Platelet-derived growth factor induces the β-γ-secretase-mediated cleavage of Alzheimer's amyloid precursor protein through a Src-Rac-dependent pathway

Journal of Biological Chemistry

Volumn 278, Issue 11, 2003, Pages 9290-9297

  Gianni, Davide ^a   Zambrano, Nicola ^a   Bimonte, Marida ^a   Minopoli, Giuseppina ^a   Mercken, Luc ^c   Talamo, Fabio ^d   Scaloni, Andrea ^d   Russo, Tommaso ^a,b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

^c SANOFI   (France)

^d CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CHEMICAL ACTIVATION; GROWTH KINETICS; PROTEINS;

EXTRACELLULAR SIGNALS;

BIOCHEMISTRY;

AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; GAMMA SECRETASE; HYBRID PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE; RAC PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GAL4; UNCLASSIFIED DRUG; AMMONIUM SULFATE; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; CHLORAMPHENICOL ACETYLTRANSFERASE; COMPLEMENT COMPONENT C6; PLATELET DERIVED GROWTH FACTOR BB; PLATELET-DERIVED GROWTH FACTOR BB; PROTEINASE; SECRETASE;

ALZHEIMER DISEASE; ARTICLE; CAT GENE; ENZYME ACTIVITY; GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PURIFICATION; SIGNAL TRANSDUCTION; CULTURE MEDIUM; HELA CELL; METABOLISM; NERVE CELL; PROTEIN BINDING; TIME; WESTERN BLOTTING;

FELIS CATUS;

ALZHEIMER DISEASE; AMMONIUM SULFATE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; BLOTTING, WESTERN; CHLORAMPHENICOL O-ACETYLTRANSFERASE; COMPLEMENT C6; CULTURE MEDIA, CONDITIONED; ENDOPEPTIDASES; HELA CELLS; HUMANS; NEURONS; PLATELET-DERIVED GROWTH FACTOR; PROTEIN BINDING; RAC GTP-BINDING PROTEINS; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; SRC-FAMILY KINASES; TIME FACTORS;

EID: 0038660598     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M211899200     Document Type: Article

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