Impaired oxygen-dependent reduction of HIF-1α and -2α proteins in pre-eclamptic placentae

Placenta

Volumn 24, Issue 2-3, 2003, Pages 199-208

  Rajakumar, A ^a   Doty, K ^a   Daftary, A ^a   Harger, G ^a   Conrad, K P ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; OXYGEN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 2, ALPHA SUBUNIT; HYPOXIA-INDUCIBLE FACTOR 2, ALPHA SUBUNIT; TRANSACTIVATOR PROTEIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; EXPLANT; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; HYPOXIA; IN VIVO STUDY; INCUBATION TIME; OXYGENATION; PLACENTA; PLACENTA VILLUS; PREECLAMPSIA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN INDUCTION; SENSITIVITY ANALYSIS; TIME; CHEMISTRY; CHORION VILLUS; GESTATIONAL AGE; IN VITRO STUDY; METABOLISM; ORGAN CULTURE TECHNIQUE; PREGNANCY; WESTERN BLOTTING;

ADULT; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BLOTTING, WESTERN; CHORIONIC VILLI; DOWN-REGULATION; FEMALE; GESTATIONAL AGE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; ORGAN CULTURE TECHNIQUES; OXYGEN; PRE-ECLAMPSIA; PREGNANCY; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0038710247     PISSN: 01434004     EISSN: None     Source Type: Journal    
DOI: 10.1053/plac.2002.0893     Document Type: Article

References (54)

1. Benirschke K & Kaufmann P (2000) Pathology of the Human Placenta. Stamfort, CT: Appleton & Lange.
2. Benyo DF, Miles TM & Conrad KP (1997) Hypoxia stimulates cytokine production by villous explants from the human placenta. J Clin Endocrinol Metab, 82, 1582-1588.
3. Benyo DF, Smarason A, Redman CWG, Sims C & Conrad KP (2001) Expression of inflammatory cytokines in placentae from women with preeclampsia. J Clin Endocrinol Metab, 86, 2505-2512.
4. Berra E, Richard DE, Gothie E & Pouyssegur J (2001) HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1alpha degradation. FEBS Lett, 491, 85-90.
5. Caniggia I, Grisaru-Gravnosky S, Kuliszewsky M, Post M & Lye SJ (1999) Inhibition of TGF-beta 3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies. J Clin Invest, 103, 1641-1650.
6. Caniggia I, Mostachfi H, Winter J, Gassmann M, Lye SJ, Kuliszewski M & Post M (2000a) Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3). J Clin Invest, 105, 577-587.
7. Caniggia I, Winter J, Lye SJ & Post M (2000b) Oxygen and placental development during the first trimester: implications for the pathophysiology of pre-eclampsia. Placenta, 21(Suppl A), S25-S30.
8. Conrad KP & Benyo DF (1997) Placental cytokines and the pathogenesis of preeclampsia. Am J Reprod Immunol, 37, 240-249.
9. Cooper JC, Sharkey AM, Charnock-Jones DS, Palmer CR & Smith SK (1996) VEGF mRNA levels in placentae from pregnancies complicated by pre-eclampsia. Br J Obstet Gynaecol, 103, 1191-1196.
10. Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ & Ratcliffe PJ (2001) C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell, 107, 43-54.
11. Feldser D, Agani F, Iyer NV, Pak B, Ferreira G & Semenza GL (1999) Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2. Cancer Res, 59, 3915-3918.
12. Fisher SJ & Roberts JM (1999) Defects in placentation and placental perfusion. In Chesley's Hypertensive Disorders in Pregancy (Eds) Lindheimer MD, Cunningham FG & Roberts JM. Stamford, CT: Appleton & Lange.
13. Fox H (1964) The villous cytotrophoblast as an index of placental ischaemia. J Obstet Gynecol, 71, 885-892.
14. Fox H & Path MC (1970) Effect of hypoxia on trophoblast in organ culture. Am J Obstet Gynecol, 107, 1058-1064.
15. Genbacev O, Joslin R, Damsky CH, Polliotti BM & Fisher SJ (1996) Hypoxia alters early gestation human cytotrophoblast differentiation/invasion in vitro and models the placental defects that occur in preeclampsia. J Clin Invest, 97, 540-550.
16. Genbacev O, Zhou Y, Ludlow JW & Fisher SJ (1997) Regulation of human placental development by oxygen tension. Science, 277, 1669-1672.
17. Gilson G, Mosher M & Conrad K (1992) Systemic hemodynamics and oxygen transport during pregnancy in chronically-instrumented, conscious rats. American Journal of Physiology, 263, H1911-H1918.
18. Gu YZ, Moran SM, Hogenesch JB, Wartman L & Bradfield CA (1998) Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha. Gene Expr, 7, 205-213.
19. Hara S, Hamada J, Kobayashi C, Kondo Y & Imura N (2001) Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha. Biochem Biophys Res Commun, 287, 808-813.
20. Hogenesch JB, Gu YZ, Jain S & Bradfield CA (1998) The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc Natl Acad Sci USA, 95, 5474-5479.
21. 2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA, 95, 7987-7992.
22. 2-regulated prolyl hydroxylation. Science, 292, 468-472.
23. Jauniaux E, Watson AL, Hempstock J, Bao YP, Skepper JN & Burton GJ (2000) Onset of maternal arterial blood flow and placental oxidative stress. A possible factor in human early pregnancy failure. Am J Pathol, 157, 2111-2122.
24. Jiang BH, Agani F, Passaniti A & Semenza GL (1997) V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. Cancer Res, 57, 5328-5335.
25. Khong T, Robertson, WB (1992) Spiral Artery Disease. New York: W.W. Norton & Company.
26. Kingdom J, Kaufmann, P (1997) Oxygen and placental villous development. Placenta, 18, 613-621.
27. Lando D, Peet DJ, Whelan DA, Gorman JJ & Whitelaw ML (2002a) Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science, 295, 858-861.
28. Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML & Bruick RK (2002b) FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev, 16, 1466-1471.
29. Laughner E, Taghavi P, Chiles K, Mahon PC & Semenza GL (2001) HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol, 21, 3995-4004.
30. Lim KH, Zhou Y, Janatpour M, McMaster M, Bass K, Chun SH & Fisher SJ (1997) Human cytotrophoblast differentiation/invasion is abnormal in pre-eclampsia. Am J Pathol, 151, 1809-1818.
31. Lindheimer MD, Roberts J & Cunningham F (1999) Chesley's Hypertensive Disorders in Pregnancy. Stamford, CT: Appleton & Lange.
32. Lyall F, Young A, Boswell F, Kingdom JCP & Greer IA (1997) Placental expression of vasclar endohelial growth factor in placentae from pregnancies complicated by pre-eclampsia and intrauterine growth restriction does not support placental hypoxia at delivery. Placenta, 18, 269-276.
33. Mahon PC, Hirota K & Semenza GL (2001) FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev, 15, 2675-2686.
34. Makino Y, Cao R, Svensson K, Bertilsson G, Asman M, Tanaka H, Cao Y, Berkenstam A & Poellinger L (2001) Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature, 414, 550-554.
35. Masson N, Willam C, Maxwell PH, Pugh CW & Ratcliffe PJ (2001) Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation. Embo J, 20, 5197-5206.
36. Mayhew T (2001) Villous trophoblast of human placenta: a coherent view of its turnover, repair and contributions to villous development and maturation. Histol Histopathol, 16, 1213-1224.
37. NIH (2000) Working Group Report on High Blood Pressure in Pregnancy. 1-24.
38. Pijnenborg R, McLaughlin PJ, Vercruysse L, Hanssens M, Johnson PM, Keith JC Jr & Van Assche FA (1998a) Immunolocalization of tumour necrosis factor-alpha (TNF-alpha) in the placental bed of normotensive and hypertensive human pregnancies. Placenta, 19, 231-239.
39. Pijnenborg R, Vercruysse L, Verbist L & Van Assche FA (1998b) Interaction of interstitial trophoblast with placental bed capillaries and venules of normotensive and pre-eclamptic pregnancies. Placenta, 19, 569-575.
40. Rajakumar A & Conrad KP (2000) Expression, ontogeny, and regulation of hypoxia-inducible transcription factors in the human placenta. Biol Reprod, 63, 559-569.
41. Rajakumar A, Whitelock KA, Weissfeld LA, Daftary AR, Markovic N & Conrad KP (2001) Selective overexpression of the hypoxia-inducible transcription factor, HIF-2alpha, in placentae from women with preeclampsia. Biol Reprod, 64, 499-506, Erratum 64(3) 1019-1020.
42. Richard DE, Berra E & Pouyssegur J (2000) Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells. J Biol Chem, 275, 26765-26771.
43. Rodesch F, Simon P, Donner C & Jauniaux E (1992) Oxygen measurements in endometrial and trophoblastic tissues during early pregnancy. Obstet Gynecol, 80, 283-285.
44. Salceda S & Caro J (1997) Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem, 272, 22642-22647.
45. Shore VH, Wang TH, Wang CL, Torry RJ, Caudle MR & Torry DS (1997) Vascular endothelial growth factor, placenta growth factor and their receptors in isolated human trophoblast. Placenta, 18, 657-665.
46. Taylor CM, Stevens H, Anthony FW & Wheeler T (1997) Influence of hypoxia on vascular endothelial growth factor and chorionic gonadotrophin production in the trophoblast-derived cell lines: JEG, JAr and BeWo. Placenta, 18, 451-458.
47. Tominaga T, Page, EW (1966) Accommodation of the human placenta to hypoxia. American Journal of Obstetrics and Gynecology, 94, 679-691.
48. 2 tension. Proc Natl Acad Sci USA, 92, 5510-5514.
49. Wang GL & Semenza GL (1993) Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. Blood, 82, 3610-3615.
50. Wenger R, Gassmann, M (1999) HIF-1 and the Molecular Response to Hypoxia in Mammals. Oxford, UK: BIOS Scientific Publishers, Ltd.
51. Wheeler T, Elcock CL & Anthony FW (1995) Angiogenesis and the placental environment. Placenta, 16, 289-296.
52. Yu F, White SB, Zhao Q & Lee FS (2001) HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc Natl Acad Sci USA, 98, 9630-9635.
53. Zelzer E, Levy Y, Kahana C, Shilo BZ, Rubinstein M & Cohen B (1998) Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT. Embo J, 17, 5085-5094.
54. Zhou Y, Chiu K, Brescia RJ, Combs CA, Katz MA, Kitzmiller JL, Heilbron DC & Fisher SJ (1993) Increased depth of trophoblast invasion after chronic constriction of the lower aorta in rhesus monkeys. Am J Obstet Gynecol, 169, 224-229.