A new single-photon emission computed tomography imaging agent for serotonin transporters: [123I]IDAM, 5-Iodo-2-((2- ((dimethylamino)methyl)phenyl)thio)benzyl alcohol

Journal of Medicinal Chemistry

Volumn 42, Issue 3, 1999, Pages 333-335

  Oya, Shunichi ^a   Kung, Mei Ping ^a   Acton, Paul D ^a   Mu, Mu ^a   Hou, Catherine ^a   Kung, Hank F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,5,6,10B HEXAHYDRO 6 (4 METHYLTHIOPHENYL)PYRROLO[2,1 A]ISOQUINOLINE; 3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER I 123; 403 U 76; 5 CHLORO 2 [[2 [(DIMETHYLAMINO)METHYL]PHENYL]THIO]BENZYL ALCOHOL; 5 IODO 2 [[2 [(DIMETHYLAMINO)METHYL]PHENYL]THIO]BENZYL ALCOHOL I 123; DOPAMINE TRANSPORTER; RADIOPHARMACEUTICAL AGENT; SEROTONIN TRANSPORTER; TRACER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; BABOON; BINDING AFFINITY; CONTROLLED STUDY; DRUG SYNTHESIS; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY CELL; LETTER; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SWINE;

ANIMALS; BENZYL ALCOHOLS; BRAIN; CARRIER PROTEINS; CONTRAST MEDIA; IODINE RADIOISOTOPES; LLC-PK1 CELLS; MAGNETIC RESONANCE IMAGING; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; PAPIO; RATS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SULFIDES; SWINE; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 0032971803     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9806751     Document Type: Letter

References (23)

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23. 123I]IDAM. Forty-eight 5-min scans were carried out over a total time period of 240 min. The projection images were reconstructed by filtered-back projection. Then, a 3D low-pass Butterworth filter was applied. For uniform attenuation correction, Chang's first-order method was used. The MRI scans were acquired on a 1.5-T instrument (GE Medical Systems, Milwaukee, WI) with a spoiled GRAS sequence that produces 0.97-× 0.97-× 1-mm voxels. The MRI scans were resized and resliced in planes parallel to the one containing the anterior and posterior commissures.