Synthesis and pharmacological characterization of a new PET ligand for the serotonin transporter: [11C]5-bromo-2-[2-(dimethylaminomethylphenylsulfanyl)]phenylamine ([11C]DAPA)

Nuclear Medicine and Biology

Volumn 29, Issue 7, 2002, Pages 741-751

  Huang, Yiyun ^a   Hwang, Dah Ren ^a,b   Zhu, Zhihong ^a   Bae, Sung A ^b   Guo, Ningning ^a   Sudo, Yasuhiko ^a   Kegeles, Lawrence S ^a,b   Laruelle, Marc ^a,b  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

PET; Radioligand; Serotonin transporter; Synthesis

Indexed keywords

5 BROMO 2 [2 (DIMETHYLAMINOMETHYLPHENYLSULFANYL)]PHENYLAMINE; ANILINE DERIVATIVE; CARBON 11; CITALOPRAM; METHYL IODIDE; RADIOLIGAND; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; UNCLASSIFIED DRUG; 5 BROMO 2 (2 (DIMETHYLAMINOMETHYLPHENYLSULFANYL))PHENYLAMINE; 5-BROMO-2-(2-(DIMETHYLAMINOMETHYLPHENYLSULFANYL))PHENYLAMINE; CARRIER PROTEIN; DIAGNOSTIC AGENT; LIGAND; MEMBRANE PROTEIN; NERVE PROTEIN; RADIOPHARMACEUTICAL AGENT; SLC6A4 PROTEIN, RAT; SULFIDE;

ANIMAL EXPERIMENT; ARTICLE; BABOON; BINDING AFFINITY; BINDING ASSAY; BODY DISTRIBUTION; BRAIN REGION; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; IMAGING; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRECURSOR; RADIOACTIVITY; RADIOCHEMISTRY; RAT; TIME; ANIMAL; BRAIN; COMPARATIVE STUDY; COMPUTER ASSISTED EMISSION TOMOGRAPHY; DRUG EFFECT; FEMALE; ISOTOPE LABELING; MALE; METABOLISM; METHODOLOGY; PAPIO; REPRODUCIBILITY; SCINTISCANNING; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT; SYNTHESIS; TISSUE DISTRIBUTION;

ANILINE COMPOUNDS; ANIMALS; BRAIN; CARRIER PROTEINS; CITALOPRAM; FEMALE; ISOTOPE LABELING; LIGANDS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; PAPIO; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SULFIDES; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0036792104     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(02)00337-2     Document Type: Article

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