Application of a thermodynamic model to the prediction of phase separations in freeze-concentrated formulations for protein lyophilization

Archives of Biochemistry and Biophysics

Volumn 363, Issue 2, 1999, Pages 191-201

  Heller, Martin C ^a   Carpenter, John F ^b   Randolph, Theodore W ^a  

^a UCB 450   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Formulation excipients; Lyophilization; Phase separation; Protein stability; Virial coefficients

Indexed keywords

DEXTRAN; HEMOGLOBIN; MACROGOL; POLYMER; PROTEIN;

ARTICLE; FREEZE DRYING; INFRARED SPECTROSCOPY; MATHEMATICAL MODEL; PHASE SEPARATION; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN STABILITY; PROTEIN STRUCTURE; SCANNING ELECTRON MICROSCOPY; TEMPERATURE SENSITIVITY; THERMAL ANALYSIS; THERMODYNAMICS;

EID: 0033558793     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1006/abbi.1998.1078     Document Type: Article

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