The effect of excipients on the molecular mobility of lyophilized formulations, as measured by glass transition temperature and NMR relaxation- based critical mobility temperature

Pharmaceutical Research

Volumn 16, Issue 1, 1999, Pages 135-140

  Yoshioka, Sumie ^a   Aso, Yukio ^a   Kojima, Shigeo ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Dielectric relaxation; Excipient; Lyophilized formulation; Molecular mobility; NMR relaxation

Indexed keywords

BCG VACCINE; DEXTRAN; EXCIPIENT; METHYLCELLULOSE; POVIDONE;

ARTICLE; DRUG FORMULATION; FREEZE DRYING; LYOPHILISATE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; TEMPERATURE;

CALORIMETRY, DIFFERENTIAL SCANNING; CARBOXYMETHYLCELLULOSE; DEXTRANS; EXCIPIENTS; FREEZE DRYING; GAMMA-GLOBULINS; LACTOSE; MAGNETIC RESONANCE SPECTROSCOPY; METHYLCELLULOSE; OXAZINES; POLYHYDROXYETHYL METHACRYLATE; POVIDONE; PROTONS; TEMPERATURE;

EID: 0032960417     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018891317006     Document Type: Article

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