Inhibition of T-cell responsiveness by nasal peptide administration: Influence of the thymus and differential recovery of T-cell-dependent functions

Immunology

Volumn 97, Issue 2, 1999, Pages 257-263

  Metzler, B ^a   Wraith, D C ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; AUTOANTIGEN ACL 9; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYELIN BASIC PROTEIN; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CELL PROTECTION; CELLULAR IMMUNITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; HELPER CELL; IMMUNE RESPONSE; IMMUNOGLOBULIN PRODUCTION; IMMUNOMODULATION; IMMUNOPATHOGENESIS; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; THYMECTOMY; THYMUS;

ADMINISTRATION, INTRANASAL; ANIMALS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FEMALE; IMMUNE TOLERANCE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MALE; MICE; MICE, INBRED STRAINS; MICE, NUDE; MYELIN BASIC PROTEINS; PEPTIDES; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0032988416     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1999.00795.x     Document Type: Article

References (41)

1. METZLER B. & WRATTH D.C. (1993) Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of the encephalitogenic peptide: influence of MHC binding affinity. Intern Immunol 5, 1159.
2. METZLER B. & WRATTH D.C. (1996) Mucosal tolerance in a murine model of experimental autoimmune encephalomyelitis. Ann N Y Acad Sci 778, 228.
3. TIAN J., ATKINSON M.A., CLARE-SALZLER M. et al. (1996) Nasal administration of glutamate decrboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. J Exp Med 183, 1561.
4. DANIEL D. & WEGMANN D.R. (1996) Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9). Proc Natl Acad Sci USA 93, 956.
5. STAINES N.A., HARPER N., WARD F.J., MALMSTROM V., HOLMDAHL R. & BANSAL S. (1996) Mucosal tolerance and suppression of collagen-induced arthritis (CIA) induced by nasal inhalation synthetic peptide 184 of bovine type II collagen (CH) expressing a dominant T cell epitope. Clin Exp Immunol 103, 368.
6. PRAKKEN B.J., VAN DER ZEE R., ANDERTON S.M., VAN KOOTEN P.J.S., KUIS W. & VAN EDEN W. (1997) Peptide-induced nasal tolerance for a mycobacterial heat shock protein 60 T cell epitope in rats suppresses both adjuvant arthritis and nonmicrobially induced experimental arthritis. Proc Natl Acad Sci USA 94, 3284.
7. ANDERTON S.M. & WRAITH D.C. (1998) Hierarchy in the ability of T cell epitopes to induce tolerance to antigens from myelin. Eur J Immunol 28, 1251.
8. MARTIN R. & McFARLAND H.F. (1995) Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis. Crit Rev Clin Lab Sci 32, 121.
9. lo thymocytes in vivo. Science 250, 1720.
10. LIU G.Y., FAIRCHILD P.J., SMITH R.M., PROWLE J.R., KIOUSSIS D. & WRAITH D.C. (1995) Low avidity recognition of self-antigen by T cells permits escape from central tolerance. Immunity 3, 407.
11. LIBLAU R.S., TISCH R., SHOKAT K. et al. (1996) Intravenous injection of soluble antigen induces thymic and peripheral T-cell apoptosis. Proc Natl Acad Sci USA 93, 3031.
12. KHOURY S.J., SAYEGH M.H., HANCOCK W.W., GALLON L., CARPENTER C.B. & WEINER H.L. (1993) Acquired tolerance to experimental autoimmune encephalomyelitis by intrathymic injection of myelin basic protein or its major encephalitogenic peptide. J Exp Med 178, 559.
13. GOSS J.A., NAKAFUSA Y., ROLAND C.R., HICKEY W.F. & FLYE M.W. (1994) Immunological tolerance to a defined myelin basic protein antigen administered intrathymically. J Immunol 153, 3890.
14. SAYEGH M.H. PERICO N., GALLON L. et al. (1994) Mechanisms of acquired thymic unresponsiveness to renal altografts: thymic recognition of immunodominant allo-MHC peptides induces peripheral T cell anergy. Transplantation 58, 125.
15. CHEN W., SAYEGH M.H. & KHOURY S.J. (1998) Mechanisms of acquired thymic tolerance in vivo: intrathymic injection of antigen induces apoptosis and peripheral T cell anergy. J Immunol 160, 1504.
16. + T cells precedes the development of tolerance in vivo. Intern Immunol 8, 335.
17. AGUS D.B., SURCH C.D. & SPRENT J. (1991) Reentry of T cells to the adult thymus is restricted to activated T cells. J Exp Med 173, 1039.
18. SAOUDI A., SEDDON B., FOWELL D. & MASON D. (1996) The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients. J Exp Med 184, 2393.
19. WANG Y., GOLDSCHNEIDER I., FOSS D., WU D.Y., O'ROURKE J. & CONE R.E. (1997) Direct thymic involvement in anterior chamber-associated immune deviation. J Immunol 158, 2150.
20. GAHRING L.C., & WEIGLE W.O. (1989) The induction of peripheral T cell unresponsiveness in adult mice by monomeric human γ-globulin. J Immunol 143, 2094.
21. QIN S., WISE M., COBBOLD S.P. et al. (1990) Induction of tolerance in peripheral T cells with monoclonal antibodies. Eur J Immunol 20, 2737.
22. RAMSDELL F. & FOWLKES B.J. (1992) Maintenance of in vivo tolerance by persistence of antigen. Science 257, 1130.
23. MIGHA K. & OCHI A. (1993) The fate of anergic T cells in vivo. J Immunol 150, 763.
24. ROCHA B., TANCHOT C. & VON BOEHMER H. (1993) Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen. J Exp Med 177, 1517.
25. ALFERINK J., SCHITTEK G., SCHONRICH G., HAMMERLING G.J. & ARNOLD B. (1995) Long life span of tolerant T cells and the role of antigen in maintenance of peripheral tolerance. Intern Immunol 7, 331.
26. DEIBLER G.E., MARTENSON R.E. & KIES M.W. (1972) Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species. Preparative Biochemistry 2, 139.
27. HRUBY S., ALVORD E.C.J., GROOME N.P., DAWKES A. & MARTENSON R.E. (1987) Monoclonal antibodies reactive with myelin basic protein. Mol Immunol 12, 1359.
28. ZAMVH S.S., MITCHELL D.J., MOORE A.C., KITAMURA K., STEINMAN L. & ROTHBARD J.B. (1986) T cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis. Nature 324, 258.
29. WRAITH D.C., SMILEK D.E., MITCHELL D.J., STEINMAN L. & McDEVITT H.O. (1989) Antigen recognition in autoimmuneencephalomyelitis and the potential for peptide-mediated immunotherapy. Cell 59, 247.
30. FAIRCHILD P.J., WILDGOOSE R., ATHERTON E., WEBB S. & WRAITH D.C. (1993) An autoantigenic T cell epitope forms unstable complexes with class II MHC: a novel route for escape from tolerance induction. Intern Immunol 5, 1151.
31. LIU G.Y. & WRAITH D.C. (1995) Affinity for class II MHC determines the extent to which soluble peptides tolerize autoreactive T cells in naive and primed adult mice implications for autoimmunity. Intern Immunol 7, 1255.
32. SNAPPER C.M. & PAUL W.E. (1987) Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 236, 944.
33. + T cell population to the T helper 2 cell pathway. J Immunol 157, 3260.
34. CRITCHFIELD J.M., RACKE M.K., ZUNIGA-PFLUCKER J.C. et al. (1994) T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science 263, 1139.
35. GUERY J.-C., GALBIATI F., SMIROLDO S. & ADORINI L. (1996) Selective development of T helper (Th) 2 cells induced by continuous administration of low dose soluble proteins to normal and β2-microglobulin-deficient BALB/c mice. J Exp Med 183, 485.
36. MILLER A., ZHANG Z.J., SOBEL R.A., AL-SABBAGH A. & WEINER H.L. (1993) Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. IV. Suppression of adoptively transferred disease and differential effects of oral vs. intravenous tolerization. J Neuroimmunol 46, 73.
37. QIN S., COBBOLD S.P., POPE H. et al. (1993) 'Infectious' transplantation tolerance. Science 259, 974.
38. ADELSTIEN S., PRITCHARD-BRISCOE H., ANDERSON T.A. et al. (1991) Induction of self-tolerance in T cells but not B cells of transgenic mice expressing little self antigen. Science 251, 1223.
39. + cell subsets. J Exp Med 178, 1637.
40. HOYNE G.F., JARNICKI A.G., THOMAS W.R. & LAMB J. (1997) Characterization of the specificity and duration of T cell tolerance to intranasally administered peptides in mice: a role for intramolecular epitope suppression. Intern Immunol 9, 1165.
41. TANCHOT C. & ROCHA B. (1997) Peripheral selection of T cell repertoire: the role of continous thymic output. J Exp Med 186, 1099.