Food intake and the regulation of body weight

Annual Review of Psychology

Volumn 51, Issue , 2000, Pages 255-277

  Woods, Stephen C ^a   Schwartz, Michael W ^b   Baskin, Denis G ^b   Seeley, Randy J ^a  

^a UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Energy homeostasis; Hypothalamus; Insulin; Leptin; Neuropeptides; Satiety

Indexed keywords

INSULIN; LEPTIN; NEUROPEPTIDE;

ANIMAL; BODY WEIGHT; EATING; HOMEOSTASIS; HUMAN; HYPOTHALAMUS; METABOLISM; NERVE CELL NETWORK; OBESITY; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; REVIEW;

ANIMALS; BODY WEIGHT; EATING; HOMEOSTASIS; HUMANS; HYPOTHALAMUS; INSULIN; LEPTIN; NERVE NET; NEUROPEPTIDES; OBESITY;

EID: 0033649602     PISSN: 00664308     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.psych.51.1.255     Document Type: Article

References (178)

1. Ahren B, Mansson S, Gingerich RL, Havel PJ. 1997. Regulation of plasma leptin in mice: influence of age, high-fat diet and fasting. Am. J. Physiol. 273:R113-20
2. Altizer AM, Davidson TL. 1999. The effects of NPY and 5-TG on responding to cues for fats and carbohydrates. Physiol. Behav. 65:685-90
3. Aravich PF, Stanley EZ, Doerries LE. 1995. Exercise in food-restricted rats produces 2DG feeding and metabolic abnormalities similar to anorexia nervosa. Physiol. Behav. 57:147-53
4. Bagdade JD, Bierman EL, Porte D Jr. 1967. The significance of basal insulin levels in the evaluation of the insulin response to glucose in diabetic and nondiabetic subjects. J. Clin. Invest. 46:1549-57
5. Barrachina MD, Martinez V, Wang L, Wei JY, Tache Y. 1997. Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice. Proc. Natl. Acad. Sci. USA 94:10455-60
6. Baskin DG, Breininger JF, Schwartz MW. 1999a. Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus. Diabetes 48:828-33
7. Baskin DG, Marks JL, Schwartz MW, Figlewicz DP, Woods SC, Porte D Jr. 1990. Insulin and insulin receptors in the brain in relation to food intake and body weight. In Endocrine and Nutritional Control of Basic Biological Functions, ed. H Lehnert, R Murison, H Weiner, D Hellhammer, J Beyer, pp. 202-22. Stuttgart, Ger.: Hogrefe & Huber
8. Baskin DG, Schwartz MW, Seeley RJ, Woods SC, Porte D Jr, et al. 1999b. Leptin receptor long form splice variant protein expression in neuron cell bodies of the brain and colocalization with neuropeptide Y mRNA in the arcuate nucleus. J. Histochem. Cytochem. 47:353-62
9. Berthoud HR, Powley TL. 1992. Vagal afferent innervation of the rat fundic stomach: morphological characterization of the gastric tension receptor. J. Comp. Neurol. 319:261-76
10. Billington CJ, Briggs JE, Grace M, Levine AS. 1991. Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism. Am. J. Physiol. 260:R321-27
11. Billington CJ, Briggs JE, Harker S, Grace M, Levine AS. 1994. Neuropeptide Y in hypothalamic paraventricular nucleus: a center coordinating energy metabolism. Am. J. Physiol. 266:R1765-70
12. Bjorntorp P. 1997a. Body fat distribution, insulin reistance, and metabolic diseases. Nutrition 13:795-803
13. Bjorntorp P. 1997b. Obesity. Lancet 350:423-26
14. Boden G, Chen X, Mozzoli M, Ryan I. 1996. Effect of fasting on serum leptin in normal human subjects. J. Clin. Endocrinol. Metab. 81:3419-23
15. Bouchard C. 1995. The genetics of obesity: from genetic epidemiology to molecular markers. Mol. Med. Today 1:45-50
16. Bray GA. 1976. The Obese Patient. Philadelphia: Saunders
17. Bray GA, Popkin BM. 1998. Dietary fat does affect obesity. Am. J. Clin. Nutr. 68:1157-73
18. Brownell KD. 1998. Diet, exercise and behavioral intervention: the nonpharmacological approach. Eur. J. Clin. Invest. 28(Suppl. 2):19-21
19. Calingasan NY, Ritter S. 1993. Lateral parabrachial subnucleus lesions abolish feeding induced by mercaptoacetate but not by 2-deoxy-D-glucose. Am. J. Physiol. 265: R1168-78
20. Campfield LA, Brandon P, Smith FJ. 1985. Online continuous measurement of blood glucose and meal pattern in free-feeding rats: the role of glucose in meal initiation. Brain Res. Bull. 14:605-16
21. Campfield LA, Smith FJ. 1986a. Blood glucose and meal initiation: a role for insulin? Soc. Neurosci. Abstr. 12:109
22. Campfield LA, Smith FJ. 1986b. Functional coupling between transient declines in blood glucose and feeding behavior: temporal relationships. Brain Res. Bull. 17:427-33
23. Campfield LA, Smith FJ. 1990a. Systemic factors in the control of food intake: evidence for patterns as signals. In Handbook of Behavioral Neurobiology. Neurobiology of Food and Fluid Intake, ed. EM Stricker, pp. 183-206. New York: Plenum
24. Campfield LA, Smith FJ. 1990b. Transient declines in blood glucose signal meal initiation. Int. J. Obes. 14(Suppl. 3):15-31
25. Campfield LA, Smith FJ, Rosenbaum M, Hirsch J. 1996. Human eating: evidence for a physiological basis using a modified paradigm. Neurosci. Biobehav. Rev. 20:133-37
26. Carlson AJ. 1916. Control of Hunger in Health and Disease. Chicago: Univ. Chicago Press
27. Chavez M, Kelly L, York DA, Berthoud HR. 1997. Chemical lesion of visceral afferents causes transient overconsumption of unfamilar high-fat diets in rats. Am. J. Physiol. 272:R1657-R63
28. Cheung CC, Clifton DK, Steiner RA. 1997. Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology 138:4489-92
29. Chua SC, Chung WK, Wu-Peng XS, Zhang Y, Liu S, et al. 1996. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (Leptin) receptor. Science 271:994-96
30. Comuzzie AG, Allison DB. 1998. The search for human obesity genes. Science 280:1374-77
31. Cone RD, Lu D, Koppula S, Vage DI, Klungland H, et al. 1996. The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation. Recent Prog. Horm. Res. 51:287-320
32. Considine RV, Sinha MK, Heiman ML, Kriaucinas A, Stephens TW, et al. 1996. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 334:292-95
33. Corp ES, McQuade J, Moran TH, Smith GP. 1993. Characterization of type A and type B CCK receptor binding sites in rat vagus nerve. Brain Res. 623:161-66
34. Davidson TL, Altizer AM, Benoit SC, Walls EK, Powley TL. 1997. Encoding and selective activation of "metabolic memories" in the rat. Behav. Neurosci. 111:1014-30
35. de Castro JM. 1998. Genes and environment have gender-independent influences on the eating and drinking of free-living humans. Physiol. Behav. 63:385-95
36. de Lecea L, Kilduff TS, Peyron C, Gao XB, Foye PE, et al. 1998. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl. Acad. Sci. USA 95:322-27
37. de Vries J, Strubbe JH, Wildering WC, Gorter JA, Prins AJA. 1993. Patterns of body temperature during feeding in rats under varying ambient temperatures. Physiol. Behav. 53:229-35
38. Doucet E, Tremblay A. 1998. Body weight loss and maintenance with physical activity and diet. Coron. Artery Dis. 9:495-501
39. Edwards GL, Ladenheim EE, Ritter RC. 1986. Dorsomedial hindbrain participation in cholecystokinin-induced satiety. Am. J. Physiol. 251:R971-77
40. Elias CF, Saper CB, Maratos-Flier E, Tritos NA, Lee C, et al. 1998. Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J. Comp. Neurol. 402:442-59
41. Elmquist JK, Elias CF, Saper CB. 1999. From lesions to leptin: hypothalamic control of food intake and body weight. Neuron 22:221-32
42. Elmquist JK, Maratos-Flier E, Saper CB, Flier JS. 1998. Unraveling the central nervous system pathways underlying responses to leptin. Nat. Neurosci. 1:445-50
43. Epstein AN, Nicolaidis S, Miselis R. 1975. The glucoprivic control of food intake and the glucostatic theory of feeding behavior. In Neural Integration of Physiological Mechanisms and Behavior, ed. GJ Mogenson, FR Calaresci, pp. 148-68. Toronto: Univ. Toronto Press
44. Erlanson-Albertsson C, York D. 1997. Enterostatin - a peptide regulating fat intake. Obes. Res. 5:360-72
45. Even P, Nicolaidis S. 1985. Spontaneous and 2DG-induced metabolic changes and feeding: the ischymetric hypothesis. Brain Res. Bull. 15:429-35
46. Faust IM, Johnson PR, Hirsch J. 1977. Adipose tissue regeneration following lipectomy. Science 197:391-93
47. Faust IM, Johnson PR, Hirsch J. 1979. Adipose tissue regeneration in adult rats. Proc. Soc. Exp. Biol. Med. 161:111-14
48. Figlewicz DP, Sipols AJ, Seeley RJ, Chavez M, Woods SC, Porte D Jr. 1995. Intraventricular insulin enhances the meal-suppressive efficacy of intraventricular cholecystokinin octapeptide in the baboon. Behav. Neurosci. 109:567-69
49. Frederich RC, Hamann A, Anderson S, Lollmann B, Lowell BB, Flier JS. 1995. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat. Med. 1:1311-14
50. Friedman MI. 1998. Fuel partitioning and food intake. Am. J. Clin. Nutr. 67(Suppl. 3):513-18S
51. Friedman MI, Tordoff MG. 1986. Fatty acid oxidation and glucose utilization interact to control food intake in rats. Am. J. Physiol. 251:R840-45
52. Geary N. 1998. Glucagon and the control of meal size. See Smith 1998, pp. 164-97
53. Gibbs J, Fauser DJ, Rowe EA, Rolls ET, Maddison SP. 1979. Bombesin suppresses feeding in rats. Nature 282:208-10
54. Gibbs J, Young RC, Smith GP. 1973. Cholecystokinin decreases food intake in rats. J. Comp. Physiol. Psychol. 84:488-95
55. Goodison T, Siegel S. 1995. Learning and tolerance to the intake suppressive effect of cholecystokinin in rats. Behav. Neurosci. 109:62-70
56. Gordon CJ. 1993. Temperature Regulation in Laboratory Rodents. New York: Cambridge Univ. Press
57. Grill HJ, Friedman MI, Norgren R, Scalera G, Seeley RJ. 1995. Parabrachial nucleus lesions impair feeding response elicited by 2,5-anhydro-D-mannitol. Am. J. Physiol. 268:R676-82
58. Grossman SP. 1986. The role of glucose, insulin and glucagon in the regulation of food intake and body weight. Neurosci. Biobehav. Rev. 10:295-315
59. Hahn TM, Breininger JF, Baskin DG, Schwartz MW. 1998. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nat. Neurosci. 1:271-72
60. Halaas JL, Boozer C, Blair-West J, Fidahusein N, Denton DA, Friedman JM. 1997. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc. Natl. Acad. Sci. USA 94:8878-83
61. Havel PJ, KasimKarakas S, Mueller W, Johnson PR, Gingerich RL, Stern JS. 1996. Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss. J. Clin. Endocrinol. Metab. 81:4406-13
62. Hewson G, Leighton GE, Hill RG, Hughes J. 1988. The cholecystokinin receptor antagonist L364/718 increases food intake in the rat by attenuation of endogenous cholecystokinin. Br. J. Pharmacol. 93:79-84
63. Hill JO, Peters JC. 1998. Environmental contributions to the obesity epidemic. Science 280:1371-74
64. Horn CC, Addis A, Friedman MI. 1999. Neural substrate for an integrated metabolic control of feeding behavior. Am. J. Physiol. 276:R113-19
65. Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, et al. 1997. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88:131-41
66. Jackson AA, Langley-Evans SC, McCarthy HD. 1996. Nutritional influences in early life upon obesity and body proportions. CIBA Found. Symp. 201:129-37
67. Kalra SP, Clark JT, Sahu A, Dube MG, Kalra PS. 1988. Control of feeding and sexual behaviors by neuropeptide Y: physiological implications. Synapse 2:254-57
68. Keesey RE, Hirvonen MD. 1997. Body weight set-points: determination and adjustment. J. Nutr. 127:1875-83
69. Keim NL, Stern JS, Havel PJ. 1998. Relation between circulating leptin concentrations and appetite during a prolonged, moderate energy deficit in women. Am. J. Clin. Nutr. 68:794-801
70. Kelly LA, Chavez M, Berthoud HR. 1999. Transient overconsumption of novel foods by deafferented rats: effects of novel diet composition. Physiol. Behav. 65:793-800
71. Kiss JZ, Cassell MD, Palkovits M. 1984. Analysis of the ACTH/beta-End/alpha-MSH-immunoreactive afferent input to the hypothalamic paraventricular nucleus of rat. Brain Res. 324:91-99
72. Kristensen P, Judge ME, Thim L, Ribel U, Christjansen KN, et al. 1998. Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 393:72-76
73. Kulkosky PJ, Breckenridge C, Krinsky R, Woods SC. 1976. Satiety elicited by the C-terminal octapeptide of cholecystokinin-pancreozymin in normal and VMH-lesioned rats. Behav Biol. 18:227-34
74. Lambert PD, Couceyro PR, McGirr KM, Vechia SE, Smith Y, Kuhar MJ. 1998. CART peptides in the central control of feeding and interactions with neuropeptide Y. Synapse 29:293-98
75. Langhans W. 1996a. Metabolic and glucostatic control of feeding. Proc. Nutr. Soc. 55:497-515
76. Langhans W. 1996b. Role of the liver in the metabolic control of eating: what we know-and what we do not know. Neurosci. Biobehav. Rev. 20:145-53
77. Langhans W, Egli G, Scharrer E. 1985. Selective hepatic vagotomy eliminates the hypophagic effect of different metabolites. J. Anton. Nerv. Syst. 13:255-62
78. Langhans W, Scharrer E. 1987a. Evidence for a vagally mediated satiety signal derived from hepatic acid oxidation. J. Auton. Nerv. Syst. 18:13-18
79. Langhans W, Scharrer E. 1987b. Role of fatty acid oxidation in control of meal pattern. Behav. Neural Biol. 47:7-16
80. Lotter EC, Krinsky R, McKay JM, Treneer CM, Porte D Jr, Woods SC. 1981. Somatostatin decreases food intake of rats and baboons. J. Comp. Physiol. Psychol. 95:278-87
81. Lotter EC, Woods SC. 1977. Injections of insulin and changes of body weight. Physiol. Behav. 18:293-97
82. MacKay EM, Calloway JW, Barnes RH. 1940. Hyperalimentation in normal animals produced by protamine insulin. J. Nutr. 20:59-66
83. Matson CA, Ritter RC. 1999. Long-term CCK-leplin synergy suggests a role for CCK in the regulation of body weight. Am. J. Physiol. 276:1038-45
84. Matson CA, Wiater MF, Kuijper JL, Weigle DS. 1997. Synergy between leptin and cholecyslokinin (CCK) to control daily caloric intake. Peptides 18:1275-78
85. Mayer J. 1955. Regulation of energy intake and the body weight: the glucostatic and lipostatic hypothesis. Ann. NY Acad. Sci. 63:14-42
86. Mayer J, Thomas DW. 1967. Regulation of food intake and obesity. Science 156:328-37
87. McGowan MK, Andrews KM, Grossman SP. 1992. Chronic intrahyphothalamic infusions of insulin or insulin antibodies alter body weight and food intake in the rat. Physol. Behav. 51:753-66
88. Mercer JG, Lawrence CB. 1992. Selectivity of cholecystokinin receptor antagonists, MK-329 and L-365,260 for axonally transported CCK binding sites in the rat vagus nerve. Neurosci. Lett. 137:229-31
89. Moran TH, Ameglio PJ, Peyton HJ, Schwartz GJ, McHugh PR. 1993. Blockade of type A, but not type B, CCK receptors postpones satiety in rhesus monkeys. Am. J. Physiol. 265:R620-24
90. Moran TH, Schwartz GJ. 1994. Neurobiology of cholecystokinin. Crit. Rev. Neurobiol. 9:1-28
91. Moran TH, Shnayder L, Hostetler AM, McHugh PR. 1988. Pylorectomy reduces the satiety action of cholecystokinin. Am. J. Physiol. 255:R1059-63
92. Morley JE, Flood JF. 1991. Amylin decreases food intake in mice. Peptides 12:865-69
93. Nicolaidis S, Even P. 1984. Mesure du métabolisme de fond en relation avec la prise alimentaire: hypothese iscymétrique. C. R. Acad. Sci. Paris 298:295-300
94. Okada S, York DA, Bray GA, Erlanson-Albertsson C. 1991. Enterostatin (Val-Pro-Asp-Pro-Arg), the activation peptide of procolipase, selectively reduces fat intake. Physiol. Behav. 49:1185-89
95. Park CR, Benthem L, Seeley RJ, Wilkinson CW, Friedman MI, Woods SC. 1996. A comparison of the effects of food deprivation and of 2-5 anhydrous-D-mannitol on metabolism and ingestion. Am. J. Physiol. 270:R1250-56
96. Park CR, Seeley RJ, Benthem L, Friedman MI, Woods SC. 1995. The effect of 2-5 anhydro-D mannitol on whole body metabolic parameters. Am. J. Physiol. 268:R299-302
97. Perusse L, Chagnon YC, Bouchard C. 1998. Etiology of massive obesity: role of genetic factors. World J. Surg. 22:907-12
98. Pi-Sunyer FX, Laferrere B, Aronne LJ, Bray GA. 1999. Therapeutic controversy: obesity - a modern-day epidemic. J. Clin. Endocrinol. Metab. 84:3-12
99. Polonsky BD, Given E, Carter V. 1988. Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects. J. Clin. Invest. 81:442-48
100. Porte D Jr, Seeley PJ, Woods SC, Baskin DG, Figlewicz DP, Schwartz MW. 1998. Obesity, diabetes and the central nervous system. Diabetologia 41:863-81
101. Qu DQ, Ludwig DS, Gammeltoft S, Piper M, Pelleymounter MA, et al. 1996. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 380:243-47
102. Ramsay DS, Woods SC. 1997. Biological consequences of drug administration: implications for acute and chronic tolerance. Psychol. Rev. 104:170-93
103. Ravussin E, Gautier JF. 1999. Metabolic predictors of weight gain. Int. J. Obes. Relat. Metab. Disord. 23(Suppl. 1):37-41
104. Ravussin E, Tataranni PA. 1997. Dietary fat and human obesity. J. Am. Diet. Assoc. 97(Suppl. 7):S42-46
105. Reidelberger RD, O'Rourke MF. 1989. Potent cholecystokinin antagonist L-364,718 stimulates food intake in rats. Am. J. Physiol. 257:R1512-18
106. Riedy CA, Chavez M, Figlewicz DP, Woods SC. 1995. Central insulin enhances sensitivity to cholecystokinin. Physiol. Behav. 58:755-60
107. Rieg TS, Aravich PF. 1994. Systemic clonidine increases feeding and wheel running but does not affect rate of weight loss in rats subjected to activity-based anorexia. Pharmacol. Biochem. Behav. 47:215-18
108. Rinaman L, Hoffman GE, Dohanics J, Le WW, Stricker EM, Verbalis JG. 1995. Cholecystokinin activates catecholaminergic neurons in the caudal medulla that innervate the paraventricular nucleus of the hypothalamus in rats. J. Comp. Neurol. 360:246-56
109. Rippe JM, Hess S. 1998. The role of physical activity in the prevention and management of obesity. J. Am. Diet. Assoc. 10(Suppl. 2):S31-38
110. Ritter RC, Slusser PG, Stone S. 1981. Glucoreceptors controlling feeding and blood glucose: location in the hindbrain. Science 213:451-52
111. Ritter S, Dinh TT. 1994. 2-Mercaptoacetate and 2-deoxy-D-glucose induce Fos-like immunoreactivity in rat brain. Brain Res. 641:111-20
112. Ritter S, Llewellyn-Smith I, Dinh TT. 1998. Subgroups of hindbrain catecholamine neurons are selectively activated by 2-deoxy-D-glucose induced metabolic challenge. Brain Res. 805:41-54
113. Ritter S, Scheurink AJW, Singer LK. 1995. 2-Deoxy-D-glucose but not 2-mercaptoacetate increases Fos-like immunoreactivity in adrenal medulla and sympathetic preganglionic neurons. Obes. Res. 3(Suppl. 5):729-34S
114. Rosenbaum M, Nicolson M, Hirsch J, Heymsfield SB, Gallagher D, et al. 1996. Effects of gender, body composition, and menopause on plasma concentrations of leptin. J. Clin. Endocrinol. Metab. 81:3424-27
115. Rossi M, Kim MS, Morgan DGA, Small CJ, Edwards CMB, et al. 1998. A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo. Endocrinology 139:4428-31
116. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, et al. 1998. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92:573-85
117. Salter JM. 1960. Metabolic effects of glucagon in the Wistar rat. Am. J. Clin. Nutr. 8:535-39
118. Saris WH. 1998. Fit, fat and fat free: the metabolic aspects of weight control. Int. J. Obes. Relat. Metab. Disord. 22(Suppl. 2):S15-21
119. Scharrer E, Langhans W. 1986. Control of food intake by fatty acid oxidation. Am. J. Physiol. 250:R1003-6
120. Scheurink AJW, Ritter S. 1993. Sympathoadrenal responses to glucoprivation and lipoprivation in rats. Physiol. Behav. 53:995-1000
121. Schioth HB, Muceniece R, Wikberg JE. 1996. Characterisation of the melanocortin 4 receptor by radioligand binding. Pharmacol. Toxicol. 79:161-65
122. Schwartz GJ, McHugh PR, Moran TH. 1993. Gastric loads and cholecystokinin synergistically stimulate rat gastric vagal afferents. Am. J. Physiol. 265:R872-76
123. Schwartz GJ, Moran TH. 1996. Sub-diaphragmatic vagal afferent integration of meal-related gastrointestinal signals. Neurosci. Biobehav. Rev. 20:47-56
124. Schwartz GJ, Tougas G, Moran TH. 1995. Integration of vagal afferent responses to duodenal loads and exogenous CCK in rats. Peptides 16:707-11
125. Schwartz MW, Baskin DG, Bukowski TR, Kuijper JL, Foster D, et al. 1996a. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45:531-35
126. Schwartz MW, Figlewicz DP, Baskin DG, Woods SC, Porte D Jr. 1992a. Insulin in the brain: a hormonal regulator of energy balance. Endocr. Rev. 13:387-414
127. Schwartz MW, Marks J, Sipols AJ, Baskin DG, Woods SC, et al. 1991. Central insulin administration reduces neuropeptide Y mRNA expression in the arcuate nucleus of food-deprived lean (Fa/Fa) but not obese (fa/fa) Zucker rats. Endocrinology 128:2645-47
128. Schwartz MW, Seeley RJ. 1997a. Neuroendocrine responses to starvation and weight loss. N. Engl. J. Med. 336:1802-11
129. Schwartz MW, Seeley RJ. 1997b. The new biology of body weight regulation. J. Am. Diet. Assoc. 97:54-58
130. Schwartz MW, Seeley RJ, Campfield LA, Burn P, Baskin DG. 1996b. Identification of hypothalmic targets of leptin action. J. Clin. Invest. 98:1101-6
131. Schwartz MW, Seeley RJ, Weigle DS, Burn P, Campfield LA, Baskin DG. 1997. Leptin increases hypothalamic proopiomelanocoritin (POMC) mRNA expression in the rostral arcuate nucleus. Diabetes 46:2119-23
132. Schwartz MW, Sipols AJ, Marks JL, Sanacora G, White JD, et al. 1992b. Inhibition of hypothalamic neuropeptide Y gene expression by insulin. Endocrinology 130:3608-16
133. Sclafani A. 1997. Learned controls of ingestive behavior. Appetite 29:153-58
134. Sclafani A, Rendel A. 1978. Food deprivation-induced activity in dietary obese, dietary lean, and normal-weight rats. Behav. Biol. 24:220-28
135. Seeley RJ, Matson CA, Chavez M, Woods SC, Schwartz MW. 1996. Behavioral, endocrine and hypothalamic responses to involuntary overfeeding. Am. J. Physiol. 271:R819-23
136. Seeley RJ, Schwartz MW. 1997. Regulation of energy balance: peripheral endocrine signals and hypothalamic neuropeptides. Curr. Dir. Psychol. Sci. 6:39-44
137. Seeley RJ, Yagaloff KA, Fisher SL, Burn P, Thiele TE, et al. 1997. Role of melanocortin receptors in leptin effects. Nature 390:349
138. Shargill NS, Tsujii S, Bray GA, Erlanson-Albertsson C. 1991. Enterostatin suppresses food intake following injection into the third ventricle of rats. Brain Res. 544:137-40
139. Shimada M, Tritos NA, Lowell BB, Flier JS, Maratos-Flier E. 1998. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature 396:670-74
140. Shutter JR, Graham M, Kinsey AC, Scully S, Luthy R, Stark KL. 1997. Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes Dev. 11:593-602
141. Singer LK, Ritter S. 1996. Intraventricular glucose blocks feeding induced by 2-deoxy-D-glucose but not mercaptoacetate. Physiol. Behav. 59:921-23
142. Singer-Koegler LK, Magluyan P, Ritter S. 1996. The effects of low-, medium-, and high-fat diets on 2-deoxy-D-glucose- and mercaptoacetate-induced feeding. Physiol. Behav. 60:321-23
143. Sipols AJ, Baskin DG, Schwartz MW. 1995. Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression. Diabetes 44:147-51
144. Smith FJ, Campfield LA. 1993. Meal initiation occurs after experimental induction of transient declines in blood glucose. Am. J. Physiol. 265:R1423-29
145. Smith GP, ed. 1998. Satiation: From Gut to Brain. New York: Oxford Univ. Press
146. Smith GP, Epstein AN. 1969. Increased feeding in response to decreased glucose utilization in rat and monkey. Am. J. Physiol. 217:1083-87
147. Smith GP, Gibbs J. 1992. The development and proof of the cholecystokinin hypothesis of satiety. In Multiple Cholecystokinin Receptors in the CNS, ed. CT Dourish, SJ Cooper, SD Iversen, LL Iversen, pp. 166-82. Oxford, UK: Oxford Univ. Press
148. Smith GP, Gibbs J. 1998. The satiating effects of cholecystokinin and bombesin-like peptides. See Smith 1998, pp. 97-125
149. Smith GP, Jerome C, Cushin BJ, Eterno R, Simansky KJ. 1981. Abdominal vagotomy blocks the satiety effect of cholecystokinin in the rat. Science 213:1036-37
150. Smith GP, Jerome C, Norgren R. 1985. Afferent axons in abdominal vagus mediate satiety effect of cholecystokinin in rats. Am. J. Physiol. 249:R638-41
151. Smith GT, Moran TH, Coyle JT, Kuhar MJ, O'Donahue TL, McHugh PR. 1984. Anatomic localization of cholecystokinin receptors to the pyloric sphincter. Am. J. Physiol 246:R127-30
152. Stallone DD, Stunkard AJ. 1991. The regulation of body weight: evidence and clinical implications. Ann. Behav. Med. 13:220-30
153. Stanley BG, Kyrkouli SE, Lampert S, Leibowitz SF. 1986. Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides 7:1189-92
154. Stephens TW, Basinski M, Bristow PK, Bue-Vallesky JM, Burgett SG, et al. 1995. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377:530-34
155. Stevenson JAF, Rixon RH. 1957. Environmental temperature and deprivation of food and water on the spontaneous activity of rats. Yale J. Biol. Med. 29:575-84
156. Strubbe JH, Mein CG. 1977. Increased feeding in response to bilateral injection of insulin antibodies in the VMH. Physiol. Behav. 19:309-13
157. Thornton JE, Cheung CC, Clifton DK, Steiner RA. 1997. Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice. Endocrinology 138:5063-67
158. Trayhurn P, Hoggard N, Mercer JG, Rayner DV. 1999. Leptin: fundamental aspects. Int. J. Obes. Relat. Metab. Disord. 23(Suppl. 1):22-28
159. Tritos NA, Vicent D, Gillette J, Ludwig DS, Flier ES, Maratos-Flier E. 1998. Functional interactions between melanin-concentrating hormone, neuropeptide Y, and anorectic neuropeptides in the rat hypothalamus. Diabetes 47:1687-92
160. Tsujii S, Bray GA. 1989. Acetylation alters the feeding response to MSH and beta-endorphin. Brain Res. Bull. 23:165-69
161. van Dijk G, Scheurink AJW, Ritter S, Steffens AB. 1995. Glucose homeostasis and sympathoadrenal activity in mercaptoacetate-treated rats. Physiol. Behav. 57:759-64
162. Vrang N, Tang-Christensen M, Larsen PJ, Kristensen P. 1999. Recombinant CART peptide induces c-Fos expression in central areas involved in control of feeding behaviour. Brain Res. 818:499-509
163. Wang L, Martinez V, Barrachina MD, Tache Y. 1998. Fos expression in the brain induced by peripheral injection of CCK or leptin plus CCK in fasted lean mice. Brain Res. 791:157-66
164. Warwick ZS. 1996. Probing the causes of high-fat diet hyperphagia: a mechanistic and behavioral dissection. Neurosci. Biobehav. Rev. 16:585-96
165. Warwick ZS, Schiffman SS. 1992. Role of dietary fat in calorie intake and weight gain. Neurosci. Biobehav. Rev. 16:585-96
166. Warwick ZS, Weingarten HP. 1996. Flavor-postingestive consequence associations incorporate the behaviorally opposing effects of positive reinforcement and anticipated satiety: implications for interpreting two-bottle tests. Physiol. Behav. 60:711-15
167. West DB, Diaz J, Roddy S, Woods SC. 1987. Long-term effects of adiposity following preweaning nutritional manipulations in the gastrostomy-reared rat. J. Nutr. 117:1259-64
168. West DB, Diaz J, Woods SC. 1982. Infant gastrostomy and chronic formula infusion as a technique to overfeed and accelerate weight gain of neonatal rats. J. Nutr. 112:1339-43
169. Willett WC. 1998. Is dietary fat a major determinant of body fat? Am. J. Clin. Nutr. 67(Suppl.):S56-62
170. Woods SC, Chavez M, Park CR, Riedy C, Kaiyala K, et al. 1996. The evaluation of insulin as a metabolic signal controlling behavior via the brain. Neurosci. Biobehav. Rev. 20:139-44
171. Woods SC, Decke E, Vasselli JR. 1974. Metabolic hormones and regulation of body weight. Psychol. Rev. 81:26-43
172. Woods SC, Seeley RJ, Porte D Jr, Schwartz MW. 1998. Signals that regulate food intake and energy homeostasis. Science 280:1378-83
173. Woods SC, Strubbe JH. 1994. The psychobiology of meals. Psychonom. Bull. Rev. 1:141-55
174. Woods SC, Vasselli JR, Kaestner E, Szakmary GA, Milbum P, Vitiello MV. 1977. Conditioned insulin secretion and meal feeding in rats. J. Comp. Physiol. Psychol. 91:128-33
175. World Health Org. 1998. Obesity: Preventing and Managing the Global Epidemic. Geneva, Switzerland: WHO
176. Yoshihara T, Honma S, Honma K. 1996a. Effects of restricted daily feeding on neuropeptide Y release in the rat paraventricular nucleus. Am. J. Physiol. 270: E589-95
177. Yoshihara T, Honma S, Honma K. 1996b. Prefeeding release of paraventricular neuropeptide Y is mediated by ascending noradrenergic neurons in rats. Am. J. Physiol. 270:E596-600
178. Zhang YY, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-32