PET examination of [11C]5-methyl-6-nitroquipazine, a radioligand for visualization of the serotonin transporter

Nuclear Medicine and Biology

Volumn 29, Issue 6, 2002, Pages 651-656

  Sandell, Johan ^a   Halldin, Christer ^a   Sovago, Judith ^a   Chou, Yuan Hwa ^a   Gulyás, Balász ^a   Yu, Meixiang ^b   Emond, Patrick ^c   Någren, Kjell ^b   Guilloteau, Denis ^c   Farde, Lars ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b TURKU PET CENTRE   (Finland)

^c UNIVERSITÉ DE TOURS   (France)

Author keywords

11C 5 methyl 6 nitroquipazine; Monkey brain; PET; Serotonin transporter

Indexed keywords

5 METHYL 6 NITROQUIZAPINE C 11; PALLADIUM; RADIOLIGAND; SEROTONIN; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLOOD ANALYSIS; BRAIN REGION; BRAIN STEM; CATALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIGAND BINDING; MONKEY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; THALAMUS;

ANIMALS; BRAIN; CARRIER PROTEINS; HAPLORHINI; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; QUIPAZINE; RADIOPHARMACEUTICALS; SENSITIVITY AND SPECIFICITY; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0036702242     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(02)00318-9     Document Type: Article

References (23)

1. 13C-labelled prostacyclins. Acta Chem Scand. 52:1998;635-640.
2. 11C]methyl iodide. J Labelled Compd Radiopharm. 43:2000;1327-1334.
3. 3H]citalopram . Neuroscience. 54:1993;691-699.
4. Halldin C., Swahn C.-G., Farde L., Sedvall G. Radioligand disposition and metabolism. Key information in early drug development. Comar D., PET for drug development and evaluation. 1995;55-65 Kluwer Academic Publishers, Dordrecht.
5. 3H]6-nitroquipazine binding sites in rat brain. Eur J Pharmacol. 180:1990;273-281.
6. 3H]6-nitroquipazine. Pharmacol Exper Ther. 255:1990;146-153.
7. Helfenbein J., Sandell J., Halldin C., Chalon S., Emond P., Okubo Y., Chou Y.-H., Frangin Y., Douziech L., Garreau L., Swahn C.-G., Besnard J.-C., Farde L., Guilloteau D. PET examination of three potent cocaine derivatives as specific radioligands for the serotonin transporter. Nucl Med Biol. 26:1999;491-499.
8. 11C]DASB . Eur J Nucl Med. 27:2000;1719-1722.
9. Jagust W.J., Eberling J.L., Biegon A., Taylor S.E., VanBrocklin H.F., Jordan S., Hanrahan S.M., Roberts J.A., Brennan K.M., Mathis C.A. Iodine-123-5-iodo-6-nitroquipazine SPECT radiotracer to image the serotonin transporter . J Nucl Med. 37:1996;1207-1214.
10. 11C]NNC 756 as new radioligands for the D1-dopamine receptor. Psychopharmacology. 113:1993;149-156.
11. Lundkvist C., Loc'h C., Halldin C., Bottlaender M., Ottaviani M., Coulon C., Fuseau C., Mathis C., Farde L., Maziere B. Characterization of bromine-76-labelled 5-bromo-6-nitroquipazine for PET studies of the serotonin transporter. Nucl Med Biol. 26:1999;501-507.
12. Martin D.C., Introna R.P., Aronstam R.S. Inhibition of neuronal 5-HT uptake by ketamine, but not halothane, involves disruption of substrate recognition by the transporter. Neuroscience Lett. 112:(1):1990;99-103.
13. Mathis C.A., Taylor S.E., Enas J.D., Akgün E. Binding potency of 6-nitroquipazine analogues for the 5-hydroxytryptamine reuptake complex. J Pharm Pharmacol. 46:1994;751-754.
14. Owens M.J., Nemeroff C.B. Role of serotonin in the pathophysiology of depression focus on the serotonin transporter . Clin Chem. 40:1994;288-295.
15. Oya S., Choi S.-R., Hou C., Mu M., Kung M.-P., Acton P.D., Siciliano M., Kung H. 2-((2-((Dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM) An improved serotonin transporter ligand . Nucl Med Biol. 27:2000;249-254.
16. Rickels K., Schweizer E. Clinical overview of serotonin reuptake inhibitors. J Clin Psychiatry. 51:1990;9-12.
17. 11C]FLB 457 by use of the GE Medical Systems PETtrace MeI MicroLab. J Labelled Compd Radiopharm. 42:1999;1183-1193.
18. Stille J.K. The palladium-catalyzed cross-coupling reactions of organotin reagents with organic electrophiles. Angew Chem Int Ed Eng. 25:1986;508-524.
19. 11C](+)McN5652. Synapse. 20:1995;37-43.
20. Tejani-Butt S.M., Yang J., Pawlyk A.C. Altered serotonin transporter sites in Alzheimer's disease raphe and hippocampus. NeuroReport. 6:1995;1207-1210.
21. Vaatstra W.J., Deiman-Van Aalst W.M.A., Eigeman L. DU 24565, A quipazine derivative, a potent selective serotonin uptake inhibitor. Eur J Pharmacol. 70:1981;195-202.
22. Wienhard K., Dahlbom M., Eriksson L., Michel C., Bruckbauer T., Pietrzyk U., Heiss W.-D. The ECAT EXACT HR Performance of a new high resolution positron scanner . J Comput Assist Tomogr. 18:1994;110-118.
23. 11C]RTI-32 A new tool for the in vivo evaluation of the metabolism of phenyltropane dopamine reuptake compounds . J Labelled Compd Radiopharm. 42:(Suppl. 1):1999;S469-S471.