Ghrelin: Central and peripheral effects of a novel peptydil hormone

Medical Science Monitor

Volumn 9, Issue 9, 2003, Pages

  De Ambrogi, Marco ^b   Volpe, Sara ^b   Tamanini, Carlo ^a  

^a SOPRA   (France)

^b NONE

Author keywords

Energy balance; GH; Ghrelin; Metabolism

Indexed keywords

AGOUTI RELATED PROTEIN; GHRELIN; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; LEPTIN; NEUROPEPTIDE Y;

ANTINEOPLASTIC ACTIVITY; ENERGY BALANCE; FOOD INTAKE; HALF LIFE TIME; HEART; HOMEOSTASIS; HORMONE RELEASE; HUMAN; HYPOPHYSIS; HYPOTHALAMUS; IN VITRO STUDY; INTESTINE; KIDNEY; LIPID STORAGE; NONHUMAN; OBESITY; PANCREAS; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REVIEW; STOMACH; TESTIS; WEIGHT GAIN;

ANIMALS; CENTRAL NERVOUS SYSTEM; ENERGY METABOLISM; GROWTH HORMONE; HUMANS; PEPTIDE HORMONES; RECEPTORS, CELL SURFACE; TISSUE DISTRIBUTION;

EID: 0142122029     PISSN: 12341010     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (92)

1. Kojima M, Hosoda H, Date Y et al: Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature, 1999; 402: 656-660
2. Casanueva FF, Diéguez C: Ghrelin: the link connecting growth with metabolism and energy homeostasis. Reviews in Endocrine and Metabolic Disorders, 2002; 3: 325-338
3. Tschöp M, Smiley DL, Heiman ML: Ghrelin induces adiposity in rodents. Nature, 2000; 407: 908-913
4. Muccioli G, Tschop M, Papotti M et al: Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity. Eur J Pharmacol, 2002; 440(2-3): 235-254
5. Barreiro ML, Gaytn F, Caminos JE et al: (2002a) Cellular location and hormonal regulation of ghrelin expression in rat testis. Biol Reprod, 2002a; 67: 1768-1776
6. Horvath T, Diano S, Sotonyi P et al: Minireview: Ghrelin and the regulation of energy balance- A hypothalamic perspective. Endocrinology, 2001; 142(10): 4163-4169
7. Bowers CY, Momany F, Reynolds GA et al: Structure-activity relationships of a synthetic pentapeptide that specifically releases growth hormone in vitro. Endocrinology, 1980; 106: 663-667
8. Howard HD, Feighner SD, Cully DF et al: A receptor in pituitary and hypothalamus that functions in growth hormone release. Science, 1996; 273: 974-976.
9. Papotti M, Ghe C, Cassoni P et al: Growth hormone secretagogue binding sites in peripheral human tissues. J Clin Endocrinol Metab. 2000; 85(10): 3803-3807
10. Wajnrajch MP, Ten IS, Gertner JM, Leibel RL: Genomic organization of human ghrelin gene. J Endocr Genet, 2000; 1: 231-233
11. Kojima M, Hosoda H, Matsuo H, Kangawa K: Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor. Trends in Endocrinology and Metabolism, 2001; 12(3): 118-122
12. Tanaka M, Hayashida Y, Iguchi T, et al: Organization of the mouse ghrelin gene and promoter: occurrence of a short noncoding first exon. Endocrinology, 2001; 142: 3697-3700
13. Hosoda H. Kojima M, Matsuo H, Kangawa K: Purification and characterization of rat des-Gln14-ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor. J Biol Chem. 2000; 29: 1995-2000
14. Bednarek MA, Feighner SD, Pong SS et al: Structure-function studies on the new growth hormone realising peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a. J Med Chem, 2000; 43: 4370-4376
15. Hosoda H, Kojima M, Matsuo H, Kangawa K: Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun, 2000; 29: 909-913
16. Beaumont NJ, Skinner VO, Tan TM et al: Ghrelin can bind to a species of high density lipoprotein associated with paraoxanase. J Biol Chem, 2003; 14: 8877-8880
17. Bagnasco M, Kalra PS, Kalra SP: Ghrelin and leptin pulse discharge in fed and fasted rats. Endocrinology, 2002; 143: 726-729
18. Tolle V, Bassant MH, Zizzarri P et al: Ultradian rhythmicity of ghrelin secretion in relation with GH, feeding behaviour, and sleep-wake patterns in rats. Endocrinology, 2002; 143: 1353-1361
19. Bowers CY: Unnatural growth hormone-releasing peptide begets natural ghrelin. J Clin Endocrinol Metab, 2001; 86: 1464-1469
20. Mori K, Yoshimoto A, Takaya K et al: Kidney produces a novel acylated peptide, ghrelin. FEBS Lett, 2000; 486: 213-216
21. Kanamoto N, Akamizu T, Hosoda H et al: Substantial production of ghrelin by a human medullary thyroid carcinoma cell line. J Clin Endocrinol Metab, 2001; 86: 4984-4990
22. Hattori N, Saito T, Yagyu T et al: GH, GH receptor, GH-secretagogue receptor and ghrelin expression in human T cells. B cells and neutrophils. J Clin Endocrinol Metab, 2001; 86: 4284-4291
23. Volante M, Allia E, Gugliotta P et al: Expression of ghrelin and GHS receptor by pancreatic islet cells and related endocrine tumours. J Clin Endocrinol Metab, 2002a; 87: 1300-1308
24. Volante M, Fulcheri E, Allia E et al: Ghrelin expression in fetal, infant, and adult human lung. J Histochem Cytochem 2002b; 50: 1013-1021
25. Gaytan F, Barreiro ML, Chopin LK et al: Immunolocalization of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in the cyclic human ovary. J Clin Endocrinol Metabol, 2003; 88(2): 879-887
26. Korbonits M, Bustin SA, Kojima M et al: The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumours. J Clin Endocrinol Metab. 2001; 86: 881-887
27. Dornonville de la Cour C, Bjorkqvist M, Sandvik AK et al: A-like cells in the rat stomach contain ghrelin and do not operate under gastrine control. Regulatory Peptides, 2001; 99: 141-150
28. Date Y, Kojilna M, Hosoda H et al: Ghrelin, a novel hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology, 2000; 141(11): 4255-4261
29. Rindi G, Necchi V, Savio A et al: Characterisation of gastric ghrelin cells in man and other mammals: studies in adult and fetal tissues. Histochem Cell Biol, 2002; 117: 511-519
30. Murakami N, Murakami K, Mogi K et al. Ghrelin in domestic animals: distribution in stomach and its possible role. Dom Anim Endocrinol, 2001; 21: 17-24
31. Kaiya H, Kojima M, Hosoda H et al: Bullfrog ghrelin is modified by n-octanoic acid at its third threonine residue. J Biol Chem, 2001; 276: 40441-40448
32. Kaiya H, Van Der Geyten S, Kojima M et al: Chicken ghrelin: purification, cDNA cloning and biological activity. Endocrinology, 2002; 143: 3454-3463
33. Gualillo O, Caminos J, Blanco M et al: Ghrelin, a novel placental-derived hormone. Endocrinology, 2001; 142: 788-794
34. Ariyasu H, Takaya K, Hosoda H et al: Delayed short-term secretory regulation of ghrelin in obese animals: evidenced by a specific RIA for the active form of ghrelin. Endocrinology, 2002; 143: 3341-3350
35. Toshinai K, Mondal MS, Nakazato M et al: Upregulation of ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia and leptin administration. Biochem Biophys Res Commun, 2001; 281: 1220-1225
36. Cummings DE, Purnell JQ, Frayo RS et al: A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes, 2001; 50: 1714-1719
37. Tschöp M, Wawarta R, Riepl RL et al: Post-prandial decrease of circulating human ghrelin levels. J Endocrinol Invest, 2001; 24: 19-21
38. Sugino T, Yamaura J, Yamagishi M et al: A transient surge of ghrelin secretion before feeding is modified by different feeding regimens in sheep. Biochem Biophys Res Commun, 2002; 298: 785-788
39. Shiiya T, Nakazato M, Mizuta M et al: Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab, Jan, 2002; 87(1): 240-244
40. Otto B, Cuntz U, Fruehauf E, Wawarta R et al: Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa. Eur J Endocrinol, 2001; 145: 669-673
41. Nieminen P, Mustonen AM, Asikainen J, Hyvarinen H: Seasonal weight regulation of the raccoon dog (Nyctereutes procyonoides): interactions between melatonin, leptin, ghrelin and growth hormone. J Biol Rhythms, 2002; 17: 155-163
42. Gualillo O, Caminos JE, Kojima M et al: Gender and gonadal influences on ghrelin mRNA levels in rat stomach. Eur J Endocrinol, 2001; 144: 687-690
43. Rigamonti AE, Pincelli AI, Corra B et al: Plasma ghrelin concentrations in elderly subjects: comparison with anorexic and obese patients. J Endocrinol, 2002; 175: R1-5
44. Haqq AM, Farooqi IS, O'Rahilly S et al: Serum ghrelin levels are inversely correlated with body mass index, age and insulin concentrations in normal children and are markedly increased in Prader-Willy syndrome. J Clin Endocrinol Metab, 2003; 88: 174-178
45. Hewson AK, Dickson SL: Systemic administration of ghrelin induces Fos and Egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats. J Neuroendocrinol, 2000; 12: 1047-1049
46. Lee HM, Wang G, Englander EW et al: Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: enteric distribution, ontogeny, influence of endocrine, and dietary manipulations. Endocrinology, 2002; 143: 185-190
47. Wren AM, Small CJ, Ward HL et al: The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology. 2000; 141: 4325-4328
48. Petersenn S: Structure and regulation of the growth hormone secretagogue receptor. Minerva Endocrinol, 2002; 27(4): 243-256
49. Smith RG, Leonard R, Bailey AR et al: Growth hormone secretagogue receptor family members and ligands. Endocrine, 2001; 14(1): 9-14
50. Cunha SR, Mayo KE: Ghrelin and GH secretagogues potentiate GH-releasing hormone (GHRH) induced cyclic adenosine 3′,5′-monophosphate production in cells expressing transfected GHRH and GH secretagogue receptors. Endocrinology, 2002; 143(12): 4570-4582
51. Torsello A, Ghè C, Bresciani E et al: Short ghrelin peptides neither displace ghrelin binding in vitro nor stimulate GH release in vivo. Endocrinology, 2002; 143(5): 1968-1971
52. Casanueva F: (1992) Physiology of growth hormone secretion and action. Endocrinol Metab Clin N Amer, 1992; 21: 484-517
53. Dieguez C, Casanueva F: Influence of metabolic substrates and obesity on growth hormone secretion. Trends Endocrinol Metab, 1995; 6: 55-59
54. Torsello A, Bresciani E, Avallone R, Locatelli V: Ghrelin and GH secretion. Minerva Endocrinol, 2002; 27(4): 257-264
55. Yoshihara F, Kojima M, Hosoda H et al: Ghrelin: a novel peptide for growth hormone release and feeding regulation. Curr Opin Clin Nutr Metab Care, 2002; 5(4): 391-5
56. Ghigo E, Arvat E, Giordano R et al: Biologic activities of growth hormone secretagogues in humans. Endocrine, 2001; 14(1): 87-93
57. Tannenbaum GS, Bowers CY: Interactions of growth hormone secretagogues and growth hormone releasing hormone/somatostatin. Endocrine, 2001; 14: 21-27
58. Bowers CY: Synergistic release of growth hormone by GHRP and GHRH: scope and implications. In: Bercu BB, Walker BF, eds. Growth hormone secretagogues in clinical practice. New York: Marcel Dekker Inc, 1998; 1: 1-27
59. Inui A: Ghrelin: an orexigenic and somatotrophic signal from the stomach. Nature Rev Neurosci, 2001; 2: 551-560
60. Hashizume T, Horiuchi M, Tate N et al: Effects of ghrelin on growth hormone secretion from cultured adenohypophysial cells in pigs. Animal Endocrinology, 2003; 24: 209-218
61. Baratta M: Leptin from a signal of adiposity to a hormonal mediator in peripheral tissues. Med Sci Monit, 2002; 8(12): 282-292
62. Garcia A, Alvarez CV, Smith RG, Dieguez C: Regulation of Pit-1 expression by ghrelin and GHRP-6 through the GH secretagogue receptor. Mol Endocrinol, 2000; 15(9): 1484-1495
63. Muller AF, Lamberts SWJ, Janssen JAMJL et al: Ghrelin drives GH secretion during fasting in man. Eur J Endocrinol, 2002; 146: 203-207
64. Ghigo E, Arvat E, Camanni F: Growth hormone secretagogues as corticotrophin-releasing factors. Growth hormone IGF Res, 1998; 8: 145-148
65. Arvat E, Gianotti L, Giordano R et al: Growth hormone-releasing hormone and growth hormone secretagogue-receptor ligands. Endocrine, 2001; 14(1): 35-43
66. Arvat E, Maccario L, Di Vito L et al: Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a non-natural peptidyl GHS, and GH-releasing hormone. J Clin Endocrinol Metab, 2001; 86: 1169-1174
67. Barriero ML, Pinilla L, Aguilar E, Tena-Sempere M: Expression and homologous regulation of GH secretagogue receptor mRNA in rat adrenal gland. Eur J Endocrinol, 2002; 147(5): 677-688
68. Carlini VP, Monzòn ME, Varas MM et al: Ghrelin increases anxiety-like behaviour and memory retention in rats. Biochemical and Biophysical Research Communications, 2002; 299(5): 739-743
69. Masuda Y, Tanaka T, Inomata N et al: Ghrelin stimulates gastric acid secretion and motility in rats. Biochem Biophys Res Commun, 2000; 276: 905-908
70. Date Y, Nakazato M, Murakami N et al: Ghrelin acts in the central nervous system to stimulate gastric acid secretion and motility in rats. Biochem Biophys Res Commun, 2001; 280: 904-907
71. Sibilia V, Rindi G, Pagani F et al: Ghrelin protects against ethanol induced gastric ulcers in rats: studies on the mechanisms of action. Endocrinology, 2003; 144: 353-359
72. Oates PJ, Hakkinen JP: Studies on the mechanism of ethanol-induced gastric damage in rats. Gastroenterology, 1988; 94: 10-21
73. Murata M, Okimura Y, Iida K et al: Ghrelin modulates the downstream of insulin signaling in hepatoma cells. J Biol Chem, 2001; 27: 27
74. Muller AF, Janssen JA, Hofland LJ et al: Blockade of the growth hormone (GH) receptor unmasks rapid GH-releasing peptide-6-mediated tissue-specific insulin resistance. J Clin Endocrinol Metab, 2001; 86: 4984-4990
75. Cassoni P, Papotti M, Catapano F et al: Specific binding sites for synthetic growth hormone secretagogue in non-tumoral and neoplastic human thyroid tissue. J Endocrinol, 2000; 165: 139-146
76. Beltowski J: Adiponectin and resistin- new hormones of white adipose tissue. Med Sci Monit, 2003; 9(2): 55-61
77. Shintani M, Ogawa Y, Ebihara K et al: Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes, 2001; 50: 227-239
78. Spiegelman BM, Flier JS: Obesity and the regulation of energy balance. Cell, 2001; 104: 531-543
79. Toth DW, Hellmann PH, Gordon DA et al: Evidence that the orexigenic effect of ghrelin is mediated by a distinct GHS-R subtype. Proceedings of the 83rd Ann Meet of the Endocrine Society, Denver CO, 2001; 169
80. Asakawa A, Inui A, Kaya T et al: Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology, 2001; 120: 337-345
81. Ukkob O, Ravussin E, Jacobson P et al: Mutation in the preproghrelin gene associated with obesity in humans. J Clin Endocrinol Metab, 2001; 86: 3996-3999
82. Laron Z, Frenkel J, Deghenghi R et al: Intranasal administration of thee GHRP hexarelin accelerates growth in short children. Clin Endocrinol, 1995; 43: 631-635
83. Svensson J, Lonn L, Jansson JO et al: Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure. J Clin Endocrinol Metab, 1998; 83: 362-369
84. King MK, Gay DM, Pan LC et al: Treatment with a growth hormone secretagogue in a model of developing heart failure. Effects on ventricular and myocyte function. Circulation, 2001; 103: 308-312
85. Tivesten A, Bollano E, Caidahl K et al: The growth hormone secretagogue hexarelin improves cardiac function in rats after experimental myocardial infarction. Endocrinology, 2000; 141: 60-66
86. Svensson S, Lall S, Dickson SL et al: Effects of growth hormone and its secretagogues on bone. Endocrine, 2001; 141: 60-66
87. Popovic V, Leal A, Micic D, Koppeschaar HP et al: GH-releasing hormone and GH-releasing peptide-6 for diagnostic testing in GH-deficient adults. Lancet, 2000; 356: 1137-1142
88. Ho KK: Diagnosis of adult GH deficiency. Lancet, 2000; 356: 1125-1126
89. Wren AM, Small CJ, Abbott CR et al: Ghrelin causes hyperphagia and obesity, in rats. Diabetes, 2001; 50: 2540-2547
90. Cassoni P, Papotti M, Ghé C et al: Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines. J Clin Endocrinol Metab, 2001; 81: 4249-4257
91. Deghenghi R: Diazaspiro, azepino and azabicyclo therapeutic peptides. United States Patent, 2000; 6: 425-471
92. Ghé C, Cassoni P, Catalano F et al: The anti-proliferative effect of synthetic peptidyl GH secretagogues in human calu-1 lung carcinoma cells. Endocrinology, 2002; 143: 484-491