Selective in vitro and in vivo binding of [125I]ADAM to serotonin transporters in rat brain

Synapse

Volumn 38, Issue 4, 2000, Pages 403-412

  Choi, Seok Rye ^a   Hou, Catherine ^a   Oya, Shunichi ^a   Mu, Mu ^a   Kung, Mei Ping ^a   Siciliano, Michael ^a   Acton, Paul D ^a   Kung, Hank F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Autoradiography; Brain imaging; Receptor binding; Selective serotonin reuptake inhibitors; Serotonergic neuron

Indexed keywords

1,2,3,5,6,10B HEXAHYDRO 6 (4 METHYLTHIOPHENYL)PYRROLO[2,1 A]ISOQUINOLINE; 2 [[2 [(DIMETHYLAMINO)METHYL] PHENYL]THIO] 5 IODOPHENYLAMINE I 125; IODINE 125; KETANSERIN; METHYLPHENIDATE; PAROXETINE; RACLOPRIDE; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN CORTEX; BRAIN TISSUE; CENTRAL GRAY MATTER; CEREBELLUM; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; GLOBUS PALLIDUS; HIPPOCAMPUS; HYPOTHALAMUS; INTERPEDUNCULAR NUCLEUS; LOCUS CERULEUS; MALE; MEDIAN RAPHE NUCLEUS; NONHUMAN; OLFACTORY BULB; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SUBSTANTIA NIGRA; SUPERIOR COLLICULUS; THALAMUS NUCLEUS;

ANIMALS; AUTORADIOGRAPHY; BRAIN; CARRIER PROTEINS; CINANSERIN; FEMALE; HUMANS; IODINE RADIOISOTOPES; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEX CHARACTERISTICS; TISSUE DISTRIBUTION;

EID: 0034672791     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/1098-2396(20001215)38:4<403::AID-SYN5>3.0.CO;2-Z     Document Type: Article

References (48)

1. SPECT imaging of serotonin transporters in the non-human primate brain with the selective tracer [123I]IDAM
2. Single-photon emission tomography imaging of serotonin transporters in the non-human primate brain with the selective radioligand [(123)I]IDAM
3. 123I]ODAM
4. In vitro and in vivo characterisation of nor-beta-CIT: A potential radioligand for visualisation of the serotonin transporter in the brain
5. [125I]5-Iodo-6-nitroquipazine: A potent and selective ligand for the 5-hydroxytryptamine uptake complex II in vivo studies in rats
6. 3 Beta-(4-ethyl-3-iodophenyl)nortropane-2 beta-carboxylic acid methyl ester as a high-affinity selective ligand for the serotonin transporter
7. Autoradiography of antidepressant binding sites in the human brain: Localization using [3H] paroxetine
8. 3H]-imipramine
9. 3H-paroxetine-labeled serotonin uptake sites in rat brain
10. Parmacological properties of 403U76, a new chemical class of 5-hydroxytryptamine- and noradrenaline-reuptake inhibitor
11. 123I]beta-CIT binding to dopamine and serotonin transporters
12. Iodine-123 labeled nor-beta-CIT as a potential tracer for serotonin transporter imaging in the human brain with single-photon emission tomography
13. Paroxetine. A review of its pharmacology, therapeutic use in depression and therapeutic potential in diabetic neuropathy
14. 3H]imipramine localization and relationship to serotonin transporter
15. Iodine-123-5-iodo-6-nitroquipazine: SPECT radiotracer to image the serotonin transporter
16. Long-term biochemical and behavioral effects of p-chloroamphetamine in the rat
17. Quantitative autoradiography of serotonin uptake sites in rat brain using [3H]cyanoimipramine
18. Dosimetry of iodine-123-beta-CIT
19. 2 dopamine receptor binding of IBZM and NMSP in rat brain
20. 2 receptor imaging agent
21. 4-Iodotomoxetin: A novel ligand for serotonin uptake sites
22. Characterization of [(123)I]IDAM as a novel single-photon emission tomography tracer for serotonin transporters
23. 11C] sertraline
24. Protein measurement with Folin phenol reagent
25. Reduced brain serotonin transporter availability in major depression as measured by [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and single photon emission computed tomography
26. The neurobiology of suicide
27. [I-125]5-Iodo-6-nitroquipazine: Synthesis and evaluation of potent and selective presynpatic serotonin ligand
28. [I-125]5-Iodo-6-nitro-2-piperazinylquinoline: A potent and selective ligand for the serotonin uptake complex
29. Serotonin in aging, late-life depression, and Alzheimer's disease: The emerging role of functional imaging
30. LIGAND: A versatile computerized approach for characterization of ligand binding system
31. A new single-photon emission computed tomography imaging agent for serotonin transporters: [123I]IDAM, 5-Iodo-2-((2-((dimethylamino)methyl)phenyl)thio)benzyl alcohol
32. 2-((2-((Dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM): An Improved Serotonin Transporter Ligand
33. Decreased imiprimine binding in the brains of patients with depressive illness
34. beta-CIT SPECT demonstrates blockade of 5HT-uptake sites by citalopram in the human brain in vivo
35. Paroxetine as an in vivo indicator of 3,4-methylenedioxymethamphetamine neurotoxicity: A presynaptic serotonergic positron emission tomography ligand?
36. Chiral synthesis via orbanoboranes. 18 Selective reductions, 43 diisopinocampheylchloroborane as an excellent chiral reducing reagent for synthesis of halo alcohols of high enantiomeric purity. A highly enantioselective synthesis of both optical isomers of tomoxetine, fluoxetine and nisoxetine
37. Imaging of the serotonergic system: Interactions of neuroanatomical and functional abnormalities of depression
38. A PET radiotracer for studying serotonin uptake sites: Carbon-11-McN-5652Z
39. An improved method for the synthesis of radiolabeled MCN5652 via thioester precursors
40. 11C]MCN5652 extraction of characteristic images by artificial neural-network analysis
41. Positron emission tomography of 5-HT transporter sites in the baboon brain with [11C]McN5652
42. Impulse-response function and kinetic-model of C-11-labeled (+)MCN5652
43. Single-photon emission tomography imaging of monoamine transporters in impulsive violent behaviour
44. [(123)I]-beta-CIT SPECT imaging shows reduced brain serotonin transporter availability in drug-free depressed patients with seasonal affective disorder
45. Development of antidepressant drugs. Fluoxetine (Prozac) and other selective serotonin uptake inhibitors
46. Derivatives of 4-(2'-methoxy-phenyl)-1-[2'-(N-2''-pyridinyl)-p-iodobenzamido]ethyl-piperazin e (p-MPPI) as 5-HT(1A) ligands
47. A novel serotonin transporter ligand: (5-iodo-2-(2-dimethylaminomethylphenoxy)-benzyl alcohol(ODAM)