Grass Pollen Immunotherapy Induces Mucosal and Peripheral IL-10 Responses and Blocking IgG Activity

Journal of Immunology

Volumn 172, Issue 5, 2004, Pages 3252-3259

  Nouri Aria, Kayhan T ^a   Wachholz, Petra A ^a   Francis, James N ^a   Jacobson, Mikila R ^a   Walker, Samantha M ^a   Wilcock, Louisa K ^a   Staple, Steven Q ^b   Aalberse, Robert C ^b   Till, Stephen J ^a   Durham, Stephen R ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b CENTRAL LABORATORY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; CD3 ANTIGEN; CD68 ANTIGEN; GRASS POLLEN EXTRACT; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G4; INTERLEUKIN 10; MESSENGER RNA; PLACEBO;

ADULT; ANTIBODY RESPONSE; ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; ANTIGEN SPECIFICITY; ARTICLE; CELL CULTURE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; FEMALE; GRASS POLLEN; HUMAN; HUMAN TISSUE; IMMUNOLOGICAL TOLERANCE; IMMUNOPROPHYLAXIS; IMMUNOTHERAPY; MACROPHAGE; MALE; NOSE MUCOSA; PERIPHERAL LYMPHOCYTE; PHLEUM PRATENSE; POLLEN ALLERGY; PRIORITY JOURNAL; SEASONAL VARIATION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TREATMENT OUTCOME;

EID: 10744232817     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.5.3252     Document Type: Article

References (49)

1. Malling, H. J. 1998. Immunotherapy as an effective tool in allergy treatment. Allergy 53:461.
2. Bousquet, J., R. Lockey, and H. J. Malling. 1998. Allergen immunotherapy: therapeutic vaccines for allergic diseases: a WHO position paper. J. Allergy Clin. Immunol. 102:558.
3. Durham, S. R., S. M. Walker, E. M. Varga, M. R. Jacobson, F. O'Brien, W. Noble, S. J. Till, Q. A. Hamid, and K. T. Nouri-Aria. 1999. Long-term clinical efficacy of grass-pollen immunotherapy. N. Engl. J. Med. 341:468.
4. Walker, S. M., G. B. Pajno, M. T. Lima, D. R. Wilson, and S. R. Durham. 2001. Grass pollen immunotherapy for seasonal rhinitis and asthma: a randomized, controlled trial. J. Allergy Clin. Immunol. 107:87.
5. Ewan, P. W., J. Deighton, A. B. Wilson, and P. J. Lachmann. 1993. Venom-specific IgG antibodies in bee and wasp allergy: lack of correlation with protection from stings. Clin. Exp. Allergy 23:647.
6. Muller, U., A. Helbling, and M. Bischof. 1989. Predictive value of venom-specific IgE, IgG and IgG subclass antibodies in patients on immunotherapy with honey bee venom. Allergy 44:412.
7. van Ree, R., W. A. van Leeuwen, P. H. Dieges, R. G. van Wijk, N. de Jong, P. Z. Brewczyski, A. M. Kroon, P. P. Schilte, K. Y. Tan, I. F. Simon-Licht, et al. 1997. Measurement of IgG and IgG antibodies against purified grass pollen allergens (Lol p 1, 2, 3 and 5) during immunotherapy. Clin. Exp. Allergy 27:68.
8. Devey, M. E., D. V. Wilson, and A. W. Wheeler. 1976. The IgG subclasses of antibodies to grass pollen allergens produced in hay fever patients during hyposensitization. Clin. Allergy 6:227.
9. Aalberse, R. C., R. van der Gaag, and J. van Leeuwen. 1983. Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response. J. Immunol. 130:722.
10. Gehlhar, K., M. Schlaak, W. Becker, and A. Bufe. 1999. Monitoring allergen immunotherapy of pollen-allergic patients: the ratio of allergen-specific IgG4 to IgG1 correlates with clinical outcome. Clin. Exp. Allergy 29:497.
11. Wilson, D. R., A. M. A. Irani, S. M. Walker, M. R. Jacobson, I. S. Mackay, L. B. Schwartz, and S. R. Durham. 2001. Grass pollen immunotherapy inhibits seasonal increase in basophils and eosinophils in the nasal epithelium. Clin. Exp. Allergy 31:1705.
12. Kimura, I., Y. Tanizaki, Y. Goda, H. Komagoe, and H. Kitani. 1985. Decrease in reactivity of basophils by immunotherapy with house dust extract. Clin. Allergy 15:1.
13. + T lymphocytes in atopic patients. J. Immunol. 144:4651.
14. Jutel, M., W. J. Pichler, D. Skrbic, A. Urwyler, C. Dahinden, and U. R. Muller. 1995. Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-γ secretion in specific allergen-stimulated T cell cultures. J. Immunol. 154:4187.
15. McHugh, S. M., J. Deighton, A. G. Stewart, P. J. Lachmann, and P. W. Ewan. 1995. Bee venom immunotherapy induces a shift in cytokine responses from a Th2 to a Th1 dominant pattern: comparison of rush and conventional immunotherapy. Clin. Exp. Allergy 25:828.
16. Akoum, H., A. Tsicopoulos, H. Vorng, B. Wallaert, J. P. Dessaint, M. Joseph, Q. Hamid, and A. B. Tonnel. 1996. Venom immunotherapy modulates IL-4 and IFN-γ mRNA expression of peripheral T-cells. Immunology 87:593.
17. + T-cells from allergic individuals. J. Exp. Med. 178:2123.
18. Wachholz, P. A., K. T. Nouri-Aria, D. R. Wilson, A. Verhoef, S. M. Walker, S. J. Till, and S. R. Durham SR. 2002. Grass pollen immunotherapy for hay fever is associated with increases in local nasal mucosal but not peripheral Th1/Th2 ratios. Immunology 105:56.
19. Varney, V. A., Q. A. Hamid, M. Gaga, S. Ying, M. R. Jacobson, A. J. Frew, A. B. Kay, and S. R. Durham. 1993. Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses. J. Clin. Invest. 92:644.
20. + T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing mRNA for interferon-γ. J. Allergy Clin. Immunol. 97:1356.
21. Klimek, L., D. Dormann, E. R. Jarman, O. Cromwell, H. Riechelmann, and A. B. Reske-Kunz. 1999. Short-term preseasonal birch pollen allergoid immunotherapy influences symptoms, specific nasal provocation and cytokine levels in nasal secretions, but not peripheral T-cell responses, in patients with allergic rhinitis. Clin. Exp. Allergy 29:1326.
22. Akdis, C. A., A. Joss, M. Akdis, A. Faith, and K. Blaser. 2000. A molecular basis for T-cell suppression by IL-10: CD28-associated IL-10 receptor inhibits CD28 tyrosine phosphorylation and phosphatidylinositol 3-kinase binding. FASEB J. 14:1666.
23. Jeannin, P., S. Lecoanet, Y. Delneste, J. F. Gauchat, and J. Y. Bonnefoy. 1998. IgE versus IgG4 production can be differentially regulated by IL-10. J. Immunol. 160:3555.
24. Akdis, C. A., T. Blesken, M. Akdis, B. Wuthrich, and K. Blaser. 1998. Role of interleukin 10 in specific immunotherapy. J. Clin. Invest. 102:98.
25. Akbari, O., R. H. DeKruyff, and D. T. Umetsu. 2001. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat. Immunol. 2:725.
26. + regulatory T-cells by oral antigen administration. J. Immunol. 167:4245.
27. + regulatory T-cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J. Immunol. 168:1080.
28. Masuyama, K., S. J. Till, M. R. Jacobson, A. Kamil, L. Cameron, S. Juliusson, O. Lowhagen, A. B. Kay, Q. A. Hamid, and S. R. Durham. 1998. Nasal eosinophilia and IL-5 mRNA expression in seasonal allergic rhinitis: effect of topical corticosteroids. J. Allergy Clin. Immunol. 102:610.
29. Cameron, L. A., S. R. Durham, M. R. Jacobson, K. Masuyama, S. Juliusson, H. J. Gould, O. Lowhagen, E. M. Minshall, and Q. A. Hamid. 1998. Expression of IL-4, Cε RNA, and Iε RNA in the nasal mucosa of patients with seasonal rhinitis: effect of topical corticosteroids. J. Allergy Clin. Immunol. 101:330.
30. Wachholz, P. A., N. K. Soni, S. J. Till, and S. R. Durham. 2003. Inhibition of allergen-IgE binding to B cells by IgG antibodies after grass pollen immunotherapy. J. Allergy Clin. Immunol. 112:915.
31. Nouri-Aria, K. T., D. Wilson, J. N. Francis, L. A. Jopling, M. R. Jacobson, M. R. Hodge, D. P. Andrew, S. J. Till, E. M. Varga, et al. 2002. CCR4 in human allergen-induced late responses in the skin and lung. Eur. J. Immunol. 32:1933.
32. Wachholz, P. A., R. J. van Neerven, N. Kristensen, J. N. Larsen, S. J. Till, and S. R. Durham. 2002. FACS-FAP: a novel method for detecting the influence of grass pollen immunotherapy on IgE-facilitated antigen presentation. J. Allergy Clin. Immunol. 109:5202.
33. Akids, C. A., A. Joss, M. Akids, and K. Blaser. 2001. Mechanism of IL-10-induced T cell inactivation in allergic inflammation and normal response to allergens. Int. Arch. Allergy Immunol. 124:180.
34. Jutel, M., M. Akdis, F. Budak, C. Aebischer-Casaulta, M. Wrzyszcz, K. Blaser, and C. A. Akdis. 2003. IL-10 and TGF-β cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur. J. Immunol. 33:1205.
35. + T cells by grass pollen immunotherapy. J. Allergy Clin. Immunol. 111:1255.
36. Nasser, S. M., S. Ying, Q. Meng, A. B. Kay, and P. W. Ewan. 2001. IL-10 levels increase in cutaneous biopsies of patients undergoing wasp venom immunotherapy. Eur. J. Immunol. 31:3704.
37. Maloy, K. J., and F. Powrie. 2001. Regulatory T cells in the control of immune pathology. Nat. Immunol. 2:816.
38. + regulatory T cells. Curr. Opin. Immunol. 13:644.
39. + regulatory T-cells is mediated by cell surface-bound transforming growth factor β. J. Exp. Med. 194:629.
40. H3 regulatory cells. Nat. Immunol. 2:671.
41. Durham, S. R., H. J. Gould, C. P. Thienes, M. R. Jacobson, K. Masuyama, S. Rak, O. Lowhagen, E. Schotman, L. Cameron, and Q. A. Hamid. 1997. Expression Of ε germ-line transcripts and mRNA for the ε heavy chain of IgE in nasal B cells and the effects of topical corticosteroid. Eur. J. Immunol. 27:2899.
42. Smurthwaite, L., S. N. Walker, D. R. Wilson, D. S. Birch, T. G. Merrett, S. R. Durham, and H. G. Gould. 2001. Persistent IgE synthesis in the nasal mucosa of hay fever patients. Eur. J. Immunol. 31:3422.
43. Ying, S., M. Humbert, Q. Meng, G. Menz, R. Pfister, H. J. Gould, A. B. Kay, and S. R. Durham. 2001. Local expression of ε germ-line gene transcripts (Iε) and RNA for the ε heavy chain of IgE (Cε) in the bronchial mucosa in atopic and non-atopic asthma. J. Allergy Clin. Immunol. 107:686.
44. Wilson, D. R., T. G. Merrett, E. M. Varga, L. Smurthwaite, H. J. Gould, M. Kemp, J. Hooper, S. J. Till, and S. R. Durham. 2002. Increases in allergen specific IgE in BAL after segmental allergen challenge in atopic asthmatics. Am. J. Respir. Crit. Care Med. 165:22.
45. Larché, M., S. J. Till, B. M. Haselden, J. North, J. Barkans, C. J. Corrigan, A. B. Kay, and D. S. Robinson. 1998. Co-stimulation through CD86 is involved in airway antigen presenting cell and T cell responses to allergen in atopic asthmatics. J. Immunol. 161:6375.
46. Bellinghausen, I., U. Brand, K. Steinbrink, A. H. Enk, J. Knop, and J. Saloga. 2001. Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells. J. Allergy Clin. Immunol. 108:242.
47. 2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro. J. Clin. Invest. 98:1676.
48. Varga, E. M., P. Wachholz, K. T. Nouri-Aria, A. Verhoef, C. J. Corrigan, S. J. Till, and S. R. Durham. 2000. T cells from human allergen-induced late asthmatic responses express IL-12 receptor β2 subunit mRNA and respond to IL-12 in vitro. J. Immunol. 165:2877.
49. + cells accompany inhibition of allergen-induced late skin responses after successful grass pollen immunotherapy. J. Allergy Clin. Immunol. 99:254.