C75 activates malonyl-CoA sensitive and insensitive components of the CPT system

Biochemical and Biophysical Research Communications

Volumn 325, Issue 3, 2004, Pages 660-664

  Nicot, Carine ^a   Napal, Laura ^a   Relat, Joana ^a   González, Silvia ^b   Llebaria, Amadeu ^b   Woldegiorgis, Gebre ^c   Marrero, Pedro F ^a   Haro, Diego ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b DEPARTMENT OF ENVIRONMENTAL CHEMISTRY   (Spain)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

C75; CPT system; Fatty acid oxidation; Malonyl CoA

Indexed keywords

CARNITINE PALMITOYLTRANSFERASE; ENZYME INHIBITOR; FATTY ACID SYNTHASE; MALONYL COENZYME A; PROTEIN SUBUNIT; RECOMBINANT ENZYME;

ARTICLE; PICHIA PASTORIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; YEAST;

4-BUTYROLACTONE; ANIMALS; CARNITINE O-PALMITOYLTRANSFERASE; ENZYME ACTIVATION; HUMANS; MALONYL COENZYME A; PICHIA; RATS; RECOMBINANT PROTEINS;

PICHIA; PICHIA PASTORIS;

EID: 8444235572     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.10.085     Document Type: Article

References (21)

1. F.P. Kuhajda, E.S. Pizer, J.N. Li, N.S. Mani, G.L. Frehywot, and C.A. Townsend Synthesis and antitumor activity of an inhibitor of fatty acid synthase Proc. Natl. Acad. Sci. USA 97 2000 3450 3454
2. J.D. McGarry, and N.F. Brown The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis Eur. J. Biochem. 244 1997 1 14
3. J.N. Thupari, L.E. Landree, G.V. Ronnett, and F.P. Kuhajda C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity Proc. Natl. Acad. Sci. USA 99 2002 9498 9502
4. M.V. Kumar, T. Shimokawa, T.R. Nagy, and M.D. Lane Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice Proc. Natl. Acad. Sci. USA 99 2002 1921 1925
5. T.M. Loftus, D.E. Jaworsky, G.L. Frehywot, C.A. Townsend, G.V. Ronnett, M.D. Lane, and F.P. Kuhajda Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors Science 288 2000 2379 2381
6. T. Shimokawa, M.V. Kumar, and M.D. Lane Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides Proc. Natl. Acad. Sci. USA 99 2002 66 71
7. E. Sekoguchi, N. Sato, A. Yasui, S. Fukada, Y. Nimura, H. Aburatani, K. Ikeda, and A. Matsuura A novel mitochondrial carnitine-acylcarnitine translocase induced by partial hepatectomy and fasting J. Biol. Chem. 278 2003 38796 38802
8. M.J. Barrero, N. Camarero, P.F. Marrero, and D. Haro Control of human carnitine palmitoyltransferase II gene transcription by peroxisome proliferator-activated receptor through a partially conserved peroxisome proliferator-responsive element Biochem. J. 369 2003 721 729
9. H. Zhu, J. Shi, Y. de Vries, D.N. Arvidson, J.M. Cregg, and G. Woldegiorgis Functional studies of yeast-expressed human heart muscle carnitine palmitoyltransferase I Arch. Biochem. Biophys. 347 1997 53 61
10. H. Zhu, J. Shi, J.M. Cregg, and G. Woldegiorgis Reconstitution of highly expressed human heart muscle carnitine palmitoyltransferase I Biochem. Biophys. Res. Commun. 239 1997 498 502
11. Y. de Vries, D.N. Arvidson, H.R. Waterham, J.M. Cregg, and G. Woldegiorgis Functional characterization of mitochondrial carnitine palmitoyltransferases I and II expressed in the yeast Pichia pastoris Biochemistry 36 1997 5285 5292
12. m for carnitine and high sensitivity to malonyl-CoA inhibition, is a natural chimera of rat liver and muscle enzymes Biochemistry 40 2001 2260 2266
13. C. Nicot, J. Relat, G. Woldegiorgis, D. Haro, and P.F. Marrero Pig liver carnitine palmitoyltransferase. Chimera studies show that both the N- and C-terminal regions of the enzyme are important for the unusual high malonyl-CoA sensitivity J. Biol. Chem. 277 2002 10044 10049
14. m for carnitine and low sensitivity to malonyl-CoA inhibition, has kinetic characteristics similar to those of the rat liver (CPTIalpha) enzyme Biochemistry 43 2004 12686 12691
15. K.F. Woeltje, V. Esser, B.C. Weis, A. Sen, W.F. Cox, M.J. McPhaul, C.A. Slaughter, D.W. Foster, and J.D. McGarry Cloning, sequencing, and expression of a cDNA encoding rat liver mitochondrial carnitine palmitoyltransferase II J. Biol. Chem. 265 1990 10720 107255
16. N.F. Brown, J.K. Hill, V. Esser, J.L. Kirkland, B.E. Corkey, D.W. Foster, and J.D. McGarry Mouse white adipocytes and 3T3-L1 cells display an anomalous pattern of carnitine palmitoyltransferase (CPT) I isoform expression during differentiation. Inter-tissue and inter-species expression of CPT I and CPT II enzymes Biochem. J. 327 1997 225 231
17. H.R. Waterham, M.E. Digan, P.J. Koutz, S.V. Lair, and J.M. Cregg Isolation of the Pichia pastoris glyceraldehyde-3-phosphate dehydrogenase gene and regulation and use of its promoter Gene 186 1997 37 44
18. J. Shi, H. Zhu, D.N. Arvidson, and G. Woldegiorgis The first 28 N-terminal aminoacid residues of human heart muscle carnitine palmitoyltransferase I are essential for malonyl-CoA sensitivity and high-affinity binding Biochemistry 39 1999 712 717
19. J. Dai J, H. Zhu, J. Shi, and G. Woldegiorgis Identification by mutagenesis of conserved arginine and tryptophan residues in rat liver carnitine palmitoyltransferase I important for catalytic activity J. Biol. Chem. 275 2000 22020 22024
20. K.F. Woeltje, M. Kuwajima, D.W. Foster, and J.D. McGarry Characterization of the mitochondrial carnitine palmitoyltransferase enzyme system. II. Use of detergents and antibodies J. Biol. Chem. 262 1987 9822 9827
21. F. Djouadi, J.P. Bonnefont, L. Thuillier, V. Droin, N. Khadom, A. Munnich, and J. Bastin Correction of fatty acid oxidation in carnitine palmitoyl transferase 2-deficient cultured skin fibroblasts by bezafibrate Pediatr. Res. 54 2003 446 451