proc Natl Acad Sci USA 99:1921-1925
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 1921-1925
    • Kumar, M.V.1    Shimokawa, T.2    Nagy, T.R.3    Lane, M.D.4
  • 11
    • 0037039456 scopus 로고    scopus 로고
    • Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides
    • Shimokawa T, Kumar MV, Lane MD 2002 Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides. Proc Natl Acad Sci USA 99:66-71
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 66-71
    • Shimokawa, T.1    Kumar, M.V.2    Lane, M.D.3
  • 14
    • 0034981271 scopus 로고    scopus 로고
    • Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat
    • Butler AA, Marks DL, Fan W, Kuhn CM, Bartolome M, Cone RD 2001 Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. Nat Neurosci 4:605-611
    • (2001) Nat Neurosci , vol.4 , pp. 605-611
    • Butler, A.A.1    Marks, D.L.2    Fan, W.3    Kuhn, C.M.4    Bartolome, M.5    Cone, R.D.6
  • 16
    • 0004155427 scopus 로고
    • New York: W. H. Freeman and Company
    • Stryer L 1995 Biochemistry. 4th ed. New York: W. H. Freeman and Company; 614-628
    • (1995) Biochemistry. 4th Ed. , pp. 614-628
    • Stryer, L.1
  • 18
    • 0030614331 scopus 로고    scopus 로고
    • Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
    • Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD 1997 Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385:165-168
    • (1997) Nature , vol.385 , pp. 165-168
    • Fan, W.1    Boston, B.A.2    Kesterson, R.A.3    Hruby, V.J.4    Cone, R.D.5
  • 19
    • 0025038674 scopus 로고
    • Altered expression of hypothalamic neuropeptide mRNAs in food-restricted and food-deprived rats
    • Brady LS, Smith MA, Gold PW, Herkenham M 1990 Altered expression of hypothalamic neuropeptide mRNAs in food-restricted and food-deprived rats. Neuroendocrinology 52:441-447
    • (1990) Neuroendocrinology , vol.52 , pp. 441-447
    • Brady, L.S.1    Smith, M.A.2    Gold, P.W.3    Herkenham, M.4
  • 20
    • 0027058673 scopus 로고
    • Short-term starvation decreases POMC mRNA but does not alter GnRH mRNA in the brain of adult male rats
    • Bergendahl M, Wiemann JN, Clifton DK, Huhtaniemi I, Steiner RA 1992 Short-term starvation decreases POMC mRNA but does not alter GnRH mRNA in the brain of adult male rats. Neuroendocrinology 56:913-920
    • (1992) Neuroendocrinology , vol.56 , pp. 913-920
    • Bergendahl, M.1    Wiemann, J.N.2    Clifton, D.K.3    Huhtaniemi, I.4    Steiner, R.A.5
  • 23
    • 0030729210 scopus 로고    scopus 로고
    • Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice
    • Thornton JE, Cheung CC, Clifton DK, Steiner RA 1997 Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice. Endocrinology 138:5063-5066
    • (1997) Endocrinology , vol.138 , pp. 5063-5066
    • Thornton, J.E.1    Cheung, C.C.2    Clifton, D.K.3    Steiner, R.A.4
  • 26
    • 0032863468 scopus 로고    scopus 로고
    • Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
    • Yaswen L, Diehl N, Brennan MB, Hochgeschwender U 1999 Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nat Med 5:1066-1070
    • (1999) Nat Med , vol.5 , pp. 1066-1070
    • Yaswen, L.1    Diehl, N.2    Brennan, M.B.3    Hochgeschwender, U.4
  • 27
    • 0031838353 scopus 로고    scopus 로고
    • Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
    • Krude H, Biebermann H, Luck W, Horn R, Brabant G, Gruters A 1998 Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 19:155-157
    • (1998) Nat Genet , vol.19 , pp. 155-157
    • Krude, H.1    Biebermann, H.2    Luck, W.3    Horn, R.4    Brabant, G.5    Gruters, A.6
  • 31
    • 0033928278 scopus 로고    scopus 로고
    • Haploinsufficiency of the melanocortin-4 receptor: Part of a thrifty genotype?
    • Cone RD 2000 Haploinsufficiency of the melanocortin-4 receptor: part of a thrifty genotype? J Clin Invest 106:185-187
    • (2000) J Clin Invest , vol.106 , pp. 185-187
    • Cone, R.D.1
  • 32
    • 0033927916 scopus 로고    scopus 로고
    • Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
    • Vaisse C, Clement K, Durand E, Hercberg S, Guy-Grand B, Froguel P 2000 Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. J Clin Invest 106:253-262
    • (2000) J Clin Invest , vol.106 , pp. 253-262
    • Vaisse, C.1    Clement, K.2    Durand, E.3    Hercberg, S.4    Guy-Grand, B.5    Froguel, P.6
  • 33
    • 0026072307 scopus 로고
    • Food deprivation and hypothalamic neuropeptide gene expression: Effects of strain background and the diabetes mutation
    • Chua Jr SC, Brown AW, Kim J, Hennessey KL, Leibel RL, Hirsch J 1991 Food deprivation and hypothalamic neuropeptide gene expression: effects of strain background and the diabetes mutation. Brain Res Mol Brain Res 11:291-299
    • (1991) Brain Res Mol Brain Res , vol.11 , pp. 291-299
    • Chua Jr., S.C.1    Brown, A.W.2    Kim, J.3    Hennessey, K.L.4    Leibel, R.L.5    Hirsch, J.6
  • 34
    • 0032915413 scopus 로고    scopus 로고
    • Hypothalamic agouti-related protein messenger ribonudeic acid is inhibited by leptin and stimulated by fasting
    • Mizuno TM, Mobbs CV 1999 Hypothalamic agouti-related protein messenger ribonudeic acid is inhibited by leptin and stimulated by fasting. Endocrinology 140:814-817
    • (1999) Endocrinology , vol.140 , pp. 814-817
    • Mizuno, T.M.1    Mobbs, C.V.2
  • 35
    • 0022873040 scopus 로고
    • Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity
    • Stanley BG, Kyrkouli SE, Lampert S, Leibowitz SF 1986 Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides 7:1189-1192
    • (1986) Peptides , vol.7 , pp. 1189-1192
    • Stanley, B.G.1    Kyrkouli, S.E.2    Lampert, S.3    Leibowitz, S.F.4
  • 38
    • 0032942045 scopus 로고    scopus 로고
    • Characterization of the neuroanatomical distribution of agouti-related protein immunoreactivity in the rhesus monkey and the rat
    • Haskell-Luevano C, Chen P, Li C, Chang K, Smith MS, Cameron JL, Cone RD 1999 Characterization of the neuroanatomical distribution of agouti-related protein immunoreactivity in the rhesus monkey and the rat. Endocrinology 140:1408-1415
    • (1999) Endocrinology , vol.140 , pp. 1408-1415
    • Haskell-Luevano, C.1    Chen, P.2    Li, C.3    Chang, K.4    Smith, M.S.5    Cameron, J.L.6    Cone, R.D.7
  • 40
    • 0033200153 scopus 로고    scopus 로고
    • Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: Evidence of a cellular basis for the adipostat
    • Cowley MA, Pronchuk N, Fan W, Dinulescu DM, Colmers WF, Cone RD 1999 Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Neuron 24:155-163
    • (1999) Neuron , vol.24 , pp. 155-163
    • Cowley, M.A.1    Pronchuk, N.2    Fan, W.3    Dinulescu, D.M.4    Colmers, W.F.5    Cone, R.D.6
  • 44
    • 0346993035 scopus 로고    scopus 로고
    • Deleted in proof
    • Deleted in proof
  • 45
    • 0033083490 scopus 로고    scopus 로고
    • Using GFP in FRET-based applications
    • Pollok BA, Heim R 1999 Using GFP in FRET-based applications. Trends Cell Biol 9:57-60
    • (1999) Trends Cell Biol , vol.9 , pp. 57-60
    • Pollok, B.A.1    Heim, R.2
  • 46
    • 0026756317 scopus 로고
    • Patch voltage clamping with low-resistance seals: Loose patch clamp
    • Roberts WM, Almers W 1992 Patch voltage clamping with low-resistance seals: loose patch clamp. Methods Enzymol 207:155-176
    • (1992) Methods Enzymol , vol.207 , pp. 155-176
    • Roberts, W.M.1    Almers, W.2
  • 47
    • 0033832261 scopus 로고    scopus 로고
    • Disproportionate inhibition of feeding in A(y) mice by certain stressors: A cautionary note
    • De Souza J, Butler AA, Cone RD 2000 Disproportionate inhibition of feeding in A(y) mice by certain stressors: a cautionary note. Neuroendocrinology 72:126-132
    • (2000) Neuroendocrinology , vol.72 , pp. 126-132
    • De Souza, J.1    Butler, A.A.2    Cone, R.D.3
  • 48
    • 0342460538 scopus 로고    scopus 로고
    • Tonic synaptic inhibition modulates neuronal output pattern and spatiotemporal synaptic integration
    • Hausser M, Clark BA 1997 Tonic synaptic inhibition modulates neuronal output pattern and spatiotemporal synaptic integration. Neuron 19:665-678
    • (1997) Neuron , vol.19 , pp. 665-678
    • Hausser, M.1    Clark, B.A.2
  • 49
    • 0018910555 scopus 로고
    • Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices
    • Llinas R, Sugimori M 1980 Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices. J Physiol 305:171-195
    • (1980) J Physiol , vol.305 , pp. 171-195
    • Llinas, R.1    Sugimori, M.2
  • 50
    • 0036829858 scopus 로고    scopus 로고
    • Comparison of central and peripheral administration of C75 on food intake, body weight, and conditioned taste aversion
    • Clegg DJ, Wortman MD, Benoit SC, McOsker CC, Seeley RJ 2002 Comparison of central and peripheral administration of C75 on food intake, body weight, and conditioned taste aversion. Diabetes 51:3196-3201
    • (2002) Diabetes , vol.51 , pp. 3196-3201
    • Clegg, D.J.1    Wortman, M.D.2    Benoit, S.C.3    McOsker, C.C.4    Seeley, R.J.5
  • 52
    • 0037610811 scopus 로고    scopus 로고
    • Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem
    • Gao S, Lane MD 2003 Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem. Proc Natl Acad Sci USA 100:5628-5633
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 5628-5633
    • Gao, S.1    Lane, M.D.2
  • 53
    • 0019763102 scopus 로고
    • Cerulenin
    • Omura S 1981 Cerulenin. Methods Enzymol 72:520-532
    • (1981) Methods Enzymol , vol.72 , pp. 520-532
    • Omura, S.1
  • 54
    • 0020453356 scopus 로고
    • Cerulenin blocks fatty acid acylation of glycoproteins and inhibits vesicular stomatitis and Sindbis virus particle formation
    • Schlesinger MJ, Malfer C 1982 Cerulenin blocks fatty acid acylation of glycoproteins and inhibits vesicular stomatitis and Sindbis virus particle formation. J Biol Chem 257:9887-9890
    • (1982) J Biol Chem , vol.257 , pp. 9887-9890
    • Schlesinger, M.J.1    Malfer, C.2
  • 55
    • 0028827388 scopus 로고
    • Inhibitory effects of cerulenin on protein palmitoylation and insulin internalization in rat adipocytes
    • Jochen AL, Hays J, Mick G 1995 Inhibitory effects of cerulenin on protein palmitoylation and insulin internalization in rat adipocytes. Biochim Biophys Acta 1259:65-72
    • (1995) Biochim Biophys Acta , vol.1259 , pp. 65-72
    • Jochen, A.L.1    Hays, J.2    Mick, G.3
  • 56
    • 0033518174 scopus 로고    scopus 로고
    • Structure-activity studies of cerulenin analogues as protein palmitoylation inhibitors
    • Lawrence DS, Zilfou JT, Smith CD 1999 Structure-activity studies of cerulenin analogues as protein palmitoylation inhibitors. J Med Chem 42:4932-4941
    • (1999) J Med Chem , vol.42 , pp. 4932-4941
    • Lawrence, D.S.1    Zilfou, J.T.2    Smith, C.D.3
  • 57
    • 0024615234 scopus 로고
    • Covalent reaction of cerulenin at the active site of acyl-CoA reductase of Photobacterium phosphoreum
    • Wall L, Meighen E 1989 Covalent reaction of cerulenin at the active site of acyl-CoA reductase of Photobacterium phosphoreum. Biochem Cell Biol 67: 163-167
    • (1989) Biochem Cell Biol , vol.67 , pp. 163-167
    • Wall, L.1    Meighen, E.2
  • 58
    • 0034806134 scopus 로고    scopus 로고
    • Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity
    • Thupari JN, Pinn ML, Kuhajda FP 2001 Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity. Biochem Biophys Res Commun 285:217-223
    • (2001) Biochem Biophys Res Commun , vol.285 , pp. 217-223
    • Thupari, J.N.1    Pinn, M.L.2    Kuhajda, F.P.3
  • 59
    • 0012457490 scopus 로고    scopus 로고
    • Hyperpolarization-activated cation currents: From molecules to physiological function
    • Robinson RB, Siegelbaum SA 2003 Hyperpolarization-activated cation currents: from molecules to physiological function. Annu Rev Physiol 65:453-480
    • (2003) Annu Rev Physiol , vol.65 , pp. 453-480
    • Robinson, R.B.1    Siegelbaum, S.A.2
  • 60
    • 0037561112 scopus 로고    scopus 로고
    • Subthreshold sodium currents and pacemaking of subthalamic neurons. Modulation by slow inactivation
    • Do MT, Bean BP 2003 Subthreshold sodium currents and pacemaking of subthalamic neurons. Modulation by slow inactivation. Neuron 39:109-120
    • (2003) Neuron , vol.39 , pp. 109-120
    • Do, M.T.1    Bean, B.P.2
  • 61
    • 0037115030 scopus 로고    scopus 로고
    • Active contribution of dendrites to the tonic and trimodal patterns of activity in cerebellar Purkinje neurons
    • Womack M, Khodakhah K 2002 Active contribution of dendrites to the tonic and trimodal patterns of activity in cerebellar Purkinje neurons. J Neurosci 22:10603-10612
    • (2002) J Neurosci , vol.22 , pp. 10603-10612
    • Womack, M.1    Khodakhah, K.2
  • 62
    • 0036428586 scopus 로고    scopus 로고
    • Characterization of large conductance Ca2+-activated K+ channels in cerebellar Purkinje neurons
    • Womack MD, Khodakhah K 2002 Characterization of large conductance Ca2+-activated K+ channels in cerebellar Purkinje neurons. Eur J Neurosci 16:1214-1222
    • (2002) Eur J Neurosci , vol.16 , pp. 1214-1222
    • Womack, M.D.1    Khodakhah, K.2
  • 63
    • 0037390411 scopus 로고    scopus 로고
    • Somatic and dendritic small-conductance calcium-activated potassium channels regulate the output of cerebellar purkinje neurons
    • Womack MD, Khodakhah K 2003 Somatic and dendritic small-conductance calcium-activated potassium channels regulate the output of cerebellar purkinje neurons. J Neurosci 23:2600-2607
    • (2003) J Neurosci , vol.23 , pp. 2600-2607
    • Womack, M.D.1    Khodakhah, K.2
  • 64
    • 0023582915 scopus 로고
    • Cerulenin is a potent inhibitor of antigen processing by antigen-presenting cells
    • Falo Jr LD, Benacerraf B, Rothstein L, Rock KL 1987 Cerulenin is a potent inhibitor of antigen processing by antigen-presenting cells. J Immunol 139: 3918-3923
    • (1987) J Immunol , vol.139 , pp. 3918-3923
    • Falo Jr., L.D.1    Benacerraf, B.2    Rothstein, L.3    Rock, K.L.4
  • 65
    • 0033766469 scopus 로고    scopus 로고
    • Involvement of fatty acid synthase in axonal development in mouse embryos
    • Ueno K 2000 Involvement of fatty acid synthase in axonal development in mouse embryos. Genes Cells 5:859-869
    • (2000) Genes Cells , vol.5 , pp. 859-869
    • Ueno, K.1
  • 68
    • 0035078799 scopus 로고    scopus 로고
    • Cerulenin mimics effects of leptin on metabolic rate, food intake, and body weight independent of the melanocortin system, but unlike leptin, cerulenin fails to block neuroendocrine effects of fasting
    • Makimura H, Mizuno TM, Yang XJ, Silverstein J, Beasley J, Mobbs CV 2001 Cerulenin mimics effects of leptin on metabolic rate, food intake, and body weight independent of the melanocortin system, but unlike leptin, cerulenin fails to block neuroendocrine effects of fasting. Diabetes 50:733-739
    • (2001) Diabetes , vol.50 , pp. 733-739
    • Makimura, H.1    Mizuno, T.M.2    Yang, X.J.3    Silverstein, J.4    Beasley, J.5    Mobbs, C.V.6
  • 69
    • 0141973370 scopus 로고    scopus 로고
    • Cerulenin, an inhibitor of protein acylation, selectively attenuates nutrient stimulation of insulin release: A study in rat pancreatic islets
    • Yajima H, Komatsu M, Yamada S, Straub SG, Kaneko T, Sato Y, Yamauchi K, Hashizume K, Sharp GW, Aizawa T 2000 Cerulenin, an inhibitor of protein acylation, selectively attenuates nutrient stimulation of insulin release: a study in rat pancreatic islets. Diabetes 49:712-717
    • (2000) Diabetes , vol.49 , pp. 712-717
    • Yajima, H.1    Komatsu, M.2    Yamada, S.3    Straub, S.G.4    Kaneko, T.5    Sato, Y.6    Yamauchi, K.7    Hashizume, K.8    Sharp, G.W.9    Aizawa, T.10
  • 71
    • 0027164198 scopus 로고
    • Cerulenin inhibits the cytotoxicity of ricin, modeccin, Pseudomonas toxin, and diphtheria toxin in brefeldin A-resistant cell lines
    • Oda T, Wu HC 1993 Cerulenin inhibits the cytotoxicity of ricin, modeccin, Pseudomonas toxin, and diphtheria toxin in brefeldin A-resistant cell lines. J Biol Chem 268:12596-12602
    • (1993) J Biol Chem , vol.268 , pp. 12596-12602
    • Oda, T.1    Wu, H.C.2
  • 72
    • 0036311248 scopus 로고    scopus 로고
    • The effects of cerulenin, an inhibitor of protein acylation, on the two phases of glucose-stimulated insulin secretion
    • Straub SG, Yajima H, Komatsu M, Aizawa T, Sharp GW 2002 The effects of cerulenin, an inhibitor of protein acylation, on the two phases of glucose-stimulated insulin secretion. Diabetes 51(Suppl 1):S91-S95
    • (2002) Diabetes , vol.51 , Issue.1 SUPPL.
    • Straub, S.G.1    Yajima, H.2    Komatsu, M.3    Aizawa, T.4    Sharp, G.W.5
  • 74
    • 0346363116 scopus 로고    scopus 로고
    • Approach to the patient with diarrhea
    • Humes HD, ed. Philadelphia: Lippincott Williams, Wilkins
    • Semrad CE, Chang EB 2000 Approach to the patient with diarrhea. In: Humes HD, ed. Kelley's textbook of internal medicine. Philadelphia: Lippincott Williams, Wilkins; 738-755
    • (2000) Kelley's Textbook of Internal Medicine , pp. 738-755
    • Semrad, C.E.1    Chang, E.B.2
  • 76
    • 0036773262 scopus 로고    scopus 로고
    • Leptin and neuropeptide y have opposing modulatory effects on nucleus of the solitary tract neurophysiological responses to gastric loads: Implications for the control of food intake
    • Schwartz GJ, Moran TH 2002 Leptin and neuropeptide y have opposing modulatory effects on nucleus of the solitary tract neurophysiological responses to gastric loads: implications for the control of food intake. Endocrinology 143:3779-3784
    • (2002) Endocrinology , vol.143 , pp. 3779-3784
    • Schwartz, G.J.1    Moran, T.H.2
  • 77
    • 0033780625 scopus 로고    scopus 로고
    • The role of gastrointestinal vagal afferents in the control of food intake: Current prospects
    • Schwartz GJ 2000 The role of gastrointestinal vagal afferents in the control of food intake: current prospects. Nutrition 16:866-873
    • (2000) Nutrition , vol.16 , pp. 866-873
    • Schwartz, G.J.1
  • 78
    • 0025668049 scopus 로고
    • Microvascular specializations promoting rapid interstitial solute dispersion in nucleus tractus solitarius
    • Gross PM, Wall KM, Pang JJ, Shaver SW, Wainman DS 1990 Microvascular specializations promoting rapid interstitial solute dispersion in nucleus tractus solitarius. Am J Physiol 259:R1131-R1138
    • (1990) Am J Physiol , vol.259
    • Gross, P.M.1    Wall, K.M.2    Pang, J.J.3    Shaver, S.W.4    Wainman, D.S.5


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