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Volumn 100, Issue 12, 1997, Pages 3027-3035

Prevention of experimental myasthenia gravis by nasal administration of synthetic acetylcholine receptor T epitope sequences

Author keywords

Acetylcholine receptor; Autoimmunity; Mice; Nasal tolerance; T cells

Indexed keywords

CHOLINERGIC RECEPTOR; EPITOPE;

EID: 0031452406     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119857     Document Type: Article
Times cited : (75)

References (49)
  • 1
    • 0028201732 scopus 로고
    • Tolerance, danger, and the extended family
    • Matzinger, P. 1994. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12:991-1045.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 2
    • 0028943268 scopus 로고
    • Choices following antigen entry: Antibody formation or immunologic tolerance?
    • Nossal, G. 1995. Choices following antigen entry: antibody formation or immunologic tolerance? Annu. Rev. Immunol. 13:1-27.
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 1-27
    • Nossal, G.1
  • 3
    • 0027380361 scopus 로고
    • Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of the encephalitogenic peptide: Influence of MHC binding affinity
    • Metzler, B., and D.C. Wraith. 1993. Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of the encephalitogenic peptide: influence of MHC binding affinity. Int. Immunol. 5: 1159-1169.
    • (1993) Int. Immunol. , vol.5 , pp. 1159-1169
    • Metzler, B.1    Wraith, D.C.2
  • 4
    • 0028288584 scopus 로고
    • Orally administered myelin basic protein in neonates primes for immune responses and enhances experimental autoimmune encephalomyelitis in adult animals
    • Miller, A., O. Lider, O. Abramsky, and H.L. Weiner. 1994. Orally administered myelin basic protein in neonates primes for immune responses and enhances experimental autoimmune encephalomyelitis in adult animals. Eur. J. Immunol. 24:1026-1032.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 1026-1032
    • Miller, A.1    Lider, O.2    Abramsky, O.3    Weiner, H.L.4
  • 6
    • 0030578412 scopus 로고    scopus 로고
    • Antigen-driven peripheral immune tolerance - Suppression of experimental autoimmune encephalomyelitis and collagen-induced arthritis by aerosol administration of myelin basic protein or type II collagen
    • Al-Sabbagh, A., P. Nelson, Y. Akselband, R. Sobel, and H. Weiner. 1996. Antigen-driven peripheral immune tolerance - suppression of experimental autoimmune encephalomyelitis and collagen-induced arthritis by aerosol administration of myelin basic protein or type II collagen. Cell. Immunol. 171:111-119.
    • (1996) Cell. Immunol. , vol.171 , pp. 111-119
    • Al-Sabbagh, A.1    Nelson, P.2    Akselband, Y.3    Sobel, R.4    Weiner, H.5
  • 8
    • 0027410872 scopus 로고
    • Antigen acquisition by dendritic cells: Intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo
    • Liu, L., and G.G. MacPherson. 1993 Antigen acquisition by dendritic cells: intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo. J. Exp. Med. 177:1299-1307.
    • (1993) J. Exp. Med. , vol.177 , pp. 1299-1307
    • Liu, L.1    MacPherson, G.G.2
  • 9
    • 0028207219 scopus 로고
    • Oral tolerance in humans. T cell but not B cell tolerance after antigen feeding
    • Husby, S., J. Mestecky, Z. Moldoveanu, S. Holland, and C. Elson. 1994. Oral tolerance in humans. T cell but not B cell tolerance after antigen feeding. J. Immunol. 152:4663-4670.
    • (1994) J. Immunol. , vol.152 , pp. 4663-4670
    • Husby, S.1    Mestecky, J.2    Moldoveanu, Z.3    Holland, S.4    Elson, C.5
  • 10
    • 0030000550 scopus 로고    scopus 로고
    • Antigen sampling across epithelial barriers and induction of mucosal immune response
    • Neutra, M., E. Pringult, and J. Kraehenbuhl. 1996. Antigen sampling across epithelial barriers and induction of mucosal immune response. Ann. Rev. Immunol. 14:275-300.
    • (1996) Ann. Rev. Immunol. , vol.14 , pp. 275-300
    • Neutra, M.1    Pringult, E.2    Kraehenbuhl, J.3
  • 11
    • 0029847368 scopus 로고    scopus 로고
    • Functional diversity of helper T lymphocytes
    • Abbas, A.K., K.M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature. 383:787-793.
    • (1996) Nature , vol.383 , pp. 787-793
    • Abbas, A.K.1    Murphy, K.M.2    Sher, A.3
  • 12
    • 0029974176 scopus 로고    scopus 로고
    • Antibodies as a tool to study the structure of membrane proteins. The case of the nicotinic receptor
    • Conti-Fine, B.M, K.E. McLane, and S. Lei. 1996. Antibodies as a tool to study the structure of membrane proteins. The case of the nicotinic receptor. Annu. Rev. Biophys. Biomol. Struct. 25:197-229.
    • (1996) Annu. Rev. Biophys. Biomol. Struct. , vol.25 , pp. 197-229
    • Conti-Fine, B.M.1    McLane, K.E.2    Lei, S.3
  • 13
    • 0029741439 scopus 로고    scopus 로고
    • Inhibition of relapsing experimental autoimmune encephalomyelitis in SJL mice by feeding the immunodominant PLP 139-151 peptide
    • Karpus, W.J., K.J. Kennedy, W.S. Smith, and S.D. Miller. 1996. Inhibition of relapsing experimental autoimmune encephalomyelitis in SJL mice by feeding the immunodominant PLP 139-151 peptide. Neurosci. Res. 45:410-423.
    • (1996) Neurosci. Res. , vol.45 , pp. 410-423
    • Karpus, W.J.1    Kennedy, K.J.2    Smith, W.S.3    Miller, S.D.4
  • 14
    • 0027467135 scopus 로고
    • Nasal administration of retinal antigens suppresses the inflammatory response in experimental allergic uveoretinitis. A preliminary report of intranasal induction of tolerance with retinal antigens
    • Dick, A., Y. Cheng, A. McKinnon, J. Liversidge, and J. Forrester. 1993. Nasal administration of retinal antigens suppresses the inflammatory response in experimental allergic uveoretinitis. A preliminary report of intranasal induction of tolerance with retinal antigens. Brit. J. Ophthalmol. 77:171-175.
    • (1993) Brit. J. Ophthalmol. , vol.77 , pp. 171-175
    • Dick, A.1    Cheng, Y.2    McKinnon, A.3    Liversidge, J.4    Forrester, J.5
  • 15
    • 0028968686 scopus 로고
    • Suppression of experimental autoimmune myasthenia gravis by nasal administration of acetylcholine receptor
    • Ma, C., G. Zhang, B. Xiao, J. Link, T. Olsson, and H. Link. 1995. Suppression of experimental autoimmune myasthenia gravis by nasal administration of acetylcholine receptor. J. Neuroimmunol. 58:51-60.
    • (1995) J. Neuroimmunol. , vol.58 , pp. 51-60
    • Ma, C.1    Zhang, G.2    Xiao, B.3    Link, J.4    Olsson, T.5    Link, H.6
  • 16
    • 0030048452 scopus 로고    scopus 로고
    • Cellular mRNA of interferon-gamma (IFN-gamma), IL-4 and transforming growth factor-beta (TGF-beta) in rats nasally tolerized against experimental autoimmune myasthenia gravis (EAMG)
    • Ma, C., G. Zhang, B. Xiao, and H. Link. 1996. Cellular mRNA of interferon-gamma (IFN-gamma), IL-4 and transforming growth factor-beta (TGF-beta) in rats nasally tolerized against experimental autoimmune myasthenia gravis (EAMG). Clin. Exp. Immunol. 104:509-516.
    • (1996) Clin. Exp. Immunol. , vol.104 , pp. 509-516
    • Ma, C.1    Zhang, G.2    Xiao, B.3    Link, H.4
  • 17
    • 0029915770 scopus 로고    scopus 로고
    • Mucosal tolerance to experimental autoimmune myasthenia gravis is associated with down-regulation of AChR-specific IFN-gamma-expressing Th1-like cells and up-regulation of TGF-beta mRNA in mononuclear cells
    • Ma, C., G. Zhang, B. Xiao, Z.Y. Wang, J. Link, T. Olsson, and H. Link. 1996. Mucosal tolerance to experimental autoimmune myasthenia gravis is associated with down-regulation of AChR-specific IFN-gamma-expressing Th1-like cells and up-regulation of TGF-beta mRNA in mononuclear cells. Ann. N.Y. Acad. Sci. 778:273-287.
    • (1996) Ann. N.Y. Acad. Sci. , vol.778 , pp. 273-287
    • Ma, C.1    Zhang, G.2    Xiao, B.3    Wang, Z.Y.4    Link, J.5    Olsson, T.6    Link, H.7
  • 19
    • 0000478940 scopus 로고
    • General method for the rapid solid phase synthesis of large numbers of peptides: Specificity of antigen-antibody interaction at the level of individual amino acids
    • Houghten, R. 1985. General method for the rapid solid phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. Proc. Natl. Acad. Sci. USA. 82:5131-5135.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 5131-5135
    • Houghten, R.1
  • 20
    • 0029557484 scopus 로고
    • Epitopes for human CD41 cells on diphtheria toxin: Structural features of sequence segments forming epitopes recognized by most subjects
    • Raju, R., D. Navaneetham, D. Okita, B. Diethelm-Okita, D. McCormick, and B. Conti-Fine. 1995. Epitopes for human CD41 cells on diphtheria toxin: structural features of sequence segments forming epitopes recognized by most subjects. Eur. J. Immunol. 25:3207-3214.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 3207-3214
    • Raju, R.1    Navaneetham, D.2    Okita, D.3    Diethelm-Okita, B.4    McCormick, D.5    Conti-Fine, B.6
  • 21
    • 0025941769 scopus 로고
    • Experimental myasthenia gravis in congenic mice. Sequence mapping and H-2 restriction of T helper epitopes on the a subunits of Torpedo californica and murine acctylcholine receptors
    • Bellone, M., N. Ostlie, S. Lei, and B. Conti-Tronconi. 1991. Experimental myasthenia gravis in congenic mice. Sequence mapping and H-2 restriction of T helper epitopes on the a subunits of Torpedo californica and murine acctylcholine receptors. Eur. J. Immunol. 21:2303-2310.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 2303-2310
    • Bellone, M.1    Ostlie, N.2    Lei, S.3    Conti-Tronconi, B.4
  • 22
    • 0015607082 scopus 로고
    • A simple assay for the study of solubilized acetylcholine receptors
    • Schmidt, J., and M. Raftery. 1973. A simple assay for the study of solubilized acetylcholine receptors. Anal. Biochem. 52:349-354.
    • (1973) Anal. Biochem. , vol.52 , pp. 349-354
    • Schmidt, J.1    Raftery, M.2
  • 24
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.1
  • 25
    • 0028982495 scopus 로고
    • Mechanisms by which the I-Abm12 mutation influences susceptibility to experimental myasthenia gravis: A study in homozygous and heterozygous mice
    • Karachunski, P., N. Ostlie, M. Bellone, A. Infante, and B. Conti-Fine. 1995. Mechanisms by which the I-Abm12 mutation influences susceptibility to experimental myasthenia gravis: a study in homozygous and heterozygous mice. Scand. J. Immunol. 42:215-225.
    • (1995) Scand. J. Immunol. , vol.42 , pp. 215-225
    • Karachunski, P.1    Ostlie, N.2    Bellone, M.3    Infante, A.4    Conti-Fine, B.5
  • 26
    • 0025791940 scopus 로고
    • Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation
    • DeSilva, D.R., K.B. Urdahl, and M.K. Jenkins. 1991. Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation. J. Immunol. 147:3261-3267.
    • (1991) J. Immunol. , vol.147 , pp. 3261-3267
    • DeSilva, D.R.1    Urdahl, K.B.2    Jenkins, M.K.3
  • 27
    • 0010702177 scopus 로고
    • Determinant preferences in the relationship between T and B cell specific for lysozyme
    • S. Smith-Gill, and E. Sercarz, editors. Academic Press, New York
    • Palmer, M., and E. Sercarz, 1989. Determinant preferences in the relationship between T and B cell specific for lysozyme. In The Immune Response to Structurally Defined Proteins: The Lysozyme Model. S. Smith-Gill, and E. Sercarz, editors. Academic Press, New York. 285-321.
    • (1989) The Immune Response to Structurally Defined Proteins: The Lysozyme Model , pp. 285-321
    • Palmer, M.1    Sercarz, E.2
  • 28
    • 0025943760 scopus 로고
    • Role of B cell antigen processing and presentation in the humoral immune response
    • Myers, C.D. 1991. Role of B cell antigen processing and presentation in the humoral immune response. FASEB (Fed. Am. Soc. Exp. Biol.) J. 5:2547-2553.
    • (1991) FASEB (Fed. Am. Soc. Exp. Biol.) J. , vol.5 , pp. 2547-2553
    • Myers, C.D.1
  • 29
    • 0028349398 scopus 로고
    • Preferential pairing of T and B cells for production of antibodies without covalent association of T and B epitopes
    • Bellone, M., P. Karachunski, N. Ostlie, S. Lei, and B. Conti-Tronconi. 1994. Preferential pairing of T and B cells for production of antibodies without covalent association of T and B epitopes. Eur. J. Immunol. 24:799-804.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 799-804
    • Bellone, M.1    Karachunski, P.2    Ostlie, N.3    Lei, S.4    Conti-Tronconi, B.5
  • 30
    • 0027497943 scopus 로고
    • Suppression of experimental autoimmune myasthenia gravis by epitope-specific neonatal tolerance to synthetic region alpha 146-162 of acetylcholine receptor
    • Shenoy, M., M. Oshima, M. Atassi, and P. Christadoss. 1993. Suppression of experimental autoimmune myasthenia gravis by epitope-specific neonatal tolerance to synthetic region alpha 146-162 of acetylcholine receptor. Clin. Immunol. Immunopathol. 66:230-238.
    • (1993) Clin. Immunol. Immunopathol. , vol.66 , pp. 230-238
    • Shenoy, M.1    Oshima, M.2    Atassi, M.3    Christadoss, P.4
  • 31
    • 0028081476 scopus 로고
    • The pathogenic role of acetylcholine receptor a chain epitope with in a146-162 in the development of experimental autoimmune myasthenia gravis in C57B1/6 mice
    • Shenoy, M., E. Goluszko, and P. Christadoss. 1994. The pathogenic role of acetylcholine receptor a chain epitope with in a146-162 in the development of experimental autoimmune myasthenia gravis in C57B1/6 mice. Clin. Immunol. Immunopathol. 73:1-6.
    • (1994) Clin. Immunol. Immunopathol. , vol.73 , pp. 1-6
    • Shenoy, M.1    Goluszko, E.2    Christadoss, P.3
  • 32
    • 0025923907 scopus 로고
    • The I-A bm12 mutation, which confers resistance to experimental myasthenia gravis, drastically affects the epitope repertoire of murine CD41 cells sensitized to nicotinic acetylcholine receptor
    • Bellone, M., N. Ostlie, S. Lei, X.-D. Wu, and B. Conti-Tronconi. 1991. The I-A bm12 mutation, which confers resistance to experimental myasthenia gravis, drastically affects the epitope repertoire of murine CD41 cells sensitized to nicotinic acetylcholine receptor. J. Immunol. 147:1484-1491.
    • (1991) J. Immunol. , vol.147 , pp. 1484-1491
    • Bellone, M.1    Ostlie, N.2    Lei, S.3    Wu, X.-D.4    Conti-Tronconi, B.5
  • 33
    • 0025730455 scopus 로고
    • Determinant selection in murine experimental autoimmune myasthenia gravis: Effect of the bm12 mutation on T-cell recognition of acetylcholine receptor epitopes
    • Infante, A., P. Thompson, K. Krolik, and K. Wall. 1991. Determinant selection in murine experimental autoimmune myasthenia gravis: effect of the bm12 mutation on T-cell recognition of acetylcholine receptor epitopes. J. Immunol. 146:2977-2982.
    • (1991) J. Immunol. , vol.146 , pp. 2977-2982
    • Infante, A.1    Thompson, P.2    Krolik, K.3    Wall, K.4
  • 34
    • 0025322456 scopus 로고
    • T cells reactive with a small synthetic peptide of the acetylcholine receptor can provide help for a clonotypically heterogeneous antibody response and subsequently impaired muscle function
    • Yeh, T.M., and K.A. Krolick. 1990. T cells reactive with a small synthetic peptide of the acetylcholine receptor can provide help for a clonotypically heterogeneous antibody response and subsequently impaired muscle function. J. Immunol. 144:1654-1660.
    • (1990) J. Immunol. , vol.144 , pp. 1654-1660
    • Yeh, T.M.1    Krolick, K.A.2
  • 37
    • 0029031681 scopus 로고
    • Peripheral deletion of antigen-reactive T cells in oral tolerance
    • Chen, Y., J. Inobe, R. Marks, P. Gonnella, V. Kuchroo, and H. Weiner. 1995. Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature. 376:177-180.
    • (1995) Nature , vol.376 , pp. 177-180
    • Chen, Y.1    Inobe, J.2    Marks, R.3    Gonnella, P.4    Kuchroo, V.5    Weiner, H.6
  • 38
    • 0030043855 scopus 로고    scopus 로고
    • Oral tolerance in myelin basic protein T-cell receptor transgenic mice: Suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells
    • Chen, Y., J. Inobe, V. Kuchroo, J. Baron, C.J. Janeway, and H. Weiner. 1996. Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells. Proc. Natl. Acad. Sci. USA. 93:388-391.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 388-391
    • Chen, Y.1    Inobe, J.2    Kuchroo, V.3    Baron, J.4    Janeway, C.J.5    Weiner, H.6
  • 39
    • 0028358048 scopus 로고
    • Induction of anergy or active suppression following oral tolerance is determined by antigen dosage
    • Friedman, A., and H.L. Weiner. 1994. Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. Proc. Natl. Acad. Sci. USA. 91:6688-6692.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 6688-6692
    • Friedman, A.1    Weiner, H.L.2
  • 40
    • 0027384272 scopus 로고
    • Oral tolerance in experimental autoimmune uveoretinitis. Distinct mechanisms of resistance are induced by low dose vs. high dose feeding protocols
    • Gregerson, D., W. Obritsch, and L. Donoso. 1993. Oral tolerance in experimental autoimmune uveoretinitis. Distinct mechanisms of resistance are induced by low dose vs. high dose feeding protocols. J. Immunol. 151:5751-5761.
    • (1993) J. Immunol. , vol.151 , pp. 5751-5761
    • Gregerson, D.1    Obritsch, W.2    Donoso, L.3
  • 41
    • 0027272744 scopus 로고
    • Cryptic epitopes on the nicotinic acetylcholine receptor are recognized by autoreactive CD41 cells
    • Bellone, M., N. Ostlie, P. Karachunski, A. Manfredi, and B. Conti-Tronconi. 1993. Cryptic epitopes on the nicotinic acetylcholine receptor are recognized by autoreactive CD41 cells. J. Immunol. 151:1025-1038.
    • (1993) J. Immunol. , vol.151 , pp. 1025-1038
    • Bellone, M.1    Ostlie, N.2    Karachunski, P.3    Manfredi, A.4    Conti-Tronconi, B.5
  • 42
    • 0029000750 scopus 로고
    • Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis
    • McRae, B., C. Vanderlugt, M. Dal Canto, and S. Miller. 1995. Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis. J. Exp. Med. 182:75-85.
    • (1995) J. Exp. Med. , vol.182 , pp. 75-85
    • McRae, B.1    Vanderlugt, C.2    Dal Canto, M.3    Miller, S.4
  • 43
    • 0029975898 scopus 로고    scopus 로고
    • A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: A basis for peptide-specific therapy after onset of clinical disease
    • Yu, M., J. Johnson, and V. Tuohy. 1996. A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: a basis for peptide-specific therapy after onset of clinical disease. J. Exp. Med. 183:1777-1788.
    • (1996) J. Exp. Med. , vol.183 , pp. 1777-1788
    • Yu, M.1    Johnson, J.2    Tuohy, V.3
  • 44
    • 0030749930 scopus 로고    scopus 로고
    • TH1 epitope repertoire on the alpha subunit of human muscle acetylcholine receptor in Myasthenia Gravis
    • Wang, Z.-Y., D. Okita, J. Howard, Jr., and B. Conti-Fine. 1997. TH1 epitope repertoire on the alpha subunit of human muscle acetylcholine receptor in Myasthenia Gravis. Neurology. 48:1643-1653.
    • (1997) Neurology , vol.48 , pp. 1643-1653
    • Wang, Z.-Y.1    Okita, D.2    Howard Jr., J.3    Conti-Fine, B.4
  • 45
    • 0028037782 scopus 로고
    • Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
    • Chen, Y., V.K. Kuchroo, J. Inobe, D.A. Hafler, and H.L. Weiner. 1994. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science. 265:1237-1240.
    • (1994) Science , vol.265 , pp. 1237-1240
    • Chen, Y.1    Kuchroo, V.K.2    Inobe, J.3    Hafler, D.A.4    Weiner, H.L.5
  • 46
    • 0027476846 scopus 로고
    • Immunological memory
    • Gray, D. 1993. Immunological memory. Annu. Rev. Immunol. 11:49-77.
    • (1993) Annu. Rev. Immunol. , vol.11 , pp. 49-77
    • Gray, D.1
  • 47
    • 0024796883 scopus 로고
    • Universally immunogenic T cell epitopes: Promiscuous binding to human MHC class H and promiscuous recognition by T cells
    • Panina-Bordignon, P., A. Tan, A. Termijtelen, S. Demotz, G. Corradin, and A. Lanzavecchia. 1989. Universally immunogenic T cell epitopes: promiscuous binding to human MHC class H and promiscuous recognition by T cells. Eur. J. Immunol. 19:2237-2242.
    • (1989) Eur. J. Immunol. , vol.19 , pp. 2237-2242
    • Panina-Bordignon, P.1    Tan, A.2    Termijtelen, A.3    Demotz, S.4    Corradin, G.5    Lanzavecchia, A.6
  • 49
    • 0031033860 scopus 로고    scopus 로고
    • Epitope repertoire of human CD41 T cells on tetanus toxin: Identification of immunodominant sequence segments
    • Diethelem-Okita, B., R. Raju, D. Okita, and B. Conti-Fine. 1997. Epitope repertoire of human CD41 T cells on tetanus toxin: identification of immunodominant sequence segments. J. Infect. Dis. 175:382-391.
    • (1997) J. Infect. Dis. , vol.175 , pp. 382-391
    • Diethelem-Okita, B.1    Raju, R.2    Okita, D.3    Conti-Fine, B.4


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