메뉴 건너뛰기




Volumn 14, Issue 3, 2005, Pages 243-250

Advances in anti-obesity therapeutics

Author keywords

CNS control; Energy balance; Feeding behaviour; Obesity

Indexed keywords

AMFEBUTAMONE; ANTIOBESITY AGENT; CANNABINOID 1 RECEPTOR; CENTRAL NERVOUS SYSTEM AGENTS; CHOLECYSTOKININ A RECEPTOR; DEXFENFLURAMINE; DOPAMINE TRANSPORTER; FENFLURAMINE; GI 181771; LEPTIN; LEPTIN RECEPTOR; MELANOCORTIN 4 RECEPTOR; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; NALMEFENE; NALOXONE; NALTREXONE; NEUROPEPTIDE Y RECEPTOR; NORADRENALIN TRANSPORTER; OPIATE ANTAGONIST; PHENTERMINE; PLACEBO; RADAFAXINE; RECOMBINANT CILIARY NEUROTROPHIC FACTOR; RIMONABANT; SEROTONIN; SEROTONIN 2C AGONIST; SEROTONIN UPTAKE INHIBITOR; SIBUTRAMINE; TETRAHYDROLIPSTATIN; UNINDEXED DRUG;

EID: 17144409447     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.14.3.243     Document Type: Review
Times cited : (20)

References (81)
  • 1
    • 0034890568 scopus 로고    scopus 로고
    • Long-term pharmacotherapy of obesity 2000: A review of efficacy and safety
    • GLAZER G: Long-term pharmacotherapy of obesity 2000: a review of efficacy and safety. Arch. Intern. Med. (2001) 161 1814-1824.
    • (2001) Arch. Intern. Med. , vol.161 , pp. 1814-1824
    • Glazer, G.1
  • 2
    • 0037298936 scopus 로고    scopus 로고
    • Treatment of obesity: An update on anti-obesity medications
    • HALPERN A, MANCINI MC: Treatment of obesity: an update on anti-obesity medications. Obes. Rev. (2003) 4:25-42.
    • (2003) Obes. Rev. , vol.4 , pp. 25-42
    • Halpern, A.1    Mancini, M.C.2
  • 4
    • 0036325531 scopus 로고    scopus 로고
    • Genetic approaches to studying energy balance: Perception and integration
    • BARSH GS, SCHWARTZ MW. Genetic approaches to studying energy balance: Perception and integration. Nat. Rev. Genet. (2002) 3 589-600.
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 589-600
    • Barsh, G.S.1    Schwartz, M.W.2
  • 5
    • 2942716780 scopus 로고    scopus 로고
    • Modern science versus the stigma of obesity
    • FRIEDMAN JM: Modern science versus the stigma of obesity. Nat. Med. (2004) 10:563-569.
    • (2004) Nat. Med. , vol.10 , pp. 563-569
    • Friedman, J.M.1
  • 6
    • 0035709038 scopus 로고    scopus 로고
    • The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis
    • CONE RD, COWLEY MA, BUTLER AA et al.: The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis. Int. J. Obes. Relat. Metab. Disord. (2001) 25(Suppl. 5):S63-S67.
    • (2001) Int. J. Obes. Relat. Metab. Disord. , vol.25 , Issue.SUPPL. 5
    • Cone, R.D.1    Cowley, M.A.2    Butler, A.A.3
  • 8
    • 0037057755 scopus 로고    scopus 로고
    • Getting formal with dopamine and reward
    • SCHULTZ W. Getting formal with dopamine and reward. Neuron (2002) 36:241-263.
    • (2002) Neuron , vol.36 , pp. 241-263
    • Schultz, W.1
  • 9
    • 0032913283 scopus 로고    scopus 로고
    • Biochemical mechanisms responsible for the attenuation of diabetic and obese conditions in ob/ob mice treated with dopaminergic agonists
    • SCISLOWSKI PW, TOZZO E, ZHANG Y et al.: Biochemical mechanisms responsible for the attenuation of diabetic and obese conditions in ob/ob mice treated with dopaminergic agonists. Int. J. Obes. Relat. Metab. Disord. (1999) 23:425-431.
    • (1999) Int. J. Obes. Relat. Metab. Disord. , vol.23 , pp. 425-431
    • Scislowski, P.W.1    Tozzo, E.2    Zhang, Y.3
  • 12
    • 0032461050 scopus 로고    scopus 로고
    • Cannabinoid transmission and reward-related events
    • GARDNER EL, VOREL SR: Cannabinoid transmission and reward-related events. Neurobiol. Dis. (1998) 5:502-533.
    • (1998) Neurobiol. Dis. , vol.5 , pp. 502-533
    • Gardner, E.L.1    Vorel, S.R.2
  • 13
    • 0036669295 scopus 로고    scopus 로고
    • Tetrahydrocannabinol and endocannabinoids in feeding and appetite
    • BERRY EM, MECHOULAM R: Tetrahydrocannabinol and endocannabinoids in feeding and appetite. Pharmacol. Ther. (2002) 95:185-190.
    • (2002) Pharmacol. Ther. , vol.95 , pp. 185-190
    • Berry, E.M.1    Mechoulam, R.2
  • 14
    • 0032466390 scopus 로고    scopus 로고
    • The functional neuroanatomy of brain cannabinoid receptors
    • BREIVOGEL CS, CHILDERS SR: The functional neuroanatomy of brain cannabinoid receptors. Neurobiol Dis. (1998) 5:417-431.
    • (1998) Neurobiol. Dis. , vol.5 , pp. 417-431
    • Breivogel, C.S.1    Childers, S.R.2
  • 15
    • 0037430140 scopus 로고    scopus 로고
    • Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat
    • KISHI T, ASCHKENASI CJ, LEE CE et al.: Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat. J. Comp. Neurol. (2003) 457:213-235.
    • (2003) J. Comp. Neurol. , vol.457 , pp. 213-235
    • Kishi, T.1    Aschkenasi, C.J.2    Lee, C.E.3
  • 16
    • 0032889771 scopus 로고    scopus 로고
    • Expression of μ-, κ-, and δ-opioid receptor messenger RNA in the human CNS: A 33P in situ hybridisation study
    • PECKYS D, LANDWEHRMEYER GB: Expression of μ-, κ-, and δ-opioid receptor messenger RNA in the human CNS: a 33P in situ hybridisation study. Neuroscience (1999) 88:1093-1135.
    • (1999) Neuroscience , vol.88 , pp. 1093-1135
    • Peckys, D.1    Landwehrmeyer, G.B.2
  • 17
    • 0017668698 scopus 로고
    • Set points, settling points and the control of body weight
    • WIRTSHAFTER D, DAVID JD: Set points, settling points and the control of body weight. Physiol. Behav. (1977) 19:75-78.
    • (1977) Physiol. Behav. , vol.19 , pp. 75-78
    • Wirtshafter, D.1    David, J.D.2
  • 18
    • 2442701355 scopus 로고    scopus 로고
    • Motivation concepts in behavioral neuroscience
    • BERRIDGE KC: Motivation concepts in behavioral neuroscience. Physiol. Behav. (2004) 81:179-209.
    • (2004) Physiol. Behav. , vol.81 , pp. 179-209
    • Berridge, K.C.1
  • 19
    • 0036627597 scopus 로고    scopus 로고
    • Multiple neural systems controlling food intake and body weight
    • BERTHOUD HR: Multiple neural systems controlling food intake and body weight. Neurosci. Biobehav. Rev. (2002) 26:393-428.
    • (2002) Neurosci. Biobehav. Rev. , vol.26 , pp. 393-428
    • Berthoud, H.R.1
  • 21
    • 0035854112 scopus 로고    scopus 로고
    • Evidence of interactions between melanocortin and opioid systems in regulation of feeding
    • OLSZEWSKI PK, WIRTH MM, GRACE MK, LEVINE AS, GIRAUDO SQ: Evidence of interactions between melanocortin and opioid systems in regulation of feeding. Neuroreport (2001) 12:1727-1730.
    • (2001) Neuroreport , vol.12 , pp. 1727-1730
    • Olszewski, P.K.1    Wirth, M.M.2    Grace, M.K.3    Levine, A.S.4    Giraudo, S.Q.5
  • 22
    • 0029839328 scopus 로고    scopus 로고
    • Morphine down-regulates melanocortin-4 receptor expression in brain regions that mediate opiate addiction
    • ALVARO JD, TATRO JB, QUILLAN JM et al.: Morphine down-regulates melanocortin-4 receptor expression in brain regions that mediate opiate addiction. Mol. Pharmacol. (1996) 50:583-591.
    • (1996) Mol. Pharmacol. , vol.50 , pp. 583-591
    • Alvaro, J.D.1    Tatro, J.B.2    Quillan, J.M.3
  • 23
    • 0028228615 scopus 로고
    • Neuropeptide Y and energy balance: One way ahead for the treatment of obesity?
    • DRYDEN S, FRANKISH H, WANG Q, WILLIAMS G: Neuropeptide Y and energy balance: one way ahead for the treatment of obesity? Eur. J. Clin. Invest. (1994) 24:293-308.
    • (1994) Eur. J. Clin. Invest. , vol.24 , pp. 293-308
    • Dryden, S.1    Frankish, H.2    Wang, Q.3    Williams, G.4
  • 24
    • 0037178730 scopus 로고    scopus 로고
    • Activation of central melanocortin pathways by fenfluramine
    • HEISLER LK, COWLEY MA, TECOTT LH et al.: Activation of central melanocortin pathways by fenfluramine. Science (2002) 297:609-611.
    • (2002) Science , vol.297 , pp. 609-611
    • Heisler, L.K.1    Cowley, M.A.2    Tecott, L.H.3
  • 25
    • 0034264256 scopus 로고    scopus 로고
    • Effects of sibutramine plus orlistat in obese women following 1 year of treatment by sibutramine alone: A placebo-controlled trial
    • WADDEN TA, BERKOWITZ RI, WOMBLE LG et al.: Effects of sibutramine plus orlistat in obese women following 1 year of treatment by sibutramine alone: a placebo-controlled trial. Obes. Res. (2000) 8:431-437.
    • (2000) Obes. Res. , vol.8 , pp. 431-437
    • Wadden, T.A.1    Berkowitz, R.I.2    Womble, L.G.3
  • 27
    • 0031902759 scopus 로고    scopus 로고
    • 1 cannabinoid receptor antagonist, selectively reduces sweet food intake in marmoset
    • 1 cannabinoid receptor antagonist, selectively reduces sweet food intake in marmoset. Behav. Pharmacol. (1998) 9:179-181.
    • (1998) Behav. Pharmacol. , vol.9 , pp. 179-181
    • Simiad, J.1    Keane, M.2    Keane, P.E.3    Soubrie, P.4
  • 28
    • 0032541111 scopus 로고    scopus 로고
    • Appetite suppression and weight loss after the cannabinoid antagonist SR-141716
    • COLOMBO G, AGABIO R, DIAZ C, et al.: Appetite suppression and weight loss after the cannabinoid antagonist SR-141716. Life Sci. (1998) 63:113-117.
    • (1998) Life Sci. , vol.63 , pp. 113-117
    • Colombo, G.1    Agabio, R.2    Diaz, C.3
  • 29
    • 0345791451 scopus 로고    scopus 로고
    • Consumption of high carbohydrate, high fat, and normal chow is equally suppressed by a cannabinoid receptor antagonist in non-deprived rats
    • VERTY AN, McGREGOR IS, MALLET PE: Consumption of high carbohydrate, high fat, and normal chow is equally suppressed by a cannabinoid receptor antagonist in non-deprived rats. Neurosci. Lett. (2004) 354:217-220.
    • (2004) Neurosci. Lett. , vol.354 , pp. 217-220
    • Verty, A.N.1    McGregor, I.S.2    Mallet, P.E.3
  • 30
    • 0035543768 scopus 로고    scopus 로고
    • Activity of SR-141716 on post-reinforcement pauses in operant responding for sucrose reward in rats
    • PERIO A, BARNOUIN MC, PONCELET M, SOUBRIE P: Activity of SR-141716 on post-reinforcement pauses in operant responding for sucrose reward in rats. Behav. Pharmacol. (2001) 12:641-645.
    • (2001) Behav. Pharmacol. , vol.12 , pp. 641-645
    • Perio, A.1    Barnouin, M.C.2    Poncelet, M.3    Soubrie, P.4
  • 31
    • 0033585499 scopus 로고    scopus 로고
    • Weight control and risk factor reduction in obese subjects treated for 2 years with orlistat: A randomised controlled trial
    • DAVIDSON MH, HAUPTMAN J, DIGIROLAMO M et al.: Weight control and risk factor reduction in obese subjects treated for 2 years with orlistat: a randomised controlled trial. JAMA (1999) 281 235-242.
    • (1999) JAMA , vol.281 , pp. 235-242
    • Davidson, M.H.1    Hauptman, J.2    Digirolamo, M.3
  • 32
    • 0034516930 scopus 로고    scopus 로고
    • Effect of sibutramine on weight maintenance after weight loss: A randomised trial
    • STORM Study Group. Sibutramine Trial of Obesity Reduction and Maintenance
    • JAMES WP, ASTRUP A, FINER N et al.: Effect of sibutramine on weight maintenance after weight loss: a randomised trial. STORM Study Group. Sibutramine Trial of Obesity Reduction and Maintenance. Lancet (2000) 356:2119-2125.
    • (2000) Lancet , vol.356 , pp. 2119-2125
    • James, W.P.1    Astrup, A.2    Finer, N.3
  • 33
    • 20844454912 scopus 로고    scopus 로고
    • Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension
    • BATKAI S, PACHER P, OSEI-HYIAMAN D et al.: Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension. Circulation (2004) 110 1996-2002.
    • (2004) Circulation , vol.110 , pp. 1996-2002
    • Batkai, S.1    Pacher, P.2    Osei-Hyiaman, D.3
  • 34
    • 2542555018 scopus 로고    scopus 로고
    • The complexities of the cardiovascular actions of cannabinoids
    • RANDALL MD, KENDALL DA, O'SULLIVAN S: The complexities of the cardiovascular actions of cannabinoids. Br. J. Pharmacol. (2004) 142:20-26.
    • (2004) Br. J. Pharmacol. , vol.142 , pp. 20-26
    • Randall, M.D.1    Kendall, D.A.2    O'Sullivan, S.3
  • 35
    • 16544373950 scopus 로고    scopus 로고
    • Cannabinoid system as a potential target for drug development in the treatment of cardiovascular disease
    • MENDIZABAL VE, ADLER-GRASCHINSKY E: Cannabinoid system as a potential target for drug development in the treatment of cardiovascular disease. Curr. Vasc. Pharmacol. (2003) 1:301-313.
    • (2003) Curr. Vasc. Pharmacol. , vol.1 , pp. 301-313
    • Mendizabal, V.E.1    Adler-Graschinsky, E.2
  • 38
    • 0028149838 scopus 로고
    • The tripartite CNTF receptor complex: Activation and signaling involves components shared with other cytokines
    • STAHL N, YANCOPOULOS GD: The tripartite CNTF receptor complex: activation and signaling involves components shared with other cytokines. J. Neurobiol. (1994) 25:1454-1466.
    • (1994) J. Neurobiol. , vol.25 , pp. 1454-1466
    • Stahl, N.1    Yancopoulos, G.D.2
  • 39
    • 0345121142 scopus 로고    scopus 로고
    • Ciliary neurotropic factor corrects obesity and diabetes associated with leptin deficiency and resistance
    • GLOAGUEN I, COSTA P, DEMARTIS A et al.: Ciliary neurotropic factor corrects obesity and diabetes associated with leptin deficiency and resistance. Proc. Natl. Acad. Sci. USA (1997) 94 6456-6461.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 6456-6461
    • Gloaguen, I.1    Costa, P.2    Demartis, A.3
  • 40
    • 0035836760 scopus 로고    scopus 로고
    • Ciliary neurotropic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity
    • LAMBERT PD, ANDERSON KD, SLEEMAN MW et al.: Ciliary neurotropic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity. Proc. Natl. Acad. Sci. USA (2001) 98:4652-4657.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 4652-4657
    • Lambert, P.D.1    Anderson, K.D.2    Sleeman, M.W.3
  • 41
    • 0032900284 scopus 로고    scopus 로고
    • Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides
    • MARSH DJ, HOLLOPETER G, HUSZAR D et al.: Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat. Genet. (1999) 21:119-122.
    • (1999) Nat. Genet. , vol.21 , pp. 119-122
    • Marsh, D.J.1    Hollopeter, G.2    Huszar, D.3
  • 42
    • 0033760590 scopus 로고    scopus 로고
    • Unlike leptin, ciliary neurotropic factor does not reverse the starvation-induced changes of serum corticosterone and hypothalamic neuropeptide levels but induces expression of hypothalamic inhibitors of leptin signaling
    • ZIOTOPOULOU M, ERANI DM, HILEMAN SM, BJORBAEK C, MANTZOROS CS: Unlike leptin, ciliary neurotropic factor does not reverse the starvation-induced changes of serum corticosterone and hypothalamic neuropeptide levels but induces expression of hypothalamic inhibitors of leptin signaling. Diabetes (2000) 49:1890-1896.
    • (2000) Diabetes , vol.49 , pp. 1890-1896
    • Ziotopoulou, M.1    Erani, D.M.2    Hileman, S.M.3    Bjorbaek, C.4    Mantzoros, C.S.5
  • 43
    • 0031788012 scopus 로고    scopus 로고
    • Anorectic effects of the cytokine, ciliary neurotropic factor, are mediated by hypothalamic neuropeptide Y: Comparison with leptin
    • XU B, DUBE MG, KALRA PS et al.: Anorectic effects of the cytokine, ciliary neurotropic factor, are mediated by hypothalamic neuropeptide Y: comparison with leptin. Endocrinology (1998) 139 466-473.
    • (1998) Endocrinology , vol.139 , pp. 466-473
    • Xu, B.1    Dube, M.G.2    Kalra, P.S.3
  • 44
    • 0034029565 scopus 로고    scopus 로고
    • Comparison of either norepinephrine-uptake inhibitors or phentermine combined with serotonergic agents on food intake in rats
    • ROWLAND NE, MARSHALL M, ROTH JD: Comparison of either norepinephrine-uptake inhibitors or phentermine combined with serotonergic agents on food intake in rats. Psychopharmacology (2000) 149:77-83.
    • (2000) Psychopharmacology , vol.149 , pp. 77-83
    • Rowland, N.E.1    Marshall, M.2    Roth, J.D.3
  • 45
    • 0032462875 scopus 로고    scopus 로고
    • The selective norepinephrine reuptake inhibitor, LY368975, reduces food consumption in animal models of feeding
    • GEHLERT DR, DRESHFIELD L, TINSLEY F et al.: The selective norepinephrine reuptake inhibitor, LY368975, reduces food consumption in animal models of feeding. J. Pharmacol. Exp. Ther. (1998) 287:122-127.
    • (1998) J. Pharmacol. Exp. Ther. , vol.287 , pp. 122-127
    • Gehlert, D.R.1    Dreshfield, L.2    Tinsley, F.3
  • 46
    • 0036636368 scopus 로고    scopus 로고
    • Bupropion SR enhances weight loss: A 48-week double-blind, placebo-controlled trial
    • ANDERSON JW, GREENWAY FL, FUJIOKA K et al.: Bupropion SR enhances weight loss: a 48-week double-blind, placebo-controlled trial. Obes. Res. (2002) 10:633-641.
    • (2002) Obes. Res. , vol.10 , pp. 633-641
    • Anderson, J.W.1    Greenway, F.L.2    Fujioka, K.3
  • 47
    • 0032754965 scopus 로고    scopus 로고
    • Cholecystokinin: Proofs and prospects for involvement in control of food intake and body weight
    • RITTER RC, COVASA M, MATSON CA: Cholecystokinin: proofs and prospects for involvement in control of food intake and body weight. Neuropeptides (1999) 33:387-399.
    • (1999) Neuropeptides , vol.33 , pp. 387-399
    • Ritter, R.C.1    Covasa, M.2    Matson, C.A.3
  • 49
    • 0032951467 scopus 로고    scopus 로고
    • Long-term CCK-leptin synergy suggests a role for CCK in the regulation of body weight
    • MATSON CA, RITTER RC: Long-term CCK-leptin synergy suggests a role for CCK in the regulation of body weight. Am. J. Physiol. (1999) 276:R1038-R1045.
    • (1999) Am. J. Physiol. , vol.276
    • Matson, C.A.1    Ritter, R.C.2
  • 50
    • 1242306691 scopus 로고    scopus 로고
    • Analysis of the anorectic efficacy of HMR1426 in rodents and its effects on gastric emptying in rats
    • BICKEL M, GOSSEL M, GEISEN K et al.: Analysis of the anorectic efficacy of HMR1426 in rodents and its effects on gastric emptying in rats. Int. J. Obes. Relat. Metab. Disord. (2004) 28 211-221.
    • (2004) Int. J. Obes. Relat. Metab. Disord. , vol.28 , pp. 211-221
    • Bickel, M.1    Gossel, M.2    Geisen, K.3
  • 51
    • 0032940913 scopus 로고    scopus 로고
    • δ-9-tetrahydrocannabinol delays the gastric emptying of solid food in humans: A double-blind, randomized study
    • McCALLUM RW, SOYKAN I, SRIDHAR KR et al.: δ-9-tetrahydrocannabinol delays the gastric emptying of solid food in humans: a double-blind, randomized study. Aliment. Pharmacol. Ther. (1999) 13:77-80.
    • (1999) Aliment Pharmacol. Ther. , vol.13 , pp. 77-80
    • McCallum, R.W.1    Soykan, I.2    Sridhar, K.R.3
  • 53
    • 13544253065 scopus 로고    scopus 로고
    • Metabolic syndrome - A clinical and molecular perspective
    • MOLLER DM, KAUFMAN KD: Metabolic syndrome - a clinical and molecular perspective. Ann. Rev. Med. (2005) 56:45-62.
    • (2005) Ann. Rev. Med. , vol.56 , pp. 45-62
    • Moller, D.M.1    Kaufman, K.D.2
  • 54
    • 4544247230 scopus 로고    scopus 로고
    • Targeting metabolic syndrome
    • FONG TM: Targeting metabolic syndrome. Expert Opin. Investig. Drugs (2004) 13:1203-1206.
    • (2004) Expert Opin. Investig. Drugs , vol.13 , pp. 1203-1206
    • Fong, T.M.1
  • 55
    • 0033891368 scopus 로고    scopus 로고
    • Obesity: An epidemic in need of therapeutics
    • VAN DER PLOEG LH: Obesity: an epidemic in need of therapeutics. Curr. Opin. Chem. Biol. (2000) 4:452-460.
    • (2000) Curr. Opin. Chem. Biol. , vol.4 , pp. 452-460
    • Van Der Ploeg, L.H.1
  • 57
    • 0037456768 scopus 로고    scopus 로고
    • Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene
    • FAROOQI IS, KEOGH JM, YEO GS et al.: Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N. Engl. J. Med. (2003) 348:1085-1095.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 1085-1095
    • Farooqi, I.S.1    Keogh, J.M.2    Yeo, G.S.3
  • 58
    • 0030889192 scopus 로고    scopus 로고
    • Targeted disruption of the melanocortin-4 receptor results in obesity in mice
    • HUSZAR D, LYNCH CA, FAIR-HUNTRESS V et al.: Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell (1997) 88:131-141.
    • (1997) Cell , vol.88 , pp. 131-141
    • Huszar, D.1    Lynch, C.A.2    Fair-Huntress, V.3
  • 61
    • 0036443705 scopus 로고    scopus 로고
    • Chronic infusion of a melanocortin receptor agonist modulates dopamine receptor binding in the rat brain
    • LINDBLOM J, KASK A, HAGG E et al.: Chronic infusion of a melanocortin receptor agonist modulates dopamine receptor binding in the rat brain. Pharmacol. Res. (2002) 45:119-124.
    • (2002) Pharmacol. Res. , vol.45 , pp. 119-124
    • Lindblom, J.1    Kask, A.2    Hagg, E.3
  • 62
    • 0036235622 scopus 로고    scopus 로고
    • The melanocortin receptor agonist MTII augments the rewarding effect of amphetamine in ad-libitum-fed and food-restricted rats
    • CABEZA DE VACA S, KIM G, CARR KD: The melanocortin receptor agonist MTII augments the rewarding effect of amphetamine in ad-libitum-fed and food-restricted rats. Psychopharmacology (2002) 161:77-85.
    • (2002) Psychopharmacology , vol.161 , pp. 77-85
    • Cabeza De Vaca, S.1    Kim, G.2    Carr, K.D.3
  • 63
    • 1642414475 scopus 로고    scopus 로고
    • Melanocortin-4 receptor agonists and antagonists: Chemistry and potential therapeutic utilities
    • SEBHAT I, YE Z, BEDNAREK M et al.: Melanocortin-4 receptor agonists and antagonists: chemistry and potential therapeutic utilities. Ann. Rep. Med. Chem. (2003) 38:31-40.
    • (2003) Ann. Rep. Med. Chem. , vol.38 , pp. 31-40
    • Sebhat, I.1    Ye, Z.2    Bednarek, M.3
  • 64
    • 0035912709 scopus 로고    scopus 로고
    • Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R
    • SAILER AW, SANO H, ZENG Z et al.: Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc. Natl. Acad. Sci. USA (2001) 98:7564-7569.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 7564-7569
    • Sailer, A.W.1    Sano, H.2    Zeng, Z.3
  • 65
    • 0033566084 scopus 로고    scopus 로고
    • Molecular characterization of the melanin-concentrating-hormone receptor
    • SAITO Y, NOTHACKER HP, WANG Z et al.: Molecular characterization of the melanin-concentrating-hormone receptor. Nature (1999) 400:265-269.
    • (1999) Nature , vol.400 , pp. 265-269
    • Saito, Y.1    Nothacker, H.P.2    Wang, Z.3
  • 67
    • 0037022667 scopus 로고    scopus 로고
    • Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive and hyperphagic and have altered metabolism
    • MARSH DJ, WEINGARTH DT, NOVI DE et al.: Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive and hyperphagic and have altered metabolism. Proc. Natl. Acad. Sci. USA (2002) 99:3240-3245.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 3240-3245
    • Marsh, D.J.1    Weingarth, D.T.2    Novi, D.E.3
  • 68
    • 18444375866 scopus 로고    scopus 로고
    • Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity
    • CHEN Y, HU C, HSU CK et al.: Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity. Endocrinology (2002) 143 2469-2477.
    • (2002) Endocrinology , vol.143 , pp. 2469-2477
    • Chen, Y.1    Hu, C.2    Hsu, C.K.3
  • 69
    • 4544374046 scopus 로고    scopus 로고
    • Therapeutic potential of melanin-concentrating hormone-1 receptor antagonists for the treatment of obesity
    • KOWALSKI TJ, McBRIAR MD: Therapeutic potential of melanin-concentrating hormone-1 receptor antagonists for the treatment of obesity. Expert Opin. Investig. Drugs (2004) 13:1113-1122.
    • (2004) Expert Opin. Investig. Drugs , vol.13 , pp. 1113-1122
    • Kowalski, T.J.1    McBriar, M.D.2
  • 70
    • 0027489212 scopus 로고
    • Long-term treatment of obese Zucker rats with LY255582 and other appetite suppressants
    • SHAW WN: Long-term treatment of obese Zucker rats with LY255582 and other appetite suppressants. Pharmacol. Biochem. Behav. (1993) 46:653-659.
    • (1993) Pharmacol. Biochem. Behav. , vol.46 , pp. 653-659
    • Shaw, W.N.1
  • 71
    • 0032750456 scopus 로고    scopus 로고
    • Opioids and food intake: Distributed functional neural pathways?
    • GLASS M, BILLINGTON CJ, LEVINE AS: Opioids and food intake: distributed functional neural pathways? Neuropeptides (1999) 33 360-368.
    • (1999) Neuropeptides , vol.33 , pp. 360-368
    • Glass, M.1    Billington, C.J.2    Levine, A.S.3
  • 72
    • 0038515754 scopus 로고    scopus 로고
    • Peptides that regulate food intake: Antagonism of opioid receptors reduces body fat in obese rats by decreasing food intake and stimulating lipid utilization
    • STATNICK MA, TINSLEY FC, EASTWOOD BJ et al.: Peptides that regulate food intake: antagonism of opioid receptors reduces body fat in obese rats by decreasing food intake and stimulating lipid utilization. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2003) 284:R1399-R1408.
    • (2003) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.284
    • Statnick, M.A.1    Tinsley, F.C.2    Eastwood, B.J.3
  • 73
    • 2542460126 scopus 로고    scopus 로고
    • Endogenous opioids and feeding behavior: A 30-year historical perspective
    • BODNAR RJ: Endogenous opioids and feeding behavior: a 30-year historical perspective. Peptides (2004) 25:697-725.
    • (2004) Peptides , vol.25 , pp. 697-725
    • Bodnar, R.J.1
  • 74
    • 0029566187 scopus 로고
    • Metabolic determinants of binge eating
    • DREWNOWSKI A: Metabolic determinants of binge eating. Addictive Behav. (1995) 20:733-745.
    • (1995) Addictive Behav. , vol.20 , pp. 733-745
    • Drewnowski, A.1
  • 75
    • 0027079916 scopus 로고
    • Opiate antagonists and eating behaviour in humans: A review
    • DE ZWAAN M, MITCHELL JE: Opiate antagonists and eating behaviour in humans: a review. J. Clin. Pharmacol. (1992) 32 1060-1072.
    • (1992) J. Clin. Pharmacol. , vol.32 , pp. 1060-1072
    • De Zwaan, M.1    Mitchell, J.E.2
  • 76
    • 0030659004 scopus 로고    scopus 로고
    • Longer occupancy of opioid receptors by nalmefene compared to naloxone as measured in vivo by a dual-detector system
    • KIM S, WAGNER HN, VILLEMAGNE VL et al.: Longer occupancy of opioid receptors by nalmefene compared to naloxone as measured in vivo by a dual-detector system. J. Nuc. Med. (1997) 38:1726-1731.
    • (1997) J. Nuc. Med. , vol.38 , pp. 1726-1731
    • Kim, S.1    Wagner, H.N.2    Villemagne, V.L.3
  • 77
    • 3042631016 scopus 로고    scopus 로고
    • Chronic administration of nalmefene leads to increased food intake and body weight gain in mice
    • CHEN RZ, HUANG RR, SHEN CP, MACNEIL DJ, FONG TM: Chronic administration of nalmefene leads to increased food intake and body weight gain in mice. Eur. J. Pharmacol. (2004) 495:63-66.
    • (2004) Eur. J. Pharmacol. , vol.495 , pp. 63-66
    • Chen, R.Z.1    Huang, R.R.2    Shen, C.P.3    Macneil, D.J.4    Fong, T.M.5
  • 78
    • 0026664550 scopus 로고
    • Microinjection of opioid antagonists into the substantia nigra reduces stress-induced eating in rats
    • HAWKINS MF, CUBIC B, BAUMEISTER AA, BARTON C: Microinjection of opioid antagonists into the substantia nigra reduces stress-induced eating in rats. Brain Res. (1992) 584:261-265.
    • (1992) Brain Res. , vol.584 , pp. 261-265
    • Hawkins, M.F.1    Cubic, B.2    Baumeister, A.A.3    Barton, C.4
  • 79
    • 0036826863 scopus 로고    scopus 로고
    • Combined blockade of both μ-and κ-opioid receptors prevents the acute orexigenic action of agouti-related protein
    • BRUGMAN S, CLEGG DJ, WOODS SC, SEELEY RJ: Combined blockade of both μ-and κ-opioid receptors prevents the acute orexigenic action of agouti-related protein. Endocrinology (2002) 143 4265-4270.
    • (2002) Endocrinology , vol.143 , pp. 4265-4270
    • Brugman, S.1    Clegg, D.J.2    Woods, S.C.3    Seeley, R.J.4
  • 80
    • 0038779278 scopus 로고    scopus 로고
    • 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro
    • SETOLA V, HUFEISEN SJ, GRANDE-ALLEN KJ et al.: 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro. Mol. Pharmacol. (2003) 63 1223-1229.
    • (2003) Mol. Pharmacol. , vol.63 , pp. 1223-1229
    • Setola, V.1    Hufeisen, S.J.2    Grande-Allen, K.J.3
  • 81
    • 0028959193 scopus 로고
    • Changes in energy expenditure resulting from altered body weight
    • LEIBEL RL, ROSENBAUM M, HIRSCH J: Changes in energy expenditure resulting from altered body weight. N. Engl. J. Med. (1995) 332:621-628.
    • (1995) N. Engl. J. Med. , vol.332 , pp. 621-628
    • Leibel, R.L.1    Rosenbaum, M.2    Hirsch, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.