Cholecystokinin: Proofs and prospects for involvement in control of food intake and body weight

Neuropeptides

Volumn 33, Issue 5, 1999, Pages 387-399

  Ritter, R C ^a   Covasa, M ^a   Matson, C A ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLECYSTOKININ; CHOLECYSTOKININ A RECEPTOR;

ANIMAL EXPERIMENT; BODY WEIGHT; CONTROLLED STUDY; FOOD INTAKE; MEAL; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; REVIEW; VAGUS NERVE;

ANIMALIA;

EID: 0032754965     PISSN: 01434179     EISSN: None     Source Type: Journal    
DOI: 10.1054/npep.1999.0051     Document Type: Article

References (120)

1. Ivy A. C., Oldberg E. A hormone mechanism for gallbladder contraction and evacuation. Am J Physiol. 86:1928;599-613.
2. Jorpes J. E. On the biological activity and amino acid composition of secretin. Acta Chem Scand. 15:1961;1790-1791.
3. Jorpes J. E., Mutt V., Toczko K. Further purification of cholecystokinin and pancreozymin. Acta Chem Scand. 18:1964;2408-2410.
4. Jorpes J. E. Isolation and chemistry of secretin and cholecystokinin. Gastroenterology. 55:1968;157-164.
5. Buffa R., Solcia E., Go V. L. Immunohistochemical identification of the cholecystokinin cell in the intestinal mucosa. Gastroenterology. 70:1976;528-532.
6. Polak J. M., Bloom S. R., Rayford P. L., Pearse A. G., Buchan A. M., Thompson J. C. Identification of cholecystokinin-secreting cells. Lancet. 2:1975;1016-1018.
7. Konturek S. J., Radecki T., Mikos E., Thor J. The effect of exogenous and endogenous secretin and cholecystokinin on pancreatic secretion in cats. Scand J Gastroenterol. 6:1971;423-428.
8. MacLagan N. F. The role of appetite in the control of body weight. J Physiol. 90:1937;385-394.
9. Gibbs J., Young R. C., Smith G. P. Cholecystokinin decreases food intake in rats. J Comp Physiol Psychol. 84:1973;488-495.
10. Smith G. P., Jerome C., Cushin B. J., Eterno R., Simansky K. J. Abdominal vagotomy blocks the satiety effect of cholecystokinin in the rat. Science. 213:1981;1036-1037.
11. Ritter S., Dinh T. T. Capsaicin-induced neuronal degeneration: silver impregnation of cell bodies, axons, and terminals in the central nervous system of the adult rat. J Comp Neurol. 271:1988;79-90.
12. Ritter R. C., Ladenheim E. E. Capsaicin pretreatment attenuates suppression of food intake by cholecystokinin. Am J Physiol. 248:1985;R501-R504.
13. Ritter R. C., Ritter S., Ewart W. R., Wingate D. L. Capsaicin attenuates hindbrain neuron responses to circulating cholecystokinin. Am J Physiol. 257:1989;R1162-R1168.
14. Mercer J. G., Farningham D. A., Lawrence C. B. Effect of neonatal capsaicin treatment on cholecystokinin-(CCK8) satiety and axonal transport of CCK binding sites in the rat vagus nerve. Brain Res. 569:1992;311-316.
15. South E. H., Ritter R. C. Capsaicin application to central or peripheral vagal fibers attenuates CCK satiety. Peptides. 9:1988;601-612.
16. Smith G. P., Jerome C., Norgren R. Afferent axons in abdominal vagus mediate satiety effect of cholecystokinin in rats. Am J Physiol. 249:1985;R638-R641.
17. Le-Sauter J. G. B. G. N. CCK inhibits real and sham feeding in gastric vagotomized rats. Physiol Behav. 44:1988;527-534.
18. Le-Sauter J. G. N. Redundant vagal mediation of the synergistic satiety effect of pancreatic glucagon and cholecystokinin in sham feeding rats. J Auton Nerv Syst. 30:1990;13-22.
19. Moran T. H., Smith G. P., Hostetler A. M., McHugh P. R. Transport of cholecystokinin (CCK) binding sites in subdiaphragmatic vagal branches. Brain Res. 415:1987;149-152.
20. Berthoud H. R., Carlson N. R., Powley T. L. Topography of efferent vagal innervation of the rat gastrointestinal tract. Am J Physiol. 260:1991;R200-R207.
21. Zittel T. T., Elm B. V., Teichmann R. K., Becker H. D., Raybould H. E. Cholecystokinin inhibits food intake at a peripheral extragastric site. Ann N Y Acad Sci. 713:1994;431-434.
22. Richards W., Hillsley K., Eastwood C., Grundy D. Sensitivity of vagal mucosal afferents to cholecystokinin and its role in afferent signal transduction in the rat. J Physiol Lond. 497:1996;473-481.
23. Davison J. S., Clarke G. D. Mechanical properties and sensitivity to CCK of vagal gastric slowly adapting mechanoreceptors. Am J Physiol. 255:1988;G55-G61.
24. Schwartz G. J., McHugh P. R., Moran T. H. Integration of vagal afferent responses to gastric loads and cholecystokinin in rats. Am J Physiol. 261:1991;R64-R69.
25. Schwartz G. J., McHugh P. R., Moran T. H. Gastric loads and cholecystokinin synergistically stimulate rat gastric vagal afferents. Am J Physiol. 265:1993;R872-R876.
26. Wank S. A., Pisegna J. R., de-Weerth A. Brain and gastrointestinal cholecystokinin receptor family: structure and functional expression. Proc Natl Acad Sci U S A. 89:1992;8691-8695.
27. Melville L. D., Smith G. P., Gibbs J. Devazepide antagonizes the inhibitory effect of cholecystokinin on intake in sham-feeding rats. Pharmacol Biochem Behav. 43:1992;975-977.
28. Moran T. H., Ameglio P. J., Schwartz G. J., McHugh P. R. Blockade of type A, not type B, CCK receptors attenuates satiety actions of exogenous and endogenous CCK. Am J Physiol. 262:1992;R46-R50.
29. Brenner L. A., Ritter R. C. Intracerebroventricular cholecystokinin A-receptor antagonist does not reduce satiation by endogenous CCK. Physiol Behav. 63:1998;711-716.
30. Corp E. S., Curcio M., Gibbs J., Smith G. P. The effect of centrally administered CCK-receptor antagonists on food intake in rats. Physiol Behavior. 61:1997;823-827.
31. Brenner L., Ritter R. C. Peptide cholecystokinin receptor antagonist increases food intake in rats. Appetite. 24:1995;1-9.
32. Moran T. H., Robinson P. H., Goldrich M. S., McHugh P. R. Two brain cholecystokinin receptors: implications for behavioral actions. Brain Res. 362:1986;175-179.
33. Moran T. H., Norgren R., Crosby R. J., McHugh P. R. Central and peripheral vagal transport of cholecystokinin binding sites occurs in afferent fibers. Brain Res. 526:1990;95-102.
34. Hill D. R., Campbell N. J., Shaw T. M., Woodruff G. N. Autoradiographic localization and biochemical characterization of peripheral type CCK receptors in rat CNS using highly selective nonpeptide CCK antagonists. J Neurosci. 7:1987;2967-2976.
35. Hill D. R., Woodruff G. N. Differentiation of central cholecystokinin receptor binding sites using the non-peptide antagonists MK-329 and L-365,260. Brain Res. 526:1990;276-283.
36. Ladenheim E. E., Speth R. C., Ritter R. C. Reduction of CCK-8 binding in the nucleus of the solitary tract in unilaterally nodosectomized rats. Brain Res. 474:1988;125-129.
37. Ladenheim E. E., Speth R. C., Ritter R. C. Reduction of CCK-8 binding in the nucleus of the solitary tract of capsaicin pretreated rats. Soc Neurosci Abstr. 12:1986;828.
38. Moriarty P., Dimaline R., Thompson D. G., Dockray G. J. Characterization of cholecystokinin-A and cholecystokinin-B receptors expressed by vagal afferent neurons. Neuroscience. 79:1997;905-913.
39. Ritter, R. C. Brenner, L. A. Tamura, C. S. Exogenous CCK and the peripheral nerual substrates of intestinal satiety. Reeve, J. R. Cholecystokinin. Ann NY Acad Sci, 1993, 255, 267.
40. Beart P. M., Krstew E., Widdop R. E. Electrophysiological studies of the cholecystokininA receptor antagonists SR27897B and PD140548 in the rat isolated nodose ganglion. Naunyn Schmiedebergs Arch Pharmacol. 353:1996;693-697.
41. Widdop R. E., Krstew E., Mercer L. D., Carlberg M., Beart P. M., Jarrott B. Electrophysiological and autoradiographical evidence for cholecystokinin A receptors on rat isolated nodose ganglia. J Auton Nerv Syst. 46:1994;65-73.
42. Della-Fera M. A., Baile C. A. CCK-octapeptide injected in CSF decreases meal size and daily food intake in sheep. Peptides. 1:1980;51-54.
43. Schick R. R., Stevens C. W., Yaksh T. L., Go V. L. Chronic intraventricular administration of cholecystokinin octapeptide (CCK-8) suppresses feeding in rats. Brain Res. 448:1988;294-298.
44. Schick R. R., Yaksh T. L., Go V. L. Intracerebroventricular injections of cholecystokinin octapeptide suppress feeding in rats - pharmacological characterization of this action. Regul Pept. 14:1986;277-291.
45. Della-Fera M. A., Baile C. A., Peikin S. R. Feeding elicited by injection of the cholecystokinin antagonist dibutyryl cyclic GMP into the cerebral ventricles of sheep. Physiol Behav. 26:1981;799-801.
46. Woltman T., Reidelberger R. Role of cholecystokinin in the anorexia produced by duodenal delivery of peptone in rats. Am J Physiol. 45:1999;R1701-R1709.
47. Dorr'e D., Smith G. P. Cholecystokinin B receptor antagonist increases food intake in rats. Physiol Behav. 65:1998;11-14.
48. Weller A., Corp E. S., Tyrka A., Ritter R. C., Brenner L., Gibbs J., Smith G. P. Trypsin inhibitor and maternal reunion increase plasma cholecystokinin in neonatal rats. Peptides. 13:1992;939-941.
49. Brenner L., Yox D. P., Ritter R. C. Suppression of sham feeding by intraintestinal nutrients is not correlated with plasma cholecystokinin elevation. Am J Physiol. 264:1993;R972-R976.
50. Liddle R. A., Green G. M., Conrad C. K., Williams J. A. Proteins but not amino acids, carbohydrates, or fats stimulate cholecystokinin secretion in the rat. Am J Physiol. 251:1986;G243-G248.
51. Iwai K., Fushiki T., Fukuoka S. Pancreatic enzyme secretion mediated by novel peptide: monitor peptide hypothesis. Pancreas. 3:1988;720-728.
52. Lin Y. Z., Isaac D. D., Tam J. P. Synthesis and properties of cholecystokinin-releasing peptide (monitor peptide), a 61-residue trypsin inhibitor. Int J Pept Protein Res. 36:1990;433-439.
53. Fukuda M., Fujiyama Y., Sasaki M., Andoh A., Bamba T., Fushiki T. Monitor peptide (rat pancreatic secretory trypsin inhibitor) directly stimulates the proliferation of the nontransformed intestinal epithelial cell line, IEC-6. Digestion. 59:1998;326-330.
54. Spannagel A. W., Reeve J. R. Jr, Greeley G. H. Jr, Yanaihara N., Liddle R. A., Green G. M. Bioactivity of intraduodenally and intravenously infused fragments of luminal cholecystokinin releasing factor (LCRF). Regul Pept. 73:1998;161-164.
55. Spannagel A. W., Green G. M., Guan D., Liddle R. A., Faull K., Reeve J. R. Jr. Purification and characterization of a luminal cholecystokinin-releasing factor from rat intestinal secretion. Proc Natl Acad Sci USA. 93:1996;4415-4420.
56. Tarasova N., Spannagel A. W., Green G. M., Gomez G., Reed J. T., Thompson J. C., Hellmich M. R., Reeve J. R. Jr, Liddle R. A., Greeley G. H. Jr. Distribution and localization of a novel cholecystokinin-releasing factor in the rat gastrointestinal tract. Endocrinology. 138:1997;5550-5554.
57. Raybould H. E., Meyer J. H., Tabriz Y., Liddle R. A., Tso P. Inhibition of gastric emptying in response to intestinal lipid is dependent on chylomicron formation. Am J Physiol. 274:1998;R1834-R1838.
58. Ballinger A. B., Clark M. L. L-phenylalanine releases cholecystokinin (CCK) and is associated with reduced food intake in humans: evidence for a physiological role of CCK in control of eating. Metabolism. 43:1994;735-738.
59. Yox D. P., Ritter R. C. Capsaicin attenuates suppression of sham feeding induced by intestinal nutrients. Am J Physiol. 255:1988;R569-R574.
60. Yox D. P., Stokesberry H., Ritter R. C. Fourth ventricular capsaicin attenuates suppression of sham feeding induced by intestinal nutrients. Am J Physiol. 260:1991;R681-R687.
61. Yox D. P., Stokesberry H., Ritter R. C. Vagotomy attenuates suppression of sham feeding induced by intestinal nutrients. Am J Physiol. 260:1991;R503-R508.
62. Walls E. K., Phillips R. J., Wang F. B., Holst M. C., Powley T. L. Suppression of meal size by intestinal nutrients is eliminated by celiac vagal deafferentation. Am J Physiol. 38:1995;R1410-R1419.
63. Brenner L. A., Ritter R. C. Type A CCK receptors mediate satiety effects of intestinal nutrients. Pharmacol Biochem Behav. 54:1996;625-631.
64. Yox D. P., Brenner L., Ritter R. C. CCK-receptor antagonists attenuate suppression of sham feeding by intestinal nutrients. Am J Physiol. 262:1992;R554-R561.
65. Greenberg D., Torres G. P., Smith G. P., Gibbs J. The satiating effects of fats is attenuated by the cholecystokinin antagonist lorglumide. Ann N Y Acad Sci. 575:1989;517-520.
66. Woltman T., Castellanos D., Reidelberger R. Role of cholecystokinin in the anorexia produced by duodenal delivery of oleic acid in rats. Am J Physiol. 269:1995;R1420-R1433.
67. Woltman T. A., Reidelberger R. D. Effects of CCK-A antagonist devazepide on inhibition of feeding by duodenal infusion of oleic acid in rats. Ann N Y Acad Sci. 713:1994;372-373.
68. Lieverse R. J., Jansen J. B., Masclee A. A., Rovati L. C., Lamers C. B. Effect of a low dose of intraduodenal fat on satiety in humans: studies using the type A cholecystokinin receptor antagonist loxiglumide. Gut. 35:1994;501-505.
69. Trigazis L., Orttmann A., Anderson G. H. Effect of a cholecystokinin-A receptor blocker on protein-induced food intake suppression in rats. Am J Physiol. 272:1997;R1826-R1833.
70. Moran T. H., Field D. G., Knipp S., Carrigan T. S., Schwartz G. J. Endogenous CCK in the control of gastric emptying of glucose and maltose. Peptides. 18:1997;547-550.
71. Greenberg D., Smith G. P., Gibbs J. Infusion of CCK-8 into hepatic-portal vein fails to reduce food intake in rats. Am J Physiol. 252:1987;R1015-R1018.
72. Ritter R. C., Brenner L. A., Tamura C. S. Endogenous CCK and the peripheral neural substrates of intestinal satiety. Ann N Y Acad Sci. 713:1994;255-267.
73. Greenberg D., Smith G. P. Hepatic-portal infusion reduces the satiating potency of CCK-8. Physiol Behav. 44:1988;535-538.
74. Turkelson C. M., Solomon T. E. Molecular forms of cholecystokinin in rat intestine. Am J Physiol. 259:1990;G364-G371.
75. Smith G. P., Dorr'e D., Melville L. CCK-33 inhibits food intake after intraportal and intravenous administration. Soc Neurosci Abstr. 22:1996;17.
76. Kanayama S., Himeno S., Yamasaki Y., Shinomura Y., Kitani T., Tarui S. Effect of synthetic trypsin inhibitor on plasma immunoreactive cholecystokinin in rats. Gastroenterol Jpn. 22:1987;211-217.
77. Folsch U. R., Cantor P., Wilms H. M., Schafmayer A., Becker H. D., Creutzfeldt W. Role of cholecystokinin in the negative feedback control of pancreatic enzyme secretion in conscious rats. Gastroenterology. 92:1987;449-458.
78. Smith G. P., Greenberg D., Falasco J. D., Avilion A. A., Gibbs J., Liddle R. A., Williams J. A. Endogenous cholecystokinin does not decrease food intake or gastric emptying in fasted rats. Am J Physiol. 257:1989;R1462-R1466.
79. Garlicki J., Konturek P. K., Majka J., Kwiecien N., Konturek S. J. Cholecystokinin receptors and vagal nerves in control of food intake in rats. Am J Physiol. 258:1990;E40-E45.
80. Weller A., Smith G. P., Gibbs J. Endogenous cholecystokinin reduces feeding in young rats. Science. 247:1990;1589-1591.
81. Moran T. H., Ameglio P. J., Peyton H. J., Schwartz G. J., McHugh P. R. Blockade of type A, but not type B, CCK receptors postpones satiety in rhesus monkeys. Am J Physiol. 265:1993;R620-R624.
82. Strohmayer A. J., Greenberg D. Devazepide alters meal patterns in lean, but not obese, male Zucker rats. Physiol Behav. 56:1994;1037-1039.
83. Reidelberger R. D., Varga G., Solomon T. E. Effects of selective cholecystokinin antagonists L364,718 and L365,260 on food intake in rats. Peptides. 12:1991;1215-1221.
84. Cox J. E. Cholecystokinin satiety involves CCKA receptors perfused by the superior pancreaticoduodenal artery. Am J Physiol. 274:1998;R1390-R1396.
85. Reidelberger R. D. Abdominal vagal mediation of the satiety effects of exogenous and endogenous cholecystokinin in rats. Am J Physiol. 263:1992;R1354-R1358.
86. Ritter R. C., Malbasa Z. CCK-A receptor antagonist increases food intake in capsaicin-treated rats. Soc Neurosci Abstr. 21:1995;460.
87. Miller L. J., Holicky E. L., Ulrich C. D., Wieben E. D. Abnormal processing of the human cholecystokinin receptor gene in association with gallstones and obesity. Gastroenterology. 109:1995;1375-1380.
88. Schneider H., Sanger P., Hanisch E. In vitro effects of cholecystokinin fragments on human gallbladders. Evidence for an altered CCK-receptor structure in a subgroup of patients with gallstones. J Hepatol. 26:1997;1063-1068.
89. Kopin A. S., Mathes W. F., McBride E. W., Nguyen M., Al-Haider W., Schmitz F., Bonner-Weir S., Kanarek R., Beinborn M. The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight. J Clin Invest. 103:1999;383-391.
90. Nakamura H., Kihara Y., Tashiro M., Kanagawa K., Shirohara H., Yamamoto M., Yoshikawa H., Fukumitsu K., Hirohata Y., Otsuki M. Defects of cholecystokinin (CCK)-A receptor gene expression and CCK-A receptor-mediated biological functions in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. J Gastroenterol. 33:1998;702-709.
91. Funakoshi A., Miyasaka K., Jimi A., Kawanai T., Takata Y., Kono A. Little or no expression of the cholecystokinin-A receptor gene in the pancreas of diabetic rats (Otsuka Long-Evans Tokushima Fatty = OLETF rats). Biochem Biophys Res Commun. 199:1994;482-488.
92. Moran T. H., Katz L. F., Plata-Salaman C. R., Schwartz G. J. Disordered food intake and obesity in rats lacking cholecystokinin A receptors. Am J Physiol. 274:1998;R618-R625.
93. West D. B., Greenwood M. R., Sullivan A. C., Prescod L., Marzullo L. R., Triscari J. Infusion of cholecystokinin between meals into free-feeding rats fails to prolong the intermeal interval. Physiol Behav. 39:1987;111-115.
94. Wisner J. R. Jr, Ozawa S., Xue B. G., Renner I. G. Chronic administration of a potent cholecystokinin receptor antagonist, L-364,718, fails to inhibit pancreas growth in preweanling rats [see comments]. Pancreas. 5:1990;434-438.
95. Pekas J. C., Trou W. E. Stimulation of food intake and growth of swine by cholecystokinin immunization. Growth Dev Aging. 54:1990;51-56.
96. Pekas J. C. Effect of cholecystokinin immunization, enhanced food intake and growth of swine on lean yield and carcass composition. J Nutr. 121:1991;563-567.
97. Dulawa S. C., Vanderweele D. A. Cholecystokinin and estradiol synergistically potentiate satiety in rats. Peptides. 15:1994;913-918.
98. Geary N., Trace D., McEwen B., Smith G. P. Cyclic estradiol replacement increases the satiety effect of CCK-8 in ovariectomized rats. Physiol Behav. 56:1994;281-289.
99. Hinton V., Rosofsky M., Granger J., Geary N. Combined injection potentiates the satiety effects of pancreatic glucagon, cholecystokinin and bombesin. Brain Res Bull. 17:1986;615-619.
100. Reidy C. A., Chavez M., Figlewicz D. P., Woods S. C. Central insulin enhances sensitivity to cholecystokinin. Physiol Behav. 58:1995;755-760.
101. Figlewicz D. P., Stein L. J., West D., Porte D. Jr, Woods S. C. Intracisternal insulin alters sensitivity to CCK-induced meal suppression in baboons. Am J Physiol. 250:1986;R856-R860.
102. Barrachina M. D., Martinez V., Wang L., Wei J. Y., Tache Y. Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice. Proc Natl Acad Sci USA. 94:1997;10,455-10,460.
103. Emond M., Schwartz G. J., Ladenheim E. E., Moran T. H. Central leptine modulates behavioral and neural responsivity to CCK. Am J Physiol. 276:1999;R1545-R1549.
104. Matson C. A., Wiater M. F., Kuijper J. L., Weigle D. S. Synergy between leptin and cholecystokinin (CCK) to control daily caloric intake. Peptides. 18:1997;1275-1278.
105. Matson C. S., Ritter R. C. Long-term CCK-leptin synergy suggests a role for CCK in the regulation of body weight. Am J Physiol. 276:1999;R1038-R1045.
106. Sabb J. E., Godfrey P. M., Brannon P. M. Adaptive response of rat pancreatic lipase to dietary fat: effects of amount and type of fat. J Nutr. 116:1986;892-899.
107. Karasov W. H., Diamond J. M. Adaptation of intestinal nutrient transport. Johnson L. R. Physiology of the Gastrointestinal Tract, Second edn. 1987;1489-1497 Raven Press, New York.
108. Spannagel A. W., Nakano I., Tawil T., Chey W. Y., Liddle R. A., Green G. M. Adaptation to fat markedly increases pancreatic secretory response to intraduodenal fat in rats. Am J Physiol. 270:1996;G128-G135.
109. Singh A., Balint J. A., Edmonds R. H., Rodgers J. B. Adaptive changes of the rat small intestine in response to a high fat diet. Biochim Biophys Acta. 260:1972;708-715.
110. Balint J. A., Fried M. B., Imai C. Ileal uptake of oleic acid: evidence for adaptive response to high fat feeding. Am J Clin Nutr. 33:1980;2276-2280.
111. Brenner L. A., Covasa M., Ritter R. C. Dietary adaptation increases digestive capacity and decreases satiety response to macronutrients. Soc Neurosci Abstr. 23:1997;253.
112. Covasa M., Ritter R. C. Reduced fos expression in enteric and hindbrain neurons of rats maintained on high fat diet following intestinal oleate infusion. Soc Neurosci Abstr. 24:1998;1440.
113. Covasa M., Ritter R. C. Rats maintained on high-fat diets exhibit reduced satiety in response to CCK and bombesin. Peptides. 19:1998;1407-1415.
114. French S. J., Murray B., Rumsey R. D., Fadzlin R., Read N. W. Adaptation to high-fat diets: effects on eating behaviour and plasma cholecystokinin. Br J Nutr. 73:1995;179-189.
115. Cunningham K. M., Daly J., Horowitz M., Read N. W. Gastrointestinal adaptation to diets of differing fat composition in human volunteers. Gut. 32:1991;483-486.
116. Raybould H. E., Tache Y. Cholecystokinin inhibits gastric motility and emptying via a capsaicin-sensitive vagal pathway in rats. Am J Physiol. 255:1988;G242-G246.
117. Raybould H. E. Capsaicin-sensitive vagal afferents and CCK in inhibition of gastric motor function induced by intestinal nutrients. Peptides. 12:1991;1279-1283.
118. Covasa M., Grahn J., Ritter R. C. Attenuated cholecystokinin satiety and hindbrain Fos expression following adaptation to high fat diet in rats. Soc Neurosci Abstr. 23:1997;1047.
119. Covasa M., Ritter R. C. Reduced sensitivity to the satiating effect of intestinal oleate in rats adapted to high fat diet. Am J Physiol. 277:1999;R279-R285.
120. Lin L., York D. A. Chronic ingestion of dietary fat is a prerequisite for inhibition of feeding by enterostatin. Am J Physiol. 275:1998;R619-R623.