Rapid induction of apoptosis in human keratinocytes with the photosensitizer QLT0074 via a direct mitochondrial action

Apoptosis

Volumn 8, Issue 3, 2003, Pages 269-275

  Li, R ^a   Bounds, D J ^a   Granville, D ^a   Ip, S H ^a   Jiang, H ^a   Margaron, P ^a   Hunt, David W C ^a  

^a QLT Inc   (United States)

Author keywords

Apoptosis; Caspases; Cytochrome c; Mitochondria; Photodynamic therapy; QLT0074

Indexed keywords

ANTIOXIDANT; BENZOPORPHYRIN DERIVATIVE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 6; CASPASE 7; CASPASE 8; CASPASE 9; CYTOCHROME C; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOTOSENSITIZING AGENT; PYRROLIDINE DITHIOCARBAMATE; QLT 0074; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BLUE LIGHT; CELL DEATH; CONCENTRATION RESPONSE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; KERATINOCYTE; MITOCHONDRION; PHOTODYNAMIC THERAPY; PHOTOSENSITIZATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANTIOXIDANTS; APOPTOSIS; CASPASES; CELL COMPARTMENTATION; CELL LINE, TRANSFORMED; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; KERATINOCYTES; MEMBRANE PROTEINS; MITOCHONDRIA; PHOTIC STIMULATION; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; POLY(ADP-RIBOSE) POLYMERASES; PORPHYRINS; PROTEINS; PYRROLIDINES; REACTION TIME; REACTIVE OXYGEN SPECIES; THIOCARBAMATES;

EID: 0037898884     PISSN: 13608185     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1023624922787     Document Type: Article

References (30)

1. Dougherty TJ, Gomer CJ, Henderson BW, et al. Photodynamic therapy. J Natl Cancer Inst 1998; 90: 889-905.
2. Bressler NM, Bressler SB. Photodynamic therapy with verteporfin (Visudyne): Impact on ophthalmology and visual sciences. Invest Ophthalmol Vis Sci 2000; 41: 624-628.
3. Green DR, Reed JC. Mitochondria and apoptosis. Science 1998; 281: 1309-1312.
4. Ferri KF, Kroemer G. Organelle-specific initiation of cell death pathways. Nat Cell Biol 2001; 3: E255-E263.
5. Oleinick NL, Morris RL, I. B, The role of apoptosis in response to photodynamic therapy: What, where, why, and how. Photochem & Photobiol Sci 2002; 1: 1-21.
6. Moor AC. Signaling pathways in cell death and survival after photodynamic therapy. J Photochem Photobiol 2000; 57: 1-13.
7. Granville DJ, McManus BM, Hunt DW. Photodynamic therapy: Shedding light on the biochemical pathways regulating porphyrin-mediated cell death. Histol Histopathol 2001; 16: 309-317.
8. Kessel D, Luo Y. Photodynamic therapy: A mitochondrial inducer of apoptosis. Cell Death Differ 1999; 6: 28-35.
9. Granville DJ, Hunt DWC. Porphyrin-mediated photosensitization-Taking the apoptosis fast lane. Curr Opi Drug Discovery & Development 2000; 3: 2 232-243.
10. Yang J, Liu X, Bhalla K, et al. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked. Science 1997; 275: 1129-1132.
11. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis. Science 1997; 275: 1132-1136.
12. Nicholson DW. Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ 1999; 6: 1028-1042.
13. Levy JG. Photosensitizers in photodynamic therapy. Semi Oncol 1994; 21(6 Suppl 15): 4-10.
14. Jiang H, Granville DJ, North JR, Richter AM, Hunt DWC. Selective action of the photosensitizer QLT0074 on activated human T lymphocytes. Photochem Photobiol 2002; 76: 224-231.
15. Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A, Fusenig NE. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 1988; 106: 761-771.
16. Mosmann T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55-63.
17. Carthy CM, Granville DJ, Jiang H, et al. Early release of mitochondrial cytochrome c and expression of mitochondrial epitope 7A6 with a porphyrin-derived photosensitizer: Bcl-2 and Bcl-xL overexpression do not prevent early mitochondrial events but still depress caspase activity. Lab Invest 1999; 79: 953-965.
18. Zhang C, Ao Z, Seth A, Schlossman SF. A mitochondrial membrane protein defined by a novel monoclonal antibody is preferentially detected in apoptotic cells. J Immunol 1996; 157: 3980-3987.
19. Granville DJ, Gottlieb RA. Mitochondria: Regulators of cell death and survival. Scientific World J 2002; 2: 1569-1578.
20. Granville DJ, Carthy CM, Hunt DW, McManus BM. Apoptosis: Molecular aspects of cell death and disease. Lab Invest 1998; 78: 893-913.
21. Schreck R, Meier B, Mannel DN, Droge W, Baeuerle PA. Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells. J Exp Med 1992; 175: 1181-1194.
22. Matroule JY, Carthy CM, Granville DJ, Jolois O, Hunt DW, Piette J. Mechanism of colon cancer cell apoptosis mediated by pyropheophorbide-a methylester photosensitization. Oncogene 2001; 20: 4070-4084.
23. Aguilar-Lemarroy A, Gariglio P, Whitaker NJ, et al. Restoration of p53 expression sensitizes human papillomavirus type 16 immortalized human keratinocytes to CD95-mediated apoptosis. Oncogene 2002; 21: 165-175.
24. Pablos JL, Santiago B, Galindo M, Carreira PE, Ballestin C, Gomez-Reino JJ. Keratinocyte apoptosis and p53 expression in cutaneous lupus and dermatomyositis. J Pathol 1999; 188: 63-68.
25. Teraki Y, Shiohara T. Apoptosis and the skin. Eur J Dermatol 1999; 9: 413-425.
26. Tomkova H, Fujimoto W, Arata J. Expression pattern of the bcl-2 homologous protein bad in normal skin, psoriasis vulgaris and keratinocytic tumors. J Dermatol Sci 2000; 22: 132-137.
27. Cho SH, Delehedde M, Rodriguez-Villanueva J, Brisbay S, McDonnell TJ. Bax gene disruption alters the epidermal response to ultraviolet irradiation and in vivo induced skin carcinogenesis. Int J Mol Med 2001; 7: 235-241.
28. Takahashi H, Manabe A, Ishida-Yamamoto A, Hashimoto Y, Iizuka H. Aberrant expression of apoptosis-related molecules in psoriatic epidermis. J Dermatol Sci 2002; 28: 187-197.
29. Wrone-Smith T, Mitra RS, Thompson CB, Jasty R, Castle VP, Nickoloff BJ. Keratinocytes derived from psoriatic plaques are resistant to apoptosis compared with normal skin. Am J Pathol 1997; 151: 1321-1329.
30. + stores during photodynamic therapy-induced apoptosis. Cell Calcium 2001; 30: 343-350.