Synthesis, Radiosynthesis, and Biological Evaluation of Carbon-11 and Iodine-123 Labeled 2β-Carbomethoxy-3β-[4′ -((Z)-2-haloethenyl)phenyl]tropanes: Candidate Radioligands for in Vivo Imaging of the Serotonin Transporter

Journal of Medicinal Chemistry

Volumn 47, Issue 5, 2004, Pages 1122-1135

  Plisson, Christophe ^a   McConathy, Jonathan ^a   Martarello, Laurent ^a   Malveaux, Eugene J ^a   Camp, Vernon M ^a   Williams, Larry ^a   Votaw, John R ^a   Goodman, Mark M ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2BETA CARBOMETHOXY 3BETA [4' (2 BROMOETHENYL)PHENYL]TROPANE; 2BETA CARBOMETHOXY 3BETA [4' (2 IODOETHENYL)PHENYL]TROPANE; 2BETA CARBOMETHOXY 3BETA [4' (2 TRIMETHYLSTANNYLETHENYL)PHENYL]TROPANE; 3BETA (4 CHLOROPHENYL) 2BETA TROPANECARBOXYLIC ACID PHENYL ESTER; 3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; CARBON 11; CITALOPRAM; IODINE 123; METHYL IODIDE; NISOXETINE; NORTROPANE DERIVATIVE; RADIOLIGAND; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; TROPANE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN REGION; BRAIN STEM; CAUDATE NUCLEUS; CORPUS STRIATUM; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG UPTAKE; HUMAN; HUMAN CELL; MALE; MEDULLA OBLONGATA; MESENCEPHALON; MONKEY; NEUROIMAGING; NONHUMAN; PONS; POSITRON EMISSION TOMOGRAPHY; PUTAMEN; QUANTUM YIELD; RADIOACTIVITY; RADIOCHEMISTRY; RAT; STRUCTURE ACTIVITY RELATION; THALAMUS;

ANIMALS; BINDING, COMPETITIVE; BRAIN; CARBON RADIOISOTOPES; CARRIER PROTEINS; CELL LINE; DOGS; HUMANS; IODINE RADIOISOTOPES; ISOTOPE LABELING; LIGANDS; MACACA FASCICULARIS; MACACA MULATTA; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TOMOGRAPHY, EMISSION-COMPUTED; TROPANES;

EID: 1242273831     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030384e     Document Type: Article

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