Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 98, Issue 8, 2001, Pages 4652-4657

  Lambert, P D ^a   Anderson, K D ^a   Sleeman, M W ^a   Wong, V ^b   Tan, J ^a   Hijarunguru, A ^a   Corcoran, T L ^a   Murray, J D ^a   Thabet, K E ^a   Yancopoulos, G D ^a   Wiegand, S J ^a  

^a REGENERON PHARMACEUTICALS INC   (United States)

^b PhytoMedica Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; CYCLOOXYGENASE 2; INTERLEUKIN 1; LEPTIN; LEPTIN RECEPTOR; NEUROPEPTIDE Y; RECOMBINANT CILIARY NEUROTROPHIC FACTOR; RNA; STAT3 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; CACHEXIA; CONTROLLED STUDY; DRUG MECHANISM; FOOD INTAKE; HYPOTHALAMUS NUCLEUS; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; TASTE AVERSION; WEIGHT GAIN; WEIGHT REDUCTION;

ADIPOSE TISSUE; ANIMALS; CACHEXIA; CILIARY NEUROTROPHIC FACTOR; CORTICOSTERONE; DNA-BINDING PROTEINS; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-1; LEPTIN; MALE; MICE; MICE, INBRED C57BL; OBESITY; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; WEIGHT GAIN; WEIGHT LOSS;

ANIMALIA;

EID: 0035836760     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.061034298     Document Type: Article

References (34)