Cannabinoid antagonist SR-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CB1 or CB2 receptors

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 287, Issue 2 56-2, 2004, Pages

  Bátkai, Sándor ^a   Pacher, Pál ^a   Járai, Zoltán ^a,b   Wagner, Jens A ^a,c   Kunos, George ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Cannabinoids; Endotoxin; Negative inotropy

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; ANANDAMIDE; CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; ENDOTOXIN; LIPOPOLYSACCHARIDE; PENTOBARBITAL; RIMONABANT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOSYNTHESIS; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; ENDOTOXEMIA; HEART MUSCLE CONTRACTILITY; HEMODYNAMICS; HYPOTENSION; INOTROPISM; KNOCKOUT MOUSE; MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TACHYCARDIA; VASCULAR RESISTANCE;

ANIMALS; CANNABINOIDS; ENDOTOXINS; HEART; HEART RATE; HEMODYNAMIC PROCESSES; HYPOTENSION; MALE; MICE; MICE, KNOCKOUT; MYOCARDIAL CONTRACTION; PIPERIDINES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; VASCULAR RESISTANCE;

EID: 17144470921     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00184.2004     Document Type: Article

References (51)

1. Araujo CV, Barbosa-Filho JM, Cordeiro RS, and Tibirica E. Protective effects of yangambin on cardiovascular hyporeactivity to catecholamines in rats with endotoxin-induced shock. Naunyn Schmiedebergs Arch Pharmacol 363: 267-275, 2001.
2. 1 receptors mediate the vasodilated state in advanced liver cirrhosis. Nat Med 7: 827-832, 2001.
3. Bátkai S, Pacher P, Osei-Hyiaman D, Radaeva S, Offertáler L, Bukoski RD, and Kunos G. Endocannabinoids are involved in regulating cardiovascular function in spontaneously hypertensive rats (Abstract). Hypertension 42: A263, 2003.
4. Benowitz NL and Jones RT. Cardiovascular effects of prolonged Δ-9-tetrahydro-cannabinol ingestion. Clin Pharmacol Ther 18: 287-297, 1975.
5. 1 receptors decrease contractile performance in human atrial muscle. J Cardiovasc Pharmacol 41: 657-664, 2003.
6. t) receptor antagonist, blocks the motivational and dopamine-releasing effects of nicotine in rats. Behav Pharmacol 13: 451-463, 2002.
7. Di Marzo V, Goparaju SK, Wang L, Liu J, Batkai S, Jarai Z, Fezza F, Miura GI, Palmiter RD, Sugiura T, and Kunos G. Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature 410: 822-825, 2001.
8. Ford WR, Honan SA, White R, and Hiley CR. Evidence of a novel site mediating anandamide-induced negative inotropic and coronary vasodilator responses in rat isolated hearts. Br J Pharmacol 135: 1191-1198, 2002.
9. Gardiner SM, Kemp PA, March JE, and Bennett T. Influence of FR 167653, an inhibitor of TNF-α and IL-1, on the cardiovascular responses to chronic infusions of lipopolysaccharide in conscious rats. J Cardiovasc Pharmacol 34: 64-69, 1999.
10. Gardiner SM, Kemp PA, March JE, and Bennett T. Regional haemodynamic responses to infusion of lipopolysaccharide in conscious rats: effects of pre- or post-treatment with glibenclamide. Br J Pharmacol 128: 1772-1778, 1999.
11. Gardiner SM, March JE, Kemp PA, and Bennett T. Influence of the CB1 receptor antagonist, AM 251, on the regional haemodynamic effects of WIN-55212-2 or HU 210 in conscious rats. Br J Pharmacol 136: 581-587, 2002.
12. Gatley SJ, Lan R, Pyatt B, Gifford AN, Volkow ND, and Makriyannis A. Binding of the non-classical cannabinoid CP 55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors. Life Sci 61: PL191-PL197, 1997, 1997.
13. 2+ channel current. Am J Physiol Heart Circ Physiol 276: H2085-H2093, 1999.
14. Hajos N and Freund TF. Pharmacological separation of cannabinoid sensitive receptors on hippocampal excitatory and inhibitory fibers. Neuropharmacology 43: 503-510, 2002.
15. 2, a peripheral cannabinoid receptor. Proc Natl Acad Sci USA 96: 14228-14233, 1999.
16. Herkenham M, Lynn AB, Little MD, Johnson MR, Melvin LS, de Costa BR, and Rice KC. Cannabinoid receptor localization in brain. Proc Natl Acad Sci USA 87: 1932-1936, 1990.
17. Hillard CJ. Endocannabinoids and vascular function. J Pharmacol Exp Ther 294: 27-32, 2000.
18. Ho WS and Hiley CR. Vasodilator actions of abnormal-cannabidiol in rat isolated small mesenteric artery. Br J Pharmacol 138: 1320-1332, 2003.
19. Hock CE, Yin K, and Wong PY. Effects of inhibition of nitric oxide synthase by aminoguanidine in acute endotoxemia. Am J Physiol Heart Circ Physiol 272: H843-H850, 1997.
20. 1 receptors on peripheral sympathetic nerves. Br J Pharmacol 118: 2023-2028, 1996.
21. Iwase M, Yokota M, Kitaichi K, Wang L, Takagi K, Nagasaka T, Izawa H, and Hasegawa T. Cardiac functional and structural alterations induced by endotoxin in rats: importance of platelet-activating factor. Crit Care Med 29: 609-617, 2001.
22. Járai Z, Wagner JA, Goparaju SK, Wang L, Razdan RK, Sugiura T, Zimmer AM, Bonner TI, Zimmer A, and Kunos G. Cardiovascular effects of 2-arachidonoyl glycerol in anaesthetized mice. Hypertension 35: 679-684, 2000.
23. 2 receptors. Proc Natl Acad Sci USA 96: 14136-14141, 1999.
24. 9- THC (cannabis) on cardiac performance with or without beta blockade. Circulation 53: 703-709, 1976.
25. Kunos G. Endocannabinoids as cardiovascular modulators. Chem Phys Lipids 108: 159 -168, 2002.
26. 1-like cannabinoid receptors. J Pharmacol Exp Ther 281: 1030-1037, 1997.
27. 1 receptor knockout mice. Science 283: 401- 404, 1999.
28. Liu J, Bátkai S, Pacher P, Harvey-White J, Wagner JA, Cravatt BF, Gao B, and Kunos G. Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-κB independently of platelet-activating factor. J Biol Chem 278: 45034-45039, 2003.
29. t cannabinoid receptors in vascular endothelial cells. Biochem J 346: 835-840, 2000.
30. Malinowska B, Godlewski G, Bucher B, and Schlicker E. Cannabinoid CB1 receptor-mediated inhibition of the neurogenic vasopressor response in the pithed rat. Naunyn Schmiedebergs Arch Pharmacol 356: 197-202, 1997.
31. Miura K, Yamanak S, Ebara T, Okamura M, Imanishi M, Kim S, Nakatani T, and Iwao H. Effects of nitric oxide scavenger carboxy-PTIO on endotoxin-induced alterations in systemic hemodynamics in rats. Jpn J Pharmacol 82: 261-264, 2000.
32. Mukhopadhyay S, Chapnick BM, and Howlett AC. Anandamide-induced vasorelaxation in rabbit aortic rings has two components: G protein dependent and independent. Am J Physiol Heart Circ Physiol 282: H2046-H2054, 2002.
33. Munro S, Thomas KL, and Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 365: 61-65, 1993.
34. Offertáler L, Mo FM, Bátkai S, Liu J, Begg M, Razdan RK, Martin BR, Bukoski RD, and Kunos G. Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor. Mol Pharmacol 63: 699-705, 2003.
35. Orliac ML, Peroni R, Celuch SM, and Adler-Graschinsky E. Potentiation of anandamide effects in mesenteric beds isolated from endotoxemic rats. J Pharmacol Exp Ther 304: 179-184, 2003.
36. Pacher P, Cziraki A, Mabley JG, Liaudet L, Papp L, and Szabo C. Role of poly(ADP-ribose) polymerase activation in endotoxin-induced cardiac collapse in rodents. Biochem Pharmacol 64: 1785-1791, 2002.
37. Pacher P, Liaudet L, Bai P, Mabley JG, Kaminski PM, Virag L, Deb A, Szabo E, Ungvari Z, Wolin MS, Groves JT, and Szabo C. Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction. Circulation 107: 896-904, 2003.
38. Pacher P, Liaudet L, Mabley J, Komjati K, and Szabo C. Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure. J Am Coll Cardiol 40: 1006-1016, 2002.
39. Palacios B and Pang CC. Protective effects of ethynylestradiol on the hemodynamic changes induced by lipopolysaccharide in anesthetized rats. J Cardiovasc Pharmacol 31: 479-483, 1998.
40. Rinaldi-Carmona M, Barth F, Héaulme M, Shire D, Calandra B, Congy C, Martinez S, Maruani J, Néliat G, Caput D, Ferrar P, Soubrié P, Brelière JC, and Le Fur G. SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett 350: 240-244, 1994.
41. Ros J, Claria J, To-Figueras J, Planaguma A, Cejudo-Martin P, Fernandez-Varo G, Martin-Ruiz R, Arroyo V, Rivera F, Rodes J, and Jimenez W. Endogenous cannabinoids: a new system involved in the homeostasis of arterial pressure in experimental cirrhosis in the rat. Gastroenterology 122: 85-93, 2002.
42. Sharma AC, Sam AD 2nd, Alden KJ, Moore SL, Law WR, and Ferguson JL. Central versus peripheral mediation of naloxone's perfusion effects in endotoxic rats. Shock 14: 441-446, 2000.
43. Stamm C, Cowan DB, Friehs I, Noria S, del Nido PJ, and McGowan FX Jr. Rapid endotoxin-induced alterations in myocardial calcium handling: obligatory role of cardiac TNF-α. Anesthesiology 95: 1396-1405, 2001.
44. Van Lambalgen AA, van Kraats AA, Mulder MF, van den Bos GC, Teerlink T, and Thijs LG. Organ blood flow and distribution of cardiac output in dopexamine- and dobutamine-treated endotoxemic rats. J Crit Care 8: 117-127, 1993.
45. Varga K, Lake K, Martin BR, and Kunos G. Novel antagonist implicates the CB1 cannabinoid receptor in the hypotensive action of anandamide. Eur J Pharmacol 278: 279-283, 1995.
46. Varga K, Wagner JA, Bridgen DT, and Kunos G. Platelet- and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension. FASEB J 12: 1035-1044, 1998.
47. Wagner JA, Hu K, Bauersachs J, Karcher J, Wiesler M, Goparaju SK, Kunos G, and Ertl G. Endogenous cannabinoids mediate hypotension after experimental myocardial infarction. J Am Coll Cardiol 38: 2048-2054, 2001.
48. Wagner JA, Varga K, Ellis EF, Rzigalinski BA, Martin BR, and Kunos G. Activation of peripheral CB1 cannabinoid receptors in haemorrhagic shock. Nature 390: 518-521, 1997.
49. Wang L, Liu J, Harvey-White J, Zimmer A, and Kunos G. Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice. Proc Natl Acad Sci USA 100: 1393-1398, 2003.
50. Wang Y, Liu Y, Ito Y, Hashiguchi T, Kitajima I, Yamakuchi M, Shimizu H, Matsuo S, Imaizumi H, and Maruyama I. Simultaneous measurement of anandamide and 2-arachidonoylglycerol by polymyxin B-selective adsorption and subsequent high-performance liquid chromatography analysis: increase in endogenous cannabinoids in the sera of patients with endotoxic shock. Anal Biochem 294: 73-82, 2001.
51. Zygmunt PM, Petersson J, Andersson DA, Chuang H, Sørgard M, Di Marzo V, Julius D, and Högestätt ED. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 400: 452-457, 1999.