Antigen-specific immunosuppression: Nasal tolerance to P0 protein peptides for the prevention and treatment of experimental autoimmune neuritis in Lewis rats

Journal of Neuroimmunology

Volumn 94, Issue 1-2, 1999, Pages 109-121

  Zou, Li Ping ^a   Ma, Di Hui ^a   Levi, Michael ^b   Wahren, Britta ^b   Wei, Lei ^a   Mix, Eilhard ^c   Van Der Meide, Peter H ^d   Link, Hans ^a   Zhu, Jie ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF ROSTOCK   (Germany)

^d BIOMEDICAL PRIMATE RESEARCH CENTRE   (Netherlands)

Author keywords

Experimental autoimmune neuritis; Immunosuppression; Nasal tolerance; P0 peptides

Indexed keywords

INTERLEUKIN 4; NEUROPEPTIDE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; DISEASE SEVERITY; DRUG EFFECT; GUILLAIN BARRE SYNDROME; IMMUNOREGULATION; INTRANASAL DRUG ADMINISTRATION; NEURITIS; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE;

ADMINISTRATION, INTRANASAL; ANIMALS; B-LYMPHOCYTES; CATTLE; CD4-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; EPITOPES; GENE EXPRESSION; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNIZATION; IMMUNOGLOBULIN G; IMMUNOSUPPRESSION; INTERFERON TYPE II; INTERLEUKIN-4; LYMPH NODES; MALE; MYELIN P0 PROTEIN; NEURITIS, AUTOIMMUNE, EXPERIMENTAL; PEPTIDE FRAGMENTS; POLYRADICULONEUROPATHY; RATS; RATS, INBRED LEW; RNA, MESSENGER; SCIATIC NERVE; TRANSFORMING GROWTH FACTOR BETA;

EID: 0033081134     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(98)00232-X     Document Type: Article

References (30)

1. Adelmann M., Linington C. Molecular mimicry and the autoimmune response to the peripheral nerve myelin P0 glycoprotein. Neurochem. Res. 17:1992;887-891.
2. Archelos J.J., Roggenbuck K., Schneider-Schaulies J., Toyka K.V., Hartung H.P. Detection and quantification of antibodies to the extracellular domain of P0 during experimental allergic neuritis. J. Neurol. Sci. 117:1993;197-205.
3. Cibotti R., Kanellopoulos J.M., Cabaniols J.P., Halle-Panenko O., Kosmatopoulos K., Sercarz E., Kourilsky P. Tolerance to a self-protein involves its immunodominant but does not involve its subdominant determinants. Proc. Natl. Acad. Sci. USA. 89:1992;416-420.
4. Derynck R., Jarrett J.A., Chen E.Y., Eaton D.H., Bell J.R., Assoian R.K., Roberts A.B., Sporn M.B., Goeddel D.V. Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells. Nature. 316:1985;701-705.
5. Dick A.D., Cheng Y.F., McKinnon A., Liversidge J., Forrester J.V. Nasal administration of retinal antigens suppresses the inflammatory response in experimental allergic uveoretinitis. Br. J. Ophthalmol. 77:1993;171-175.
6. Franko M.C., Koski C.L., Gibbs C.L. Jr., McFarlin D.E., Gajdusek D.C. Monoclonal antibody specific for myelin glycoprotein P0: derivation and characterization. Proc. Natl. Acad. Sci. USA. 79:1992;3618-3622.
7. Fujihashi K., McGhee J.R., Beagley K.W., McPherson D.T., McPherson S.A., Huang C.M., Kiyono H. Cytokine-specific ELISPOT assay: single cell analysis of IL-2, IL-4 and IL-6 producing cells. J. Immunol. Meth. 160:1993;181-189.
8. Gaupp S., Hartung H.P., Toyka K., Jung S. Modulation of experimental autoimmune neuritis in Lewis rats by oral application of mylin antigens. J. Neuroimmunol. 79:1997;129-137.
9. Gregorian S.K., Clark L., Heber-Ketz E., Amento E.P., Rostami A. Induction of peripheral tolerance with peptide-specific anergy in experimental autoimmune neuritis. Cell. Immunol. 150:1993;298-310.
10. Hahn A.F. Experimental allergic neuritis (EAN) as a model for the immune-mediated demyelinating neuropathies. Rev. Neurol. 152:1996;328-332.
11. Hartung H.P., Pollard J.D., Harvey G., Toyka K.V. Immunopathogenesis and treatment of the Guillain-Barré syndrome. Muscle Nerve. 18:1995;137-153. Part I.
12. Kadlubowski M., Hughes R.A. Identification of the neuritogen for experimental allergic neuritis. Nature. 277:1979;140-141.
13. Lee M., Brennan A., Blanchard A., Zoidl G., Dong Z., Tabernero A., Zoidl C., Dent M.A., Jessen K.R., Mirsky R. P0 is constitutively expressed in the rat neural crest and embryonic nerves and is negatively and positively regulated by axons to generate non-myelin-forming and myelin-forming Schwann cells, respectively. Mol. Cell. Neurosci. 8:1997;336-350.
14. Lehmann P.V., Forsthuber T., Miller A., Sercarz E.E. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature. 358:1992;155-157.
15. Linington C., Izumo S., Suzuki M., Uyemura K., Meyermann R., Wekerle H.A. A permanent rat T cell line that mediates experimental allergic neuritis in the Lewis rat in vivo. J. Immunol. 133:1984;1946-1950.
16. Linington C., Lassmann H., Ozawa K., Kosin S., Mongan L. Cell adhesion molecules of the immunoglobulin supergene family as tissue-specific autoantigens: induction of experimental allergic neuritis (EAN) by P0 protein-specific T cell lines. Eur. J. Immunol. 22:1992;1813-1817.
17. Milner P., Lovelidge C.A., Taylor W.A., Hughes R.A. P0 myelin protein produces experimental allergic neuritis in Lewis rats. J. Neurol. Sci. 79:1987;275-285.
18. Norton W.I., Poduslo S.E. Myelination in rat nerve: method of myelin isolation. J. Neurochem. 21:1973;749-757.
19. Olsson T., Wang W.Z., Höjeberg B., Kostulas V., Jiang Y.-P., Andersson G., Ekre H.-P., Link H. Autoreactive T lymphocytes in multiple sclerosis determined by antigen induced secretion of interferon-γ J. Clin. Invest. 86:1990;981-985.
20. Sercarz E.E., Lehmann P.V., Ametani A., Benichou G., Miller A., Moudgil K. Dominance and crypticity of T cell antigenic determinants. Annu. Rev. Immunol. 11:1993;729-766.
21. Shapiro L., Doyle J.P., Hensley P., Colman D.R., Hendrickson W.A. Crystal structure of the extracellular domain from P0, the major structural protein of peripheral nerve myelin. Neuron. 17:1996;435-449.
22. Waksman N.H., Adams R.D. Allergic neuritis: an experimental disease of rabbits induced by the injection of peripheral nervous tissue and adjuvant. J. Exp. Med. 102:1955;213-225.
23. Weiner H.L. Oral tolerance: immune mechanisms and treatment of autoimmune diseases. Immunol. Today. 18:1997;335-342.
24. Wood J.C., McLaughlin B.J. The visualization of concanavalin-A binding sites in the interperiod line of rat sciatic nerve myelin. J. Neurochem. 24:1975;233-235.
25. Wraith D.C. Induction of antigen-specific unresponsiveness with synthetic peptides: specific immunotherapy for treatment of allergic and autoimmune conditions. Int. Arch. Allergy Immunol. 108:1995;355-359.
26. Yoshida M., Colman D.R. Parallel evolution and coexpression of the proteolipid proteins and protein zero in vertebrate myelin. Neuron. 16:1996;1115-1126.
27. Zhang K., Merazga Y., Filbin M.T. Mapping the adhesive domains of the myelin P0 protein. J. Neurosci. Res. 45:1996;525-533.
28. Zhu J., Mix E., Olsson T., Link H. Cellular mRNA expression of interferon-γ, interleukin 4 and transforming growth factor-β by rat mononuclear cells stimulated with peripheral nerve antigens in experimental allergic neuritis. Clin. Exp. Immunol. 98:1994;306-312.
29. Zhu J., Deng G.M., Levi M., Wahren B., Diab A., van Der, Meide P.H., Link H. Prevention of experimental autoimmune neuritis by nasal administration of P2 protein peptide 57-81. J. Neuropathol. Exp. Neurol. 57:1998;291-301.
30. Zou L.P., Zhu J., Deng G.M., Levi M., Wahren B., Diab A., Hillert J., Link H. Treatment with P2 protein peptide 57-81 by nasal route is effective in Lewis rat experimental autoimmune neuritis. J. Neuroimmunol. 85:1998;137-145.