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Volumn 33, Issue 1, 2004, Pages 149-162

Engineering islets: Lessons from stem cells and embryonic development

Author keywords

[No Author keywords available]

Indexed keywords

CELL DIFFERENTIATION; CELL GROWTH; CELL ISOLATION; EMBRYO DEVELOPMENT; GENETIC ENGINEERING; GENETIC MANIPULATION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; NONHUMAN; PANCREAS CELL; PRIORITY JOURNAL; REVIEW; STEM CELL;

EID: 1842422063     PISSN: 08898529     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0889-8529(03)00100-2     Document Type: Review
Times cited : (4)

References (93)
  • 1
    • 0037303120 scopus 로고    scopus 로고
    • Stem/progenitor cells derived from adult tissues: Potential for the treatment of diabetes mellitus
    • Lechner A., Habener J.F. Stem/progenitor cells derived from adult tissues: potential for the treatment of diabetes mellitus. Am J Physiol Endocrinol Metab. 284:(2):2003;E259-E266.
    • (2003) Am J Physiol Endocrinol Metab , vol.284 , Issue.2 , pp. 259-E266
    • Lechner, A.1    Habener, J.F.2
  • 2
    • 0034721255 scopus 로고    scopus 로고
    • Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
    • Shapiro A.M., Lakey J.R., Ryan E.A., et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med. 343:(4):2000;230-238.
    • (2000) N Engl J Med , vol.343 , Issue.4 , pp. 230-238
    • Shapiro, A.M.1    Lakey, J.R.2    Ryan, E.A.3
  • 3
    • 0033919390 scopus 로고    scopus 로고
    • Accelerated telomere shortening and senescence in human pancreatic islet cells stimulated to divide in vitro
    • Halvorsen T.L., Beattie G.M., Lopez A.D., et al. Accelerated telomere shortening and senescence in human pancreatic islet cells stimulated to divide in vitro. J Endocrinol. 166:(1):2000;103-109.
    • (2000) J Endocrinol , vol.166 , Issue.1 , pp. 103-109
    • Halvorsen, T.L.1    Beattie, G.M.2    Lopez, A.D.3
  • 4
    • 0034633526 scopus 로고    scopus 로고
    • Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells
    • Schuldiner M., Yanuka O., Itskovitz-Eldor J., et al. Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells. Proc Natl Acad Sci U S A. 97:(21):2000;11307-11312.
    • (2000) Proc Natl Acad Sci U S a , vol.97 , Issue.21 , pp. 11307-11312
    • Schuldiner, M.1    Yanuka, O.2    Itskovitz-Eldor, J.3
  • 5
    • 0035906902 scopus 로고    scopus 로고
    • Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets
    • Lumelsky N., Blondel O., Laeng P., et al. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science. 292:(5520):2001;1389-1394.
    • (2001) Science , vol.292 , Issue.5520 , pp. 1389-1394
    • Lumelsky, N.1    Blondel, O.2    Laeng, P.3
  • 6
    • 0025190642 scopus 로고
    • CNS stem cells express a new class of intermediate filament protein
    • Lendahl U., Zimmerman L.B., McKay R.D. CNS stem cells express a new class of intermediate filament protein. Cell. 60:(4):1990;585-595.
    • (1990) Cell , vol.60 , Issue.4 , pp. 585-595
    • Lendahl, U.1    Zimmerman, L.B.2    McKay, R.D.3
  • 7
    • 0037058934 scopus 로고    scopus 로고
    • Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells
    • Hori Y., Rulifson I.C., Tsai B.C., et al. Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells. Proc Natl Acad Sci U S A. 99:(25):2002;16105-16110.
    • (2002) Proc Natl Acad Sci U S a , vol.99 , Issue.25 , pp. 16105-16110
    • Hori, Y.1    Rulifson, I.C.2    Tsai, B.C.3
  • 8
    • 0023949396 scopus 로고
    • Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons
    • Alpert S., Hanahan D., Teitelman G. Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons. Cell. 53:(2):1988;295-308.
    • (1988) Cell , vol.53 , Issue.2 , pp. 295-308
    • Alpert, S.1    Hanahan, D.2    Teitelman, G.3
  • 9
    • 17744373453 scopus 로고    scopus 로고
    • Insulin production in a neuroectodermal tumor that expresses islet factor-1, but not pancreatic-duodenal homeobox 1
    • Nakamura T., Kishi A., Nishio Y., et al. Insulin production in a neuroectodermal tumor that expresses islet factor-1, but not pancreatic-duodenal homeobox 1. J Clin Endocrinol Metab. 86:(4):2001;1795-1800.
    • (2001) J Clin Endocrinol Metab , vol.86 , Issue.4 , pp. 1795-1800
    • Nakamura, T.1    Kishi, A.2    Nishio, Y.3
  • 10
    • 0032525981 scopus 로고    scopus 로고
    • Beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes
    • Ahlgren U., Jonsson J., Jonsson L., et al. Beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev. 12:(12):1998;1763-1768.
    • (1998) Genes Dev , vol.12 , Issue.12 , pp. 1763-1768
    • Ahlgren, U.1    Jonsson, J.2    Jonsson, L.3
  • 11
    • 0042767581 scopus 로고    scopus 로고
    • Pancreatic precursors and differentiated islet cell types from murine embryonic stem cells: An in vitro model to study islet differentiation
    • Kahan B.W., Jacobson L.M., Hullett D.A., et al. Pancreatic precursors and differentiated islet cell types from murine embryonic stem cells: an in vitro model to study islet differentiation. Diabetes. 52:(8):2003;2016-2024.
    • (2003) Diabetes , vol.52 , Issue.8 , pp. 2016-2024
    • Kahan, B.W.1    Jacobson, L.M.2    Hullett, D.A.3
  • 12
    • 0038280156 scopus 로고    scopus 로고
    • Genes expressed in the developing endocrine pancreas and their importance for stem cell and diabetes research
    • Wells J.M. Genes expressed in the developing endocrine pancreas and their importance for stem cell and diabetes research. Diabetes Metab Res Rev. 19:(3):2003;191-201.
    • (2003) Diabetes Metab Res Rev , vol.19 , Issue.3 , pp. 191-201
    • Wells, J.M.1
  • 13
    • 0031011659 scopus 로고    scopus 로고
    • Involvement of hepatocyte nuclear factor 3 in endoderm differentiation of embryonic stem cells
    • Levinson-Dushnik M., Benvenisty N. Involvement of hepatocyte nuclear factor 3 in endoderm differentiation of embryonic stem cells. Mol Cell Biol. 17:(7):1997;3817-3822.
    • (1997) Mol Cell Biol , vol.17 , Issue.7 , pp. 3817-3822
    • Levinson-Dushnik, M.1    Benvenisty, N.2
  • 14
    • 0033979603 scopus 로고    scopus 로고
    • Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice
    • Soria B., Roche E., Berna G., et al. Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes. 49:(2):2000;157-162.
    • (2000) Diabetes , vol.49 , Issue.2 , pp. 157-162
    • Soria, B.1    Roche, E.2    Berna, G.3
  • 15
    • 0035434048 scopus 로고    scopus 로고
    • Insulin production by human embryonic stem cells
    • Assady S., Maor G., Amit M., et al. Insulin production by human embryonic stem cells. Diabetes. 50:(8):2001;1691-1697.
    • (2001) Diabetes , vol.50 , Issue.8 , pp. 1691-1697
    • Assady, S.1    Maor, G.2    Amit, M.3
  • 16
    • 0037449573 scopus 로고    scopus 로고
    • Insulin staining of ES cell progeny from insulin uptake
    • Rajagopal J., Anderson W.J., Kume S., et al. Insulin staining of ES cell progeny from insulin uptake. Science. 299:(5605):2003;363.
    • (2003) Science , vol.299 , Issue.5605 , pp. 363
    • Rajagopal, J.1    Anderson, W.J.2    Kume, S.3
  • 17
    • 0034614576 scopus 로고    scopus 로고
    • Stem cells: Units of development, units of regeneration, and units in evolution
    • Weissman I.L. Stem cells: units of development, units of regeneration, and units in evolution. Cell. 100:(1):2000;157-168.
    • (2000) Cell , vol.100 , Issue.1 , pp. 157-168
    • Weissman, I.L.1
  • 19
    • 0034042959 scopus 로고    scopus 로고
    • Islet growth and development in the adult
    • Bonner-Weir S. Islet growth and development in the adult. J Mol Endocrinol. 24:(3):2000;297-302.
    • (2000) J Mol Endocrinol , vol.24 , Issue.3 , pp. 297-302
    • Bonner-Weir, S.1
  • 20
    • 0033867213 scopus 로고    scopus 로고
    • Linear correlation between beta-cell mass and body weight throughout the lifespan in Lewis rats: Role of beta-cell hyperplasia and hypertrophy
    • Montanya E., Nacher V., Biarnes M., et al. Linear correlation between beta-cell mass and body weight throughout the lifespan in Lewis rats: role of beta-cell hyperplasia and hypertrophy. Diabetes. 49:(8):2000;1341-1346.
    • (2000) Diabetes , vol.49 , Issue.8 , pp. 1341-1346
    • Montanya, E.1    Nacher, V.2    Biarnes, M.3
  • 21
    • 0036319371 scopus 로고    scopus 로고
    • Pancreatic beta-cell growth and survival - A role in obesity-linked type 2 diabetes?
    • Lingohr M.K., Buettner R., Rhodes C.J. Pancreatic beta-cell growth and survival - a role in obesity-linked type 2 diabetes? Trends Mol Med. 8:(8):2002;375-384.
    • (2002) Trends Mol Med , vol.8 , Issue.8 , pp. 375-384
    • Lingohr, M.K.1    Buettner, R.2    Rhodes, C.J.3
  • 22
    • 0021045550 scopus 로고
    • The endocrine pancreas during pregnancy and lactation in the rat
    • Marynissen G., Aerts L., Van Assche F.A. The endocrine pancreas during pregnancy and lactation in the rat. J Dev Physiol. 5:(6):1983;373-381.
    • (1983) J Dev Physiol , vol.5 , Issue.6 , pp. 373-381
    • Marynissen, G.1    Aerts, L.2    Van Assche, F.A.3
  • 23
    • 0029739583 scopus 로고    scopus 로고
    • Induction of beta-cell neogenesis by islet injury
    • Teitelman G. Induction of beta-cell neogenesis by islet injury. Diabetes Metab Rev. 12:(2):1996;91-102.
    • (1996) Diabetes Metab Rev , vol.12 , Issue.2 , pp. 91-102
    • Teitelman, G.1
  • 24
    • 0034032317 scopus 로고    scopus 로고
    • Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas
    • Stoffers D.A., Kieffer T.J., Hussain M.A., et al. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes. 49:(5):2000;741-748.
    • (2000) Diabetes , vol.49 , Issue.5 , pp. 741-748
    • Stoffers, D.A.1    Kieffer, T.J.2    Hussain, M.A.3
  • 25
    • 0034748027 scopus 로고    scopus 로고
    • Regeneration of pancreatic beta cells from intra-islet precursor cells in an experimental model of diabetes
    • Guz Y., Nasir I., Teitelman G. Regeneration of pancreatic beta cells from intra-islet precursor cells in an experimental model of diabetes. Endocrinology. 142:(11):2001;4956-4968.
    • (2001) Endocrinology , vol.142 , Issue.11 , pp. 4956-4968
    • Guz, Y.1    Nasir, I.2    Teitelman, G.3
  • 26
    • 0027449197 scopus 로고
    • A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development
    • Bonner-Weir S., Baxter L.A., Schuppin G.T., et al. A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes. 42:(12):1993;1715-1720.
    • (1993) Diabetes , vol.42 , Issue.12 , pp. 1715-1720
    • Bonner-Weir, S.1    Baxter, L.A.2    Schuppin, G.T.3
  • 27
    • 0036070177 scopus 로고    scopus 로고
    • Pancreatic stem cells
    • Bonner-Weir S., Sharma A. Pancreatic stem cells. J Pathol. 197:(4):2002;519-526.
    • (2002) J Pathol , vol.197 , Issue.4 , pp. 519-526
    • Bonner-Weir, S.1    Sharma, A.2
  • 28
    • 0033960256 scopus 로고    scopus 로고
    • Early pattern of differentiation in the human pancreas
    • Polak M., Bouchareb-Bonaei L., Scharfmann R., et al. Early pattern of differentiation in the human pancreas. Diabetes. 49:(2):2000;225-232.
    • (2000) Diabetes , vol.49 , Issue.2 , pp. 225-232
    • Polak, M.1    Bouchareb-Bonaei, L.2    Scharfmann, R.3
  • 29
    • 0036323269 scopus 로고    scopus 로고
    • Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells
    • Abraham E.J., Leech C.A., Lin J.C., et al. Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells. Endocrinology. 143:(8):2002;3152-3161.
    • (2002) Endocrinology , vol.143 , Issue.8 , pp. 3152-3161
    • Abraham, E.J.1    Leech, C.A.2    Lin, J.C.3
  • 30
    • 0034608816 scopus 로고    scopus 로고
    • In vitro cultivation of human islets from expanded ductal tissue
    • Bonner-Weir S., Taneja M., Weir G.C., et al. In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci U S A. 97:(14):2000;7999-8004.
    • (2000) Proc Natl Acad Sci U S a , vol.97 , Issue.14 , pp. 7999-8004
    • Bonner-Weir, S.1    Taneja, M.2    Weir, G.C.3
  • 31
    • 0034100823 scopus 로고    scopus 로고
    • Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells
    • Ramiya V.K., Maraist M., Arfos K.E., et al. Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells. Nat Med. 6:(3):2000;278-282.
    • (2000) Nat Med , vol.6 , Issue.3 , pp. 278-282
    • Ramiya, V.K.1    Maraist, M.2    Arfos, K.E.3
  • 32
    • 0035119871 scopus 로고    scopus 로고
    • Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes
    • Zulewski H., Abraham E.J., Gerlach M.J., et al. Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes. 50:(3):2001;521-533.
    • (2001) Diabetes , vol.50 , Issue.3 , pp. 521-533
    • Zulewski, H.1    Abraham, E.J.2    Gerlach, M.J.3
  • 33
    • 0037931407 scopus 로고    scopus 로고
    • Differentiation and proliferation of endocrine cells in the regenerating rat pancreas after 90% pancreatectomy
    • Hayashi K.Y., Tamaki H., Handa K., et al. Differentiation and proliferation of endocrine cells in the regenerating rat pancreas after 90% pancreatectomy. Arch Histol Cytol. 66:(2):2003;163-174.
    • (2003) Arch Histol Cytol , vol.66 , Issue.2 , pp. 163-174
    • Hayashi, K.Y.1    Tamaki, H.2    Handa, K.3
  • 34
    • 0029166144 scopus 로고
    • In vivo cell transformation: Neogenesis of beta cells from pancreatic ductal cells
    • Rosenberg L. In vivo cell transformation: neogenesis of beta cells from pancreatic ductal cells. Cell Transplant. 4:(4):1995;371-383.
    • (1995) Cell Transplant , vol.4 , Issue.4 , pp. 371-383
    • Rosenberg, L.1
  • 35
    • 0034728764 scopus 로고    scopus 로고
    • Nestin-expressing cells in the pancreatic islets of Langerhans
    • Hunziker E., Stein M. Nestin-expressing cells in the pancreatic islets of Langerhans. Biochem Biophys Res Commun. 271:(1):2000;116-119.
    • (2000) Biochem Biophys Res Commun , vol.271 , Issue.1 , pp. 116-119
    • Hunziker, E.1    Stein, M.2
  • 36
    • 0036230386 scopus 로고    scopus 로고
    • Nestin is expressed in mesenchymal and not epithelial cells of the developing mouse pancreas
    • Selander L., Edlund H. Nestin is expressed in mesenchymal and not epithelial cells of the developing mouse pancreas. Mech Dev. 113:(2):2002;189-192.
    • (2002) Mech Dev , vol.113 , Issue.2 , pp. 189-192
    • Selander, L.1    Edlund, H.2
  • 37
    • 0036082806 scopus 로고    scopus 로고
    • Nestin expression in pancreatic stellate cells and angiogenic endothelial cells
    • Lardon J., Rooman I., Bouwens L. Nestin expression in pancreatic stellate cells and angiogenic endothelial cells. Histochem Cell Biol. 117:(6):2002;535-540.
    • (2002) Histochem Cell Biol , vol.117 , Issue.6 , pp. 535-540
    • Lardon, J.1    Rooman, I.2    Bouwens, L.3
  • 38
    • 0345736922 scopus 로고    scopus 로고
    • Nestin expression in pancreatic exocrine cell types
    • Delacour A., Nepote V., Trumpp A., et al. Nestin expression in pancreatic exocrine cell types. Mechanisms of Development. 121:(1):2004;3-14.
    • (2004) Mechanisms of Development , vol.121 , Issue.1 , pp. 3-14
    • Delacour, A.1    Nepote, V.2    Trumpp, A.3
  • 39
    • 0043268785 scopus 로고    scopus 로고
    • Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture
    • Gao R., Ustinov J., Pulkkinen M.A., et al. Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture. Diabetes. 52:(8):2003;2007-2015.
    • (2003) Diabetes , vol.52 , Issue.8 , pp. 2007-2015
    • Gao, R.1    Ustinov, J.2    Pulkkinen, M.A.3
  • 41
    • 0037364517 scopus 로고    scopus 로고
    • In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion
    • Ianus A., Holz C.G., Theise N.D., et al. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest. 111:(6):2003;843-850.
    • (2003) J Clin Invest , vol.111 , Issue.6 , pp. 843-850
    • Ianus, A.1    Holz, C.G.2    Theise, N.D.3
  • 42
    • 0037002096 scopus 로고    scopus 로고
    • Pancreatic cell lineage analyses in mice
    • Herrera P.L., Nepote V., Delacour A. Pancreatic cell lineage analyses in mice. Endocrine. 19:(3):2002;267-278.
    • (2002) Endocrine , vol.19 , Issue.3 , pp. 267-278
    • Herrera, P.L.1    Nepote, V.2    Delacour, A.3
  • 43
    • 10744233909 scopus 로고    scopus 로고
    • Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells
    • Choi J.B., Uchino H., Azuma K., et al. Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells. Diabetologia. 46:(10):2003;1366-1374.
    • (2003) Diabetologia , vol.46 , Issue.10 , pp. 1366-1374
    • Choi, J.B.1    Uchino, H.2    Azuma, K.3
  • 44
    • 0037820427 scopus 로고    scopus 로고
    • Bone marrow-derived stem cells initiate pancreatic regeneration
    • Hess D., Li L., Martin M., et al. Bone marrow-derived stem cells initiate pancreatic regeneration. Nat Biotechnol. 21:(7):2003;763-770.
    • (2003) Nat Biotechnol , vol.21 , Issue.7 , pp. 763-770
    • Hess, D.1    Li, L.2    Martin, M.3
  • 45
    • 0037183884 scopus 로고    scopus 로고
    • Little evidence for developmental plasticity of adult hematopoietic stem cells
    • Wagers A.J., Sherwood R.I., Christensen J.L., et al. Little evidence for developmental plasticity of adult hematopoietic stem cells. Science. 297:(5590):2002;2256-2259.
    • (2002) Science , vol.297 , Issue.5590 , pp. 2256-2259
    • Wagers, A.J.1    Sherwood, R.I.2    Christensen, J.L.3
  • 46
    • 0037019337 scopus 로고    scopus 로고
    • Pluripotency of mesenchymal stem cells derived from adult marrow
    • Jiang Y., Jahagirdar B.N., Reinhardt R.L., et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 418:(6893):2002;41-49.
    • (2002) Nature , vol.418 , Issue.6893 , pp. 41-49
    • Jiang, Y.1    Jahagirdar, B.N.2    Reinhardt, R.L.3
  • 47
    • 0034068602 scopus 로고    scopus 로고
    • Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia
    • Ferber S., Halkin A., Cohen H., et al. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med. 6:(5):2000;568-572.
    • (2000) Nat Med , vol.6 , Issue.5 , pp. 568-572
    • Ferber, S.1    Halkin, A.2    Cohen, H.3
  • 48
    • 0037458120 scopus 로고    scopus 로고
    • Experimental conversion of liver to pancreas
    • Horb M.E., Shen C.N., Tosh D., et al. Experimental conversion of liver to pancreas. Curr Biol. 13:(2):2003;105-115.
    • (2003) Curr Biol , vol.13 , Issue.2 , pp. 105-115
    • Horb, M.E.1    Shen, C.N.2    Tosh, D.3
  • 49
    • 0037062515 scopus 로고    scopus 로고
    • In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells
    • Yang L., Li S., Hatch H., et al. In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells. Proc Natl Acad Sci U S A. 99:(12):2002;8078-8083.
    • (2002) Proc Natl Acad Sci U S a , vol.99 , Issue.12 , pp. 8078-8083
    • Yang, L.1    Li, S.2    Hatch, H.3
  • 50
    • 0141895080 scopus 로고    scopus 로고
    • Molecular development of the pancreatic beta cell: Implications for cell replacement therapy
    • Ball S.G., Barber T.M. Molecular development of the pancreatic beta cell: implications for cell replacement therapy. Trends Endocrinol Metab. 14:(8):2003;349-355.
    • (2003) Trends Endocrinol Metab , vol.14 , Issue.8 , pp. 349-355
    • Ball, S.G.1    Barber, T.M.2
  • 51
    • 0037213587 scopus 로고    scopus 로고
    • Gene expression cascades in pancreatic development
    • Wilson M.E., Scheel D., German M.S. Gene expression cascades in pancreatic development. Mech Dev. 120:(1):2003;65-80.
    • (2003) Mech Dev , vol.120 , Issue.1 , pp. 65-80
    • Wilson, M.E.1    Scheel, D.2    German, M.S.3
  • 53
    • 0029027780 scopus 로고
    • Developmental biology of the pancreas
    • Slack J.M. Developmental biology of the pancreas. Development. 121:(6):1995;1569-1580.
    • (1995) Development , vol.121 , Issue.6 , pp. 1569-1580
    • Slack, J.M.1
  • 54
    • 0035688260 scopus 로고    scopus 로고
    • Purification and distribution of ghrelin: The natural endogenous ligand for the growth hormone secretagogue receptor
    • Kojima M., Hosoda H., Kangawa K. Purification and distribution of ghrelin: the natural endogenous ligand for the growth hormone secretagogue receptor. Horm Res. 56:(Suppl 1):2001;93-97.
    • (2001) Horm Res , vol.56 , Issue.SUPPL. 1 , pp. 93-97
    • Kojima, M.1    Hosoda, H.2    Kangawa, K.3
  • 55
    • 0036097362 scopus 로고    scopus 로고
    • Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion
    • Date Y., Nakazato M., Hashiguchi S., et al. Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes. 51:(1):2002;124-129.
    • (2002) Diabetes , vol.51 , Issue.1 , pp. 124-129
    • Date, Y.1    Nakazato, M.2    Hashiguchi, S.3
  • 56
    • 0036959760 scopus 로고    scopus 로고
    • Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors
    • Volante M., Allia E., Gugliotta P., et al. Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors. J Clin Endocrinol Metab. 87:(3):2002;1300-1308.
    • (2002) J Clin Endocrinol Metab , vol.87 , Issue.3 , pp. 1300-1308
    • Volante, M.1    Allia, E.2    Gugliotta, P.3
  • 57
    • 0037098974 scopus 로고    scopus 로고
    • The ghrelin cell: A novel developmentally regulated islet cell in the human pancreas
    • Wierup N., Svensson H., Mulder H., et al. The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas. Regul Pept. 107:(1-3):2002;63-69.
    • (2002) Regul Pept , vol.107 , Issue.13 , pp. 63-69
    • Wierup, N.1    Svensson, H.2    Mulder, H.3
  • 58
    • 0142122029 scopus 로고    scopus 로고
    • Ghrelin: Central and peripheral effects of a novel peptydil hormone
    • De Ambrogi M., Volpe S., Tamanini C. Ghrelin: central and peripheral effects of a novel peptydil hormone. Med Sci Monit. 9:(9):2003;RA217-RA224.
    • (2003) Med Sci Monit , vol.9 , Issue.9 , pp. 217-RA224
    • De Ambrogi, M.1    Volpe, S.2    Tamanini, C.3
  • 59
    • 1542267814 scopus 로고    scopus 로고
    • Ghrelin cells replace insulin producing β cells in tow mouse models of pancreas development
    • in press.
    • Prado C, Pugh-Bernard AE, Elghazi L, Sosa-Pineda B, Sussel L. Ghrelin cells replace insulin producing β cells in tow mouse models of pancreas development. PNAS 2004, in press.
    • (2004) PNAS
    • Prado, C.1    Pugh-Bernard, A.E.2    Elghazi, L.3    Sosa-Pineda, B.4    Sussel, L.5
  • 61
    • 0041508755 scopus 로고    scopus 로고
    • Formation of the digestive system in zebrafish: II. Pancreas morphogenesis
    • Field H.A., Dong P.D., Beis D., et al. Formation of the digestive system in zebrafish II. Pancreas morphogenesis. Dev Biol. 261:(1):2003;197-208.
    • (2003) Dev Biol , vol.261 , Issue.1 , pp. 197-208
    • Field, H.A.1    Dong, P.D.2    Beis, D.3
  • 62
    • 2642589990 scopus 로고    scopus 로고
    • Notochord repression of endodermal sonic hedgehog permits pancreas development
    • Hebrok M., Kim S.K., Melton D.A. Notochord repression of endodermal sonic hedgehog permits pancreas development. Genes Dev. 12:(11):1998;1705-1713.
    • (1998) Genes Dev , vol.12 , Issue.11 , pp. 1705-1713
    • Hebrok, M.1    Kim, S.K.2    Melton, D.A.3
  • 63
    • 0035072545 scopus 로고    scopus 로고
    • A bipotential precursor population for pancreas and liver within the embryonic endoderm
    • Deutsch G., Jung J., Zheng M., et al. A bipotential precursor population for pancreas and liver within the embryonic endoderm. Development. 128:(6):2001;871-881.
    • (2001) Development , vol.128 , Issue.6 , pp. 871-881
    • Deutsch, G.1    Jung, J.2    Zheng, M.3
  • 64
    • 0028172289 scopus 로고
    • TGF-beta 1 influences the relative development of the exocrine and endocrine pancreas in vitro
    • Sanvito F., Herrera P.L., Huarte J., et al. TGF-beta 1 influences the relative development of the exocrine and endocrine pancreas in vitro. Development. 120:(12):1994;3451-3462.
    • (1994) Development , vol.120 , Issue.12 , pp. 3451-3462
    • Sanvito, F.1    Herrera, P.L.2    Huarte, J.3
  • 65
    • 0032476723 scopus 로고    scopus 로고
    • TGF-beta plays a key role in morphogenesis of the pancreatic islets of Langerhans by controlling the activity of the matrix metalloproteinase MMP-2
    • Miralles F., Battelino T., Czernichow P., et al. TGF-beta plays a key role in morphogenesis of the pancreatic islets of Langerhans by controlling the activity of the matrix metalloproteinase MMP-2. J Cell Biol. 143:(3):1998;827-836.
    • (1998) J Cell Biol , vol.143 , Issue.3 , pp. 827-836
    • Miralles, F.1    Battelino, T.2    Czernichow, P.3
  • 66
    • 0033636981 scopus 로고    scopus 로고
    • Regulation of pancreas development by hedgehog signaling
    • Hebrok M., Kim S.K., St Jacques B., et al. Regulation of pancreas development by hedgehog signaling. Development. 127:(22):2000;4905-4913.
    • (2000) Development , vol.127 , Issue.22 , pp. 4905-4913
    • Hebrok, M.1    Kim, S.K.2    St Jacques, B.3
  • 67
    • 0037212983 scopus 로고    scopus 로고
    • Hedgehog signaling in pancreas development
    • Hebrok M. Hedgehog signaling in pancreas development. Mech Dev. 120:(1):2003;45-57.
    • (2003) Mech Dev , vol.120 , Issue.1 , pp. 45-57
    • Hebrok, M.1
  • 68
    • 0033606972 scopus 로고    scopus 로고
    • Notch signalling controls pancreatic cell differentiation
    • Apelqvist A., Li H., Sommer L., et al. Notch signalling controls pancreatic cell differentiation. Nature. 400:(6747):1999;877-881.
    • (1999) Nature , vol.400 , Issue.6747 , pp. 877-881
    • Apelqvist, A.1    Li, H.2    Sommer, L.3
  • 69
    • 18544404101 scopus 로고    scopus 로고
    • Control of endodermal endocrine development by Hes-1
    • Jensen J., Pedersen E.E., Galante P., et al. Control of endodermal endocrine development by Hes-1. Nat Genet. 24:(1):2000;36-44.
    • (2000) Nat Genet , vol.24 , Issue.1 , pp. 36-44
    • Jensen, J.1    Pedersen, E.E.2    Galante, P.3
  • 70
    • 0035694459 scopus 로고    scopus 로고
    • Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis
    • Bhushan A., Itoh N., Kato S., et al. Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis. Development. 128:(24):2001;5109-5117.
    • (2001) Development , vol.128 , Issue.24 , pp. 5109-5117
    • Bhushan, A.1    Itoh, N.2    Kato, S.3
  • 71
    • 0032991511 scopus 로고    scopus 로고
    • Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas
    • Miralles F., Czernichow P., Ozaki K., et al. Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas. Proc Natl Acad Sci U S A. 96:(11):1999;6267-6272.
    • (1999) Proc Natl Acad Sci U S a , vol.96 , Issue.11 , pp. 6267-6272
    • Miralles, F.1    Czernichow, P.2    Ozaki, K.3
  • 72
    • 0035863135 scopus 로고    scopus 로고
    • Intercellular signals regulating pancreas development and function
    • Kim S.K., Hebrok M. Intercellular signals regulating pancreas development and function. Genes Dev. 15:(2):2001;111-127.
    • (2001) Genes Dev , vol.15 , Issue.2 , pp. 111-127
    • Kim, S.K.1    Hebrok, M.2
  • 73
    • 0035495728 scopus 로고    scopus 로고
    • In-vitro differentiation of pancreatic beta-cells
    • Soria B. In-vitro differentiation of pancreatic beta-cells. Differentiation. 68:(4-5):2001;205-219.
    • (2001) Differentiation , vol.68 , Issue.45 , pp. 205-219
    • Soria, B.1
  • 74
    • 0037213351 scopus 로고    scopus 로고
    • Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis
    • Gu G., Brown J.R., Melton D.A. Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis. Mech Dev. 120:(1):2003;35-43.
    • (2003) Mech Dev , vol.120 , Issue.1 , pp. 35-43
    • Gu, G.1    Brown, J.R.2    Melton, D.A.3
  • 75
    • 0034652287 scopus 로고    scopus 로고
    • Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    • Gradwohl G., Dierich A., LeMeur M., et al. neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A. 97:(4):2000;1607-1611.
    • (2000) Proc Natl Acad Sci U S a , vol.97 , Issue.4 , pp. 1607-1611
    • Gradwohl, G.1    Dierich, A.2    Lemeur, M.3
  • 76
    • 0036340074 scopus 로고    scopus 로고
    • Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
    • Gu G., Dubauskaite J., Melton D.A. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development. 129:(10):2002;2447-2457.
    • (2002) Development , vol.129 , Issue.10 , pp. 2447-2457
    • Gu, G.1    Dubauskaite, J.2    Melton, D.A.3
  • 77
    • 0029868156 scopus 로고    scopus 로고
    • PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
    • Offield M.F., Jetton T.L., Labosky P.A., et al. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development. 122:(3):1996;983-995.
    • (1996) Development , vol.122 , Issue.3 , pp. 983-995
    • Offield, M.F.1    Jetton, T.L.2    Labosky, P.A.3
  • 78
    • 0029950724 scopus 로고    scopus 로고
    • The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice
    • Ahlgren U., Jonsson J., Edlund H. The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice. Development. 122:(5):1996;1409-1416.
    • (1996) Development , vol.122 , Issue.5 , pp. 1409-1416
    • Ahlgren, U.1    Jonsson, J.2    Edlund, H.3
  • 79
    • 0030897629 scopus 로고    scopus 로고
    • The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas
    • Sosa-Pineda B., Chowdhury K., Torres M., et al. The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas. Nature. 386:(6623):1997;399-402.
    • (1997) Nature , vol.386 , Issue.6623 , pp. 399-402
    • Sosa-Pineda, B.1    Chowdhury, K.2    Torres, M.3
  • 80
    • 0030914931 scopus 로고    scopus 로고
    • Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas
    • St-Onge L., Sosa-Pineda B., Chowdhury K., et al. Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. Nature. 387:(6631):1997;406-409.
    • (1997) Nature , vol.387 , Issue.6631 , pp. 406-409
    • St-Onge, L.1    Sosa-Pineda, B.2    Chowdhury, K.3
  • 81
    • 1842330860 scopus 로고    scopus 로고
    • Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development
    • Sander M., Neubuser A., Kalamaras J., et al. Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes Dev. 11:(13):1997;1662-1673.
    • (1997) Genes Dev , vol.11 , Issue.13 , pp. 1662-1673
    • Sander, M.1    Neubuser, A.2    Kalamaras, J.3
  • 82
    • 0031843386 scopus 로고    scopus 로고
    • Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells
    • Sussel L., Kalamaras J., Hartigan-O'Connor D.J., et al. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development. 125:(12):1998;2213-2221.
    • (1998) Development , vol.125 , Issue.12 , pp. 2213-2221
    • Sussel, L.1    Kalamaras, J.2    Hartigan-O'Connor, D.J.3
  • 83
    • 0034524101 scopus 로고    scopus 로고
    • Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas
    • Sander M., Sussel L., Conners J., et al. Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas. Development. 127:(24):2000;5533-5540.
    • (2000) Development , vol.127 , Issue.24 , pp. 5533-5540
    • Sander, M.1    Sussel, L.2    Conners, J.3
  • 84
    • 0032860478 scopus 로고    scopus 로고
    • Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice
    • Harrison K.A., Thaler J., Pfaff S.L., et al. Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice. Nat Genet. 23:(1):1999;71-75.
    • (1999) Nat Genet , vol.23 , Issue.1 , pp. 71-75
    • Harrison, K.A.1    Thaler, J.2    Pfaff, S.L.3
  • 85
    • 0029090829 scopus 로고
    • Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeobox gene Nkx2-5
    • Lyons I., Parsons L.M., Hartley L., et al. Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeobox gene Nkx2-5. Genes Dev. 9:(13):1995;1654-1666.
    • (1995) Genes Dev , vol.9 , Issue.13 , pp. 1654-1666
    • Lyons, I.1    Parsons, L.M.2    Hartley, L.3
  • 86
    • 0032844643 scopus 로고    scopus 로고
    • Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9
    • Li H., Arber S., Jessell T.M., et al. Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9. Nat Genet. 23:(1):1999;67-70.
    • (1999) Nat Genet , vol.23 , Issue.1 , pp. 67-70
    • Li, H.1    Arber, S.2    Jessell, T.M.3
  • 87
    • 0028149890 scopus 로고
    • Insulin-promoter-factor 1 is required for pancreas development in mice
    • Jonsson J., Carlsson L., Edlund T., et al. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature. 371:(6498):1994;606-609.
    • (1994) Nature , vol.371 , Issue.6498 , pp. 606-609
    • Jonsson, J.1    Carlsson, L.2    Edlund, T.3
  • 88
    • 0028869514 scopus 로고
    • Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny
    • Guz Y., Montminy M.R., Stein R., et al. Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development. 121:(1):1995;11-18.
    • (1995) Development , vol.121 , Issue.1 , pp. 11-18
    • Guz, Y.1    Montminy, M.R.2    Stein, R.3
  • 89
    • 0030886674 scopus 로고    scopus 로고
    • Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice
    • Naya F.J., Huang H.P., Qiu Y., et al. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev. 11:(18):1997;2323-2334.
    • (1997) Genes Dev , vol.11 , Issue.18 , pp. 2323-2334
    • Naya, F.J.1    Huang, H.P.2    Qiu, Y.3
  • 90
    • 0030927342 scopus 로고    scopus 로고
    • The beta cell transcription factors and development of the pancreas
    • Sander M., German M.S. The beta cell transcription factors and development of the pancreas. J Mol Med. 75:(5):1997;327-340.
    • (1997) J Mol Med , vol.75 , Issue.5 , pp. 327-340
    • Sander, M.1    German, M.S.2
  • 91
    • 0037417958 scopus 로고    scopus 로고
    • Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells
    • Blyszczuk P., Czyz J., Kania G., et al. Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells. Proc Natl Acad Sci U S A. 100:(3):2003;998-1003.
    • (2003) Proc Natl Acad Sci U S a , vol.100 , Issue.3 , pp. 998-1003
    • Blyszczuk, P.1    Czyz, J.2    Kania, G.3
  • 92
    • 0042453495 scopus 로고    scopus 로고
    • Analysis of insulin-producing cells during in vitro differentiation from feeder-free embryonic stem cells
    • Moritoh Y., Yamato E., Yasui Y., et al. Analysis of insulin-producing cells during in vitro differentiation from feeder-free embryonic stem cells. Diabetes. 52:(5):2003;1163-1168.
    • (2003) Diabetes , vol.52 , Issue.5 , pp. 1163-1168
    • Moritoh, Y.1    Yamato, E.2    Yasui, Y.3
  • 93
    • 0036730427 scopus 로고    scopus 로고
    • The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
    • Kawaguchi Y., Cooper B., Gannon M., et al. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet. 32:(1):2002;128-134.
    • (2002) Nat Genet , vol.32 , Issue.1 , pp. 128-134
    • Kawaguchi, Y.1    Cooper, B.2    Gannon, M.3


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