Combined blockade of both μ- and κ-opioid receptors prevents the acute orexigenic action of Agouti-related protein

Endocrinology

Volumn 143, Issue 11, 2002, Pages 4265-4270

  Brugman, S ^a   Clegg, D J ^b   Woods, S C ^b   Seeley, R J ^b  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN; BETA FUNALTREXAMINE; KAPPA OPIATE RECEPTOR; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; MU OPIATE RECEPTOR; NORBINALTORPHIMINE; OPIATE ANTAGONIST; AGOUTI RELATED PROTEIN (83 132); AGOUTI-RELATED PROTEIN-(83-132); BETA-FUNALTREXAMINE; DRUG DERIVATIVE; NALTREXONE; NARCOTIC ANTAGONIST; PEPTIDE FRAGMENT;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; FAT INTAKE; FEEDING BEHAVIOR; FOOD INTAKE; GENE OVEREXPRESSION; HYPOTHALAMUS; INCREASED APPETITE; MALE; NONHUMAN; NUTRIENT CONTENT; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; DRUG EFFECT; DRUG INTERACTION; EATING; LONG EVANS RAT; PHYSIOLOGY;

ANIMALS; DRUG INTERACTIONS; EATING; MALE; NALTREXONE; NARCOTIC ANTAGONISTS; PEPTIDE FRAGMENTS; RATS; RATS, LONG-EVANS; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU;

EID: 0036826863     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2002-220230     Document Type: Article

References (51)

1. Cone RD 1999 The central melanocortin system and energy homeostasis. Trends Endocrinol Metab 10:211-216
2. Benoit SC, Schwartz MW, Baskin DG, Woods SC, Seeley RJ 2000 CNS melanocortin system involvement in the regulation of food intake and body weight. Horm Behav 37:299-308
3. Thiele T, van DG, Yagaloff K, Fisher S, Schwartz M, Burn P, Seeley R 1998 Central infusion of melanocortin agonist MTII in rats: Assessment of c-fos expression and taste aversion. Am J Physiol 274:R248-R254
4. Fan W, Boston B, Kesterson R, Hruby V, Cone R 1997 Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385: 165-168
5. Cone RD, Lu D, Koppula S, Vage DI, Klungland H, Boston B, Chen W, Orth DN, Pouton C, Kesterson RA 1996 The melanocortin receptors: Agonists, antagonists, and the hormonal control of pigmentation. Recent Prog Horm Res 51:287-320
6. Ollmann MM, Lamoreux ML, Wilson BD, Barsh GS 1998 Interaction of agouti protein with the melanocortin 1 receptor in vitro and in vivo. Genes Dev 12:316-330
7. Fong T, Mao C, MacNeil T, Kalyani R, Smith T, Weinberg D, Tota M, Van dPL 1997 ART (protein product of agouti-related transcript) as an antagonist of MC-3 and MC-4 receptors. Biochem Biophy Res Commun 237:629-631
8. Hahn TM, Breininger JF, Baskin DG, Schwartz MW 1998 Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nat Neurosci 1:271-272
9. Chen P, Li C, Haskell-Luevano C, Cone RD, Smith MS 1999 Altered expression of agouti-related protein and its colocalization with neuropeptide Y in the arcuate nucleus of the hypothalamus during lactation. Endocrinology 140: 2645-2650
10. Ollmann M, Wilson B, Yang Y, Kerns J, Chen Y, Gantz I, Barsh G 1997 Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278:135-138
11. Schwartz MW, Seeley RJ, Weigle DS, Burn P, Campfield LA, Baskin DG 1997 Leptin increases hypothalamic proopiomelanocortin (POMC) mRNA expression in the rostral arcuate nucleus. Diabetes 46:2119-2123
12. Elias CF, Aschkenasi C, Lee C, Kelly J, Ahima RS, Bjorbaek C, Flier JS, Saper CB, Elmquist JK 1999 Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 23:775-786
13. Mizuno T, Kleopoulos S, Bergen H, Roberts J, Priest C, Mobbs C 1998 Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and in ob/ob and db/db mice, but is stimulated by leptin. Diabetes 47:294-297
14. Hagan MM, Rushing PA, Pritchard LM, Schwartz MW, Strack AM, Van der Ploeg HT, Woods SC, Seeley RJ 2000 Long-term orexigenic effects of AgRP-(83-132) involve mechanisms other than melanocortin receptor blockade. Am J Physiol 279:R47-R52
15. Rossi M, Kim M, Morgan D, Small C, Edwards C, Sunter D, Abusnana S, Goldstone A, Russell S, Stanley S, Smith D, Yagaloff K, Ghatei M, Bloom S 1998 A C-terminal fragment of agouti-related protein increases feeding and antagonizes the effect of α-melanocyte stimulating hormone in vivo. Endocrinology 139:4428-4431
16. Kotz CM, Grace MK, Briggs J, Levine AS, Billington CJ 1995 Effects of opioid antagonists naloxone and naltrexone on neuropeptide Y-induced feeding and brown fat thermogenesis in the rat. Neural site of action. J Clin Invest 96: 163-170
17. Hagan MM, Rushing PA, Benoit SC, Woods SC, Seeley RJ 2001 Opioid receptor involvement in the effect of AgRP-(83-132) on food intake and food selection. Am J Physiol Regul Integr Comp Physiol 280:R814-R821
18. Schmidhammer H 1998 Opioid receptor antagonists. Prog Med Chem 35: 83-132
19. Glass MJ, Billington CJ, Levine AS 1999 Opioids and food intake: Distributed functional neural pathways? Neuropeptides 33:360-368
20. Takemori AE, Ho BY, Naeseth JS, Portoghese PS 1988 Nor-Binaltorphimine, a highly selective κ-opioid antagonist in analgesic and receptor binding assays. J Pharmacol Exp Ther 246:255-258
21. Levine AS, Grace M, Billington CJ, Portoghese PS 1990 Nor-Binaltorphimine decreases deprivation and opioid-induced feeding. Brain Res 534:60-64
22. Leventhal L, Kirkham TC, Cole JL, Bodnar RJ 1995 Selective actions of central μ and κ opioid antagonists upon sucrose intake in sham-fed rats. Brain Res 685:205-210
23. Ward SJ, Portoghese PS, Takemori AE 1982 Pharmacological characterization in vivo of the novel opiate, β-funaltrexamine. J Pharmacol Exp Ther 220: 494-498
24. Koch JE, Bodnar RJ 1994 Selective alterations in macronutrient intake of food-deprived or glucoprivic rats by centrally-administered opioid receptor subtype antagonists in rats. Brain Res 657:191-201
25. Kotz CM, Grace MK, Billington CJ, Levine AS 1993 The effect of norbinaltorphimine, β-funaltrexamine and naltrindole on NPY-induced feeding. Brain Res 631:325-328
26. Broberger C, De Lecea L, Sutcliffe JG, Hokfelt T 1998 Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: Relationship to the neuropeptide Y and agouti gene-related protein systems. J Comp Neurol 402:460-474
27. Shutter J, Graham M, Kinsey A, Scully S, Luthy R, Stark K 1997 Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes Dev 11:593-602
28. Hagan MM, Benoit SC, Rushing PA, Pritchard LM, Woods SC, Seeley RJ 2001 Immediate and prolonged patterns of agouti-related peptide-(83-132)-induced c-fos activation in hypothalamic and extrahypothalamic sites. Endocrinology 142:1050-1056
29. Glass MJ, Billington CJ, Levine AS 1999 Opioids and food intake: Distributed functional neuronal pathways? Neuropeptides 33:360-368
30. Glass MJ, Grace M, Cleary JP, Billington CJ, Levine AS 1996 Potency of naloxone's anorectic effect in rats is dependent on diet preference. Am J Physiol 271:R217-R221
31. Islam AK, Bodnar RJ 1990 Selective opioid receptor antagonist effects upon intake of a high-fat diet in rats. Brain Res 508:293-296
32. Giraudo SQ, Grace MK, Billington CJ, Levine AS 1999 Differential effects of neuropeptide Y and the μ-agonist DAMGO on 'palatability' vs. 'energy'. Brain Res 834:160-163
33. Zhang M, Gosnell BA, Kelley AE 1998 Intake of high-fat food is selectively enhanced by μ opioid receptor stimulation within the nucleus accumbens. J Pharmacol Exp Ther 285:908-914
34. Schroeder RL, Weinger MB, Vakassian L, Koob GF 1991 Methylnaloxonium diffuses out of the rat brain more slowly than naloxone after direct intracerebral injection. Neurosci Lett 121:173-177
35. Zheng H, Corkern M, Crousillac S, Patterson L, Phifer C, Berthoud H 2002 Neurochemical phenotype of hypothalamic neurons showing fos expression 23 hours following intracranial AgRP. Am J Physiol 282:R1773-R1781
36. Mansour A, Fox CA, Burke S, Meng F, Thompson RC, Akil H, Watson SJ 1994 μ, δ, and κ opioid receptor mRNA expression in the rat CNS: An in situ hybridization study. J Comp Neurol 350:412-438
37. Mansour A, Fox CA, Thompson RC, Akil H, Watson SJ 1994 μ-opioid receptor mRNA expression in the rat CNS: Comparison to μ-receptor binding. Brain Res 643:245-265
38. Rothman RB, Bykov V, Mahboubi A, Long JB, Jiang Q, Porreca F, de Costa BR, Jacobson AE, Rice KC, Holaday JW 1991 Interaction of β-funaltrexamine with [3H]cycloFOXY binding in rat brain: Further evidence that β-FNA alkylates the opioid receptor complex. Synapse 8:86-99
39. Gomes I, Jordan BA, Gupta A, Trapaidze N, Nagy V, Devi LA 2000 Heterodimerization of μ and δ opioid receptors: A role in opiate synergy. J Neurosci 20:RC110
40. Chang KJ, Cooper BR, Hazum E, Cuatrecasas P 1979 Multiple opiate receptors: Different regional distribution in the brain and differential binding of opiates and opioid peptides. Mol Pharmacol 16:91-104
41. Schulz R, Wuster M, Herz A 1979 Supersensitivity to opioids following the chronic blockade of endorphin action by naloxone. Naunyn Schmiedebergs Arch Pharmacol 306:93-96
42. Akil H, Hewlett WA, Barchas JD, Li CH 1980 Binding of 3H-β-endorphin to rat brain membranes: Characterization of opiate properties and interaction with ACTH. Eur J Pharmacol 64:1-8
43. Watson SJ, Akil H, Richard 3rd CW, Barchas JD 1978 Evidence for two separate opiate peptide neuronal systems. Nature 275:226-228
44. Haskell-Luevano C, Chen P, Li C, Chang K, Smith MS, Cameron JL, Cone RD 1999 Characterization of the neuroanatomical distribution of agouti-related protein immunoreactivity in the rhesus monkey and the rat. Endocrinology 140:1408-1415
45. Bagnol D, Lu XY, Kaelin CB, Day HE, Ollmann M, Gantz I, Akil H, Barsh GS, Watson SJ 1999 Anatomy of an endogenous antagonist: Relationship between agouti-related protein and proopiomelanocortin in brain. J Neurosci 19:RC26
46. Olson GA, Olson RD, Kastin AJ 1990 Endogenous opiates: 1989. Peptides 11:1277-1304
47. Silva RM, Hadjimarkou MM, Rossi GC, Pasternak GW, Bodnar RJ 2001 β-endorphin-induced feeding: Pharmacological characterization using selective opioid antagonists and antisense probes in rats. J Pharmacol Exp Ther 297:590-596
48. Watson SJ, Khachaturian H, Taylor L, Fischli W, Goldstein A, Akil H 1983 Pro-dynorphin peptides are found in the same neurons throughout rat brain: Immunocytochemical study. Proc Natl Acad Sci USA 80:891-894
49. Chou TC, Lee CE, Lu J, Elmquist JK, Hara J, Willie JT, Beuckmann CT, Chemelli RM, Sakurai T, Yanagisawa M, Saper CB, Scammell TE 2001 Orexin (hypocretin) neurons contain dynorphin. J Neurosci 21:RC168
50. Rubinstein M, Mogil JS, Japon M, Chan EC, Allen RG, Low MJ 1996 Absence of opioid stress-induced analgesia in mice lacking β-endorphin by site-directed mutagenesis. Proc Natl Acad Sci USA 93:3995-4000
51. Bernstein HG, Keilhoff G, Seidel B, Stanarius A, Huang PL, Fishman MC, Reiser M, Bogerts B, Wolf G 1998 Expression of hypothalamic peptides in mice lacking neuronal nitric oxide synthase: Reduced β-END immunoreactivity in the arcuate nucleus. Neuroendocrinology 68:403-411