메뉴 건너뛰기




Volumn 9, Issue 1, 1997, Pages 1-17

The role of serotonin in the pathophysiology and treatment of schizophrenia

Author keywords

[No Author keywords available]

Indexed keywords

AMPHETAMINE; CLOZAPINE; DOPAMINE; HALOPERIDOL; RISPERIDONE; RITANSERIN; SEROTONIN; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

EID: 0031034035     PISSN: 08950172     EISSN: None     Source Type: Journal    
DOI: 10.1176/jnp.9.1.1     Document Type: Review
Times cited : (200)

References (243)
  • 1
    • 0001902397 scopus 로고
    • Drug antagonistic to 5-hydroxytryptamine
    • edited by Wolstenholme GW. Boston, Little, Brown
    • Gaddum JH: Drug antagonistic to 5-hydroxytryptamine, in Ciba Foundation Symposium on Hypertension, edited by Wolstenholme GW. Boston, Little, Brown, 1954, pp 75-77
    • (1954) Ciba Foundation Symposium on Hypertension , pp. 75-77
    • Gaddum, J.H.1
  • 2
    • 0000358118 scopus 로고
    • A biological and pharmacological suggestion about certain mental disorders
    • Wooley DW, Shaw E: A biological and pharmacological suggestion about certain mental disorders. Proc Natl Acad Sci USA 1954; 40:228-231
    • (1954) Proc Natl Acad Sci USA , vol.40 , pp. 228-231
    • Wooley, D.W.1    Shaw, E.2
  • 3
    • 0015383552 scopus 로고
    • Catecholamines in the brain as mediator of amphetamine psychosis
    • Snyder SH: Catecholamines in the brain as mediator of amphetamine psychosis. Arch Gen Psychiatry 1972; 27:169-179
    • (1972) Arch Gen Psychiatry , vol.27 , pp. 169-179
    • Snyder, S.H.1
  • 4
    • 0023812652 scopus 로고
    • Clozapine for the treatment-resistant schizophrenic
    • Kane J, Honigfeld G, Singer J, et al: Clozapine for the treatment-resistant schizophrenic. Arch Gen Psychiatry 1988; 45:789-796
    • (1988) Arch Gen Psychiatry , vol.45 , pp. 789-796
    • Kane, J.1    Honigfeld, G.2    Singer, J.3
  • 5
    • 0026091799 scopus 로고
    • The mechanism of action of novel antipsychotic drugs
    • Meltzer HY: The mechanism of action of novel antipsychotic drugs. Schizophr Bull 1991; 17:263-286
    • (1991) Schizophr Bull , vol.17 , pp. 263-286
    • Meltzer, H.Y.1
  • 6
    • 0025003934 scopus 로고
    • Atypical neuroleptics: Role of multiple receptors, endogenous dopamine, and receptor linkage
    • Seeman P: Atypical neuroleptics: Role of multiple receptors, endogenous dopamine, and receptor linkage. Acta Psychiatr Scand 1990; 82:14-20
    • (1990) Acta Psychiatr Scand , vol.82 , pp. 14-20
    • Seeman, P.1
  • 7
    • 0028342655 scopus 로고
    • Risperidone in the treatment of schizophrenia
    • Marder SR, Meibach RC:Risperidone in the treatment of schizophrenia. Am J Psychiatry 1994; 151:825-835
    • (1994) Am J Psychiatry , vol.151 , pp. 825-835
    • Marder, S.R.1    Meibach, R.C.2
  • 8
    • 0027475985 scopus 로고
    • A Canadian multicenter placebo-controlled study of fixed doses of risperidone and haloperidol in the treatment of chronic schizophrenic patients
    • Chouinard G, Jones B, Remington G, et al: A Canadian multicenter placebo-controlled study of fixed doses of risperidone and haloperidol in the treatment of chronic schizophrenic patients. J Clin Psychopharmacol 1993; 13:25-40
    • (1993) J Clin Psychopharmacol , vol.13 , pp. 25-40
    • Chouinard, G.1    Jones, B.2    Remington, G.3
  • 9
    • 0001989283 scopus 로고
    • Evidence for the existence of monoamine-containing neurons in the central-nervous system, I: Demonstration of monoamines in the cell bodies of brain stem neurons
    • Dahlström A, Fuxe K: Evidence for the existence of monoamine-containing neurons in the central-nervous system, I: Demonstration of monoamines in the cell bodies of brain stem neurons. Acta Physiol Scand 1964; 62:1-55
    • (1964) Acta Physiol Scand , vol.62 , pp. 1-55
    • Dahlström, A.1    Fuxe, K.2
  • 10
    • 0018200286 scopus 로고
    • Autoradiographic analysis of the differential ascending projection of the dorsal and median raphe nuclei in the rat
    • Azmitia EC, Segal M: Autoradiographic analysis of the differential ascending projection of the dorsal and median raphe nuclei in the rat. J Comp Neurol 1978; 179:641-668
    • (1978) J Comp Neurol , vol.179 , pp. 641-668
    • Azmitia, E.C.1    Segal, M.2
  • 11
    • 0019464864 scopus 로고
    • Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminal
    • Steinbusch HWM: Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminal. Neuroscience 1981; 6:557-618
    • (1981) Neuroscience , vol.6 , pp. 557-618
    • Steinbusch, H.W.M.1
  • 12
    • 0016766822 scopus 로고
    • Hippocampal innervation by serotonin neurons of the midbrain raphe in the rat
    • Moore A, Halaris A: Hippocampal innervation by serotonin neurons of the midbrain raphe in the rat. J Comp Neurol 1975; 164:171-184
    • (1975) J Comp Neurol , vol.164 , pp. 171-184
    • Moore, A.1    Halaris, A.2
  • 13
    • 0017274390 scopus 로고
    • Histologic and enzymatic studies of the mesolimbic and mesostriatal serotonergic pathways
    • Geyer M, Puerto A, Dawsey W, et al: Histologic and enzymatic studies of the mesolimbic and mesostriatal serotonergic pathways. Brain Res 1976; 106:241-256
    • (1976) Brain Res , vol.106 , pp. 241-256
    • Geyer, M.1    Puerto, A.2    Dawsey, W.3
  • 14
    • 0023507323 scopus 로고
    • Serotonin axon terminals in the ventral tegmental area of the rat: Fine structure and synaptic input to dopaminergic neurons
    • Herve D, Pickel VM, Joh TH, et al: Serotonin axon terminals in the ventral tegmental area of the rat: Fine structure and synaptic input to dopaminergic neurons. Brain Res 1987; 435:71-83
    • (1987) Brain Res , vol.435 , pp. 71-83
    • Herve, D.1    Pickel, V.M.2    Joh, T.H.3
  • 15
    • 0017140194 scopus 로고
    • Evidence of the existence of a raphe projection to the substantia nigra in rat
    • Dray A, Gonye T, Oakley N, et al: Evidence of the existence of a raphe projection to the substantia nigra in rat. Brain Res 1976; 113:45-57
    • (1976) Brain Res , vol.113 , pp. 45-57
    • Dray, A.1    Gonye, T.2    Oakley, N.3
  • 16
    • 0017849970 scopus 로고
    • The dorsal and medial raphe projections to the substantia nigra in the rat: Electrophysiological, biochemical and behavioural observations
    • Dray A, Davies J. Oakley NR, et al: The dorsal and medial raphe projections to the substantia nigra in the rat: Electrophysiological, biochemical and behavioural observations. Brain Res 1978; 151:431-442
    • (1978) Brain Res , vol.151 , pp. 431-442
    • Dray, A.1    Davies, J.2    Oakley, N.R.3
  • 17
    • 0000121561 scopus 로고
    • An anatomical and electrophysiological investigation of the serotonergic projection from the dorsal raphe nucleus to the substantia nigra in the rat
    • Fibiger HC, Miller JJ: An anatomical and electrophysiological investigation of the serotonergic projection from the dorsal raphe nucleus to the substantia nigra in the rat. Neuroscience 1977; 2:975-987
    • (1977) Neuroscience , vol.2 , pp. 975-987
    • Fibiger, H.C.1    Miller, J.J.2
  • 18
    • 0018646928 scopus 로고
    • Afferent projections to the ventral tegmental area of Tsai and interfascicular nucleus: A horseradish peroxydase study in the rat
    • Phillipson OT: Afferent projections to the ventral tegmental area of Tsai and interfascicular nucleus: A horseradish peroxydase study in the rat. J Comp Neurol 1979; 187:117-144
    • (1979) J Comp Neurol , vol.187 , pp. 117-144
    • Phillipson, O.T.1
  • 19
    • 0022444356 scopus 로고
    • Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine
    • Bradley PB, Engel G, Fenuik W, et al: Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine. Neuropharmacol 1986; 6:563-576
    • (1986) Neuropharmacol , vol.6 , pp. 563-576
    • Bradley, P.B.1    Engel, G.2    Fenuik, W.3
  • 20
    • 0028183017 scopus 로고
    • International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin)
    • Hoyer D, Clarke DE, Fozard JR, et al: International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin) [review]. Pharmacol Rev 1994; 46:157-203
    • (1994) Pharmacol Rev , vol.46 , pp. 157-203
    • Hoyer, D.1    Clarke, D.E.2    Fozard, J.R.3
  • 21
    • 0028342977 scopus 로고
    • Classification review: Receptors for 5-hydroxytryptamine: Current perspectives on classification and nomenclature
    • Martin G, Humphrey P: Classification review: Receptors for 5-hydroxytryptamine: Current perspectives on classification and nomenclature. Neuropharmacology 1994; 33:261-273
    • (1994) Neuropharmacology , vol.33 , pp. 261-273
    • Martin, G.1    Humphrey, P.2
  • 22
    • 0028985633 scopus 로고
    • Comparative localization of serotonin, (1A), (1C) and (2) receptor subtype mRNAs in rat brain
    • Wright DE, Seroogy KB, Lundgren KH, et al: Comparative localization of serotonin, (1A), (1C) and (2) receptor subtype mRNAs in rat brain. J Comp Neurol 1995; 351:357-373
    • (1995) J Comp Neurol , vol.351 , pp. 357-373
    • Wright, D.E.1    Seroogy, K.B.2    Lundgren, K.H.3
  • 28
    • 0027282204 scopus 로고
    • Molecular cloning and expression of a 5-hydroxytryptamine-7 serotonin receptor subtype
    • Shen Y, Monsma F Jr, Metcalf MA, et al: Molecular cloning and expression of a 5-hydroxytryptamine-7 serotonin receptor subtype. J Biol Chem 1993; 268:18200-18204
    • (1993) J Biol Chem , vol.268 , pp. 18200-18204
    • Shen, Y.1    Monsma Jr., F.2    Metcalf, M.A.3
  • 29
    • 0028261434 scopus 로고
    • Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors
    • Roth BL, Craigo SC, Choudhary MS, et al: Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther 1994; 268:1403-1410
    • (1994) J Pharmacol Exp Ther , vol.268 , pp. 1403-1410
    • Roth, B.L.1    Craigo, S.C.2    Choudhary, M.S.3
  • 30
    • 0027481384 scopus 로고
    • Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs
    • Monsma FJ Jr, Shen Y, Ward RP, et al: Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol 1993; 43:320-327
    • (1993) Mol Pharmacol , vol.43 , pp. 320-327
    • Monsma Jr., F.J.1    Shen, Y.2    Ward, R.P.3
  • 31
    • 0008025566 scopus 로고
    • Experimental psychiatry II: Clinical and physio-chemical observations in experimental psychosis
    • Rinkel M, Hyde R, Solomon H, et al: Experimental psychiatry II: Clinical and physio-chemical observations in experimental psychosis. Am J Psychiatry 1955; 111:881-895
    • (1955) Am J Psychiatry , vol.111 , pp. 881-895
    • Rinkel, M.1    Hyde, R.2    Solomon, H.3
  • 32
    • 0002180940 scopus 로고
    • Drug-induced psychoses and schizophrenic reactions: A critical comparison
    • Hollister LE: Drug-induced psychoses and schizophrenic reactions: A critical comparison. Ann NY Acad Sci 1962; 96:80-88
    • (1962) Ann NY Acad Sci , vol.96 , pp. 80-88
    • Hollister, L.E.1
  • 33
    • 0015899847 scopus 로고
    • Early subjective experiences in schizophrenic episodes
    • Freedman B, Chapman L: Early subjective experiences in schizophrenic episodes. J Abnorm Psychol 1973; 82:46-54
    • (1973) J Abnorm Psychol , vol.82 , pp. 46-54
    • Freedman, B.1    Chapman, L.2
  • 35
    • 0014316940 scopus 로고
    • Lysergic acid diethylamide (LSD-25) and schizophrenic reactions
    • Langs RJ, Barr HL: Lysergic acid diethylamide (LSD-25) and schizophrenic reactions. J Nerv Ment Dis 1968; 147:163-172
    • (1968) J Nerv Ment Dis , vol.147 , pp. 163-172
    • Langs, R.J.1    Barr, H.L.2
  • 36
    • 0020615595 scopus 로고
    • Dreams, hallucinogenic drug states and schizophrenia: A psychological and biological comparison
    • Fishman L: Dreams, hallucinogenic drug states and schizophrenia: A psychological and biological comparison. Schizophr Bull 1983; 9:73-94
    • (1983) Schizophr Bull , vol.9 , pp. 73-94
    • Fishman, L.1
  • 37
    • 21344493422 scopus 로고
    • Serotonin and the action of LSD in the brain
    • Aghajanian GK: Serotonin and the action of LSD in the brain. Psychiatric Annals 1994; 24:137-141
    • (1994) Psychiatric Annals , vol.24 , pp. 137-141
    • Aghajanian, G.K.1
  • 38
    • 0021646446 scopus 로고
    • 2 involvement in the mechanism of action of hallucinogenic agents
    • 2 involvement in the mechanism of action of hallucinogenic agents. Life Sci 1984; 35:2505-2511
    • (1984) Life Sci , vol.35 , pp. 2505-2511
    • Glennon, R.1    Titeler, M.2
  • 39
    • 0023882042 scopus 로고
    • 2 receptor as a site of action for LSD and phenylisopropylamine hallucinogens
    • 2 receptor as a site of action for LSD and phenylisopropylamine hallucinogens. Psychopharmacology 1988; 94:231-316
    • (1988) Psychopharmacology , vol.94 , pp. 231-316
    • Titeler, M.1    Lyon, R.A.2    Glennon, R.A.3
  • 41
    • 0023772609 scopus 로고
    • The role of serotonin in schizophrenia
    • Bleich A, Brown S-L, Kahn R, et al: The role of serotonin in schizophrenia. Schizophr Bull 1988; 14:297-315
    • (1988) Schizophr Bull , vol.14 , pp. 297-315
    • Bleich, A.1    Brown, S.-L.2    Kahn, R.3
  • 42
    • 0014013394 scopus 로고
    • 5-Hydroxyindole compounds in the cerebrospinal fluid of patients with psychiatric or neurological diseases
    • Ashcroft GW, Crawford TBB, Eccleston D, et al: 5-Hydroxyindole compounds in the cerebrospinal fluid of patients with psychiatric or neurological diseases. Lancet 1966; 2:1049-1052
    • (1966) Lancet , vol.2 , pp. 1049-1052
    • Ashcroft, G.W.1    Crawford, T.B.B.2    Eccleston, D.3
  • 44
    • 0019131248 scopus 로고
    • Noradrenergic overactivity in schizophrenia: Evidence based on cerebrospinal fluid noradrenaline and cyclic nucleotide concentrations
    • Gomes UCR, Shanley BC, Potgieter L, et al: Noradrenergic overactivity in schizophrenia: Evidence based on cerebrospinal fluid noradrenaline and cyclic nucleotide concentrations. Br J Psychiatry 1980; 137:346-351
    • (1980) Br J Psychiatry , vol.137 , pp. 346-351
    • Gomes, U.C.R.1    Shanley, B.C.2    Potgieter, L.3
  • 45
    • 0017708186 scopus 로고
    • Effect of chlorpromazine treatment on monoamine metabolite levels in cerebrospinal fluids on psychotic patients
    • Wode-Helgodt B, Fyro B, Gillberg B, et al: Effect of chlorpromazine treatment on monoamine metabolite levels in cerebrospinal fluids on psychotic patients. Acta Psychiatr Scand 1977; 56:280-293
    • (1977) Acta Psychiatr Scand , vol.56 , pp. 280-293
    • Wode-Helgodt, B.1    Fyro, B.2    Gillberg, B.3
  • 46
    • 0014457235 scopus 로고
    • Acid metabolites from monoamines in cerebrospinal fluid of chronic schizophrenics
    • Persson T, Roos BE: Acid metabolites from monoamines in cerebrospinal fluid of chronic schizophrenics. Br J Psychiatry 1969; 115:95-98
    • (1969) Br J Psychiatry , vol.115 , pp. 95-98
    • Persson, T.1    Roos, B.E.2
  • 47
    • 0015122418 scopus 로고
    • The content of 5-hydroxy-indolacetic acid and homovanillic acid in the cerebrospinal fluid of patients with acute schizophrenia
    • Rimon R, Roos BE, Räkköläinen V, et al: The content of 5-hydroxy-indolacetic acid and homovanillic acid in the cerebrospinal fluid of patients with acute schizophrenia. J Psychosom Res 1971; 15:375-378
    • (1971) J Psychosom Res , vol.15 , pp. 375-378
    • Rimon, R.1    Roos, B.E.2    Räkköläinen, V.3
  • 48
    • 0016676549 scopus 로고
    • Cerebrospinal fluid amine metabolites in acute schizophrenia
    • Post RM, Fink E, Carpenter WT, et al: Cerebrospinal fluid amine metabolites in acute schizophrenia. Arch Gen Psychiatry 1975; 32:1063-1069
    • (1975) Arch Gen Psychiatry , vol.32 , pp. 1063-1069
    • Post, R.M.1    Fink, E.2    Carpenter, W.T.3
  • 49
    • 0016138355 scopus 로고
    • Central dopamine turnover in schizophrenic syndromes
    • Bowers MB Jr: Central dopamine turnover in schizophrenic syndromes. Arch Gen Psychiatry 1974; 31:50-54
    • (1974) Arch Gen Psychiatry , vol.31 , pp. 50-54
    • Bowers Jr., M.B.1
  • 50
    • 0020573843 scopus 로고
    • Cerebroventricular size and monoamine metabolites in schizophrenic patients and healthy volunteers
    • Nybäck H, Berggren BM, Hindmarsh T, et al: Cerebroventricular size and monoamine metabolites in schizophrenic patients and healthy volunteers. Psychiatry Res 1983; 9:301-308
    • (1983) Psychiatry Res , vol.9 , pp. 301-308
    • Nybäck, H.1    Berggren, B.M.2    Hindmarsh, T.3
  • 51
    • 0020696725 scopus 로고
    • Low CSF 5-hydroxyindoleacetic acid in schizophrenic brains with enlarged ventricules
    • Potkin S, Weinberger DR, Linnoila M, et al: Low CSF 5-hydroxyindoleacetic acid in schizophrenic brains with enlarged ventricules. Am J Psychiatry 1983; 140:21-25
    • (1983) Am J Psychiatry , vol.140 , pp. 21-25
    • Potkin, S.1    Weinberger, D.R.2    Linnoila, M.3
  • 52
    • 0022476796 scopus 로고
    • Correlates of lateral ventricular size in chronic schizophrenia, II: Biological measures
    • Losonczy MF, Song IS, Mohs RC, et al: Correlates of lateral ventricular size in chronic schizophrenia, II: Biological measures. Am J Psychiatry 1986; 143:1113-1118
    • (1986) Am J Psychiatry , vol.143 , pp. 1113-1118
    • Losonczy, M.F.1    Song, I.S.2    Mohs, R.C.3
  • 53
    • 0022195563 scopus 로고
    • Brain ventricular size and CSF monoamine metabolite in an adolescent inpatient population
    • Jennings WS, Schultz SC, Narasimhachar N, et al: Brain ventricular size and CSF monoamine metabolite in an adolescent inpatient population. Psychiatry Res 1984; 16:87-94
    • (1984) Psychiatry Res , vol.16 , pp. 87-94
    • Jennings, W.S.1    Schultz, S.C.2    Narasimhachar, N.3
  • 54
    • 0022983428 scopus 로고
    • Suicide and aggression in schizophrenia: Neurobiologic correlates
    • Pickar D, Roy A, Brieer A, et al: Suicide and aggression in schizophrenia: Neurobiologic correlates. Ann NY Acad Sci 1986; 189-196
    • (1986) Ann NY Acad Sci , pp. 189-196
    • Pickar, D.1    Roy, A.2    Brieer, A.3
  • 55
    • 0023918477 scopus 로고
    • Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia, III: A new cohort and evidence for a monoaminergic mechanism
    • Weinberger DR, Berman KF, Illowsky BP: Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia, III: A new cohort and evidence for a monoaminergic mechanism. Arch Gen Psychiatry 1988; 45:609-615
    • (1988) Arch Gen Psychiatry , vol.45 , pp. 609-615
    • Weinberger, D.R.1    Berman, K.F.2    Illowsky, B.P.3
  • 56
    • 0024207207 scopus 로고
    • A critical appraisal of CSF monoamine metabolite studies in schizophrenia
    • Widerlöv E: A critical appraisal of CSF monoamine metabolite studies in schizophrenia. Ann NY Acad Sci 1988; 537:309-323
    • (1988) Ann NY Acad Sci , vol.537 , pp. 309-323
    • Widerlöv, E.1
  • 57
    • 0027169458 scopus 로고
    • Effect of neuroleptic medication on cerebrospinal fluid monoamine metabolite concentrations in schizophrenia: Serotonin-dopamine interactions as a target for treatment
    • Kahn RS, Davidson M, Knott P, et al: Effect of neuroleptic medication on cerebrospinal fluid monoamine metabolite concentrations in schizophrenia: Serotonin-dopamine interactions as a target for treatment. Arch Gen Psychiatry 1993; 50:599-605
    • (1993) Arch Gen Psychiatry , vol.50 , pp. 599-605
    • Kahn, R.S.1    Davidson, M.2    Knott, P.3
  • 58
    • 0018360019 scopus 로고
    • Monoamines and monoamine metabolites in brains from demented schizophrenics
    • Winblad B, Bucht G, Gottfries CG, et al: Monoamines and monoamine metabolites in brains from demented schizophrenics. Acta Psychiatr Scand 1979; 60:17-28
    • (1979) Acta Psychiatr Scand , vol.60 , pp. 17-28
    • Winblad, B.1    Bucht, G.2    Gottfries, C.G.3
  • 59
    • 0018422873 scopus 로고
    • Brain tryptophan metabolism in schizophrenia: A post mortem study of metabolites on the serotonin and kynurenine pathways in schizophrenic and control subjects
    • Joseph MH, Baker HF, Crow TJ, et al: Brain tryptophan metabolism in schizophrenia: A post mortem study of metabolites on the serotonin and kynurenine pathways in schizophrenic and control subjects. Psychopharmacology 1979; 62:279-285
    • (1979) Psychopharmacology , vol.62 , pp. 279-285
    • Joseph, M.H.1    Baker, H.F.2    Crow, T.J.3
  • 60
    • 0018425601 scopus 로고
    • Monoamine mechanisms in chronic schizophrenia: Post-mortem neurochemical findings
    • Crow TJ, Baker HF, Cross AJ, et al: Monoamine mechanisms in chronic schizophrenia: Post-mortem neurochemical findings. Br J Psychiatry 1979; 134:249-256
    • (1979) Br J Psychiatry , vol.134 , pp. 249-256
    • Crow, T.J.1    Baker, H.F.2    Cross, A.J.3
  • 61
    • 0018845915 scopus 로고
    • Brain monoamine changes in chronic paranoid schizophrenia and their possible relation to increased receptor sensitivity
    • edited by Pepeu G, Kuhar MJ, Enna SJ. New York, Raven
    • Farley IJ, Shannak KS, Hornykiewicz O: Brain monoamine changes in chronic paranoid schizophrenia and their possible relation to increased receptor sensitivity, in Receptors for Neurotransmitters and Peptides, edited by Pepeu G, Kuhar MJ, Enna SJ. New York, Raven, 1980, pp 427-133
    • (1980) Receptors for Neurotransmitters and Peptides , pp. 427-1133
    • Farley, I.J.1    Shannak, K.S.2    Hornykiewicz, O.3
  • 62
    • 0028569126 scopus 로고
    • Evidence for biochemical heterogeneity in schizophrenia: A multivariate study of monoaminergic indices in human post-mortal brain tissue
    • Hansson LO, Waters N, Winblad B, et al: Evidence for biochemical heterogeneity in schizophrenia: A multivariate study of monoaminergic indices in human post-mortal brain tissue. J Neural Transm General Section 1994; 98:217-235
    • (1994) J Neural Transm General Section , vol.98 , pp. 217-235
    • Hansson, L.O.1    Waters, N.2    Winblad, B.3
  • 63
    • 0027437017 scopus 로고
    • Selective abnormalities of prefrontal serotonergic receptors in schizophrenia: A postmortem study
    • Laruelle M, Abi-Dargham A, Casanova MF, et al: Selective abnormalities of prefrontal serotonergic receptors in schizophrenia: A postmortem study. Arch Gen Psychiatry 1993; 50:810-818
    • (1993) Arch Gen Psychiatry , vol.50 , pp. 810-818
    • Laruelle, M.1    Abi-Dargham, A.2    Casanova, M.F.3
  • 64
    • 0027279038 scopus 로고
    • Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics
    • Joyce JN, Shane A, Lexow N, et al: Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics. Neuropsychopharmacology 1993; 8:315-336
    • (1993) Neuropsychopharmacology , vol.8 , pp. 315-336
    • Joyce, J.N.1    Shane, A.2    Lexow, N.3
  • 65
    • 1842278243 scopus 로고    scopus 로고
    • Reference deleted
    • Reference deleted.
  • 66
    • 1842268496 scopus 로고    scopus 로고
    • Prefrontal serotonin receptor subtypes in schizophrenia and nonpsychotic suicides: An autoradiographic study
    • in press
    • Ohuoha D, Hyde T, Herman M, et al: Prefrontal serotonin receptor subtypes in schizophrenia and nonpsychotic suicides: An autoradiographic study. Arch Gen Psychiatry (in press)
    • Arch Gen Psychiatry
    • Ohuoha, D.1    Hyde, T.2    Herman, M.3
  • 67
    • 0028985065 scopus 로고
    • [H-3]paroxetine binding is altered in the hippocampus but not the frontal cortex or caudate nucleus from subjects with schizophrenia
    • Dean B, Opeskin K, Pavey G, et al: [H-3]paroxetine binding is altered in the hippocampus but not the frontal cortex or caudate nucleus from subjects with schizophrenia. J Neurochem 1995; 64:1197-1202
    • (1995) J Neurochem , vol.64 , pp. 1197-1202
    • Dean, B.1    Opeskin, K.2    Pavey, G.3
  • 69
    • 0018606699 scopus 로고
    • Neurotransmitter receptors in frontal cortex of schizophrenics
    • Bennett JP, Enna SJ, Bylund DB, et al: Neurotransmitter receptors in frontal cortex of schizophrenics. Arch Gen Psychiatry 1979; 36:927-934
    • (1979) Arch Gen Psychiatry , vol.36 , pp. 927-934
    • Bennett, J.P.1    Enna, S.J.2    Bylund, D.B.3
  • 70
    • 0019505753 scopus 로고
    • Tritiated LSD binding in frontal cortex in schizophrenia
    • Whitaker PM, Crow TJ, Ferrier IN: Tritiated LSD binding in frontal cortex in schizophrenia. Arch Gen Psychiatry 1981; 38:278-280
    • (1981) Arch Gen Psychiatry , vol.38 , pp. 278-280
    • Whitaker, P.M.1    Crow, T.J.2    Ferrier, I.N.3
  • 74
    • 0025921604 scopus 로고
    • 2) receptor binding in frontal cortex of schizophrenic patients
    • 2) receptor binding in frontal cortex of schizophrenic patients. J Neural Transm 1991; 85:19-29
    • (1991) J Neural Transm , vol.85 , pp. 19-29
    • Arora, R.C.1    Meltzer, H.Y.2
  • 75
    • 0020652913 scopus 로고
    • 2 receptors and their involvement in schizophrenia and neuroleptic drug action
    • 2 receptors and their involvement in schizophrenia and neuroleptic drug action. J Neural Transm 1983; 18(suppl):273-277
    • (1983) J Neural Transm , vol.18 , Issue.SUPPL. , pp. 273-277
    • Reynolds, G.P.1    Rossor, M.N.2    Ivesen, L.L.3
  • 79
    • 0018150731 scopus 로고
    • Serotonergic component of neuroleptic receptors
    • Leysen J, Niemegeers C, Tollenaere J, et al: Serotonergic component of neuroleptic receptors. Nature 1978; 272:168-171
    • (1978) Nature , vol.272 , pp. 168-171
    • Leysen, J.1    Niemegeers, C.2    Tollenaere, J.3
  • 80
    • 0020004528 scopus 로고
    • 3H-ligand for serotonin-2 receptor binding sites: Binding properties, brain distribution and functional role
    • 3H-ligand for serotonin-2 receptor binding sites: Binding properties, brain distribution and functional role. Mol Pharmacol 1982; 21:301-314
    • (1982) Mol Pharmacol , vol.21 , pp. 301-314
    • Leysen, J.E.1    Niemeggers, J.E.2    Van Nueten, J.M.3
  • 82
  • 83
    • 0024380268 scopus 로고
    • 2 binding sites in the frontal cortex of suicide victims
    • 2 binding sites in the frontal cortex of suicide victims. Am J Psychiatry 1989; 146:730-736
    • (1989) Am J Psychiatry , vol.146 , pp. 730-736
    • Arora, R.C.1    Meltzer, H.V.2
  • 86
    • 0020660428 scopus 로고
    • Increased serotonin-2 binding sites in frontal cortex of suicide victims
    • Stanley M, Mann JJ: Increased serotonin-2 binding sites in frontal cortex of suicide victims. Lancet 1983; 2:214-216
    • (1983) Lancet , vol.2 , pp. 214-216
    • Stanley, M.1    Mann, J.J.2
  • 88
    • 0022645648 scopus 로고
    • Serotonergic mechanisms in brain of suicide victims
    • Owen F, Chambers DR, Cooper SJ, et al: Serotonergic mechanisms in brain of suicide victims. Brain Res 1986; 362:185-188
    • (1986) Brain Res , vol.362 , pp. 185-188
    • Owen, F.1    Chambers, D.R.2    Cooper, S.J.3
  • 89
    • 0028178026 scopus 로고
    • 2 receptors in suicide victims: Violence of death, depression and effects of antidepressant treatment
    • 2 receptors in suicide victims: Violence of death, depression and effects of antidepressant treatment. Brain Res 1994; 642:281-289
    • (1994) Brain Res , vol.642 , pp. 281-289
    • Lowther, S.1    De Paermentire, F.2    Crompton, R.3
  • 90
    • 0025195770 scopus 로고
    • 3H]ketanserin binding in the human brain postmortem: Effect of suicide
    • 3H]ketanserin binding in the human brain postmortem: Effect of suicide. Brain Res 1990; 507:208-215
    • (1990) Brain Res , vol.507 , pp. 208-215
    • Gross-Isseroff, R.1    Salama, D.2    Israeli, M.3
  • 92
    • 0026098660 scopus 로고
    • 1A receptors in prefrontal and temporal cortices of brains from patients with chronic schizophrenia
    • 1A receptors in prefrontal and temporal cortices of brains from patients with chronic schizophrenia. Life Sci 1991; 48:355-363
    • (1991) Life Sci , vol.48 , pp. 355-363
    • Hashimoto, T.1    Nishino, N.2    Nakai, H.3
  • 93
    • 0027336404 scopus 로고
    • 3 receptors in schizophrenia: A postmortem study of the amygdala
    • 3 receptors in schizophrenia: A postmortem study of the amygdala. Brain Res 1993; 616:53-57
    • (1993) Brain Res , vol.616 , pp. 53-57
    • Abi-Dargham, A.1    Laruelle, M.2    Lipska, B.3
  • 94
    • 0023895447 scopus 로고
    • 1 recognition sites
    • 1 recognition sites. J Recept Res 1988; 8:59-81
    • (1988) J Recept Res , vol.8 , pp. 59-81
    • Hoyer, D.1
  • 95
    • 0024514089 scopus 로고
    • 1-(m-chlorophenyl)piperazine (mCPP) interactions with neurotransmitter receptors in the human brain
    • Hamik A, Peroutka SJ: 1-(m-chlorophenyl)piperazine (mCPP) interactions with neurotransmitter receptors in the human brain. Biol Psychiatry 1989; 25:569-575
    • (1989) Biol Psychiatry , vol.25 , pp. 569-575
    • Hamik, A.1    Peroutka, S.J.2
  • 96
    • 0026353340 scopus 로고
    • M-Chlorophenylpiperazine as a probe of serotonin function
    • Kahn RS, Wetzler S: M-Chlorophenylpiperazine as a probe of serotonin function. Biol Psychiatry 1991; 30:1139-1166
    • (1991) Biol Psychiatry , vol.30 , pp. 1139-1166
    • Kahn, R.S.1    Wetzler, S.2
  • 98
    • 0025845119 scopus 로고
    • The 5-HT transporter is an additional site of action for the 5-HT agonists RU 24969 and TFMPP
    • Wolf WA, Kuhn DM: The 5-HT transporter is an additional site of action for the 5-HT agonists RU 24969 and TFMPP. Neurochem Int 1993; 19:39-44
    • (1993) Neurochem int , vol.19 , pp. 39-44
    • Wolf, W.A.1    Kuhn, D.M.2
  • 99
    • 0026056522 scopus 로고
    • Effects of ritanserin on the behavioral, neuroendocrine and cardiovascular response to m-chlorophenylpiperazine in healthy human subjects
    • Seibyl JP, Krystal JH, Price LH, et al: Effects of ritanserin on the behavioral, neuroendocrine and cardiovascular response to m-chlorophenylpiperazine in healthy human subjects. Psychiatry Res 1991; 38:227-236
    • (1991) Psychiatry Res , vol.38 , pp. 227-236
    • Seibyl, J.P.1    Krystal, J.H.2    Price, L.H.3
  • 100
    • 0026048271 scopus 로고
    • The MCPP challenge test in schizophrenia: Hormonal and behavioral responses
    • Iqbal N, Asnis GM, Wetzler S, et al: The MCPP challenge test in schizophrenia: Hormonal and behavioral responses. Biol Psychiatry 1991; 30:770-778
    • (1991) Biol Psychiatry , vol.30 , pp. 770-778
    • Iqbal, N.1    Asnis, G.M.2    Wetzler, S.3
  • 101
    • 0027296447 scopus 로고
    • M-Chlorophenylpiperazine effects in neuroleptic-free schizophrenic patients
    • Krystal JH, Seibyl JP, Price LH, et al: M-Chlorophenylpiperazine effects in neuroleptic-free schizophrenic patients. Arch Gen Psychiatry 1993; 50:624-635
    • (1993) Arch Gen Psychiatry , vol.50 , pp. 624-635
    • Krystal, J.H.1    Seibyl, J.P.2    Price, L.H.3
  • 102
    • 0026799438 scopus 로고
    • Serotonin function in schizophrenia: Effects of metachlorophenylpiperazine in schizophrenic patients and healthy subjects
    • Kahn RS, Siever LJ, Gabriel S, et al: Serotonin function in schizophrenia: Effects of metachlorophenylpiperazine in schizophrenic patients and healthy subjects. Psychiatry Res 1992; 43:1-12
    • (1992) Psychiatry Res , vol.43 , pp. 1-12
    • Kahn, R.S.1    Siever, L.J.2    Gabriel, S.3
  • 103
    • 0027378214 scopus 로고
    • Clozapine attenuates metachlorophenylpiperazine (mCPP)-induced plasma cortisol increases in schizophrenia
    • Breier A, Kirkpatrick B, Buchanan RW: Clozapine attenuates metachlorophenylpiperazine (mCPP)-induced plasma cortisol increases in schizophrenia. Biol Psychiatry 1993; 34:492-494
    • (1993) Biol Psychiatry , vol.34 , pp. 492-494
    • Breier, A.1    Kirkpatrick, B.2    Buchanan, R.W.3
  • 104
    • 0027165890 scopus 로고
    • Effects of clozapine and fluphenazine treatment on response to m-chlorophenylpiperazine infusions in schizophrenia
    • Owen RR, Guttierrez-Esteinou R, Hsia J, et al: Effects of clozapine and fluphenazine treatment on response to m-chlorophenylpiperazine infusions in schizophrenia. Arch Gen Psychiatry 1993; 50:636-644
    • (1993) Arch Gen Psychiatry , vol.50 , pp. 636-644
    • Owen, R.R.1    Guttierrez-Esteinou, R.2    Hsia, J.3
  • 105
    • 0023103235 scopus 로고
    • Provocative tests with psychostimulant drugs in schizophrenia
    • Lieberman JA, Kane JM, Alvir J: Provocative tests with psychostimulant drugs in schizophrenia. Psychopharmacology 1987; 91:415-433
    • (1987) Psychopharmacology , vol.91 , pp. 415-433
    • Lieberman, J.A.1    Kane, J.M.2    Alvir, J.3
  • 106
    • 0019103386 scopus 로고
    • Precursor control of neurotransmitter synthesis
    • Wurtman RJ, Heft F, Melamed E: Precursor control of neurotransmitter synthesis. Pharmacol Rev 1981; 32:315-335
    • (1981) Pharmacol Rev , vol.32 , pp. 315-335
    • Wurtman, R.J.1    Heft, F.2    Melamed, E.3
  • 107
    • 0011789971 scopus 로고
    • Observations on schizophrenic patients after iproniazid and tryptophan
    • Lauer J, Inskip W, Bernshon J, et al: Observations on schizophrenic patients after iproniazid and tryptophan. Archives of Neurology and Psychiatry 1958; 80:122-130
    • (1958) Archives of Neurology and Psychiatry , vol.80 , pp. 122-130
    • Lauer, J.1    Inskip, W.2    Bernshon, J.3
  • 108
    • 33845956755 scopus 로고
    • Effects of amino acid feedings in schizophrenic patients treated with iproniazid
    • Pollin W, Cardon PV, Kety SS: Effects of amino acid feedings in schizophrenic patients treated with iproniazid. Science 1961; 133:104-105
    • (1961) Science , vol.133 , pp. 104-105
    • Pollin, W.1    Cardon, P.V.2    Kety, S.S.3
  • 109
    • 0014879393 scopus 로고
    • Cerebrospinal fluid 5-hydroxyindoles and behavior after L-tryptophan and pyridoxine administration to psychiatric patients
    • Bowers MB Jr: Cerebrospinal fluid 5-hydroxyindoles and behavior after L-tryptophan and pyridoxine administration to psychiatric patients. Neuropharmacology 1970; 9:599-604
    • (1970) Neuropharmacology , vol.9 , pp. 599-604
    • Bowers Jr., M.B.1
  • 110
    • 0017142402 scopus 로고
    • Clinical effects of tryptophan in chronic schizophrenic patients
    • Gillin J, Kaplan J, Wyatt R: Clinical effects of tryptophan in chronic schizophrenic patients. Biol Psychiatry 1976; 11:635-639
    • (1976) Biol Psychiatry , vol.11 , pp. 635-639
    • Gillin, J.1    Kaplan, J.2    Wyatt, R.3
  • 112
    • 0020600379 scopus 로고
    • Clinical response of agressive schizophrenics to oral tryptophan
    • Morand C, Young S, Ervin F: Clinical response of agressive schizophrenics to oral tryptophan. Biol Psychiatry 1983; 18:575-578
    • (1983) Biol Psychiatry , vol.18 , pp. 575-578
    • Morand, C.1    Young, S.2    Ervin, F.3
  • 113
    • 0015520159 scopus 로고
    • Behavioral changes of chronic schizophrenic patients given L-5-hydroxytryptophan
    • Wyatt RJ, Vaughan T, Galanter M, et al: Behavioral changes of chronic schizophrenic patients given L-5-hydroxytryptophan. Science 1972; 177:1124-1126
    • (1972) Science , vol.177 , pp. 1124-1126
    • Wyatt, R.J.1    Vaughan, T.2    Galanter, M.3
  • 114
    • 0018414014 scopus 로고
    • Clinical effects of L-5-hydroxytryptophan administration in chronic schizophrenic patients
    • Bigelow L, Walls P, Gillin J, et al: Clinical effects of L-5-hydroxytryptophan administration in chronic schizophrenic patients. Biol Psychiatry 1979; 14:53-67
    • (1979) Biol Psychiatry , vol.14 , pp. 53-67
    • Bigelow, L.1    Walls, P.2    Gillin, J.3
  • 115
    • 0023079104 scopus 로고
    • Hormonal probes of central serotonergic activity: Do they really exist?
    • van Praag HM, Lemus C, Kahn R: Hormonal probes of central serotonergic activity: Do they really exist? Biol Psychiatry 1987; 22:86-98
    • (1987) Biol Psychiatry , vol.22 , pp. 86-98
    • Van Praag, H.M.1    Lemus, C.2    Kahn, R.3
  • 117
    • 0020051262 scopus 로고
    • P-Chlorophenylalanine trials in schizophrenic patients
    • DeLisi L, Freed W, Gillin J, et al: P-Chlorophenylalanine trials in schizophrenic patients. Biol Psychiatry 1982; 11:471-477
    • (1982) Biol Psychiatry , vol.11 , pp. 471-477
    • DeLisi, L.1    Freed, W.2    Gillin, J.3
  • 118
  • 119
    • 0022204797 scopus 로고
    • Pilot study on the effects of fenfluramine on negative symptoms in twelve schizophrenic patients
    • Stahl SM, Uhr SB, Berger PA: Pilot study on the effects of fenfluramine on negative symptoms in twelve schizophrenic patients. Biol Psychiatry 1985; 20:1098-1102
    • (1985) Biol Psychiatry , vol.20 , pp. 1098-1102
    • Stahl, S.M.1    Uhr, S.B.2    Berger, P.A.3
  • 120
    • 0025297134 scopus 로고
    • Effects of fenfluramine on neuropsychological and communicative functioning in treatment-refractory schizophrenia patients
    • Soper HV, Elliott RO, Rejzer AA, et al: Effects of fenfluramine on neuropsychological and communicative functioning in treatment-refractory schizophrenia patients. J Clin Psychopharmacol 1990; 10:168-175
    • (1990) J Clin Psychopharmacol , vol.10 , pp. 168-175
    • Soper, H.V.1    Elliott, R.O.2    Rejzer, A.A.3
  • 121
    • 0016592484 scopus 로고
    • Antipsychotic drugs: Direct correlation between clinical potency and presynaptic action on dopamine neurons
    • Seeman P, Lee T: Antipsychotic drugs: Direct correlation between clinical potency and presynaptic action on dopamine neurons. Science 1975; 188:1217-1219
    • (1975) Science , vol.188 , pp. 1217-1219
    • Seeman, P.1    Lee, T.2
  • 122
    • 0017255979 scopus 로고
    • Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs
    • Creese I, Burt DR, Snyder SH: Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science 1976; 19:481-483
    • (1976) Science , vol.19 , pp. 481-483
    • Creese, I.1    Burt, D.R.2    Snyder, S.H.3
  • 123
    • 0019174607 scopus 로고
    • Relationship of neuroleptic drug effects at brain dopamine, serotonin, α-adrenergic and histamine receptors to clinical potency
    • Peroutka SJ, Snyder SS: Relationship of neuroleptic drug effects at brain dopamine, serotonin, α-adrenergic and histamine receptors to clinical potency. Am J Psychiatry 1980; 137:1518-1522
    • (1980) Am J Psychiatry , vol.137 , pp. 1518-1522
    • Peroutka, S.J.1    Snyder, S.S.2
  • 125
    • 0026011938 scopus 로고
    • Mechanisms of action of atypical antipsychotic drugs: Implication for novel therapeutic strategies for schizophrenia
    • Deutch A, Moghadam B, Innis R, et al: Mechanisms of action of atypical antipsychotic drugs: Implication for novel therapeutic strategies for schizophrenia. Schizophr Res 1991; 4:121-156
    • (1991) Schizophr Res , vol.4 , pp. 121-156
    • Deutch, A.1    Moghadam, B.2    Innis, R.3
  • 126
    • 0027524992 scopus 로고
    • Understanding the mechanism of action of atypical antipsychotic drugs
    • Lieberman JA: Understanding the mechanism of action of atypical antipsychotic drugs. Br J Psychiatry 1993; 163:7-18
    • (1993) Br J Psychiatry , vol.163 , pp. 7-18
    • Lieberman, J.A.1
  • 129
    • 0026775521 scopus 로고
    • Regionally specific effects of atypical antipsychotic drugs on striatal fos expression: The nucleus accumbens shell as a locus of antipsychotic action
    • Deutch AY, Lee MC, ladarola MJ: Regionally specific effects of atypical antipsychotic drugs on striatal fos expression: The nucleus accumbens shell as a locus of antipsychotic action. Mol Cell Neurosci 1992; 3:332-341
    • (1992) Mol Cell Neurosci , vol.3 , pp. 332-341
    • Deutch, A.Y.1    Lee, M.C.2    Ladarola, M.J.3
  • 131
    • 0026427253 scopus 로고
    • 4 receptor with high affinity for the antipsychotic clozapine
    • 4 receptor with high affinity for the antipsychotic clozapine. Nature 1991; 350:610-614
    • (1991) Nature , vol.350 , pp. 610-614
    • Van Tol, H.H.M.1    Bunzow, J.R.2    Guan, H.-C.3
  • 133
    • 0024468417 scopus 로고
    • Clinical studies on the mechanism of action of clozapine: The dopamine-serotonin hypothesis of schizophrenia
    • Meltzer H: Clinical studies on the mechanism of action of clozapine: The dopamine-serotonin hypothesis of schizophrenia. Psychopharmacology 1989; 99(suppl):S18-S27
    • (1989) Psychopharmacology , vol.99 , Issue.SUPPL.
    • Meltzer, H.1
  • 134
    • 0024466603 scopus 로고
    • Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2, and serotonin2 pki values
    • Meltzer H, Matsubara S, Lee J: Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2, and serotonin2 pki values. J Pharmacol Exp Ther 1989; 251:238-246
    • (1989) J Pharmacol Exp Ther , vol.251 , pp. 238-246
    • Meltzer, H.1    Matsubara, S.2    Lee, J.3
  • 135
    • 0024385168 scopus 로고
    • Risperidone in the treatment of chronic schizophrenia with tardive dyskinesia
    • Meco G, Bedini L, Bonifati V, et al: Risperidone in the treatment of chronic schizophrenia with tardive dyskinesia. Current Therapy Research 1989; 46:876-884
    • (1989) Current Therapy Research , vol.46 , pp. 876-884
    • Meco, G.1    Bedini, L.2    Bonifati, V.3
  • 136
    • 0024462028 scopus 로고
    • Therapeutic effect and safety of increasing doses of risperidone (R 64766) in psychotic patients
    • Mesotten F, Suy E, Pietquin M, et al: Therapeutic effect and safety of increasing doses of risperidone (R 64766) in psychotic patients. Psychopharmacology 1989; 99:445-449
    • (1989) Psychopharmacology , vol.99 , pp. 445-449
    • Mesotten, F.1    Suy, E.2    Pietquin, M.3
  • 137
    • 0026550602 scopus 로고
    • Risperidone versus haloperidol in the treatment of chronic schizophrenic inpatients: A multicentre double-blind comparative study
    • Claus A, Bollen J, DeCuyper H, et al: Risperidone versus haloperidol in the treatment of chronic schizophrenic inpatients: A multicentre double-blind comparative study. Acta Psychiatr Scand 1992; 85:295-305
    • (1992) Acta Psychiatr Scand , vol.85 , pp. 295-305
    • Claus, A.1    Bollen, J.2    DeCuyper, H.3
  • 138
    • 0027146306 scopus 로고
    • Risperidone versus perphenazine in the treatment of chronic schizophrenic patients with acute exacerbations
    • Hoyberg OJ, Fensbo C, Remvig J, et al: Risperidone versus perphenazine in the treatment of chronic schizophrenic patients with acute exacerbations. Acta Psychiatr Scand 1993; 88:395-402
    • (1993) Acta Psychiatr Scand , vol.88 , pp. 395-402
    • Hoyberg, O.J.1    Fensbo, C.2    Remvig, J.3
  • 139
    • 0024366801 scopus 로고
    • Thymosthenic agents, a novel approach in the treatment of schizophrenia
    • Gelders YG: Thymosthenic agents, a novel approach in the treatment of schizophrenia. Br J Psychiatry 1989; 155:33-36
    • (1989) Br J Psychiatry , vol.155 , pp. 33-36
    • Gelders, Y.G.1
  • 140
    • 0025572228 scopus 로고
    • 2 antagonist ritanserin in neuroleptic induced parkinsonism: A double blind comparison with orphenadrine and placebo
    • 2 antagonist ritanserin in neuroleptic induced parkinsonism: A double blind comparison with orphenadrine and placebo. Clin Neuropharmacol 1990; 13:500-506
    • (1990) Clin Neuropharmacol , vol.13 , pp. 500-506
    • Bersani, G.1    Grispini, A.2    Marini, S.3
  • 143
    • 0028358082 scopus 로고
    • An open clinical and biochemical study of ritanserin in acute patients with schizophrenia
    • Wiesel F-A, Nordstrom A-L, Farde L, et al: An open clinical and biochemical study of ritanserin in acute patients with schizophrenia. Psychopharmacology 1994; 114:31-38
    • (1994) Psychopharmacology , vol.114 , pp. 31-38
    • Wiesel, F.-A.1    Nordstrom, A.-L.2    Farde, L.3
  • 144
    • 0027340586 scopus 로고
    • 2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: Behavioral, electrophysiological and neurochemical studies
    • 2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: Behavioral, electrophysiological and neurochemical studies, J Pharmacol Exp Ther 1993; 266:684-691
    • (1993) J Pharmacol Exp Ther , vol.266 , pp. 684-691
    • Sorensen, S.M.1    Kehne, J.H.2    Fadayel, G.M.3
  • 145
    • 0013893886 scopus 로고
    • The significance of dopamine receptor blockade for the mechanism of action of neuroleptic drugs
    • Rossum V: The significance of dopamine receptor blockade for the mechanism of action of neuroleptic drugs. Arch Int Pharmacodyn Ther 1966; 160:492-494
    • (1966) Arch int Pharmacodyn Ther , vol.160 , pp. 492-494
    • Rossum, V.1
  • 146
    • 78651116398 scopus 로고
    • Effect of chlorpromazine or haloperidol on formation of 3-methoxytyramine and normetanephrine in mouse brain
    • Carlsson A, Lindqvist M: Effect of chlorpromazine or haloperidol on formation of 3-methoxytyramine and normetanephrine in mouse brain. Acta Pharmacol Toxicol 1963; 20:140-144
    • (1963) Acta Pharmacol Toxicol , vol.20 , pp. 140-144
    • Carlsson, A.1    Lindqvist, M.2
  • 147
    • 0015536067 scopus 로고
    • Amphetamine psychosis: A "model" schizophrenia mediated by catecholamines
    • Snyder SH: Amphetamine psychosis: A "model" schizophrenia mediated by catecholamines. Am J Psychiatry 1973; 130:61-67
    • (1973) Am J Psychiatry , vol.130 , pp. 61-67
    • Snyder, S.H.1
  • 148
    • 0021169482 scopus 로고
    • CNS stimulants as a tool in the study of schizophrenia
    • Angrist B, van Kammen DP: CNS stimulants as a tool in the study of schizophrenia. Trends Neurosci 1984; 7:388-390
    • (1984) Trends Neurosci , vol.7 , pp. 388-390
    • Angrist, B.1    Van Kammen, D.P.2
  • 149
    • 0011016085 scopus 로고
    • Dopamine deficiency and dopamine substitution in Parkinson's disease
    • edited by Winlow W, Markstein R. Manchester, UK, Manchester University Press
    • Hornykiewicz O: Dopamine deficiency and dopamine substitution in Parkinson's disease, in The Neurobiology of Dopamine Systems, edited by Winlow W, Markstein R. Manchester, UK, Manchester University Press; 1986; 312-328
    • (1986) The Neurobiology of Dopamine Systems , pp. 312-328
    • Hornykiewicz, O.1
  • 150
    • 0015747180 scopus 로고
    • An anatomy of schizophrenia?
    • Stevens J: An anatomy of schizophrenia? Arch Gen Psychiatry 1973; 29:177-189
    • (1973) Arch Gen Psychiatry , vol.29 , pp. 177-189
    • Stevens, J.1
  • 151
    • 0023215296 scopus 로고
    • Implications of the normal brain development for the pathogenesis of schizophrenia
    • Weinberger DR: Implications of the normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 1987; 44:660-669
    • (1987) Arch Gen Psychiatry , vol.44 , pp. 660-669
    • Weinberger, D.R.1
  • 152
    • 0026070134 scopus 로고
    • Dopamine in schizophrenia: A review and reconceptualization
    • Davis KL, Kahn RS, Ko G, et al: Dopamine in schizophrenia: A review and reconceptualization. Am J Psychiatry 1991; 148:1474-1486
    • (1991) Am J Psychiatry , vol.148 , pp. 1474-1486
    • Davis, K.L.1    Kahn, R.S.2    Ko, G.3
  • 153
    • 0026059697 scopus 로고
    • Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia
    • Grace AA: Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia. Neuroscience 1991; 41:1-24
    • (1991) Neuroscience , vol.41 , pp. 1-24
    • Grace, A.A.1
  • 154
    • 0014355676 scopus 로고
    • Studies on behavioural and biochemical changes in rats after lesion of midbrain raphe
    • Kostowski W, Giacalone E, Garattini S, et al: Studies on behavioural and biochemical changes in rats after lesion of midbrain raphe. Eur J Pharmacol 1968; 4:371-376
    • (1968) Eur J Pharmacol , vol.4 , pp. 371-376
    • Kostowski, W.1    Giacalone, E.2    Garattini, S.3
  • 155
    • 0014989170 scopus 로고
    • The effect of para-chlorophenylalanine on spontaneous locomotor activity in the rat
    • Fibiger HC, Campbell BA: The effect of para-chlorophenylalanine on spontaneous locomotor activity in the rat. Neuropharmacology 1971; 10:25-32
    • (1971) Neuropharmacology , vol.10 , pp. 25-32
    • Fibiger, H.C.1    Campbell, B.A.2
  • 156
    • 0016259783 scopus 로고
    • Differential behavioral and neuro- Chemical effects following lesions of the dorsal or median raphe nuclei in rats
    • Jacobs BL, Wise WD, Taylor KM: Differential behavioral and neuro- chemical effects following lesions of the dorsal or median raphe nuclei in rats. Brain Res 1974; 79:353-361
    • (1974) Brain Res , vol.79 , pp. 353-361
    • Jacobs, B.L.1    Wise, W.D.2    Taylor, K.M.3
  • 157
    • 0016797889 scopus 로고
    • Hippocampal mediation of raphe lesion- And PCPA-induced hyperactivity in the rat
    • Jacobs BL, Trimbach C, Eubanks EE, et al: Hippocampal mediation of raphe lesion- and PCPA-induced hyperactivity in the rat. Brain Res 1975; 94:253-263
    • (1975) Brain Res , vol.94 , pp. 253-263
    • Jacobs, B.L.1    Trimbach, C.2    Eubanks, E.E.3
  • 158
    • 0017253117 scopus 로고
    • Behavioral studies following lesions of the mesolimbic and mesostriatal serotonergic pathways
    • Geyer M, Puerto A, Menkes D, et al: Behavioral studies following lesions of the mesolimbic and mesostriatal serotonergic pathways. Brain Res 1976; 106:257-270
    • (1976) Brain Res , vol.106 , pp. 257-270
    • Geyer, M.1    Puerto, A.2    Menkes, D.3
  • 159
    • 0015939450 scopus 로고
    • Serotonergic inhibition of catecholamine-induced behavioral arousal
    • Mabry P, Campbell B: Serotonergic inhibition of catecholamine-induced behavioral arousal. Brain Res 1973; 49:381-391
    • (1973) Brain Res , vol.49 , pp. 381-391
    • Mabry, P.1    Campbell, B.2
  • 160
    • 0016826092 scopus 로고
    • Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum
    • Kelly PH, Seviour PW, Iversen SD: Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum. Brain Res 1975; 94:507-522
    • (1975) Brain Res , vol.94 , pp. 507-522
    • Kelly, P.H.1    Seviour, P.W.2    Iversen, S.D.3
  • 161
    • 0015412359 scopus 로고
    • Selective potentiation of locomotor effects on amphetamine by midbrain raphe lesion
    • Neill D, Grant LD, Grossman SP: Selective potentiation of locomotor effects on amphetamine by midbrain raphe lesion. Physiol Behav 1972; 9:655-657
    • (1972) Physiol Behav , vol.9 , pp. 655-657
    • Neill, D.1    Grant, L.D.2    Grossman, S.P.3
  • 162
    • 0018353949 scopus 로고
    • Increased sensitivity to d- And l-amphetamine action after midbrain raphe lesions as measured by locomotor activity
    • Lucki I, Harvey JA: Increased sensitivity to d- and l-amphetamine action after midbrain raphe lesions as measured by locomotor activity. Neuropharmacology 1979; 18:243-249
    • (1979) Neuropharmacology , vol.18 , pp. 243-249
    • Lucki, I.1    Harvey, J.A.2
  • 163
    • 0016140698 scopus 로고
    • Stereotyped and circling behaviour induced by dopaminergic agonists after lesions of the midbrain raphe nuclei
    • Costall B, Naylor RJ: Stereotyped and circling behaviour induced by dopaminergic agonists after lesions of the midbrain raphe nuclei. Eur J Pharmacol 1974; 29:206-222
    • (1974) Eur J Pharmacol , vol.29 , pp. 206-222
    • Costall, B.1    Naylor, R.J.2
  • 164
    • 0016086405 scopus 로고
    • Enhancement of amphetamine action after interruption of ascending serotonergic pathways
    • Green TK, Harvey JA: Enhancement of amphetamine action after interruption of ascending serotonergic pathways. J Pharmacol Exp Ther 1974; 190:109-117
    • (1974) J Pharmacol Exp Ther , vol.190 , pp. 109-117
    • Green, T.K.1    Harvey, J.A.2
  • 165
    • 0017096948 scopus 로고
    • Differential effects of para-chlorophenylalanine on amphetamine-induced locomotion and stereotypy
    • Segal D: Differential effects of para-chlorophenylalanine on amphetamine-induced locomotion and stereotypy. Brain Res 1976; 116:267-276
    • (1976) Brain Res , vol.116 , pp. 267-276
    • Segal, D.1
  • 166
    • 0016275109 scopus 로고
    • Evidence for involvement of 5-hydroxytryptamine in the actions of amphetamine
    • Breese GR, Cooper BR, Mueller RA: Evidence for involvement of 5-hydroxytryptamine in the actions of amphetamine. Br J Pharmacol 1974; 52:307-314
    • (1974) Br J Pharmacol , vol.52 , pp. 307-314
    • Breese, G.R.1    Cooper, B.R.2    Mueller, R.A.3
  • 167
    • 0017118012 scopus 로고
    • An inhibitory role for brain serotonin-containing systems in the locomotor effects of d-amphetamine
    • Hollister A, Breese G, Moreton Kuhn C, et al: An inhibitory role for brain serotonin-containing systems in the locomotor effects of d-amphetamine. J Pharmacol Exp Ther 1976; 198:12-22
    • (1976) J Pharmacol Exp Ther , vol.198 , pp. 12-22
    • Hollister, A.1    Breese, G.2    Moreton Kuhn, C.3
  • 168
    • 0016615220 scopus 로고
    • Is there a catecholamine-serotonin interaction in the control of locomotor activity?
    • Jacobs BL, Wise WD: Is there a catecholamine-serotonin interaction in the control of locomotor activity? Neuropharmacology 1975; 14:501-506
    • (1975) Neuropharmacology , vol.14 , pp. 501-506
    • Jacobs, B.L.1    Wise, W.D.2
  • 169
    • 0016224947 scopus 로고
    • Comparison of the locomotor stimulant mechanisms of action of d-amphetamine and d-amphetamine plus l-dopa: Possible involvement of serotonin
    • Neuburg J, Thut PD: Comparison of the locomotor stimulant mechanisms of action of d-amphetamine and d-amphetamine plus l-dopa: Possible involvement of serotonin. Biol Psychiatry 1974; 8:139-150
    • (1974) Biol Psychiatry , vol.8 , pp. 139-150
    • Neuburg, J.1    Thut, P.D.2
  • 171
    • 0016593096 scopus 로고
    • Differential effects of serotonin on turning and stereotypy induced by apomorphine
    • Baldessarini R, Amatruda T, Griffith F, et al: Differential effects of serotonin on turning and stereotypy induced by apomorphine. Brain Res 1975; 93:158-163
    • (1975) Brain Res , vol.93 , pp. 158-163
    • Baldessarini, R.1    Amatruda, T.2    Griffith, F.3
  • 172
    • 0017196483 scopus 로고
    • Serotoninergic modulation of the dopamine response from the nucleus accumbens
    • Costall B, Naylor R, Marsden C, et al: Serotoninergic modulation of the dopamine response from the nucleus accumbens. J Pharm Pharmacol 1976; 28:523-526
    • (1976) J Pharm Pharmacol , vol.28 , pp. 523-526
    • Costall, B.1    Naylor, R.2    Marsden, C.3
  • 173
    • 0019832987 scopus 로고
    • LSD, mescaline and serotonin injected into medial raphe nucleus potentiate apomorphine hypermotility
    • Fink H, Oelssner W: LSD, mescaline and serotonin injected into medial raphe nucleus potentiate apomorphine hypermotility. Eur J Pharmacol 1981; 75:289-296
    • (1981) Eur J Pharmacol , vol.75 , pp. 289-296
    • Fink, H.1    Oelssner, W.2
  • 174
    • 0014517741 scopus 로고
    • The effect of 5-hydroxytryptamine and 5-hydroxytryptophan on extra-pyramidal function
    • Hadzovic S, Ernst AM: The effect of 5-hydroxytryptamine and 5-hydroxytryptophan on extra-pyramidal function. Eur J Pharmacol 1969; 6:90-95
    • (1969) Eur J Pharmacol , vol.6 , pp. 90-95
    • Hadzovic, S.1    Ernst, A.M.2
  • 175
    • 0014541754 scopus 로고
    • Direct chemical stimulation of dopaminergic mechanisms in the neostriatum of the rat
    • Ungerstedt U, Butcher LL, Butcher SG, et al: Direct chemical stimulation of dopaminergic mechanisms in the neostriatum of the rat Brain Res 1969; 14:461-471
    • (1969) Brain Res , vol.14 , pp. 461-471
    • Ungerstedt, U.1    Butcher, L.L.2    Butcher, S.G.3
  • 176
    • 0015415822 scopus 로고
    • Relationship of the central effect of dopamine on gnawing compulsion syndrome in rats and the release of serotonin
    • Ernst AM: Relationship of the central effect of dopamine on gnawing compulsion syndrome in rats and the release of serotonin. Archives Internationales de Pharmacodynamie 1972; 199:219-225
    • (1972) Archives Internationales de Pharmacodynamie , vol.199 , pp. 219-225
    • Ernst, A.M.1
  • 177
    • 0015407566 scopus 로고
    • Absence of serotonergic influence on apomorphine-induced stereotypy
    • Rotrosen J, Angrist BM, Wallach MB, et al: Absence of serotonergic influence on apomorphine-induced stereotypy. Eur J Pharmacol 1972; 20:133-135
    • (1972) Eur J Pharmacol , vol.20 , pp. 133-135
    • Rotrosen, J.1    Angrist, B.M.2    Wallach, M.B.3
  • 178
    • 0018903301 scopus 로고
    • Turning behavior in animals
    • Pycock CJ: Turning behavior in animals. Neuroscience 1980; 5:461-514
    • (1980) Neuroscience , vol.5 , pp. 461-514
    • Pycock, C.J.1
  • 179
    • 0017236493 scopus 로고
    • Circling behavior produced by asymmetric medial raphe lesions in rats
    • Costall B, Naylor RJ, Marsden CD, et al: Circling behavior produced by asymmetric medial raphe lesions in rats. J Pharm Pharmacol 1976; 28:248-249
    • (1976) J Pharm Pharmacol , vol.28 , pp. 248-249
    • Costall, B.1    Naylor, R.J.2    Marsden, C.D.3
  • 180
    • 0018248907 scopus 로고
    • Biochemical and behavioral effects of serotonin neurotoxins on the nigro-striatal dopamine system: Comparison of injection sites
    • Giambalvo CT, Snodgrass ST: Biochemical and behavioral effects of serotonin neurotoxins on the nigro-striatal dopamine system: Comparison of injection sites. Brain Res 1978; 152:555-566
    • (1978) Brain Res , vol.152 , pp. 555-566
    • Giambalvo, C.T.1    Snodgrass, S.T.2
  • 181
    • 0019152171 scopus 로고
    • Rotational behaviour elicited by 5-HT in the rat: Evidence for an inhibitory role of 5-HT in the substantia nigra and corpus striatum
    • James TA, Starr MS: Rotational behaviour elicited by 5-HT in the rat: Evidence for an inhibitory role of 5-HT in the substantia nigra and corpus striatum. J Pharm Pharmacol 1980; 32:196-200
    • (1980) J Pharm Pharmacol , vol.32 , pp. 196-200
    • James, T.A.1    Starr, M.S.2
  • 182
    • 0018792029 scopus 로고
    • Interactions between serotonergic and dopaminergic systems in rat brain demonstrated by small unilateral lesions of the raphe nuclei
    • Nicolaou N, Garcia-Munoz M, Arbuthnott G, et al: Interactions between serotonergic and dopaminergic systems in rat brain demonstrated by small unilateral lesions of the raphe nuclei. Eur J Pharmacol 1979; 57:295-305
    • (1979) Eur J Pharmacol , vol.57 , pp. 295-305
    • Nicolaou, N.1    Garcia-Munoz, M.2    Arbuthnott, G.3
  • 183
    • 0018147558 scopus 로고
    • Circling behaviour in the rat following unilateral injections of p-chlorophenylalanine and ethanolamine-O-sulphate into the substantia nigra
    • Tanner T: Circling behaviour in the rat following unilateral injections of p-chlorophenylalanine and ethanolamine-O-sulphate into the substantia nigra. J Pharm Pharmacol 1978; 30:158-161
    • (1978) J Pharm Pharmacol , vol.30 , pp. 158-161
    • Tanner, T.1
  • 184
    • 0019498753 scopus 로고
    • Supersensitvity of nigral serotonin receptor and rat rotational behavior
    • Blackburn TP, Cox B, Heapy CG, et al: Supersensitvity of nigral serotonin receptor and rat rotational behavior. Eur J Pharmacol 1981; 71:343-346
    • (1981) Eur J Pharmacol , vol.71 , pp. 343-346
    • Blackburn, T.P.1    Cox, B.2    Heapy, C.G.3
  • 185
    • 0018732072 scopus 로고
    • Differential rotational behavior after unilateral 5-7-dihydroxytryptamine-induced lesion of the dorsal raphe nucleus
    • Blackburn TP, Foster GA, Heapy CG, et al: Differential rotational behavior after unilateral 5-7-dihydroxytryptamine-induced lesion of the dorsal raphe nucleus. Br J Pharmacol 1979; 67:431-432
    • (1979) Br J Pharmacol , vol.67 , pp. 431-432
    • Blackburn, T.P.1    Foster, G.A.2    Heapy, C.G.3
  • 186
    • 0016797889 scopus 로고
    • Hippocampal mediation of raphe lesion and PCPA induced hyperactivity in the rat
    • Jacobs BL, Trimbach C, Eubanks E, et al: Hippocampal mediation of raphe lesion and PCPA induced hyperactivity in the rat. Brain Res 1975; 94:253-261
    • (1975) Brain Res , vol.94 , pp. 253-261
    • Jacobs, B.L.1    Trimbach, C.2    Eubanks, E.3
  • 187
    • 0018579773 scopus 로고
    • Rotational responses to serotonergic and dopaminergic agonists after unilateral dihydroxytryptamine lesions of the medial forebrain bundle: Co-operative interaction of serotonin and dopamine in the neostriatum
    • Waddington JL, Crow TJ: Rotational responses to serotonergic and dopaminergic agonists after unilateral dihydroxytryptamine lesions of the medial forebrain bundle: Co-operative interaction of serotonin and dopamine in the neostriatum. Life Sci 1979; 25:1307-1314
    • (1979) Life Sci , vol.25 , pp. 1307-1314
    • Waddington, J.L.1    Crow, T.J.2
  • 188
    • 0023279206 scopus 로고
    • Modulation of striatal dopamine metabolism by the activity of dorsal raphe serotonergic afferences
    • De Simoni MG, Dal Toso G, Sokola A, et al: Modulation of striatal dopamine metabolism by the activity of dorsal raphe serotonergic afferences. Brain Res 1987; 411:81-88
    • (1987) Brain Res , vol.411 , pp. 81-88
    • De Simoni, M.G.1    Dal Toso, G.2    Sokola, A.3
  • 189
    • 0015458470 scopus 로고
    • On stereotypy and catalepsy. Studies on the effect of amphetamine and neuroleptic in rats
    • Fog R: On stereotypy and catalepsy. Studies on the effect of amphetamine and neuroleptic in rats. Acta Neurol Scand 1972; 48(suppl 50):3-66
    • (1972) Acta Neurol Scand , vol.48 , Issue.SUPPL. 50 , pp. 3-66
    • Fog, R.1
  • 190
    • 0015522358 scopus 로고
    • Reduced cataleptogenic effects of some neuroleptics in rats with lesioned midbrain raphe and treated with p-chlorophenylalanine
    • Kostowski W, Gumulka W, Czlonkowski A: Reduced cataleptogenic effects of some neuroleptics in rats with lesioned midbrain raphe and treated with p-chlorophenylalanine. Brain Res 1972; 48:443-446
    • (1972) Brain Res , vol.48 , pp. 443-446
    • Kostowski, W.1    Gumulka, W.2    Czlonkowski, A.3
  • 191
    • 0016703549 scopus 로고
    • Serotonergic involvement with neuroleptic catalepsy
    • Costall B, Fortune DH, Naylor RJ, et al: Serotonergic involvement with neuroleptic catalepsy. Neuropharmacology 1975; 14:859-868
    • (1975) Neuropharmacology , vol.14 , pp. 859-868
    • Costall, B.1    Fortune, D.H.2    Naylor, R.J.3
  • 192
    • 0017389926 scopus 로고
    • Possible importance of 5-hydroxytryptamine in neuroleptic-induced catalepsy in rats
    • Carter CJ, Pycock CJ: Possible importance of 5-hydroxytryptamine in neuroleptic-induced catalepsy in rats. Br J Pharmacol 1977; 60:267P
    • (1977) Br J Pharmacol , vol.60
    • Carter, C.J.1    Pycock, C.J.2
  • 193
    • 0018398866 scopus 로고
    • Serotonin-dopamine interactions in the nigrostriatal system
    • Waldmeier P, Delini-Srula A: Serotonin-dopamine interactions in the nigrostriatal system. Eur J Pharmacol 1979; 55:363-373
    • (1979) Eur J Pharmacol , vol.55 , pp. 363-373
    • Waldmeier, P.1    Delini-Srula, A.2
  • 194
    • 0018131973 scopus 로고
    • A study of the site of interaction between dopamine and 5-hydroxytryptamine for the production of fluphenazine-induced catalepsy
    • Carter C, Pycock C: A study of the site of interaction between dopamine and 5-hydroxytryptamine for the production of fluphenazine-induced catalepsy. Naunyn Schmiedebergs Arch Pharmacol 1978; 304:135-139
    • (1978) Naunyn Schmiedebergs Arch Pharmacol , vol.304 , pp. 135-139
    • Carter, C.1    Pycock, C.2
  • 195
    • 0025242104 scopus 로고
    • The effect of serotonergic agents on haloperidol-induced catalepsy
    • Hicks PB: The effect of serotonergic agents on haloperidol-induced catalepsy. Life Sci 1990; 47:1609-1615
    • (1990) Life Sci , vol.47 , pp. 1609-1615
    • Hicks, P.B.1
  • 196
    • 0021037292 scopus 로고
    • The involvement of 5-hydroxytryptamine in the release of dendritic dopamine from slices of substantia nigra
    • Williams J, Davies JA: The involvement of 5-hydroxytryptamine in the release of dendritic dopamine from slices of substantia nigra. J Pharm Pharmacol 1983; 35:734-373
    • (1983) J Pharm Pharmacol , vol.35 , pp. 734-1373
    • Williams, J.1    Davies, J.A.2
  • 197
    • 0023935720 scopus 로고
    • Facilitation of a dendritic calcium conductance by 5-hydroxytryptamine in the substantia nigra
    • Nedergaard S, Bolam JP, Greenfield SA: Facilitation of a dendritic
    • (1988) Nature , vol.333 , pp. 174-176
    • Nedergaard, S.1    Bolam, J.P.2    Greenfield, S.A.3
  • 198
    • 0024478415 scopus 로고
    • 2 receptor antagonist, activates midbrain dopamine neurons by blocking serotonergic inhibition
    • 2 receptor antagonist, activates midbrain dopamine neurons by blocking serotonergic inhibition. Psychopharmacology 1989; 98:45-50
    • (1989) Psychopharmacology , vol.98 , pp. 45-50
    • Ugedo, L.1    Genhoff, J.2    Svensson, T.H.3
  • 199
    • 0025924508 scopus 로고
    • 2, antagonist, ritanserin, on biogenic amines in the rat nucleus accumbens
    • 2, antagonist, ritanserin, on biogenic amines in the rat nucleus accumbens. Eur J Pharmacol 1991; 192:427-429
    • (1991) Eur J Pharmacol , vol.192 , pp. 427-429
    • Devaud, L.L.1    Hollingsworth, E.B.2
  • 200
    • 0024318577 scopus 로고
    • 2 antagonist, in electrophysiological tests predictive of antipsychotic activity
    • 2 antagonist, in electrophysiological tests predictive of antipsychotic activity. J Pharmacol Exp Ther 1989; 249:673-680
    • (1989) J Pharmacol Exp Ther , vol.249 , pp. 673-680
    • Goldstein, J.M.1    Litwin, L.C.2    Sutton, E.B.3
  • 201
    • 0028978933 scopus 로고
    • 2A receptor antagonist, MDL 100,907, increases dopamine efflux in the prefrontal cortex of the rat
    • 2A receptor antagonist, MDL 100,907, increases dopamine efflux in the prefrontal cortex of the rat. Eur J Pharmacol 1995; 273:273-279
    • (1995) Eur J Pharmacol , vol.273 , pp. 273-279
    • Schmidt, C.J.1    Fadayel, G.M.2
  • 202
    • 0027183471 scopus 로고
    • The atypical antipsychotic drug amperozide enhances rat cortical and striatal dopamine efflux
    • Pehek EA, Meltzer HY, Yamamoto BK: The atypical antipsychotic drug amperozide enhances rat cortical and striatal dopamine efflux. Eur J Pharmacol 1983; 240:107-110
    • (1983) Eur J Pharmacol , vol.240 , pp. 107-110
    • Pehek, E.A.1    Meltzer, H.Y.2    Yamamoto, B.K.3
  • 203
    • 0343550155 scopus 로고
    • Local administration of ritanserin or ICS 205,930 enhances dopamine and serotonin efflux in rat prefrontal cortex
    • Pehek EA, Meltzer HY, Yamamoto BK: Local administration of ritanserin or ICS 205,930 enhances dopamine and serotonin efflux in rat prefrontal cortex. Society for Neuroscience Abstracts 1993; 19:302
    • (1993) Society for Neuroscience Abstracts , vol.19 , pp. 302
    • Pehek, E.A.1    Meltzer, H.Y.2    Yamamoto, B.K.3
  • 204
    • 0025239750 scopus 로고
    • Acute Effects of typical and atypical antipsychotic drugs on the release of dopamine from prefrontal cortex, nucleus accumbens, and striatum of the rat: An in vivo microdialysis study
    • Moghaddam B, Bunney BS: Acute Effects of typical and atypical antipsychotic drugs on the release of dopamine from prefrontal cortex, nucleus accumbens, and striatum of the rat: An in vivo microdialysis study. J Neurochem 1990; 54:1755-1760
    • (1990) J Neurochem , vol.54 , pp. 1755-1760
    • Moghaddam, B.1    Bunney, B.S.2
  • 206
    • 0024659486 scopus 로고
    • Local cooling of pre-frontal cortex induces pace-maker-like firing of dopamine neurons in rat ventral tegumental area in vivo
    • Svensson TH, Tung CS: Local cooling of pre-frontal cortex induces pace-maker-like firing of dopamine neurons in rat ventral tegumental area in vivo. Acta Physiol Scand 1989; 136:135-136
    • (1989) Acta Physiol Scand , vol.136 , pp. 135-136
    • Svensson, T.H.1    Tung, C.S.2
  • 207
    • 0017816468 scopus 로고
    • Phencyclidine-induced psychosis
    • Allen RM, Young SJ: Phencyclidine-induced psychosis. Am J Psychiatry 1978; 135:1081-1084
    • (1978) Am J Psychiatry , vol.135 , pp. 1081-1084
    • Allen, R.M.1    Young, S.J.2
  • 208
    • 0019317286 scopus 로고
    • Phencyclidine
    • Snyder S: Phencyclidine. Nature 1980; 285:355-356
    • (1980) Nature , vol.285 , pp. 355-356
    • Snyder, S.1
  • 210
    • 0024474967 scopus 로고
    • 2 antagonist ritanserin blocks the effect of prefrontal cortex inactivation on rat A10 dopamine neurons in vivo
    • 2 antagonist ritanserin blocks the effect of prefrontal cortex inactivation on rat A10 dopamine neurons in vivo. Acta Physiol Scand 1989; 136:497-498
    • (1989) Acta Physiol Scand , vol.136 , pp. 497-498
    • Svensson, T.H.1    Tung, C.S.2    Grenhoff, J.3
  • 211
    • 0025214384 scopus 로고
    • Effects of amperozide, a putative antipsychotic drug, on rat midbrain dopamine neurons recorded in vivo
    • Grenhoff J, Tung CS, Ugedo L, et al: Effects of amperozide, a putative antipsychotic drug, on rat midbrain dopamine neurons recorded in vivo. Pharmacol Toxicol 1990; Suppl 1:29-33
    • (1990) Pharmacol Toxicol , vol.SUPPL. 1 , pp. 29-33
    • Grenhoff, J.1    Tung, C.S.2    Ugedo, L.3
  • 212
    • 0023024112 scopus 로고
    • Neural basis of psychomotor stimulant and opiate reward: Evidence suggesting an involvement of a common dopaminergic system
    • Bozarth MA: Neural basis of psychomotor stimulant and opiate reward: Evidence suggesting an involvement of a common dopaminergic system. Behav Brain Res 1986; 22:107-116
    • (1986) Behav Brain Res , vol.22 , pp. 107-116
    • Bozarth, M.A.1
  • 213
    • 0025695028 scopus 로고
    • Ketanserin pretreatment attenuates MDMA-induced dopamine release in the striatum as measured by in vivo microdialysis
    • Nash JF: Ketanserin pretreatment attenuates MDMA-induced dopamine release in the striatum as measured by in vivo microdialysis. Life Sci 1990; 47:2401-2408
    • (1990) Life Sci , vol.47 , pp. 2401-2408
    • Nash, J.F.1
  • 214
    • 0028176861 scopus 로고
    • Blockade of striatal 5-hydroxytryptamine(2) receptors reduces the increase in extracellular concentrations of dopamine produced by the amphetamine analogue 3,4-methylenedioxymethamphetamine
    • Schmidt CJ, Sullivan CK, Fadayel GM: Blockade of striatal 5-hydroxytryptamine(2) receptors reduces the increase in extracellular concentrations of dopamine produced by the amphetamine analogue 3,4-methylenedioxymethamphetamine. J Neurochem 1994; 62:1382-1389
    • (1994) J Neurochem , vol.62 , pp. 1382-1389
    • Schmidt, C.J.1    Sullivan, C.K.2    Fadayel, G.M.3
  • 215
    • 0017105801 scopus 로고
    • D-Amphetamine-induced inhibition of central dopaminergic neurons: Mediation by a striato-nigral feedback pathway
    • Bunney BS, Aghajanian GK: D-Amphetamine-induced inhibition of central dopaminergic neurons: Mediation by a striato-nigral feedback pathway. Science 1976; 192:391-393
    • (1976) Science , vol.192 , pp. 391-393
    • Bunney, B.S.1    Aghajanian, G.K.2
  • 216
    • 0019774305 scopus 로고
    • Dopaminergic neurons in the rat ventral tegmental area, III: Effects of D- And L-amphetamine
    • Wang RY: Dopaminergic neurons in the rat ventral tegmental area, III: Effects of D- and L-amphetamine. Brain Res Rev 1981; 3:153-165
    • (1981) Brain Res Rev , vol.3 , pp. 153-165
    • Wang, R.Y.1
  • 217
    • 0023945589 scopus 로고
    • Amphetamine-induced dopamine release in rat striatum: An in vivo microdialysis study
    • Butcher SP, Fairbrother IS, Kelly JS, et al: Amphetamine-induced dopamine release in rat striatum: An in vivo microdialysis study. J Neurochem 1988; 50:346-355
    • (1988) J Neurochem , vol.50 , pp. 346-355
    • Butcher, S.P.1    Fairbrother, I.S.2    Kelly, J.S.3
  • 218
    • 0027337064 scopus 로고
    • 2 mediated potentiation of dopamine synthesis and central serotonergic deficits
    • 2 mediated potentiation of dopamine synthesis and central serotonergic deficits. Eur J Pharmacol 1993; 238:291-296
    • (1993) Eur J Pharmacol , vol.238 , pp. 291-296
    • Huang, X.1    Nichols, D.E.2
  • 219
    • 0028971907 scopus 로고
    • 2A/2C receptor agonist, potentiates amphetamine-induced dopamine release in rat striatum
    • 2A/2C receptor agonist, potentiates amphetamine-induced dopamine release in rat striatum. Brain Res 1995; 698:204-208
    • (1995) Brain Res , vol.698 , pp. 204-208
    • Ichikawa, J.1    Meltzer, H.Y.2
  • 221
    • 0029787944 scopus 로고    scopus 로고
    • Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug free schizophrenic subjects
    • Laruelle M, Abi-Dargham A, van Dyck CH, et al: Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug free schizophrenic subjects. Proc Natl Acad Sci USA 1996; 93:9235-9240
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9235-9240
    • Laruelle, M.1    Abi-Dargham, A.2    Van Dyck, C.H.3
  • 223
    • 0027472962 scopus 로고
    • Pyramidal cells in piriform cortex receive a convergence of inputs from monoamine activated GABAergic interneurons
    • German RL, Aghajanian GK: Pyramidal cells in piriform cortex receive a convergence of inputs from monoamine activated GABAergic interneurons. Brain Res 1993; 600:63-73
    • (1993) Brain Res , vol.600 , pp. 63-73
    • German, R.L.1    Aghajanian, G.K.2
  • 224
    • 0028338806 scopus 로고
    • Excitation of interneurons in piriform cortex by 5-hydroxytryptamine: Blockade by MDL 100,907, a highly selective 5-HT(2A) receptor antagonist
    • Marek GJ, Aghajanian GK: Excitation of interneurons in piriform cortex by 5-hydroxytryptamine: Blockade by MDL 100,907, a highly selective 5-HT(2A) receptor antagonist. Eur J Pharmacol 1994; 259:137-141
    • (1994) Eur J Pharmacol , vol.259 , pp. 137-141
    • Marek, G.J.1    Aghajanian, G.K.2
  • 225
    • 0028173623 scopus 로고
    • 2 receptors in the rat brain: Neurochemical identification of cell types by immunocytochemistry
    • 2 receptors in the rat brain: Neurochemical identification of cell types by immunocytochemistry. Neuropsychopharmacology 1994; 11:157-166
    • (1994) Neuropsychopharmacology , vol.11 , pp. 157-166
    • Morilak, D.A.1    Somogyi, P.2    Lujan-Miras, R.3
  • 226
    • 0025786847 scopus 로고
    • Deficits in small interneurons in schizophrenic cortex
    • Benes FM, McSparren J, Bird ED, et al: Deficits in small interneurons in schizophrenic cortex. Arch Gen Psychiatry 1991; 48:996-1001
    • (1991) Arch Gen Psychiatry , vol.48 , pp. 996-1001
    • Benes, F.M.1    McSparren, J.2    Bird, E.D.3
  • 228
    • 0027434132 scopus 로고
    • Total nerve cell number in neocortex in chronic schizophrenics and controls estimated using optical disectors
    • Pakkenberg B: Total nerve cell number in neocortex in chronic schizophrenics and controls estimated using optical disectors. Biol Psychiatry 1993; 34:768-772
    • (1993) Biol Psychiatry , vol.34 , pp. 768-772
    • Pakkenberg, B.1
  • 229
    • 0028948389 scopus 로고
    • Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics
    • Akbarian S, Kim JJ, Potkin SG, et al: Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics. Arch Gen Psychiatry 1995; 52:258-266
    • (1995) Arch Gen Psychiatry , vol.52 , pp. 258-266
    • Akbarian, S.1    Kim, J.J.2    Potkin, S.G.3
  • 230
    • 0025885699 scopus 로고
    • Abnormal expression of two microtubule associated proteins (MAP2 and MAP5) in specific sub-fields of the hippocampal formation in schizophrenia
    • Arnold SE, Lee VM, Gur RE, et al: Abnormal expression of two microtubule associated proteins (MAP2 and MAP5) in specific sub-fields of the hippocampal formation in schizophrenia. Proc Natl Acad Sci USA 1991; 88:10850-10854
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 10850-10854
    • Arnold, S.E.1    Lee, V.M.2    Gur, R.E.3
  • 231
    • 0029059048 scopus 로고
    • Serotonin depletion in the adult rat causes loss of the dendritic marker MAP-2: A new animal model of schizophrenia?
    • Whitaker-Azmitia PM, Borella A, Raio N: Serotonin depletion in the adult rat causes loss of the dendritic marker MAP-2: A new animal model of schizophrenia? Neuropsychopharmacology 1995; 12:269-272
    • (1995) Neuropsychopharmacology , vol.12 , pp. 269-272
    • Whitaker-Azmitia, P.M.1    Borella, A.2    Raio, N.3
  • 232
    • 0016777583 scopus 로고
    • Attenuation of the euphoriant and activating effects of d- And l-amphetamine by lithium carbonate treatment
    • van Kammen DP, Murphy DL: Attenuation of the euphoriant and activating effects of d- and l-amphetamine by lithium carbonate treatment. Psychopharmacology (Bed) 1975; 44:215-224
    • (1975) Psychopharmacology (Bed) , vol.44 , pp. 215-224
    • Van Kammen, D.P.1    Murphy, D.L.2
  • 235
    • 0022630728 scopus 로고
    • Biochemical characterization of serotonin stimulated phosphoinositide turnover
    • Conn PJ, Sanders-Bush E: Biochemical characterization of serotonin stimulated phosphoinositide turnover. Life Sci 1986; 38:663-669
    • (1986) Life Sci , vol.38 , pp. 663-669
    • Conn, P.J.1    Sanders-Bush, E.2
  • 236
    • 0024840991 scopus 로고
    • Serotonin microinfusion into the ventral tegmental area increases accumbens dopamine release
    • Guan XM, McBride WJ: Serotonin microinfusion into the ventral tegmental area increases accumbens dopamine release. Brain Res Bull 1989; 23:541-547
    • (1989) Brain Res Bull , vol.23 , pp. 541-547
    • Guan, X.M.1    McBride, W.J.2
  • 237
    • 0027471275 scopus 로고
    • Neurotransmitter regulation of dopamine neurons in the ventral tegumental area
    • Kalivas PW: Neurotransmitter regulation of dopamine neurons in the ventral tegumental area. Brain Res Rev 1993; 18:75-113
    • (1993) Brain Res Rev , vol.18 , pp. 75-113
    • Kalivas, P.W.1
  • 238
    • 0018899460 scopus 로고
    • Molecular pathology of schizophrenia: More than one disease process?
    • Crow TJ: Molecular pathology of schizophrenia: More than one disease process? British Medical Journal 1980; 280:66-68
    • (1980) British Medical Journal , vol.280 , pp. 66-68
    • Crow, T.J.1
  • 239
    • 0019155523 scopus 로고
    • Differential effects of amphetamine and neuroleptics on negative vs. positive symptoms in schizophrenia
    • Angrist B, Rotrosen J, Gershon S: Differential effects of amphetamine and neuroleptics on negative vs. positive symptoms in schizophrenia. Psychopharmacology 1980; 72:17-19
    • (1980) Psychopharmacology , vol.72 , pp. 17-19
    • Angrist, B.1    Rotrosen, J.2    Gershon, S.3
  • 240
    • 0018099454 scopus 로고
    • Schizophrenic symptoms improve with apomorphine
    • Tamminga CA, Schaffer MH, Smith RC, et al: Schizophrenic symptoms improve with apomorphine. Science 1978; 200:567-568
    • (1978) Science , vol.200 , pp. 567-568
    • Tamminga, C.A.1    Schaffer, M.H.2    Smith, R.C.3
  • 241
    • 0027213196 scopus 로고
    • Cortical regulation of subcortical systems and its possible relevance to schizophrenia
    • Grace AA: Cortical regulation of subcortical systems and its possible relevance to schizophrenia. J Neural Transm 1993; 91:111-134
    • (1993) J Neural Transm , vol.91 , pp. 111-134
    • Grace, A.A.1
  • 242
    • 0029988896 scopus 로고    scopus 로고
    • Serotonin-dopamine interaction and its relevance to schizophrenia
    • Kapur S, Remington G: Serotonin-dopamine interaction and its relevance to schizophrenia. Am J Psychiatry 1996; 153:466-76
    • (1996) Am J Psychiatry , vol.153 , pp. 466-476
    • Kapur, S.1    Remington, G.2
  • 243
    • 0029010819 scopus 로고
    • SPECT imaging of striatal dopamine release after amphetamine challenge
    • Lamelle M, Abi-Dargham A, van Dyck CH, et al: SPECT imaging of striatal dopamine release after amphetamine challenge. J Nucl Med 1995; 36:1182-1190
    • (1995) J Nucl Med , vol.36 , pp. 1182-1190
    • Lamelle, M.1    Abi-Dargham, A.2    Van Dyck, C.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.