In-vitro differentiation of pancreatic β-cells

Differentiation

Volumn 68, Issue 4-5, 2001, Pages 205-219

  Soria, Bernat ^a  

^a MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

ANIMAL; ARTICLE; CELL DIFFERENTIATION; CELL DIVISION; CELL LINEAGE; HUMAN; IN VITRO STUDY; PANCREAS ISLET; PHYSIOLOGY; PRENATAL DEVELOPMENT; STEM CELL;

ANIMALS; CELL DIFFERENTIATION; CELL DIVISION; CELL LINEAGE; HUMANS; ISLETS OF LANGERHANS; STEM CELLS; TRANSCRIPTION FACTORS;

EID: 0035495728     PISSN: 03014681     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-0436.2001.680408.x     Document Type: Review

References (135)

1. Ahlgren, U., Pfaff, S.L., Jessell, T.M., Edlund, T. and Edlund, H. (1997) Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells. Nature 385:257-260.
2. Apelqvist, A., Li, H., Sommer, L., Beatus, P., Anderson, D.J., Honjo, T., Hrabe de Angelis, M., Lendahl, U. and Edlund, H. (1999) Notch signalling controls pancreatic cell differentiation. Nature 400:877-881.
3. Bartholomeusz, R.K., Campbell, I.L. and Harrison, L.C. (1989) Pancreatic islet A2B5- and 3G5-reactive gangliosides are markers of differentiation in rat insulinoma cells. Endocrinology 124:2680-2685.
4. Beattie, G.M., Itkin-Ansari, G., Cirulli, V., Liebowitz, G., Lopez, A.D., Bossie, S., Mally, M.I., Levne, F. and Hayek, A. (1999) Sustained proliferation of PDX-I + cells derived from human islets. Diabetes 48:1013-1019.
5. Beattie, G.M., Levine, F., Mally, M.I., Otonkoski, T., O'Brien, J.S., Salomon, D.R. and Hayek, A. (1994) Acid beta-galactosidase: a developmentally regulated marker of endocrine cell precursors in the human fetal pancreas. J Clin Endocrinol Metab 78:1232-1240.
6. Beattie, G.M., Rubin, J.S., Mally, M.I., Otonkoski, T. and Hayek, A. (1996) Regulation of proliferation and differentiation of human fetal pancreatic islet cells by extracellular matrix, hepatocyte growth factor and cell-cell contact. Diabetes 45:1223-1228.
7. Berná, G., León-Quinto, T., Enseñat-Wasser, R., Montanya, E., Martin, F. and Soria, B. (2001) Stem cells and diabetes. Biochem Pharmacother 55:1-7.
8. Billestrup, N. and Nielsen, J.H. (1991) The stimulatory effect of growth hormone, prolactin, and placental lactogen on β-cell proliferation is not mediated by insulin-like growth factor-I. Endocrinology 129:883-888.
9. Bjorson, C.R.R., Rietza, R.L., Reynolds, B.A., Magli, M.C. and Vescovi, A. (1999) Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo. Science 283:534-537.
10. Bonner-Weir, S., Deery, D., Leahy, J.L. and Weir, G.C. (1989) Compensatory growth of pancreatic cells in adult rats after short-term glucose infusion. Diabetes 38:49-53.
11. Bonner-Weir, S., Taneja, M., Weir, G.C., Tatarkiewicz, K., Song, K., Sharma, A. and O'Neil, J.J. (2000) In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci USA 97:7999-8004.
12. Bosco, D., Gonelle-Gispert, C., Wollheim, C.B., Halban, P.A. and Rouiller, D.G. (2001) Increased intracellular calcium is required for spreading of rat islet beta-cells on extracellular matrix. Diabetes 50:1039-1046.
13. Bosco, D., Meda, P., Halban, P.A. and Rouiller, D.G. (2000) Importance of cell-matrix interactions in rat islet β-cell secretion in vitro: role of α6β1 integrin. Diabetes 49:233-243.
14. Bouwens, L. and De Blay, E. (1996) Islet morphogenesis and stem cell markers in rat pancreas. J Histochem Cytochem 44:947-951.
15. Brelje, T.C., Scharp, D.W., Lacy, P.E., Ogren, L., Talamantes, F., Roberston, M., Friesen, H.G. and Sorenson, R.L. (1993) Effect of homologous placental lactogens, prolactins and growth hormones on cell division and insulin secretion in rat, mouse, and human islets: implication for placental lactogen regulation of islet function during pregnancy. Endocrinology 132:879-887.
16. Brooke, N.M., García-Fernández, J. and Holland, P.W. (1998) The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster. Nature 392:920-922.
17. Charollais, A., Gjinovci, A., Huarte, J., Bauquis, J., Nadal, A., Martin, F., Andreu, E., Sanchez-Andrés, J.V., Calabrese, A., Bosco, D., Soria, B., Wollheim, C.B., Herrera, P.L. and Meda, P. (2000) Junctional commmunication of pancreatic beta cells contributes to the control of insulin secretion and glucose tolerance. J Clin Invest 106:235-243.
18. Chatterjee, A.K., Sieradzki, J. and Schatz, H. (1986) Epidermal growth factor stimulates (pro-) insulin biosynthesis and [3H] thymidine incorporation in isolated pancreatic rat islets. Horm Metab Res 18:873-874.
19. Cirulli, V., Crisa, L., Beattie, G.M., Mally, M.I., Lopez, A.D., Fannon, A., Ptasznik, A., Inverardi, L., Ricordi, C., Deerinck, T., Ellisman, M., Reisfeld, R.A. and Hayek, A. (1998) KSA antigen Ep-CAM mediates cell-cell adhesion of pancreatic epithelial cells: morphoregulatory roles in pancreatic islet development. J Cell Biol 140:1519-1534.
20. Clarke, D.L., Johansson, C.B., Wilbertz, J., Veress, B., Nilsson, E., Karlström, H., Lendahl, V. and Frisen, J. (2000) Generalized potential of adult neural stem cells. Science 288:1660-1663.
21. Czyz, J. and Wobus, A.M. (2001) Embryonic stem cell differentiation: The role of extracellular factors. Differentiation (this issue).
22. Davidson, D. (1995) The function and evolution of Msx genes: pointers and paradoxes. Trends Genet 11:405-411.
23. DCCT. The diabetes control and complications trial research group (1993) The effect of intensive treatment of diabetes in the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Eng J Med 329:6510-6520.
24. Deutsch, G., Jung, J., Zheng, M., Lóra, J. and Zaret, K.S. (2001) A bipotential precursor population for pancreas and liver within the embryonic endoderm. Development 128:871-881.
25. De Gasparo, M., Pictet, R.L., Rall, L.B. and Rutter, W.J. (1975) Control of insulin secretion in the developing pancreatic rudiment. Dev Biol 47:106-122.
26. De Pablo, F. and de la Rosa, E.J. (1995) The developing CNS: a scenario for the action of proinsulin, insulin and insulin-like factors. Trends Neurosci 18:143-150.
27. Ferber, S., Halkin, A., Cohen, A., Ver, I., Einav, Y., Goldberg, I., Barshack, I., Seijffers, R., Kopolovic, J., Kaiser, N. and Karasik, A. (2000) Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induce hyperglycaemia. Nat Med 6:568-572.
28. Galli, R., Borello, U., Gritti, A., Minasi, M.G., Bjorson, C., Coletta, M., Mora, M., De Angelis, M.G., Fiocco, R., Cossu, G. and Vescovi, A.L. (2000) Skeletal myogenic potential of human and mouse neural stem cells. Nat Neurose 3:986-991.
29. 2+ diffusion in neuroendocrine cells. Biophysical J 78:13-33.
30. Gradwhol, G., Dierich, A., LeMeur, N. and Guillemot, F. (2000) Neurogenin 3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci USA 97:1607-1611.
31. Grapin-Botton, A., Majithia, A.R. and Melton, D.A. (2001) Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes. Genes Dev 15:444-454.
32. Hadjantonakis, A.K. and Papaioannou, V.E. (2001) Stem cell populations in early embryos. Differentiation (this issue).
33. Harrison, K.A., Thaler, J., Pfaff, S.L., Gu, H. and Kehrl, J.H. (1999) Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice. Nat Genet 23:71-75.
34. Hayek, A., Beattie, G.M., Cirulli, V., Lopez, A.D., Ricordi, C. and Rubin, J.S. (1995) Growth factor/matrix induced proliferation of human adult β-cells. Diabetes 48:722-730.
35. Hernández-Sánchez, C., Lopez-Carranza, A., Alarcón, C., de la Rosa, E.J. and de Pablo, F. (1995) Autocrine/paracrine role of insulin-related growth factors in neurogenesis: local expression and effects on cell proliferation and differentiation in retina. Proc Natl Acad Sci USA 92:9834-9838.
36. Herrera, P.L. (2000) Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. Development 127:2317-2322.
37. Hill, D.J., Strutt, B., Arany, E., Zaina, S., Coukell, S. and Graham, C.F. (2000) Increased and persistent circulating insulin-like growth factor II in neonatal transgenic mice suppresses develop-mental apoptosis in the pancreatic islets. Endocrinology 141:1151-1157.
38. Hügl, S.R., White, M.F. and Rhodes, C.J. (1998) Insulin-like growth factor I (IGF-I)-stimulated β-cell growth is glucose-dependent. J Biol Chem 273:17771-17779.
39. Hunzinger, E. and Stein, M. (2000) Nestin-expressing cells in the pancreatic islets of Langerhans. Biochem Biophys Res Commun 271:116-119.
40. Huotari, M-A., Palgi, J. and Otonkoski, T. (1998) Growth factor-mediated proliferation and differentiation of insulin-producing INS-1 and RINmSF cells: Identification of betacellulin as a novel β-cell mitogen. Endocrinology 139:1494-1499.
41. Incardona, J.P., Gaffield, W., Kapur, R.P. and Roelink, H. (1998) The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic Hedgehog signal transduction. Development 125:3553-3562.
42. Jacquemin, P., Durviaux, S.M., Jensen, J., Godfraind, C., Gradworthl, G., Guillemot, F., Madsen, O.D., Carmeliet, P., Dewerchin, M., Collen, D., Rousseau, G.G. and Lemaigre, F.P. (2000) Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3. Mol Cell Biol 20:4445-4454.
43. Jensen, J., Heller, R.S., Funder-Nielsen, T., Pedersen, E.E., Lindsell, C., Weinmaster, G., Madsen, O.D. and Serup, P. (2000a) Independent development of α- and β-cells from neurogenin-3-expressing precursors: A role for the Notch pathway in repression of premature differentiation. Diabetes 49:163-176.
44. Jensen, J., Pedersen, E.E., Galante, P., Hald, J., Heller, R.S., Ishibashi, M., Kegeyama, R., Guillemot, F., Serup, P. and Madsen, O.D. (2000b) Control of endodermal endocrine development by Hes-1. Nat Genet 24:36-44.
45. Jensen, J., Serup, P., Karlsen, C., Nielsen, T.F. and Madsen, O.D. (1996) mRNA profiling of rat islet tumors reveals Nkx6.1 as beta-cell specific homeodomain transcription factor. J Biol Chem 271:18749-18758.
46. Jiang, F-X., Cram, D.S., DeAizpurua, H.J. and Harrison, L.C. (1999) Laminin-1 promotes differentiation of fetal mouse pancreatic β-cells. Diabetes 48:722-730.
47. Jonas, J.C., Sharma, A., Hasenkap, W., Ilkowa, H., Patanel, G., Laybutt, R., Bonner-Weir, S. and Weir, G.G. (1999) Chronic hyperglycaemia triggers loss of pancreatic β-cell differentiation in an animal model of diabetes. J Biol Chem 274:14112-14121.
48. Jonsson, J., Carlsson, L., Edlund, T. and Edlund, H. (1994) Insulin-promoter factor 1 is required for pancreas development in mice. Nature 371:606-609.
49. Kim, S.K. and Melton, D.A. (1998) Pancreas development is promoted by cyclopamine, a Hedgehog signalling inhibitor. Proc Natl Acad Sci USA 95:13036-13051.
50. Klug, M.G., Soonpa, M.H., Koh, G.Y. and Field, L.J. (1996) Genetically selected cardiomyocytes from differentiating embryonic stem cells form stable intracardiac grafts. J Clin Invest 98:216-224.
51. Kritzik, M.R., Jones, E., Chen, Z., Krakowski, M., Krahl, T., Good, A., Wright, C., Fox, H. and Sarvenick, N. (1999) PDX-1 and Msx-2 expression in the regenerating and developing pancreas. J Endocrinol 163:523-530.
52. Lee, S., Clark, S.A., Gill, R.K. and Christakos, S. (1994) 1,25-Dihydroxyvitamin D3 and pancreatic β-cell expression, and insulin secretion. Endocrinology 134:1602-1610.
53. Li, H., Arber, S., Jessell, T.M. and Edlund, H. (1999) Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9. Nat Gen 23:67-70.
54. Li, M.L., Pevny, L., Lovell-Badge, R. and Smith, A. (1998) Generation of purified neural precursors from embryonic stem cells by lineage selection. Curr Biol 8:971-974.
55. Lumelsky, N., Blondel, O., Laeng, P., Velasco, I., Ravin, R. and McKay, R. (2001) Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 292:1389-1394.
56. Martin, F., Pintor, J., Rovira, J.M., Ripoll, C., Miras-Portugal, M.T. and Soria, B. (1998) Intracellular diadenosine polyphosphates: a novel second messenger in stimulus-secretion coupling. FASEB J 12:1499-1506.
57. 2+]i oscillations induced by ketoisocaproate in mouse pancreatic islets. Diabetes 44:300-305.
58. 2+]i oscillations in single mouse pancreatic islets. J Physiol (Lond) 486:361-371.
59. 2+]i oscillations in single human pancreatic islets. Cell Calcium 20:409-414.
60. Mashima, H., Ohnishi, H., Wakabayashi, K., Mine, T., Miyagawa, J., Hanafusa, T., Seno, M., Yamada, H. and Kojima, I. (1996) Betacellulin and activin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells. J Clin Invest 97:1647-1654.
61. Miralles, F., Czernichow, P. and Scharfmann, R. (1998) Follistatin regulates the relative proportions of endocrine versus exocrine tissue during pancreatic development. Development 125:1017-1024.
62. Møldrup, A., Petersen, E.D. and Nielsen, J.H. (1993) Effects of sex and pregnancy hormones on growth hormone and prolactin receptor gene expression in insulin-producing cells. Endocrinology 133:1165-1172.
63. Montanya, E., Nacher, V., Biarnes, M. and Soler, J. (2000) Linear correlation between beta-cell mass and body weight throughout the lifespan in Lewis rats: role of beta-cell hyperplasia and hypertrophy. Diabetes 49:1341-1346.
64. Müller, M., Fleischmann, B.K., Selbert, S., Ji, G.J., Endl, E., Middeler, G., Müller, O.J., Schlenke, P., Frese, S., Wobus, A.M., Hescheler, J., Katus, H.A. and Franz, W.M. (2000) Selection of ventricular-like cardiomyocytes from ES cells in vitro. FASEB J 14:2540-2548.
65. Nadal, A., Quesada, I. and Soria, B. (1999) Homologous and heterologous unsynchronicity between identified α-, β- and δ-cells within intact islet of Langerhans in the mouse. J Physiol (Lond) 517:85-93.
66. Nadal, A., Ropero, A.B., Laribi, O., Maillet, M., Fuentes, E. and Soria, B. (2000) Nongenomic actions of estrogens and xenoestrogens by binding at a plasma membrane receptor unrelated to estrogen receptor alpha and estrogen receptor beta. Proc Natl Acad Sci USA 97:11603-11608.
67. Nadal, A., Rovira, J.M., Laribi, O., Leon-Quinto, T., Andreu, E., Ripoll, C. and Soria, B. (1998) Rapid insulinotropic effect of 17beta-estradiol via a plasma membrane receptor. FASEB J 12:1341-1348.
68. Naya, F.J., Huang, H-P., Qiu, Y., Mutoh, H., DeMayo, F.J., Leiter, A.B. and Tsai, M-J. (1997) Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice. Genes Dev 11:2323-2334.
69. Nielsen, J.H., Svenson, C., Gaksgaard, E.D., Moldrup, A. and Billestrup, N. (1999) Beta cell proliferation and growth factors. J Mol Med 77:62-66.
70. Nishikawa, S.I., Nushikawa, S., Hisrashima, M., Matsuyoshi, N. and Kodama, H. (1998) Progressive lineage analysis by cell sorting and culture identifies FLK1 + VE-cadherin + cells at a diverging point of endothelial and hemopoietic lineages. Development 125:1747-1757.
71. Oberg-Welsh, C., Welsh, C., Snadler, S., Anderson, A. and Welsh, M. (1997) Effect of vascular endothelial growth factor on pancreatic duct replication and the insulin production of fetal-like clusters in vitro. Mol Cell Endocrinol 126:125-132.
72. Offield, M.F., Jetton, T.L., Labosky, P.A., Ray, M., Stein, R.W., Magnuson, M.A., Hogan, B.L. and Wright, C.V. (1996) PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 122:983-995.
73. Ohlson, H., Karlsson, K. and Edlund, T. (1993) IPF-1, a homeodomain-containing transactivator of the insulin gene. EMBO J 12:4251-4259.
74. Okamoto, H. (1997) New aspects to the functioning and regeneration of pancreatic β-cells. Cyclic ADP-ribose and Reg gene. In: Soria, B. (ed) Physiology and Pathophysiology of the Islets of Langerhans. Plenum Press, New York, pp 301-311.
75. Orci, L. (1982) Macro- and micro-domains in the endocrine pancreas. Diabetes 31:538-565.
76. Otonkoski, T., Beattie, G.M., Mally, M.I., Ricordi, C. and Hayek, A. (1993) Nicotinamide is a potent inducer of endocrine differentiation in cultured human fetal pancreatic cells. J Clin Invest 92:1459-1466.
77. Otonkoski, T., Cirulli, V., Beattie, M., Mally, M.I., Soto, G., Rubin, J.S. and Hayek, A. (1996) A role for hepatocyte growth factor/ scatter factor in fetal mesenchyme-induced pancreatic beta-cell growth. Endocrinology 137:3131-3139.
78. Otonkoski, T., Mally, M.I. and Hayek, A. (1994) Opposite effects of beta cell differentiation and growth on Reg expression in human fetal pancreatic cells. Diabetes 43:1164-1166.
79. Pang, K., Mukonoweshuro, C. and Wong, G.G. (1994) Beta cells arise from glucose transporter type 2 Glut2-expressing epithelial cells of the developing rat pancreas. Proc Natl Acad Sci USA 91:9559-9563.
80. Pertusa, J.A.G., Sanchez-Andrés, J.V., Martín, F. and Soria, B. (1999) Effects of calcium buffering on glucose-induced insulin release in mouse pancreatic islets: an approximation to the calcium sensor. J Physiol (Lond) 520:473-483.
81. Philippe, J., Drucker, D.J., Chick, W.L. and Habener, J.F. (1987) Transcriptional regulation of genes encoding insulin, glucagon and angiotensinogen by sodium butyrate in a rat islet cell line. Mol Cell Biol 7:560-563.
82. Porter, S.E., Sorenson, R.L., Dann, P., García-Ocana, A., Steward, A.F. and Vasavada, R.G. (1998) Progressive pancreatic islet hyperplasia in the islet-targeted, parathyroid hormone-related protein-overexpressing mouse. Endocrinology 139:3743-3751.
83. Ptasznik, A., Beattie, G.M., Mally, M.I., Cirulli, V., Lopez, A. and Hayek, A. (1997) Phosphatidylinositol 3-kinase is a negative regulator of cellular differentiation. J Cell Biol 137:1127-1136.
84. Quesada, I., Nadal, A. and Soria, B. (1999) Different effects of tolbutamide an diazoxide in α-, β- and δ-cells within intact islets of Langerhans. Diabetes 48:2390-2397.
85. 2+ microgradients in pancreatic islet cells. J Physiol (Lond) 525:159-167.
86. Rao, M.S., Scarpelli, D.G. and Reddy, J.K. (1986) Transdifferentiated hepatocytes in rat pancreas. Curr Top Dev Biol 20:63-78.
87. Ripoll, C., Martin, F., Rovira, J.M., Pintor, J., Miras-Portugal, M.T. and Soria, B. (1996) Diadenosine polyphosphates: a novel class of glucose-induced intracellular messengers in the pancreatic β-cell. Diabetes 45:1431-1434.
88. Roche, E., Assimacopoulos-Jeannet, F., Witters, L.A., Perruchoud, B., Yaney, G., Corkey, B., Asfari, M. and Prentki, M. (1997) Induction by glucose of genes coding for glycolytic enzymes in a pancreatic β-cell line. J Biol Chem 272:3091-3098.
89. Roche, E., Buteau, J., Aniento, I., Reig, J.A., Soria, B. and Prentki, M. (2000) Palmitate and oleate induce the immediate-early response genes c-fos and nur-77 in the pancreatic B-cell line INS-1. Diabetes 48:2007-2014.
90. Roche, E., Farfari, S., Witters, L.A., Assimacopoulos-Jeannet, F., Thumelin, S., Brun, T., Corkey, B.E., Saha, A.K. and Prentki, M. (1998) Long-term exposure to β-INS cells to high glucose concentrations increases anaplerosis, lipogenesis, and lipogenic gene expression. Diabetes 47:1086-1094.
91. Rohwedel, J., Maltsev, V., Bober, E., Arnold, H.H., Hescheler, J. and Wobus, A.M. (1994) Muscle cell differentiation of embryonic stem cells reflects myogenesis in vivo: developmentally regulated expression of myogenic determination genes and functional expression of ionic currents. Dev Biol 164:87-101.
92. Ropero, A.B., Fuentes, E., Rovira, J.M., Ripoll, C., Soria, B. and Nadal, A. (1999) Non-genomic actions of 17beta-oestradiol in mouse pancreatic beta-cells are mediated by a cGMP-dependent protein kinase. J Physiol (Lond) 521:397-407.
93. 2+]i oscillations due to bursting electrical activity in single pancreatic islets. Pflügers Arch.-Eur J Physiol 418:417-422.
94. Scarpelli, D.G. and Rao, M.S. (1981) Differentiation of regenerating pancreatic cells into hepatocyte-like cells. Proc Natl Acad Sci USA 78:2577-2581.
95. Scharfmann, R., Tazi, A., Polak, M., Kanaka, C. and Czernichow, P. (1993) Expression of functional nerve growth factor receptors in pancreatic β-cell lines and fetal rat islets in primary culture. Diabetes 42:1829-1836.
96. Schuldiner, M., Yanuka, O., Itskovitz-Eldor, J., Melton, D.A. and Benvenisty, N. (2000) Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells. Proc Natl Acad Sci USA 97:11307-11312.
97. Schwitzgebel, V.M., Scheel, D.W., Conners, J.R., Kalamaras, J., Lee, J.E., Anderson, D.J., Sussel, L., Johnson, J.D. and German, M.S. (2000) Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development 127:3533-3542.
98. Segura, J., Gil, A. and Soria, B. (2000) Modeling study of exocytosis in neuroendocrine cells: influence of the geometrical parameters. Biophys J 79:1771-1786.
99. Shamblott, M.J., Axelman, J., Littlefield, J.W., Blumenthal, P.D., Huggins, G.R., Cui, Y., Cheng, L. and Gearhart, J.D. (2000) Human embryonic germ cell derivatives express a broad range of developmentally distinct markers and proliferate extensively in vitro. Proc Natl Acad Sci USA 95:13726-13731.
100. Shamblott, M.J., Axelman, J., Wang, S., Bugg, E.M., Littlefield, J.W., Donovan, P.J., Blumenthal, P.D., Huggins, G.R. and Gearhart, J.D. (1998) Derivation of pluripotent stem cells from cultured human primordial germ cells. Proc Natl Acad Sci USA 98:113-118.
101. Shapiro, A.M.J., Lakey, J.R.T., Ryan, E.A., Korbutt, G.S., Toth, E., Warnock, G.L., Kneteman, N.M. and Rajotte, R.V. (2000) Islet transplantation in seven patients with type 1 diabetes mellitus using a corticoid-free immunosuppressive regime. N Eng J Med 343:230-238.
102. Sirica, A.E. (1995) Ductular hepatocytes. Histol Histopathol 10:433-456.
103. Sjöholm, A., Funakoshi, A., Effendic, S., Ostenson, C-G. and Hellerstrom, C. (1992) Long term inhibitory effects of pancreastatin and diazepam binding inhibitor of pancreatic β-cell deoxyrribonucleic acid replication, polyamine content and insulin secretion by rat pancreatic β-cells. Am J Physiol 262:195-391.
104. Sjöholm, A., Korsgren, O. and Andersson, A. (1994) Polyamine requirements in nicotinamide-stimulated β-cell differentiation in fetal porcine islet-like cell clusters. Endocrinology 135:1559-1565.
105. Smith, F.E., Rosen, K.M., Villa-Komaroff, L., Weir, G.C. and Bonner-Weir, S. (1991) Enhanced insulin-like growth factor I gene expression in the regenerating rat pancreas. Proc Natl Acad Sci USA 88:6152-6156.
106. Soria, B., Andreu, E., Berná, G., Fuentes, E., Gil, A., León-Quinto, T., Martín, F., Montanya, E., Nadal, A., Reig, J.A., Ripoll, C., Roche, E., Sánchez-Andrés, J.V. and Segura, J. (2000a) Engineering pancreatic islets. Pflügers Archiv-European J Physiol 440:1-18.
107. Soria, B., Roche, E., Berná, G., León-Quinto, T., Reig, J.A. and Martin, F. (2000b) Insulin-secreting cells derived from embryonic stem cells normalize glycaemia in streptozotocin-induced diabetic mice. Diabetes 49:157-162.
108. Soria, B., Skoudy, A. and Martín, F. (2001) From stem cells to β-cells: new strategies in cell therapy of diabetes mellitus. Diabetologia 44:407-415.
109. Sosa-Pineda, B., Chowdhury, K., Torres, M., Oliver, G. and Gruss, P. (1997) The Pax4 gene is essential for differentiation of insulin-producing β-cells in the mammalian pancreas. Nature 387:399-402.
110. Spaventi, R., Antica, M. and Pavelic, K. (1990) Insulin and insulin-like growth factor I (IGF I) in early mouse embryogenesis. Development 108:195-491.
111. St-Onge, L., Sosa-Pineda, B., Chowdhury, K., Mansouri, A. and Gruss, P. (1997) Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. Nature 387:406-409.
112. Studer, L., Csete, M., Lee, S.H., Kabbani, N., Walikonis, J., Wold, B. and McKay, R. (2000) Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen. J Neurosci 20:7377-7388.
113. Sugiyama, K., Yonemura, Y. and Okamoto, H. (1991) Effects of poly(ADP-rybose) synthetase inhibitor on β-cells of a canine pancreas after massive pancreatectomy. Int J Pancreatol 8:85-95.
114. Sussel, L., Kalamaras, J., Hartigan-O'Connor, D.J., Meneses, J.J., Pedersen, R.A., Rubenstein, J.L. and German, M.S. (1998) Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development 125:2213-2221.
115. Sweene, I. (1992) Pancreatic β-cell growth and diabetes mellitus. Diabetologia 35:193-201.
116. Teitelman, G., Jon, T.H. and Reis, D.J. (1981a) Transformation of catecholaminergic precursors into glucagon (A) cells in mouse embryonic pancreas. Proc Natl Acad Sci USA 78:5225-5229.
117. Teitelman, G., Jon, T.H. and Reis, D.J. (1981b) Linkage of the brain-skin-gut axis: Islet cells originate from dopaminergic precursors. Peptides 2:157-168.
118. Thomson, J.A., Itskovitz-Eldor, J., Shapiro, S.S., Waknitz, M.A., Swiergiel, J.J., Marshall, V.S. and Jones, J.M. (1998) Embyronic stem cell lines derived from human blastocysts. Science 282:1145-1147.
119. Upchurch, B.H., Aponte, G.W. and Leiter, A.B. (1994) Expression of peptide YY in all four islet cell types in the developing mouse pancreas suggests a common peptide YY-producing progenitor. Development 120:245-252.
120. Verme, T.B. and Hootman, S.R. (1990) Regulation of pancreatic duct epithelial growth in vitro. Am J Physiol 258:G833-G840.
121. Vinik, A.I., Pittenger, G.L., Rafaeloff, R., Rosenberg, L. and Dugid, W. (1997) Determinants of pancreatic islet cell neogenesis. The cellophane wrap model. In: Svarvetnik, N. (ed) Pancreatic Growth and Regeneration. Karger Landes Systems, Basel, pp 183-217.
122. Wang, R.N., Bonner-Weir, S., Oates, P.S., Chulak, M., Simon, B., Merlino, G.T., Schmidt, E.V. and Brand, S.J. (1993) Pancreatic gastrin stimulates islet differentiation of the TGF-alpha induced ductular precursor cells. J Clin Invest 92:1349-1356.
123. Wang, R.N., Rehfeld, J.F., Nielssen, F.C. and Kloppel, G. (1997) Expression of gastrin and transforming growth factor-alpha during duct to islet cell differentiation in the pancreas of duct-ligated adult rats. Diabetologia 40:887-893.
124. Watada, H., Kajimoto, Y., Miyagawa, J., Hanafusa, T., Hamaguchi, K., Matsuoka, T., Yamamoto, K., Matsuzawa, Y., Kawamori, R. and Yamasaki, Y. (1996) PDX-1 induces insulin and glucokinase gene expressions in alphaTCl clone 6 cells in the presence of betacellulin. Diabetes 45:1826-1831.
125. Wells, J.M. and Melton, D.A. (2000) Early mouse endoderm is patterned by soluble factors from adjacent germ layers. Development 127:1563-1572.
126. Weiss, M.J. and Orkin, S.H. (1996) In vitro differentiation of murine embryonic stem cells. J Clin Invest 97:195-591.
127. Wiles, M.V. and Keller, G. (1991) Multiple hematopoietic lineages develop from embryonic stem (ES) cells in culture. Development 111:259-267.
128. Wilmut, I., Schniecke, A.E., McWhir, J., Kind, A.J. and Campbell, K.H. (1997) Viable offspring derived from fetal and adult mammalian cells. Nature 385:810-813.
129. Wolf, H., Sabata, V., Frerichs, H. and Stubbe, P. (1969) Evidence for the impermeability of the human placenta for insulin. Horm Metab Res 1:274-275.
130. Wu, K., Gannon, M., Peshavaria, M., Oldfield, M.F., Henderson, E., Ray, M., Marks, A., Gamer, L.W., Wright, C.V.E. and Stein, R. (1997) Hepatocyte nuclear factor 3β is involved in pancreatic β-cell-specific transcription of the pdx-1 gene. Mol Cell Biol 17:6002-6013.
131. Xu, G., Stoffers, D.A., Habener, J.F. and Bonner-Weir, S. (1999) Exendin-4 stimulates both β-cell replication and neogenesis, resulting in increased β-cell mass and improved glucose tolerance in diabetic rats. Diabetes 48:2270-2276.
132. Yamashita, J., Itoh, H., Hirashima, M., Ogawa, M., Nishikawa, S., Yurugj, T., Naito, M., Nakao, K. and Nishikawa, S. (2000) Flk-1-positive cells derived from embryonic stem cells serve as vascular progenitors. Nature 408:92-96.
133. Zarek, K.S. (1996) Molecular genetics of early liver development. Ann Rev Physiol 58:151-231.
134. Zhou, J., Wang, X., Pineyro, M.A. and Egan, J. (1999) Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells. Diabetes 48:2358-2366.
135. Zulewski, H., Abraham, E.J., Gerlach, M.J., Daniel, P.B., Moritzs, W., Müller, B., Vallejo, M., Thomas, M.K. and Habener, J.F. (2001) Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine and hepatic phenotypes. Diabetes 50:521-533.