Kinetic analysis of [11C]McN5652: A serotonin transporter radioligand

Journal of Cerebral Blood Flow and Metabolism

Volumn 19, Issue 9, 1999, Pages 967-981

  Szabo, Zsolt ^a   Scheffel, Ursula ^a   Mathews, William B ^a   Ravert, Hayden T ^a   Szabo, Katalina ^a   Kraut, Michael ^a   Palmon, Sally ^a   Ricaurte, George A ^a   Dannals, Robert F ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Brain; Deconvolution analysis; Impulse response function; Kinetic model; Positron emission tomography; Serotonin transporter; 11C (+)McN5652

Indexed keywords

1,2,3,5,6,10B HEXAHYDRO 6 (4 METHYLTHIOPHENYL)PYRROLO[2,1 A]ISOQUINOLINE; CARBON 11; RADIOLIGAND; SEROTONIN TRANSPORTER; CARRIER PROTEIN; ISOQUINOLINE DERIVATIVE; MEMBRANE PROTEIN; NERVE PROTEIN; SEROTONIN ANTAGONIST; SLC6A4 PROTEIN, HUMAN;

ADULT; ARTICLE; BRAIN BLOOD FLOW; BRAIN REGION; CEREBELLUM; COMPARTMENT MODEL; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG BLOOD LEVEL; DRUG UPTAKE; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MESENCEPHALON; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RELIABILITY; REPRODUCIBILITY; BIOLOGICAL MODEL; BRAIN; COMPUTER ASSISTED EMISSION TOMOGRAPHY; DRUG ANTAGONISM; KINETICS; METABOLISM; RADIOASSAY; RADIOGRAPHY;

ADULT; BRAIN; CARRIER PROTEINS; FEMALE; HUMANS; ISOQUINOLINES; KINETICS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MODELS, BIOLOGICAL; NERVE TISSUE PROTEINS; RADIOLIGAND ASSAY; SEROTONIN ANTAGONISTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0033238062     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199909000-00004     Document Type: Article

References (13)

1. Anderson DH (1983) Compartmental Modeling and Tracer Kinetics, Berlin, Springer
2. Blakely RD, Berson HE, Fremeau RT Jr, Caron MG, Peek MM, Prince HK, et al (1991) Cloning and expression of a functional serotonin transporter from rat brain. Nature 354:66-70
3. Buck A, Mulholland GK, Papadopoulos SM, Koeppe RA, Frey KA (1996) Kinetic evaluation of positron-emitting muscarinic receptor ligands employing direct intracarotid injection. J Cereb Blood Flow Metab 16:1280-1287
4. Carson RE (1996) Mathematical modeling and compartmental analysis. In: Nuclear Medicine Diagnosis and Therapy (Harbert JC, Eckelman WC, Neumann RD, eds), New York, Thieme, pp 167-193
5. 3H]citalopram. Neuroscience 54:691-699
6. Cunningham VJ, Jones T (1993) Spectral analysis of dynamic PET studies. J Cereb Blood Flow Metab 13:15-23
7. Delforge J, Syrota A, Mazoyer BM (1989) Experimental design optimisation: theory and application to estimation of receptor model parameters using dynamic positron emission tomography. Phys Med Biol 34:419-435
8. 133xenon washout in dogs and man. Circ Res 32:71-84
9. Descarries L, Soucy JP, Lafaille F, Mrini A, Tanguay R (1995) Evaluation of three transporter ligands as quantitative markers of serotonin innervation density in rat brain. Synapse 21:131-139
10. DiStefano JJ, Landaw EM (1984) Multiexponential, multicompartmental, and non-compartmental modeling. I. Methodological limitations and physiological interpretations. Am J Physiol 246: R651-R664
11. Frey KA, Koeppe RA, Kilbourn MR, et al (1996) Presynaptic monoaminergic vesicles in Parkinson's disease and normal aging. Ann Neurol 40:873-884
12. Hunt BR (1970) The inverse problem of radiography. Math Biosci 8:161-179
13. Hunt BR (1972) Deconvolution of linear systems by constrained regression and its relationship to the Wiener theory. IEEE Trans Automat Contr 703-705