The secondary structure and aggregation of lyophilized tetanus toxoid

Journal of Pharmaceutical Sciences

Volumn 85, Issue 12, 1996, Pages 1290-1293

  Costantino, Henry R ^a,c   Schwendeman, Steven P ^a,d   Griebenow, Kai ^b   Klibanov, Alexander M ^b   Langer, Robert ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c GENENTECH INC   (United States)

^d OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MACROGOL; SORBITOL; TETANUS TOXOID;

ARTICLE; DRUG STABILITY; DRUG SYNTHESIS; FREEZE DRYING; PROTEIN AGGREGATION; PROTEIN SECONDARY STRUCTURE; SUSTAINED RELEASE FORMULATION; VACCINE PRODUCTION;

EID: 0030470871     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js960148+     Document Type: Article

References (25)

1. Volkin, D. B.; Klibanov, A. M. In Protein Function: A Practical Approach; Creighton, T. E., Ed.; Oxford University: Oxford, 1989; pp 1-24.
2. Manning, M. C.; Patel, K.; Borchardt, R. T. Pharm. Res. 1989, 6, 903-918.
3. Cleland, J. L.; Powell, M. F.; Shire, S. J. Crit. Rev. Ther. Drug Carrier Syst. 1993, 10, 307-377.
4. Prestrelski, S. J.; Tedeschi, N.; Arakawa, T.; Carpenter, J. F. Biophys. J. 1993, 65, 661-671.
5. Dong, A.; Prestrelski, S. J.; Allison, S. D.; Carpenter, J. F. J. Pharm. Sci. 1995, 84, 415-424.
6. Griebenow, K.; Klibanov, A. M. Proc. Natl. Acad. Sci. U.S.A. 1995, 92, 10969-10976.
7. Costantino, H. R.; Griebenow, K.; Mishra, P.; Langer, R; Klibanov, A. M. Biochim. Biophys. Acta 1995, 1253, 69-74.
8. Costantino, H. R.; Langer, R.; Klibanov, A. M. J. Pharm. Sci. 1994, 83, 1662-1669.
9. Schwendeman, S. P.; Costantino, H. R.; Gupta, R. K.; Klibanov, A. M.; Langer, R. In Controlled Drug Delivery. The Next Generation; Park, K., Ed.; ACS Books: Washington, DC, in press.
10. Alonso, M. J.; Gupta, R. K.; Min, C.; Siber, G. R.; Langer, R. Vaccine 1994, 12, 299-306.
11. Schwendeman, S. P.; Costantino, H. R., Gupta, R. K.; Siber, G. R.; Klibanov, A. M.; Langer, R. Dev. Biol. Stand. 1996, 87, 291-304
12. Esparza, I.; Kissel, T. Vaccine 1992, 10, 714-720.
13. Alonso, M. J.; Cohen, S.; Park, T. G.; Gupta, R. K.; Siber, G. R.; Langer R. Pharm. Res. 1993, 10, 945-953.
14. Alonso, M. J.; Gupta, R. K.; Min, C.; Siber, G. R.; Langer, R. Vaccine 1994, 12, 299-306.
15. Men, Y.; Thomasin, T., Merkle, H. P.; Gander, R.; Corradin, G. Vaccine 1995, 13, 683-689.
16. Aguado, M, T.; Lambert, P. H. Immunobiology 1992, 184, 113-125.
17. Schwendeman, S. P.; Costantino, H. R.; Gupta, R. K.; Siber G. R.; Klibanov, A. M.; Langer, R. Proc. Natl. Acad. Sci. U.S.A. 1995, 92, 11234-11238.
18. Singh, B. R.; DeOliveira, D. B.; Fu, F.-N.; Fuller, M. P. SPIE Biomol. Spectrosc. III 1993, 1890, 47-55.
19. Fu, F.-N.; DeOliveira, D. B.; Trumble, W. R.; Sarkar, H. K.; Singh, B. R. Appl. Spectrosc. 1994, 48, 1432-1441.
20. Singh, B. R.; Fuller, M. P.; Schiavo, G. Biophys. Chem. 1990, 46, 155-166.
21. Prestrelski, S. J.; Pikal, K. A.; Arakawa, T. Pharm. Res. 1995, 12, 1250-1259
22. Lang, K W.; Steinberg, M. P. J. Food Sci. 1980, 45, 1228-1230.
23. Desai, U. R.; Osterhout, J. J.; Klibanov, A. M. J. Am. Chem. Soc. 1994, 116, 9420-9422.
24. Hageman, M. J. In Stability of Protein Pharmaceuticals. Part A. Chemical and Physical Pathways of Protein Degradation; Ahern, T. J.; Manning, M. C., Eds.; Plenum: New York, 1992; pp 273-309.
25. Carpenter, J. F.; Crowe, J. H. Biochemistry 1989, 28, 3916-3922.