Chronic administration of nalmefene leads to increased food intake and body weight gain in mice

European Journal of Pharmacology

Volumn 495, Issue 1, 2004, Pages 63-66

  Chen, Richard Z ^a   Huang, Ruey Ruey C ^a   Shen, Chun Pyn ^a   MacNeil, Douglas J ^a   Fong, Tung M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Body weight; Food intake; Nalmefene; Opioid receptor antagonist

Indexed keywords

NALMEFENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY COMPOSITION; BODY WEIGHT; CONTROLLED STUDY; DRUG EFFECT; FOOD INTAKE; LIPID STORAGE; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; WEIGHT GAIN;

ADMINISTRATION, ORAL; ANIMALS; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG EVALUATION, PRECLINICAL; EATING; ENERGY INTAKE; INTUBATION, GASTROINTESTINAL; MALE; MICE; MICE, INBRED C57BL; NALTREXONE; RECEPTORS, OPIOID; TIME FACTORS; WEIGHT GAIN;

EID: 3042631016     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.05.025     Document Type: Article

References (28)

1. Bailey A., Hawkins R.M., Hourani S.M., Kitchen I. Quantitative autoradiography of adenosine receptors in brains of chronic naltrexone-treated mice. Br. J. Pharmacol. 139:2003;1187-1195
2. Billington C.J., Morley J.E., Levine A.S., Wright F., Seal U.S. Naloxone induced suppression of feeding in tigers. Physiol. Behav. 34:1985;641-643
3. Chen R.Z., Huang R.-R., Shen C.P., MacNeil D.J., Fong T.M. Synergistic effects of cannabinoid inverse agonist AM251 and opioid antagonist nalmefene on food intake in mice. Brain Res. 999:2004;227-230
4. Deviche P., Wohland A. Opiate antagonists stereoselectively attenuate the consumption of food but not of water by pigeons. Pharmacol. Biochem. Behav. 21:1984;507-512
5. de Zwaan M., Mitchell J.E. Opiate antagonists and eating behavior in humans: a review. J. Clin. Pharmacol. 32:1992;1060-1072
6. Dixon R., Howes J., Gentile J., Hsu H.B., Hsiao J., Garg D., Weidler D., Meyer M., Tuttle R. Nalmefene: intravenous safety and kinetics of a new opioid antagonist. Clin. Pharmacol. Ther. 39:1986;49-53
7. Dixon R., Gentile J., Hsu H.B., Hsiao J., Howes J., Garg D., Weidler D. Nalmefene: safety and kinetics after single and multiple oral doses of a new opioid antagonist. J. Clin. Pharmacol. 27:1987;233-239
8. Ferguson-Segall M., Flynn J.J., Walker J., Margules D.L. Increased immunoreactive dynorphin and leu-enkephalin in posterior pituitary of obese mice (ob/ob) and super-sensitivity to drugs that act at kappa receptors. Life Sci. 31:1982;2233-2236
9. Glass M.J., Billington C.J., Levine A.S. Opioids and food intake: distributed functional neural pathways? Neuropeptides. 33:1999;360-368
10. Glass M.J., Briggs J.E., Billington C.J., Kotz C.M., Levine A.S. Opioid receptor blockade in rat nucleus tractus solitarius alters amygdala dynorphin gene expression. Am. J. Physiol., Regul. Integr. Comp. Physiol. 283:2002;R161-R167
11. Herve C., Fellmann D. Changes in rat melanin-concentrating hormone and dynorphin messenger ribonucleic acids induced by food deprivation. Neuropeptides. 31:1997;237-242
12. Lesscher H.M., Bailey A., Burbach J.P., Van Ree J.M., Kitchen I., Gerrits M.A. Receptor-selective changes in mu-, delta- and kappa-opioid receptors after chronic naltrexone treatment in mice. Eur. J. Neurosci. 17:2003;1006-1012
13. Levine A.S., Grace M., Billington C.J., Gosnell B.A., Krahn D.D., Brown D.M., Morley J.E. Effect of morphine and nalmefene on energy balance in diabetic and non-diabetic rats. Pharmacol. Biochem. Behav. 29:1988;495-500
14. Margules D.L., Moisset B., Lewis M.J., Shibuya H., Pert C.B. Beta-Endorphin is associated with overeating in genetically obese mice (ob/ob) and rats (fa/fa). Science. 202:1978;988-991
15. Marks-Kaufman R., Balmagiya T., Gross E. Modifications in food intake and energy metabolism in rats as a function of chronic naltrexone infusions. Pharmacol. Biochem. Behav. 20:1984;911-916
16. Mason B.J., Salvato F.R., Williams L.D., Ritvo E.C., Cutler R.B. A double-blind, placebo-controlled study of oral nalmefene for alcohol dependence. Arch. Gen. Psychiatry. 56:1999;719-724
17. McLaughlin C.L., Baile C.A. Nalmefene decreases meal size, food and water intake and weight gain in Zucker rats. Pharmacol. Biochem. Behav. 19:1983;235-240
18. McLaughlin C.L., Baile C.A., Gingerich R.L., Michel M.E. Influence of nalmefene on energy balance and glucose regulation in Zucker rats. Physiol. Behav. 37:1986;899-908
19. Murthy S.S., Mathur C., Kvalo L.T., Lessor R.A., Wilhelm J.A. Disposition of the opioid antagonist, nalmefene, in rat and dog. Xenobiotica. 26:1996;779-792
20. Reid L.D. Endogenous opioid peptides and regulation of drinking and feeding. Am. J. Clin. Nutr. 42:1985;1099-1132
21. Sanger D.J., McCarthy P.S. Increased food and water intake produced in rats by opiate receptor agonists. Psychopharmacology (Berl.). 74:1981;217-220
22. Shaw W.N. Long-term treatment of obese Zucker rats with LY255582 and other appetite suppressants. Pharmacol. Biochem. Behav. 46:1993;653-659
23. Shaw W.N., Mitch C.H., Leander J.D., Mendelsohn L.G., Zimmerman D.M. The effect of the opioid antagonist LY255582 on body weight of the obese Zucker rat. Int. J. Obes. 15:1991;387-395
24. Statnick M.A., Tinsley F.C., Eastwood B.J., Suter T.M., Mitch C.H., Heiman M.L. Peptides that regulate food intake: antagonism of opioid receptors reduces body fat in obese rats by decreasing food intake and stimulating lipid utilization. Am. J. Physiol., Regul. Integr. Comp. Physiol. 284:2003;R1399-R1408
25. Welch C.C., Kim E.M., Grace M.K., Billington C.J., Levine A.S. Palatability-induced hyperphagia increases hypothalamic dynorphin peptide and mRNA levels. Brain Res. 721:1996;126-131
26. Yeomans M.R., Gray R.W. Opioid peptides and the control of human ingestive behaviour. Neurosci. Biobehav. Rev. 26:2002;713-728
27. Yeomans M.R., Wright P., Macleod H.A., Critchley J.A. Effects of nalmefene on feeding in humans. Dissociation of hunger and palatability. Psychopharmacology (Berl.). 100:1990;426-432
28. Zimmerman D.M., Leander J.D. Opioid antagonists: structure activity relationships. NIDA Res. Monogr. 96:1990;50-60