Striatal cells from mutant huntingtin knock-in mice are selectively vulnerable to mitochondrial complex II inhibitor-induced cell death through a non-apoptotic pathway

Human Molecular Genetics

Volumn 13, Issue 7, 2004, Pages 669-681

  Ruan, Qingmin ^a   Lesort, Mathieu ^a   MacDonald, Marcy E ^b   Johnson, Gail V W ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROPROPIONIC ACID; CALCIUM ION; CYCLOSPORIN A; CYTOCHROME C; HUNTINGTIN; MITOCHONDRIAL ENZYME; POLYGLUTAMINE; ROTENONE; RUTHENIUM RED;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; CALCIUM TRANSPORT; CELL IMMORTALIZATION; CELL LINE; CELL MUTANT; CHROMATIN CONDENSATION; CONTROLLED STUDY; CORPUS STRIATUM; EMBRYO; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; MEMBRANE DEPOLARIZATION; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; MOUSE; MOUSE MUTANT; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; WILD TYPE;

ANIMALS; ANTIHYPERTENSIVE AGENTS; APOPTOSIS; CASPASE 3; CASPASE 9; CASPASES; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; CHROMATIN; COLORING AGENTS; CYCLOSPORINE; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON TRANSPORT COMPLEX II; ENZYME ACTIVATION; HUMANS; IMMUNOBLOTTING; IMMUNOSUPPRESSIVE AGENTS; L-LACTATE DEHYDROGENASE; MEMBRANE POTENTIALS; MICE; MICE, TRANSGENIC; MITOCHONDRIA; MUTATION; NERVE TISSUE PROTEINS; NEURONS; NITRO COMPOUNDS; NUCLEAR PROTEINS; PEPTIDES; PROPIONIC ACIDS; ROTENONE; RUTHENIUM RED; SUBCELLULAR FRACTIONS; TIME FACTORS; TOXINS, BIOLOGICAL; UNCOUPLING AGENTS;

EID: 1842533573     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/ddh082     Document Type: Review

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