Carnitine palmitoyltransferase-1 (CPT-1) activity stimulation by cerulenin via sympathetic nervous system activation overrides cerulenin's peripheral effect

Endocrinology

Volumn 145, Issue 7, 2004, Pages 3197-3204

  Jin, Yong Jun ^a,b,d   Li, Song Zhe ^a   Zhao, Zheng Shan ^a   An, Juan Ji ^a,b,d   Kim, Ryang Yeo ^b   Kim, Yoo Mee ^a   Baik, Ja Hyun ^c   Lim, Sung Kil ^a,e  

^a Yonsei University College of Medicine   (South Korea)

^b Yonsei University   (South Korea)

^c Korea University   (South Korea)

^d YANBIAN UNIVERSITY   (China)

^e NONE   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

APPETITE STIMULANT; AUROTHIOGLUCOSE; CARNITINE PALMITOYLTRANSFERASE; CATECHOLAMINE; CERULENIN; GLUTAMATE SODIUM; METIROSINE;

ADRENALECTOMY; ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CORE TEMPERATURE; ENERGY EXPENDITURE; ENZYME ACTIVITY; FOOD INTAKE; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; IN SITU HYBRIDIZATION; INJECTION; INJECTION SITE; LIPID OXIDATION; LIVER; MALE; MOUSE; MUSCLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SOLEUS MUSCLE;

ANIMALS; ANTIBIOTICS, ANTIFUNGAL; BODY TEMPERATURE; BODY WEIGHT; CARNITINE O-PALMITOYLTRANSFERASE; CERULENIN; EATING; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; HYPOTHALAMUS; MALE; MICE; MICE, INBRED C57BL; NEUROPEPTIDES; PREGNANCY; SYMPATHETIC NERVOUS SYSTEM;

EID: 3042687459     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2004-0039     Document Type: Article

References (47)

1. Loftus TM, Jaworsky DE, Frehywot GL, Townsend CA, Ronnett GV, Lane MD, Kuhajda FP 2000 Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288:2379-2381
2. Thupari JN, Landree LE, Ronnett GV, Kuhajda FP 2002 C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci USA 99:9498-9502
3. Shimokawa T, Kumar MV, Lane MD 2002 Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides. Proc Natl Acad Sci USA 99:66-71
4. Makimura H, Mizuno TM, Yang XJ, Silverstein J, Beasley J, Mobbs CV 2001 Cerulenin mimics effects of leptin on metabolic rate, food intake, and body weight independent of the melanocortin system, but unlike leptin, cerulenin fails to block neuroendocrine effects of fasting. Diabetes 50:733-739
5. McGarry JD, Brown NF 1997 The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. Eur J Biochem 244:1-14
6. Thupari JN, Pinn ML, Kuhajda FP 2001 Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity. Biochem Biophys Res Commun 285:217-223
7. Kim EK, Miller I, Landree LE, Borisy-Rudin FF, Brown P, Tihan T, Townsend CA, Witters LA, Moran TH, Kuhajda FP, Ronnett GV 2002 Expression of FAS within hypothalamic neurons: a model for decreased food intake after C75 treatment. Am J Physiol Endocrinol Metab 283:E867-E879
8. Ruderman NB, Saha AK, Vavvas D, Witters LA 1999 Malonyl-CoA, fuel sensing, and insulin resistance. Am J Physiol 276:E1-E18
9. Kurpad AV, Khan K, Calder AG, Elia M 1994 Muscle and whole body metabolism after norepinephrine. Am J Physiol 266:E877-E884
10. Kurpad A, Khan K, Calder AG, Coppack S, Frayn K, Macdonald I, Elia M 1994 Effect of noradrenaline on glycerol turnover and lipolysis in the whole body and subcutaneous adipose tissue in humans in vivo. Clin Sci 86:177-184
11. Astrup A, Simonsen L, Bulow J, Madsen J, Christensen NJ 1989 Epinephrine mediates facultative carbohydrate-induced thermogenesis in human skeletal muscle. Am J Physiol 257:E340-E345
12. Simonsen L, Bulow J, Madsen J, Christensen NJ 1992 Thermogenic response to epinephrine in the forearm and abdominal subcutaneous adipose tissue. Am J Physiol 263:E850-E855
13. Connacher AA, Bennet WM, Jung RT, Bier DM, Smith CC, Scrimgeour CM, Rennie MJ 1991 Effect of adrenaline infusion on fatty acid and glucose turn-over in lean and obese human subjects in the postabsorptive and fed states. Clin Sci 81:635-644
14. Blaak EE, van Baak MA, Kemerink GJ, Pakbiers MTW, Heidendal AK, Saris WHM 1994 β-Adrenergic stimulation of energy expenditure and forearm skeletal muscle metabolism in lean and obese men. Am J Physiol 267:E306-E315
15. Schiffelers SLH, Saris WHM, van Baak MA 2001 β1- And β2-adrenoceptor-mediated thermogenesis and lipid utilization in obese and lean men. J Clin Endocrinol Metab 86:2191-2199
16. Blaak EE, van Baak MA, Saris WHM 1999 β-Adrenergically stimulated fat oxidation is diminished in middle-aged compared to young subjects. J Clin Endocrinol Metab 84:3764-3769
17. Makimura H, Mizuno TM, Roberts J, Silverstein J, Beasley J, Mobbs CV 2000 Adrenalectomy reverses obese phenotype and restores hypothalamic melanocortin tone in leptin-deficient ob/ob mice. Diabetes 49:1917-1923
18. Spurlock ME, Hahn KJ, Miner JL 1996 Regulation of adipsin and body composition in the monosodium glutamate (MSG)-treated mouse. Physiol Behav 60:1217-1221
19. Sanchis-Segura C, Aragon CM 2002 Consequences of monosodium glutamate or gold thioglucose arcuate nucleus lesions on ethanol-induced locomotion. Drug Alcohol Depend 68:189-194
20. Seglen PO 1973 Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. Exp Cell Res 82:391-398
21. Sleboda J, Risan KA, Spydevold O, Bremer J 1999 Short-term regulation of carnitine palmitoyltransferase I in cultured rat hepatocytes: spontaneous inactivation and reactivation by fatty acids. Biochim Biophys Acta 1436:541-549
22. Saggerson ED, Carpenter CA 1981 Carnitine palmitoyltransferase and carnitine octanoyltransferase activities in liver, kidney cortex, adipocyte, lactating mammary gland, skeletal muscle and heart. FEBS Lett 129:229-232
23. Saggerson ED 1982 Carnitine acyltransferase activities in rat liver and heart measured with palmitoyl-CoA and octanoyl-CoA. Latency, effects of K+, bivalent metal ions and malonyl-CoA. Biochem J 202:397-405
24. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ 1951 Protein measurement with the folin phenol reagent. J Biol Chem 193:265-275
25. Saggerson ED, Carpenter CA 1986 Carnitine palmitoyltransferase in liver and five extrahepatic tissues in the rat. Inhibition by DL-2-bromopalmitoyl-CoA and effect of hypothyroidism. Biochem J 236:137-141
26. Baik JH, Picetti R, Saiardi A, Thiriet G, Dierich A, Depaulis A, Le Meur M, Borrelli E 1995 Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors. Nature 377:424-428
27. Morris MJ, Tortelli CF, Filippis A, Proietto J 1998 Reduced BAT function as a mechanism for obesity in the hypophagic, neuropeptide Y deficient monosodium glutamate-treated rat. Regul Pept 75-76:441-447
28. Dellovade T, Young M, Ross EP, Henderson R, Caron K, Parker K, Tobet SA 2000 Disruption of the gene encoding SF-1 alters the distribution of hypothalamic neuronal phenotypes. J Comp Neurol 423:579-589
29. Debons AF, Silver L, Cronkite EP, Johnson HA, Brecher G, Tenzer D, Schwartz IL 1962 Localization of gold in mouse brain in relation to gold thioglucose obesity. Am J Physiol 4:743-750
30. Kelley DE, Goodpaster B, Wing RR, Simoneau JA 1999 Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am J Physiol 277:E1130-E1141
31. DeLany JP, Windhauser MM, Champagne CM, Bray GA 2000 Differential oxidation of individual dietary fatty acids in humans. Am J Clin Nutr 72:905-911
32. Iossa S, Lionetti L, Mollica MP, Crescenzo R, Barletta A, Liverini G 2000 Effect of long-term high-fat feeding on energy balance and liver oxidative activity in rats. Br J Nutr 84:377-385
33. Hoffman DJ, Sawaya AL, Verreschi I, Tucker KL, Roberts SB 2000 Why are nutritionally stunted children at increased risk for obesity? Studies of metabolic rate and fat oxidation in shantytown children from Sao Paulo, Brazil. Am J Clin Nutr 72:702-707
34. Kuhajda FP, Jenner K, Wood FD, Hennigar RA, Jacobs LB, Dick JD 1994 Fatty acid synthesis: a potential selective target for antineoplastic therapy. Proc Natl Acad Sci USA 91:6379-6383
35. Loftus TM 1999 An adipocyte-central nervous system regulatory loop in the control of adipose homeostasis. Semin Cell Dev Biol 10:11-18
36. Kumar MV, Shimokawa T, Nagy TR, Lane MD 2002 Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice. Proc Natl Acad Sci USA 99:1921-1925
37. Funabashi H, Kawaguchi A, Tomoda H, Omura S, Okuda S, Iwasaki S 1989 Binding site of cerulenin in fatty acid synthetase. J Biochem (Tokyo) 105:751-755
38. Cook GA, Mynatt RL, Kashfi K 1994 Yonetani-Theorell analysis of hepatic carnitine palmitoyltransferase-1 inhibition indicates two distinct inhibitory binding sites. J Biol Chem 269:8803-8807
39. Bremer J, Woldegiorgis G, Schalinske K, Shrago E 1985 Carnitine palmitoyltransferase. Activation by palmitoyl-CoA and inactivation by malonyl-CoA. Biochim Biophys Acta 833:9-16
40. Minokoshi Y, Kahn BB 2003 Role of AMP-activated protein kinase in leptin-induced fatty acid oxidation in muscle. Biochem Soc Trans 31(Pt 1):196-201
41. Satoh N, Ogawa Y, Katsuura G, Numata Y, Tsuji T, Hayase M, Ebihara K, Masuzaki H, Hosoda K, Yoshimasa Y, Nakao K 1999 Sympathetic activation of leptin via the ventromedial hypothalamus: leptin-induced increase in catecholamine secretion. Diabetes 48:1787-1793
42. Vander Tuig JG, Knehans AW, Romsos DR 1982 Reduced sympathetic nervous system activity in rats with ventromedial hypothalamic lesions. Life Sci 30:913-920
43. Takeda S, Elefteriou F, Levasseur R, Liu X, Zhao L, Parker KL, Armstrong D, Ducy P, Karsenty G 2002 Leptin regulates bone formation via the sympathetic nervous system. Cell 111:305-317
44. Yoshida T, Yoshioka K, Sakane N, Umekawa T, Kondo M 1995 Probucol prevents the progression of fatty liver in MSG obese mice. Exp Clin Endocrinol Diabetes 103:119-122
45. de Carvalho Papa P, Vargas AM, da Silva JL, Nunes MT, Machado UF 2002 GLUT4 protein is differently modulated during development of obesity in monosodium glutamate-treated mice. Life Sci 71:1917-1928
46. Bryson JM, Phuyal JL, Proctor DR, Blair SC, Caterson ID, Cooney GJ 1999 Plasma insulin rise precedes rise in ob mRNA expression and plasma leptin in gold thioglucose-obese mice. Am J Physiol 276:E358-E364
47. Chen C, Williams PF, Cooney GJ, Caterson ID 1994 Changes in glycogen metabolism in liver of gold thioglucose injected mice during the development of obesity. Int J Obes Relat Metab Disord 18:627-631