The melanocortin receptor agonist MTII augments the rewarding effect of amphetamine in ad-libitum-fed and food-restricted rats

Psychopharmacology

Volumn 161, Issue 1, 2002, Pages 77-85

  Cabeza de Vaca, Soledad ^a   Kim, Gye Young ^a   Carr, Kenneth D ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Amphetamine; Melanocortins; MTII; Reward; Self stimulation; SHU9119

Indexed keywords

ALPHA INTERMEDIN; AMPHETAMINE; HORMONE RECEPTOR STIMULATING AGENT; MELANOCORTIN RECEPTOR; MTII; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENTIATION; FOOD INTAKE; HYPOTHALAMUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REWARD; SELF STIMULATION; TASK PERFORMANCE;

ALPHA-MSH; AMPHETAMINE; ANIMALS; DRUG SYNERGISM; EATING; HYPOTHALAMUS; MALE; MELANOCYTE-STIMULATING HORMONES; RATS; RATS, SPRAGUE-DAWLEY; REWARD; SELF STIMULATION;

EID: 0036235622     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-002-0998-1     Document Type: Article

References (67)

1. Brain melanocortin receptors: From cloning to function
2. Morphine down-regulates melanocortin-4 receptor expression in brain regions that mediate opiate addiction
3. Melanocortins and opiate addiction
4. Anatomy of an endogenous antagonist: Relationship between agouti-related protein and pro-opiomelanocortin in brain
5. Insulin and leptin: Dual adiposoty signals to the brain for the regulation of food intake and body weight
6. Analogs of MTII, lactam derivatives of alpha-melanotropin, modified at the N-terminus, and their selectivity at human melanocortin receptors 3, 4 and 5
7. Food-deprivation increases cocaine-induced conditioned place preference and locomotor activity in rats
8. The neuropeptide Y/agouti gene related protein (AGRP) brain circuitry in normal, anorectic and monosodium glutamate-treated mice
9. Food restriction enhances the central rewarding effect of abused drugs
10. Effects of ketoconazole on the acquisition of intravenous cocaine self-administration under different feeding conditions in rats
11. Evidence that separate neural circuits in the nucleus accumbens encode cocaine versus "natural" (water and food) reward
12. Rewarding actions of phencyclidine and related drugs in nucleus accumbens shell and frontal cortex
13. Microinjections of phencyclidine (PCP) and related drugs into nucleus accumbens shell potentiate medial forebrain bundle brain stimulation reward
14. Feeding, drug abuse, and the sensitization of reward by metabolic need
15. Chronic food restriction increases Fos-like immunoreactivity (FLI) induced in rat forebrain by intraventricular amphetamine
16. Chronic food restriction and weight loss produce opioid facilitation of perifornical hypothalamic self-stimulation
17. Chronic food restriction augments the central rewarding effect of cocaine and the d-1 opioid agonist, DPDPE, but not the d-2 agonist, deltorphin-II
18. Increased drug-reinforced behavior due to food deprivation
19. Combined effects of buprenorphine and a nondrug alternative reinforcer on i.v. cocaine self-administration in rats maintained under FR schedules
20. Competition and summation between rewarding effects of sucrose and lateral hypothalamic stimulation in the rat
21. 125I-insulin binding sites in the rat hypothalamus by quantitative autoradiography
22. Tonic properties of orosensation and the modulation of intracranial self-stimulation: The CNS weighting of external and internal factors governing reward
23. Structure-activity studies of α-melanotropin fragments on cAMP production in striatal slices
24. Stress-induced sensitization and glucocorticoids. I. Sensitization of dopamine-dependent locomotor effects of amphetamine and morphine depends on stress-induced corticosterone secretion
25. Parametric analysis of brain stimulation reward in the rat. III. Effect of performance variables on the reward summation function
26. Leptin activates hypothalamic CART neurons projecting to the spinal cord
27. From lesions to leptin: Hypothalamic control of food intake and body weight
28. Intra-nucleus accumbens amphetamine: Dose-dependent effects on food intake
29. Neurotransmitter transporters: Target for endocrine regulation
30. Peptide-induced grooming behavior and caudate nucleus dopamine release
31. Modulation of brain reward circuitry by leptin
32. Dissociation of dopamine release in the nucleus accumbens from intracranial self stimulation
33. Feeding effects of hypothalamic injection of melanocortin 4 receptor ligands
34. Sucrose intake predicts rate of acquisition of cocaine self-administration
35. Intravenous morphine self-administration by rats with low vs high saccharin preferences
36. Brainstem application of melanocortin receptor ligands produces long-lasting effects on feeding and body weight
37. Role of the CNS melanocortin system in the response to overfeeding
38. Coexpression of AGRP and NPY in fasting-activated hypothalamic neurons
39. Altered energy balance causes selective changes in melanocortin-4 (MC4-R), but not melanocortin-3 (MC3-R), receptors in specific hypothalamic regions
40. Feeding and hypothalamic stimulation increase dopamine turnover in the accumbens
41. Food intake and lateral hypothalamic self-stimulation covary after medial hypothalamic lesions or ventral midbrain 6-hydroxydopamine injections that cause obesity
42. Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas
43. Self-injection of amphetamine directly into the brain
44. Cyclic lactam a-melanotropin analogues of AC-Nle4-cyclo[Asp5,D-Phe7,Lys10] a-melanocyte-stymulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors
45. Targeted disruption of the melacortin-4 receptor results in obesity in mice
46. Intraventricular insulin reduces the antinociceptive effect of DAMGO in mice
47. Selective antagonist for the melanocortin 4 receptor (HS014) increases food intake in free-feeding rats
48. 3 receptor in the regulation of food intake
49. Hypothalamic CART is a new anorectic peptide regulated by leptin
50. The MC4 receptor mediates alpha-MSH induced release of nucleus accumbens dopamine
51. Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides
52. The curve-shift paradigm in self-stimulation
53. Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting
54. Diabetes decreases limbic extracellular dopamine in rats
55. Intravenous cocaine, morphine, amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens
56. The neural basis of drug craving: An incentive-sensitization theory of addiction
57. Identification of targets of leptin action in rat hypothalamus
58. Central nervous system control of food intake
59. Leptin attenuates acute food deprivation-induced relapse to heroin seeking
60. Immunohistochemical localization of leptin receptor in the rat brain
61. Individual differences in sugar intake predict the locomotor response to acute and repeated amphetamine administration
62. Mesolimbic dopaminergic mechanisms underlying individual differences in sugar consumption and amphetamine hyperlocomotion in Wistar rats
63. Central infusion of melanocortin agonist MTII in rats: Assessment of c-Fos expression and taste aversion
64. Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice
65. Addictive drugs and brain stimulation reward
66. A psychomotor stimulant theory of addiction
67. Opiate agonists microinjected into the nucleus accumbens enhance sucrose drinking in rats