-
2
-
-
0033151572
-
Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation
-
K. Ando, M. Oishi, S. Takeda, K. Iijima, T. Isohara, A.C. Nairn, Y. Kirino, P. Greengard, and T. Suzuki Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation J. Neurosci. 19 1999 4421 4427
-
(1999)
J. Neurosci.
, vol.19
, pp. 4421-4427
-
-
Ando, K.1
Oishi, M.2
Takeda, S.3
Iijima, K.4
Isohara, T.5
Nairn, A.C.6
Kirino, Y.7
Greengard, P.8
Suzuki, T.9
-
3
-
-
0035955712
-
Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid
-
K. Ando, K.I. Iijima, J.I. Elliott, Y. Kirino, and T. Suzuki Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid J. Biol. Chem. 276 2001 40353 40361
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 40353-40361
-
-
Ando, K.1
Iijima, K.I.2
Elliott, J.I.3
Kirino, Y.4
Suzuki, T.5
-
4
-
-
0036793843
-
Caspase-cleaved amyloid precursor protein in Alzheimer's disease
-
C. Ayala-Grosso, G. Ng, S. Roy, and G.S. Robertson Caspase-cleaved amyloid precursor protein in Alzheimer's disease Brain Pathol. 12 2002 430 441
-
(2002)
Brain Pathol.
, vol.12
, pp. 430-441
-
-
Ayala-Grosso, C.1
Ng, G.2
Roy, S.3
Robertson, G.S.4
-
5
-
-
0037020265
-
Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2
-
S. Benesch, S. Lommel, A. Steffen, T.E. Stradal, N. Scaplehorn, M. Way, J. Wehland, and K. Rottner Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2 J. Biol. Chem. 277 2002 37771 37776
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 37771-37776
-
-
Benesch, S.1
Lommel, S.2
Steffen, A.3
Stradal, T.E.4
Scaplehorn, N.5
Way, M.6
Wehland, J.7
Rottner, K.8
-
6
-
-
0033586449
-
Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein
-
J. Berger-Sweeney, D.L. McPhie, J.A. Arters, J. Greenan, M.L. Oster-Granite, and R.L. Neve Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein Brain Res. Mol. Brain Res. 66 1999 150 162
-
(1999)
Brain Res. Mol. Brain Res.
, vol.66
, pp. 150-162
-
-
Berger-Sweeney, J.1
McPhie, D.L.2
Arters, J.A.3
Greenan, J.4
Oster-Granite, M.L.5
Neve, R.L.6
-
7
-
-
0029805132
-
The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein
-
J.P. Borg, J. Ooi, E. Levy, and B. Margolis The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein Mol. Cell. Biol. 16 1996 6229 6241
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 6229-6241
-
-
Borg, J.P.1
Ooi, J.2
Levy, E.3
Margolis, B.4
-
8
-
-
0032510834
-
The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion
-
J.P. Borg, Y. Yang, M. Taddeo-Borg, B. Margolis, and R.S. Turner The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion J. Biol. Chem. 273 1998 14761 14766
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 14761-14766
-
-
Borg, J.P.1
Yang, Y.2
Taddeo-Borg, M.3
Margolis, B.4
Turner, R.S.5
-
9
-
-
2642582435
-
Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation
-
X. Cao, and T.C. Sudhof Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation J. Biol. Chem. 279 2004 24601 24611
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 24601-24611
-
-
Cao, X.1
Sudhof, T.C.2
-
10
-
-
0032213730
-
Emerging roles for SH2/PTB-containing Shc adaptor proteins in the developing mammalian brain
-
E. Cattaneo, and P.G. Pelicci Emerging roles for SH2/PTB-containing Shc adaptor proteins in the developing mammalian brain Trends Neurosci. 21 1998 476 481
-
(1998)
Trends Neurosci.
, vol.21
, pp. 476-481
-
-
Cattaneo, E.1
Pelicci, P.G.2
-
11
-
-
0032438571
-
Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation
-
A.M. Cheng, T.M. Saxton, R. Sakai, S. Kulkarni, G. Mbamalu, W. Vogel, C.G. Tortorice, R.D. Cardiff, J.C. Cross, W.J. Muller, and T. Pawson Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation Cell 95 1998 793 803
-
(1998)
Cell
, vol.95
, pp. 793-803
-
-
Cheng, A.M.1
Saxton, T.M.2
Sakai, R.3
Kulkarni, S.4
Mbamalu, G.5
Vogel, W.6
Tortorice, C.G.7
Cardiff, R.D.8
Cross, J.C.9
Muller, W.J.10
Pawson, T.11
-
13
-
-
0035137171
-
Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: Implications for human breast cancer
-
D. Dankort, B. Maslikowski, N. Warner, N. Kanno, H. Kim, Z. Wang, M.F. Moran, R.G. Oshima, R.D. Cardiff, and W.J. Muller Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer Mol. Cell. Biol. 21 2001 1540 1551
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 1540-1551
-
-
Dankort, D.1
Maslikowski, B.2
Warner, N.3
Kanno, N.4
Kim, H.5
Wang, Z.6
Moran, M.F.7
Oshima, R.G.8
Cardiff, R.D.9
Muller, W.J.10
-
14
-
-
0037431082
-
Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-secretase complex
-
B. De Strooper Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-secretase complex Neuron 38 2003 9 12
-
(2003)
Neuron
, vol.38
, pp. 9-12
-
-
De Strooper, B.1
-
15
-
-
0034049944
-
Proteolytic processing and cell biological functions of the amyloid precursor protein
-
B. De Strooper, and W. Annaert Proteolytic processing and cell biological functions of the amyloid precursor protein J. Cell Sci. 113 Pt. 11 2000 1857 1870
-
(2000)
J. Cell Sci.
, vol.113
, Issue.11 PART
, pp. 1857-1870
-
-
De Strooper, B.1
Annaert, W.2
-
16
-
-
0029598484
-
The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein
-
F. Fiore, N. Zambrano, G. Minopoli, V. Donini, A. Duilio, and T. Russo The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein J. Biol. Chem. 270 1995 30853 30856
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 30853-30856
-
-
Fiore, F.1
Zambrano, N.2
Minopoli, G.3
Donini, V.4
Duilio, A.5
Russo, T.6
-
17
-
-
0036718272
-
Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease
-
H. Fukumoto, B.S. Cheung, B.T. Hyman, and M.C. Irizarry Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease Arch. Neurol. 59 2002 1381 1389
-
(2002)
Arch. Neurol.
, vol.59
, pp. 1381-1389
-
-
Fukumoto, H.1
Cheung, B.S.2
Hyman, B.T.3
Irizarry, M.C.4
-
18
-
-
0035822052
-
Alzheimer's disease. Molecular consequences of presenilin-1 mutation
-
S. Gandy, J. Naslund, and C. Nordstedt Alzheimer's disease. Molecular consequences of presenilin-1 mutation Nature 411 2001 654 656
-
(2001)
Nature
, vol.411
, pp. 654-656
-
-
Gandy, S.1
Naslund, J.2
Nordstedt, C.3
-
19
-
-
0038660598
-
Platelet-derived growth factor induces the beta-gamma-secretase-mediated cleavage of Alzheimer's amyloid precursor protein through a Src-Rac-dependent pathway
-
D. Gianni, N. Zambrano, M. Bimonte, G. Minopoli, L. Mercken, F. Talamo, A. Scaloni, and T. Russo Platelet-derived growth factor induces the beta-gamma-secretase-mediated cleavage of Alzheimer's amyloid precursor protein through a Src-Rac-dependent pathway J. Biol. Chem. 278 2003 9290 9297
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 9290-9297
-
-
Gianni, D.1
Zambrano, N.2
Bimonte, M.3
Minopoli, G.4
Mercken, L.5
Talamo, F.6
Scaloni, A.7
Russo, T.8
-
20
-
-
0037248301
-
Alzheimer disease therapy: Can the amyloid cascade be halted?
-
T.E. Golde Alzheimer disease therapy: can the amyloid cascade be halted? J. Clin. Invest 111 2003 11 18
-
(2003)
J. Clin. Invest
, vol.111
, pp. 11-18
-
-
Golde, T.E.1
-
21
-
-
0037418440
-
Physiologic and pathologic events mediated by intramembranous and juxtamembranous proteolysis
-
T.E. Golde, and C.B. Eckman Physiologic and pathologic events mediated by intramembranous and juxtamembranous proteolysis Sci. STKE 2003 2003 RE4
-
(2003)
Sci. STKE
, vol.2003
, pp. 4
-
-
Golde, T.E.1
Eckman, C.B.2
-
22
-
-
0035253794
-
Hyperphosphorylation of tau is mediated by ERK activation during anticancer drug-induced apoptosis in neuroblastoma cells
-
S. Guise, D. Braguer, G. Carles, A. Delacourte, and C. Briand Hyperphosphorylation of tau is mediated by ERK activation during anticancer drug-induced apoptosis in neuroblastoma cells J. Neurosci. Res. 63 2001 257 267
-
(2001)
J. Neurosci. Res.
, vol.63
, pp. 257-267
-
-
Guise, S.1
Braguer, D.2
Carles, G.3
Delacourte, A.4
Briand, C.5
-
23
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
J. Hardy, and D.J. Selkoe The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 2002 353 356
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
24
-
-
0033066680
-
The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids
-
B.W. Howell, L.M. Lanier, R. Frank, F.B. Gertler, and J.A. Cooper The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids Mol. Cell. Biol. 19 1999 5179 5188
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 5179-5188
-
-
Howell, B.W.1
Lanier, L.M.2
Frank, R.3
Gertler, F.B.4
Cooper, J.A.5
-
25
-
-
0033836219
-
Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5
-
K. Iijima, K. Ando, S. Takeda, Y. Satoh, T. Seki, S. Itohara, P. Greengard, Y. Kirino, A.C. Nairn, and T. Suzuki Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5 J. Neurochem. 75 2000 1085 1091
-
(2000)
J. Neurochem.
, vol.75
, pp. 1085-1091
-
-
Iijima, K.1
Ando, K.2
Takeda, S.3
Satoh, Y.4
Seki, T.5
Itohara, S.6
Greengard, P.7
Kirino, Y.8
Nairn, A.C.9
Suzuki, T.10
-
26
-
-
0038603918
-
A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1
-
H. Inomata, Y. Nakamura, A. Hayakawa, H. Takata, T. Suzuki, K. Miyazawa, and N. Kitamura A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1 J. Biol. Chem. 2003
-
(2003)
J. Biol. Chem.
-
-
Inomata, H.1
Nakamura, Y.2
Hayakawa, A.3
Takata, H.4
Suzuki, T.5
Miyazawa, K.6
Kitamura, N.7
-
27
-
-
0037339887
-
Grb2 regulates internalization of EGF receptors through clathrin-coated pits
-
X. Jiang, F. Huang, A. Marusyk, and A. Sorkin Grb2 regulates internalization of EGF receptors through clathrin-coated pits Mol. Biol. Cell 14 2003 858 870
-
(2003)
Mol. Biol. Cell
, vol.14
, pp. 858-870
-
-
Jiang, X.1
Huang, F.2
Marusyk, A.3
Sorkin, A.4
-
28
-
-
0036677928
-
Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: Association with Fe65 and translocation to the nucleus
-
A. Kinoshita, C.M. Whelan, C.J. Smith, O. Berezovska, and B.T. Hyman Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus J. Neurochem. 82 2002 839 847
-
(2002)
J. Neurochem.
, vol.82
, pp. 839-847
-
-
Kinoshita, A.1
Whelan, C.M.2
Smith, C.J.3
Berezovska, O.4
Hyman, B.T.5
-
29
-
-
0037079063
-
Fear memory formation involves p190 RhoGAP and ROCK proteins through a GRB2-mediated complex
-
R. Lamprecht, C.R. Farb, and J.E. LeDoux Fear memory formation involves p190 RhoGAP and ROCK proteins through a GRB2-mediated complex Neuron 36 2002 727 738
-
(2002)
Neuron
, vol.36
, pp. 727-738
-
-
Lamprecht, R.1
Farb, C.R.2
Ledoux, J.E.3
-
30
-
-
0033848935
-
Familial Alzheimer's disease: Site of mutation influences clinical phenotype
-
C.F. Lippa, J.M. Swearer, K.J. Kane, D. Nochlin, T.D. Bird, B. Ghetti, L.E. Nee, P. George-Hyslop, D.A. Pollen, and D.A. Drachman Familial Alzheimer's disease: site of mutation influences clinical phenotype Ann. Neurol. 48 2000 376 379
-
(2000)
Ann. Neurol.
, vol.48
, pp. 376-379
-
-
Lippa, C.F.1
Swearer, J.M.2
Kane, K.J.3
Nochlin, D.4
Bird, T.D.5
Ghetti, B.6
Nee, L.E.7
George-Hyslop, P.8
Pollen, D.A.9
Drachman, D.A.10
-
32
-
-
0345829921
-
Endocytosis of epidermal growth factor receptor regulated by Grb2-mediated recruitment of the Rab5 GTPase-activating protein RN-tre
-
L. Martinu, A. Santiago-Walker, H. Qi, and M.M. Chou Endocytosis of epidermal growth factor receptor regulated by Grb2-mediated recruitment of the Rab5 GTPase-activating protein RN-tre J. Biol. Chem. 277 2002 50996 51002
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 50996-51002
-
-
Martinu, L.1
Santiago-Walker, A.2
Qi, H.3
Chou, M.M.4
-
33
-
-
0028359319
-
Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I
-
P.S. McPherson, A.J. Czernik, T.J. Chilcote, F. Onofri, F. Benfenati, P. Greengard, J. Schlessinger, and P. De Camilli Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I Proc. Natl. Acad. Sci. U. S. A. 91 1994 6486 6490
-
(1994)
Proc. Natl. Acad. Sci. U. S. A.
, vol.91
, pp. 6486-6490
-
-
McPherson, P.S.1
Czernik, A.J.2
Chilcote, T.J.3
Onofri, F.4
Benfenati, F.5
Greengard, P.6
Schlessinger, J.7
De Camilli, P.8
-
34
-
-
0030867815
-
Neuronal expression of beta-amyloid precursor protein Alzheimer mutations causes intracellular accumulation of a C-terminal fragment containing both the amyloid beta and cytoplasmic domains
-
D.L. McPhie, R.K. Lee, C.B. Eckman, D.H. Olstein, S.P. Durham, D. Yager, S.G. Younkin, R.J. Wurtman, and R.L. Neve Neuronal expression of beta-amyloid precursor protein Alzheimer mutations causes intracellular accumulation of a C-terminal fragment containing both the amyloid beta and cytoplasmic domains J. Biol. Chem. 272 1997 24743 24746
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 24743-24746
-
-
McPhie, D.L.1
Lee, R.K.2
Eckman, C.B.3
Olstein, D.H.4
Durham, S.P.5
Yager, D.6
Younkin, S.G.7
Wurtman, R.J.8
Neve, R.L.9
-
35
-
-
0031056755
-
Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway
-
E. Migliaccio, S. Mele, A.E. Salcini, G. Pelicci, K.M. Lai, G. Superti-Furga, T. Pawson, P.P. Di Fiore, L. Lanfrancone, and P.G. Pelicci Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway EMBO J. 16 1997 706 716
-
(1997)
EMBO J.
, vol.16
, pp. 706-716
-
-
Migliaccio, E.1
Mele, S.2
Salcini, A.E.3
Pelicci, G.4
Lai, K.M.5
Superti-Furga, G.6
Pawson, T.7
Di Fiore, P.P.8
Lanfrancone, L.9
Pelicci, P.G.10
-
36
-
-
0037452461
-
Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet
-
C. Napoli, I. Martin-Padura, F. de Nigris, M. Giorgio, G. Mansueto, P. Somma, M. Condorelli, G. Sica, G. De Rosa, and P. Pelicci Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet Proc. Natl. Acad. Sci. U. S. A. 100 2003 2112 2116
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 2112-2116
-
-
Napoli, C.1
Martin-Padura, I.2
De Nigris, F.3
Giorgio, M.4
Mansueto, G.5
Somma, P.6
Condorelli, M.7
Sica, G.8
De Rosa, G.9
Pelicci, P.10
-
37
-
-
0029862137
-
Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein
-
M.L. Oster-Granite, D.L. McPhie, J. Greenan, and R.L. Neve Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein J. Neurosci. 16 1996 6732 6741
-
(1996)
J. Neurosci.
, vol.16
, pp. 6732-6741
-
-
Oster-Granite, M.L.1
McPhie, D.L.2
Greenan, J.3
Neve, R.L.4
-
38
-
-
0034488295
-
Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor
-
B. Passer, L. Pellegrini, C. Russo, R.M. Siegel, M.J. Lenardo, G. Schettini, M. Bachmann, M. Tabaton, and L. D'Adamio Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor J. Alzheimer's Dis. 2 2000 289 301
-
(2000)
J. Alzheimer's Dis.
, vol.2
, pp. 289-301
-
-
Passer, B.1
Pellegrini, L.2
Russo, C.3
Siegel, R.M.4
Lenardo, M.J.5
Schettini, G.6
Bachmann, M.7
Tabaton, M.8
D'Adamio, L.9
-
39
-
-
0038660689
-
P21-activated kinase 1 (PAK1) interacts with the Grb2 adapter protein to couple to growth factor signaling
-
L.A. Puto, K. Pestonjamasp, C.C. King, and G.M. Bokoch p21-activated kinase 1 (PAK1) interacts with the Grb2 adapter protein to couple to growth factor signaling J. Biol. Chem. 278 2003 9388 9393
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 9388-9393
-
-
Puto, L.A.1
Pestonjamasp, K.2
King, C.C.3
Bokoch, G.M.4
-
40
-
-
0037076398
-
The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling
-
R. Roncarati, N. Sestan, M.H. Scheinfeld, B.E. Berechid, P.A. Lopez, O. Meucci, J.C. McGlade, P. Rakic, and L. D'Adamio The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling Proc. Natl. Acad. Sci. U. S. A. 99 2002 7102 7107
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 7102-7107
-
-
Roncarati, R.1
Sestan, N.2
Scheinfeld, M.H.3
Berechid, B.E.4
Lopez, P.A.5
Meucci, O.6
McGlade, J.C.7
Rakic, P.8
D'Adamio, L.9
-
41
-
-
0027294981
-
The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1
-
M. Rozakis-Adcock, R. Fernley, J. Wade, T. Pawson, and D. Bowtell The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1 Nature 363 1993 83 85
-
(1993)
Nature
, vol.363
, pp. 83-85
-
-
Rozakis-Adcock, M.1
Fernley, R.2
Wade, J.3
Pawson, T.4
Bowtell, D.5
-
42
-
-
18744435477
-
Presenilin-1 mutations in Alzheimer's disease
-
C. Russo, G. Schettini, T.C. Saido, C. Hulette, C. Lippa, L. Lannfelt, B. Ghetti, P. Gambetti, M. Tabaton, and J.K. Teller Presenilin-1 mutations in Alzheimer's disease Nature 405 2000 531 532
-
(2000)
Nature
, vol.405
, pp. 531-532
-
-
Russo, C.1
Schettini, G.2
Saido, T.C.3
Hulette, C.4
Lippa, C.5
Lannfelt, L.6
Ghetti, B.7
Gambetti, P.8
Tabaton, M.9
Teller, J.K.10
-
43
-
-
0035118308
-
Amino-terminal modification and tyrosine phosphorylation of [corrected] carboxy-terminal fragments of the amyloid precursor protein in Alzheimer's disease and Down's syndrome brain
-
C. Russo, S. Salis, V. Dolcini, V. Venezia, X.H. Song, J.K. Teller, and G. Schettini Amino-terminal modification and tyrosine phosphorylation of [corrected] carboxy-terminal fragments of the amyloid precursor protein in Alzheimer's disease and Down's syndrome brain Neurobiol. Dis. 8 2001 173 180
-
(2001)
Neurobiol. Dis.
, vol.8
, pp. 173-180
-
-
Russo, C.1
Salis, S.2
Dolcini, V.3
Venezia, V.4
Song, X.H.5
Teller, J.K.6
Schettini, G.7
-
44
-
-
0037144497
-
Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain
-
C. Russo, V. Dolcini, S. Salis, V. Venezia, N. Zambrano, T. Russo, and G. Schettini Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain J. Biol. Chem. 277 2002 35282 35288
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 35282-35288
-
-
Russo, C.1
Dolcini, V.2
Salis, S.3
Venezia, V.4
Zambrano, N.5
Russo, T.6
Schettini, G.7
-
45
-
-
17644443469
-
Pyroglutamate-modified amyloid beta-peptides-AbetaN3(pE)-strongly affect cultured neuron and astrocyte survival
-
C. Russo, E. Violani, S. Salis, V. Venezia, V. Dolcini, G. Damonte, U. Benatti, C. D'Arrigo, E. Patrone, P. Carlo, and G. Schettini Pyroglutamate-modified amyloid beta-peptides-AbetaN3(pE)-strongly affect cultured neuron and astrocyte survival J. Neurochem. 82 2002 1480 1489
-
(2002)
J. Neurochem.
, vol.82
, pp. 1480-1489
-
-
Russo, C.1
Violani, E.2
Salis, S.3
Venezia, V.4
Dolcini, V.5
Damonte, G.6
Benatti, U.7
D'Arrigo, C.8
Patrone, E.9
Carlo, P.10
Schettini, G.11
-
46
-
-
0035954426
-
The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement
-
S.L. Sabo, A.F. Ikin, J.D. Buxbaum, and P. Greengard The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement J. Cell Biol. 153 2001 1403 1414
-
(2001)
J. Cell Biol.
, vol.153
, pp. 1403-1414
-
-
Sabo, S.L.1
Ikin, A.F.2
Buxbaum, J.D.3
Greengard, P.4
-
47
-
-
85047700252
-
Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis
-
C. Saucier, V. Papavasiliou, A. Palazzo, M.A. Naujokas, R. Kremer, and M. Park Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis Oncogene 21 2002 1800 1811
-
(2002)
Oncogene
, vol.21
, pp. 1800-1811
-
-
Saucier, C.1
Papavasiliou, V.2
Palazzo, A.3
Naujokas, M.A.4
Kremer, R.5
Park, M.6
-
48
-
-
0036462590
-
Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP)
-
M.H. Scheinfeld, R. Roncarati, P. Vito, P.A. Lopez, M. Abdallah, and L. D'Adamio Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP) J. Biol. Chem. 277 2002 3767 3775
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 3767-3775
-
-
Scheinfeld, M.H.1
Roncarati, R.2
Vito, P.3
Lopez, P.A.4
Abdallah, M.5
D'Adamio, L.6
-
49
-
-
0042203565
-
SH2 and PTB domains in tyrosine kinase signaling
-
J. Schlessinger, and M.A. Lemmon SH2 and PTB domains in tyrosine kinase signaling Sci. STKE 2003 2003 RE12
-
(2003)
Sci. STKE
, vol.2003
, pp. 12
-
-
Schlessinger, J.1
Lemmon, M.A.2
-
50
-
-
0036855661
-
Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease
-
D.J. Selkoe Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease J. Clin. Invest 110 2002 1375 1381
-
(2002)
J. Clin. Invest
, vol.110
, pp. 1375-1381
-
-
Selkoe, D.J.1
-
51
-
-
0041355557
-
Notch and Presenilin: Regulated intramembrane proteolysis links development and degeneration
-
D. Selkoe, and R. Kopan Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration Annu. Rev. Neurosci. 26 2003 565 597
-
(2003)
Annu. Rev. Neurosci.
, vol.26
, pp. 565-597
-
-
Selkoe, D.1
Kopan, R.2
-
52
-
-
0035875975
-
Differential regulation of cell migration and cell cycle progression by FAK complexes with Src, PI3K, Grb7 and Grb2 in focal contacts
-
T.L. Shen, and J.L. Guan Differential regulation of cell migration and cell cycle progression by FAK complexes with Src, PI3K, Grb7 and Grb2 in focal contacts FEBS Lett. 499 2001 176 181
-
(2001)
FEBS Lett.
, vol.499
, pp. 176-181
-
-
Shen, T.L.1
Guan, J.L.2
-
53
-
-
0029935765
-
Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons
-
M. Simons, B. De Strooper, G. Multhaup, P.J. Tienari, C.G. Dotti, and K. Beyreuther Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons J. Neurosci. 16 1996 899 908
-
(1996)
J. Neurosci.
, vol.16
, pp. 899-908
-
-
Simons, M.1
De Strooper, B.2
Multhaup, G.3
Tienari, P.J.4
Dotti, C.G.5
Beyreuther, K.6
-
54
-
-
0036064769
-
Evidence for a role of the nerve growth factor receptor TrkA in tyrosine phosphorylation and processing of beta-APP
-
P.E. Tarr, C. Contursi, R. Roncarati, C. Noviello, E. Ghersi, M.H. Scheinfeld, N. Zambrano, T. Russo, and L. D'Adamio Evidence for a role of the nerve growth factor receptor TrkA in tyrosine phosphorylation and processing of beta-APP Biochem. Biophys. Res. Commun. 295 2002 324 329
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.295
, pp. 324-329
-
-
Tarr, P.E.1
Contursi, C.2
Roncarati, R.3
Noviello, C.4
Ghersi, E.5
Scheinfeld, M.H.6
Zambrano, N.7
Russo, T.8
D'Adamio, L.9
-
55
-
-
0037053281
-
Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc
-
P.E. Tarr, R. Roncarati, G. Pelicci, P.G. Pelicci, and L. D'Adamio Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc J. Biol. Chem. 277 2002 16798 16804
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 16798-16804
-
-
Tarr, P.E.1
Roncarati, R.2
Pelicci, G.3
Pelicci, P.G.4
D'Adamio, L.5
-
56
-
-
4344630985
-
BACE1: The beta-secretase enzyme in Alzheimer's disease
-
R. Vassar BACE1: the beta-secretase enzyme in Alzheimer's disease J. Mol. Neurosci. 23 2004 105 114
-
(2004)
J. Mol. Neurosci.
, vol.23
, pp. 105-114
-
-
Vassar, R.1
-
57
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
R. Vassar, B.D. Bennett, S. Babu-Khan, S. Kahn, E.A. Mendiaz, P. Denis, D.B. Teplow, S. Ross, P. Amarante, R. Loeloff, Y. Luo, S. Fisher, J. Fuller, S. Edenson, J. Lile, M.A. Jarosinski, A.L. Biere, E. Curran, T. Burgess, J.C. Louis, F. Collins, J. Treanor, G. Rogers, and M. Citron Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE Science 286 1999 735 741
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
Denis, P.6
Teplow, D.B.7
Ross, S.8
Amarante, P.9
Loeloff, R.10
Luo, Y.11
Fisher, S.12
Fuller, J.13
Edenson, S.14
Lile, J.15
Jarosinski, M.A.16
Biere, A.L.17
Curran, E.18
Burgess, T.19
Louis, J.C.20
Collins, F.21
Treanor, J.22
Rogers, G.23
Citron, M.24
more..
-
58
-
-
0034234511
-
The shc adaptor protein forms interdependent phosphotyrosine-mediated protein complexes in mast cells stimulated with interleukin 3
-
L. Velazquez, G.D. Gish, G.P. van Der, L. Taylor, J. Shulman, and T. Pawson The shc adaptor protein forms interdependent phosphotyrosine-mediated protein complexes in mast cells stimulated with interleukin 3 Blood 96 2000 132 138
-
(2000)
Blood
, vol.96
, pp. 132-138
-
-
Velazquez, L.1
Gish, G.D.2
Van Der, G.P.3
Taylor, L.4
Shulman, J.5
Pawson, T.6
-
59
-
-
4544302611
-
Apoptotic cell death influences the signaling activity of the amyloid precursor protein through ShcA and Grb2 adaptor proteins in neuroblastoma SH-SY5Y cells
-
V. Venezia, C. Russo, E. Repetto, S. Salis, V. Dolcini, F. Genova, M. Nizzari, U. Mueller, and G. Schettini Apoptotic cell death influences the signaling activity of the amyloid precursor protein through ShcA and Grb2 adaptor proteins in neuroblastoma SH-SY5Y cells J. Neurochem. 90 2004 1359 1370
-
(2004)
J. Neurochem.
, vol.90
, pp. 1359-1370
-
-
Venezia, V.1
Russo, C.2
Repetto, E.3
Salis, S.4
Dolcini, V.5
Genova, F.6
Nizzari, M.7
Mueller, U.8
Schettini, G.9
-
60
-
-
0037151066
-
The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter
-
A. Ventura, L. Luzi, S. Pacini, C.T. Baldari, and P.G. Pelicci The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter J. Biol. Chem. 277 2002 22370 22376
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 22370-22376
-
-
Ventura, A.1
Luzi, L.2
Pacini, S.3
Baldari, C.T.4
Pelicci, P.G.5
-
61
-
-
0034255029
-
Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation
-
W. Xia, W.J. Ray, B.L. Ostaszewski, T. Rahmati, W.T. Kimberly, M.S. Wolfe, J. Zhang, A.M. Goate, and D.J. Selkoe Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation Proc. Natl. Acad. Sci. U. S. A. 97 2000 9299 9304
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 9299-9304
-
-
Xia, W.1
Ray, W.J.2
Ostaszewski, B.L.3
Rahmati, T.4
Kimberly, W.T.5
Wolfe, M.S.6
Zhang, J.7
Goate, A.M.8
Selkoe, D.J.9
-
62
-
-
0037236622
-
Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease
-
L.B. Yang, K. Lindholm, R. Yan, M. Citron, W. Xia, X.L. Yang, T. Beach, L. Sue, P. Wong, D. Price, R. Li, and Y. Shen Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease Nat. Med. 9 2003 3 4
-
(2003)
Nat. Med.
, vol.9
, pp. 3-4
-
-
Yang, L.B.1
Lindholm, K.2
Yan, R.3
Citron, M.4
Xia, W.5
Yang, X.L.6
Beach, T.7
Sue, L.8
Wong, P.9
Price, D.10
Li, R.11
Shen, Y.12
-
63
-
-
0028243655
-
Direct interaction between Shc and the platelet-derived growth factor beta-receptor
-
K. Yokote, S. Mori, K. Hansen, J. McGlade, T. Pawson, C.H. Heldin, and L. Claesson-Welsh Direct interaction between Shc and the platelet-derived growth factor beta-receptor J. Biol. Chem. 269 1994 15337 15343
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 15337-15343
-
-
Yokote, K.1
Mori, S.2
Hansen, K.3
McGlade, J.4
Pawson, T.5
Heldin, C.H.6
Claesson-Welsh, L.7
-
64
-
-
0035184827
-
Grb2 dominantly associates with dynamin II in human hepatocellular carcinoma HepG2 cells
-
S.Y. Yoon, M.J. Jeong, J. Yoo, K.I. Lee, B.M. Kwon, D.S. Lim, C.E. Lee, Y.M. Park, and M.Y. Han Grb2 dominantly associates with dynamin II in human hepatocellular carcinoma HepG2 cells J. Cell. Biochem. 84 2001 150 155
-
(2001)
J. Cell. Biochem.
, vol.84
, pp. 150-155
-
-
Yoon, S.Y.1
Jeong, M.J.2
Yoo, J.3
Lee, K.I.4
Kwon, B.M.5
Lim, D.S.6
Lee, C.E.7
Park, Y.M.8
Han, M.Y.9
-
65
-
-
0030894021
-
Interaction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's beta-amyloid precursor proteins
-
N. Zambrano, J.D. Buxbaum, G. Minopoli, F. Fiore, P. de Candia, S. De Renzis, R. Faraonio, S. Sabo, J. Cheetham, M. Sudol, and T. Russo Interaction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's beta-amyloid precursor proteins J. Biol. Chem. 272 1997 6399 6405
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 6399-6405
-
-
Zambrano, N.1
Buxbaum, J.D.2
Minopoli, G.3
Fiore, F.4
De Candia, P.5
De Renzis, S.6
Faraonio, R.7
Sabo, S.8
Cheetham, J.9
Sudol, M.10
Russo, T.11
-
66
-
-
0035827587
-
The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene
-
N. Zambrano, P. Bruni, G. Minopoli, R. Mosca, D. Molino, C. Russo, G. Schettini, M. Sudol, and T. Russo The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene J. Biol. Chem. 276 2001 19787 19792
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 19787-19792
-
-
Zambrano, N.1
Bruni, P.2
Minopoli, G.3
Mosca, R.4
Molino, D.5
Russo, C.6
Schettini, G.7
Sudol, M.8
Russo, T.9
-
67
-
-
2942586693
-
Growth factor receptor-bound protein 2 interaction with the tyrosine-phosphorylated tail of amyloid beta precursor protein is mediated by its Src homology 2 domain
-
D. Zhou, C. Noviello, C. D'Ambrosio, A. Scaloni, and L. D'Adamio Growth factor receptor-bound protein 2 interaction with the tyrosine-phosphorylated tail of amyloid beta precursor protein is mediated by its Src homology 2 domain J. Biol. Chem. 279 2004 25374 25380
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 25374-25380
-
-
Zhou, D.1
Noviello, C.2
D'Ambrosio, C.3
Scaloni, A.4
D'Adamio, L.5
|