Freeze-drying of proteins: Some emerging concerns

Biotechnology and Applied Biochemistry

Volumn 39, Issue 2, 2004, Pages 165-177

  Roy, Ipsita ^a   Gupta, Munishwar Nath ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY DELHI   (India)

Author keywords

Cryoprotectants; Freeze drying; Lyoprotectants; Protein aggregation; Protein lyophilization; Storage stability of pharmaceuticals

Indexed keywords

BIOCHEMISTRY; DESORPTION; FOURIER TRANSFORM INFRARED SPECTROSCOPY; FREEZING; PROTEINS; SUBLIMATION;

PRIMARY DRYING; SECONDARY DRYING;

BIOTECHNOLOGY;

BASIC FIBROBLAST GROWTH FACTOR; BUFFER; CRYOPROTECTIVE AGENT; DISULFIDE; DOXORUBICIN; GAMMA INTERFERON; INORGANIC SALT; INSULIN; INTERLEUKIN 2; PACLITAXEL; PROTEIN; SUCROSE; TETANUS TOXOID; THERMOLYSIN; WATER;

ACYLATION; ALPHA HELIX; CATALYSIS; CROSS LINKING; DESORPTION; DRUG SOLUBILITY; ENZYME ACTIVATION; ENZYME IMMOBILIZATION; FREEZE DRYING; FREEZING; INFRARED SPECTROSCOPY; MOISTURE; MOLECULE; PH; POWDER; PROTECTION; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN STABILITY; PROTEIN STRUCTURE; RANDOMIZATION; REACTION ANALYSIS; REVIEW; SAMPLE; SOLID; SOLUBILITY; STORAGE; STRUCTURE ANALYSIS; THAWING;

CRYSTALLIZATION; DRUG STABILITY; DRUG STORAGE; ENZYME ACTIVATION; ENZYME STABILITY; ENZYMES; EXCIPIENTS; FREEZE DRYING; FREEZING; KINETICS; POWDERS; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEINS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 1942472616     PISSN: 08854513     EISSN: None     Source Type: Journal    
DOI: 10.1042/BA20030133     Document Type: Review

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