Chronic infusion of a melanocortin receptor agonist modulates dopamine receptor binding in the rat brain

Pharmacological Research

Volumn 45, Issue 2, 2002, Pages 119-124

  Lindblom, Jonas ^a   Kask, Ants ^b   Hägg, Erik ^a   Härmark, Linda ^a   Bergström, Lena ^a   Wikberg, Jarl ^a,c  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF TARTU   (Estonia)

^c Box 591   (Sweden)

Author keywords

Melanotan II (MTII); NCQ 298; SCH 23982

Indexed keywords

DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; HORMONE RECEPTOR STIMULATING AGENT; MELANOCORTIN; MELANOCORTIN RECEPTOR; MELANOTAN II; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DOPAMINE RELEASE; DRUG EFFECT; MALE; NERVE CONDUCTION; NONHUMAN; NUCLEUS ACCUMBENS; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PUTAMEN; RAT; RECEPTOR BINDING; REGULATORY MECHANISM; SUBSTANTIA NIGRA; VENTRAL TEGMENTUM;

EID: 0036443705     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.2001.0913     Document Type: Article

References (35)

1. Vergoni AV, Bertolini A. Role of melanocortins in the central control of feeding. Eur J Pharmacol 2000; 405: 25-32.
2. Adan RA, Gispen WH. Brain melanocortin receptors: From cloning to function. Peptides 1997; 18: 1279-87.
3. Florijn WJ, Holtmaat AJ, de Lang H, Spierenburg H, Gispen WH, Versteeg DH. Peptide-induced grooming behavior and caudate nucleus dopamine release. Brain Res 1993; 625: 169-72.
4. Torre E, Celis ME. Cholinergic mediation in the ventral tegmental area of alpha-melanotropin induced excessive grooming: Changes of the dopamine activity in the nucleus accumbens and caudate putamen. Life Sci 1988; 42: 1651-7.
5. Lindblom J, Opmane B, Mutulis F, Mutule I, Petrovska R, Klusa V, Bergstrom L, Wikberg JE. The MC4 receptor mediates alpha-MSH induced release of nucleus accumbens dopamine. Neuroreport 2001; 12: 2155-8.
6. de Wied D. Behavioral pharmacology of neuropeptides related to melanocortins and the neurohypophyseal hormones. Eur J Pharmacol 1999; 375: 1-11.
7. 2 receptors in the effect of cocaine on sexual behaviour and stretching-yawning of male rats. Neuropharmacology 1997; 36: 769-77.
8. Stewart MG, Kabai P, Harrison E, Steele RJ, Kossut M, Gierdalski M, Csillag A. The involvement of dopamine in the striatum in passive avoidance training in the chick. Neuroscience 1996; 70: 7-14.
9. Szczypka MS, Rainey MA, Palmiter RD. Dopamine is required for hyperphagia in Lep(ob/ob) mice. Nat Genet 2000; 25: 102-4.
10. Traber J, Klein HR, Gispen WH. Actions of antidepressant and neuroleptic drugs on ACTH- and novelty-induced behavior in the rat. Eur J Pharmacol 1982; 80: 407-14.
11. Zhou QY, Palmiter RD. Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic. Cell 1995; 83: 1197-209.
12. Di Chiara G, Tanda G, Cadoni C, Acquas E, Bassareo V, Carboni E. Homologies and differences in the action of drugs of abuse and a conventional reinforcer (food) on dopamine transmission: An interpretative framework of the mechanism of drug dependence. Adv Pharmacol 1998; 42: 983-7.
13. Wang G-J, Volkow ND, Logan J, Pappas NR, Wong CT, Zhu W, Netusil N, Fowler JS. Brain dopamine and obesity. Lancet 2001; 357: 354-7.
14. Bray GA, Greenway FL. Current and potential drugs for treatment of obesity. Endocr Rev 1999; 20: 805-75.
15. Kordik CP, Reitz AB. Pharmacological treatment of obesity: Therapeutic strategies. J Med Chem 1999; 42: 181-201.
16. Kask A, Rago L, Wikberg JE, Schioth HB. Differential effects of melanocortin peptides on ingestive behaviour in rats: Evidence against the involvement of MC(3) receptor in the regulation of food intake. Neurosci Lett 2000; 283: 1-4.
17. Benoit SC et al. A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences. J Neurosci 2000; 20: 3442-8.
18. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. New York: Academic Press, 1997.
19. Gonzalez MI, Kalia V, Hole DR, Wilson CA. Alpha-Melanocyte-stimulating hormone (alpha-MSH) and melanin- concentrating hormone (MCH) modify monoaminergic levels in the preoptic area of the rat. Peptides 1997; 18: 387-92.
20. Oades RD, Halliday GM. Ventral tegmental (A10) system: Neurobiology. 1. Anatomy and connectivity. Brain Res 1987; 434: 117-65.
21. Koob GF. Drugs of abuse: Anatomy, pharmacology and function of reward pathways. Trends Pharmacol Sci 1992; 13: 177-84.
22. Jaber M, Robinson SW, Missale C, Caron MG. Dopamine receptors and brain function. Neuropharmacology 1996; 35: 1503-19.
23. Hauber W. Involvement of basal ganglia transmitter systems in movement initiation. Prog Neurobiol 1998; 56: 507-40.
24. Mountjoy KG, Mortrud MT, Low MJ, Simerly RB, Cone RD. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol 1994; 8: 1298-308.
25. Spruijt BM, Cools AR, Gispen WH. The periaqueductal gray: A prerequisite for ACTH-induced excessive grooming. Behav Brain Res 1986; 20: 19-25.
26. Jacquet YW, Wolf G. Morphine and ACTH(1-24): Correlative behavioral excitations following microinjections in rat periaqueductal gray. Brain Res 1981; 219: 214-8.
27. Arsenault MY, Parent A, Seguela P, Descarries L. Distribution and morphological characteristics of dopamine-immunoreactive neurons in the midbrain of the squirrel monkey (Saimiri sciureus). J Comp Neurol 1988; 267: 489-506.
28. Jurgens U, Lu CL. The effects of periaqueductally injected transmitter antagonists on forebrain-elicited vocalization in the squirrel monkey. Eur J Neurosci 1993; 5: 735-41.
29. Broberger C, Johansen J, Johansson C, Schalling M, Hokfelt T. The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc Natl Acad Sci USA 1998; 95: 15043-8.
30. Khachaturian H, Lewis ME, Tsou K, Watson SJ. Beta-endorphin, alpha-MSH, ACTH, and related peptides. In: Handbook of Chemical Neuroanatomy. GABA and Neuropeptides in the CNS. Part I, vol. 4. Björklund A, Hökfelt T, eds. Amsterdam: Elsevier, 1985: 216-72.
31. 2 dopamine receptors. J Neurochem 1988; 50: 1929-33.
32. 2 dopamine receptors in rat brain. Brain Res 1990; 532: 265-70.
33. Quirion R, Bayorh MA, Zerbe RL, Pert CB. Chronic phencyclidine treatment decreases phencyclidine and dopamine receptors in rat brain. Pharmacol Biochem Behav 1982; 17: 699-702.
34. 2 receptor mRNA expression in rat brain. Neuroscience 1992; 47: 771-9.
35. Cabib S, Giardino L, Calza L, Zanni M, Mele A, Puglisi-Allegra S. Stress promotes major changes in dopamine receptor densities within the mesoaccumbens and nigrostriatal systems. Neuroscience 1998; 84: 193-200.