메뉴 건너뛰기




Volumn 62, Issue 2, 2001, Pages 101-112

Mechanisms of action of statins and their pleiotropic effects;Mécanismes d'action des statines et leurs effets pléiotropes

Author keywords

Atherosclerosis; Cancer; Endothelial function; Inflammation; Osteoporosis; Pleiotropic effect; Statins; Treatment

Indexed keywords

ACETYLSALICYLIC ACID; ATORVASTATIN; BEZAFIBRATE; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; CERIVASTATIN; CIPROFIBRATE; CLOFIBRATE; FENOFIBRATE; FIBRIC ACID DERIVATIVE; FLUINDOSTATIN; GEMFIBROZIL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERLEUKIN 4; MEVINOLIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NONSTEROID ANTIINFLAMMATORY AGENT; PHOSPHONIC ACID DERIVATIVE; PLACEBO; PRAVASTATIN; PROSTAGLANDIN SYNTHASE; SIMVASTATIN;

EID: 17044448335     PISSN: 00034266     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (45)

References (124)
  • 5
    • 0030577061 scopus 로고    scopus 로고
    • The 1996 Albert Lasker Medical Research Awards. The discovery of endothelium-derived relaxing factor and its importance in the identification of nitric oxide
    • (1996) JAMA , vol.276 , pp. 1186-1188
    • Furchgott, R.F.1
  • 7
  • 8
    • 0032581015 scopus 로고    scopus 로고
    • Association of remnant lipoprotein levels with impairment of endothelium-dependent vasomotor function in human coronary arteries
    • (1998) Circulation , vol.97 , pp. 2519-2526
    • Kugiyama, K.1    Doi, H.2    Motoyama, T.3
  • 17
    • 0028283817 scopus 로고
    • Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia
    • (1994) Circulation , vol.89 , pp. 2519-2524
    • Egashira, K.1    Hirooka, Y.2    Kai, H.3
  • 20
    • 0028204078 scopus 로고
    • Short-term cholesterol lowering decreases size and severity of perfusion abnormalities by positron emission tomography after dipyridamole in patients with coronary artery disease : A potential noninvasive marker of healing coronary endothelium
    • (1994) Circulation , vol.89 , pp. 1530-1538
    • Gould, K.L.1    Martucci, J.P.2    Goldberg, D.I.3
  • 37
    • 7144263727 scopus 로고    scopus 로고
    • Rationale and design of the Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) study that evaluates Atorvastatin in unstable angina pectoris and in non-Q-wave acute myocardial infarction
    • (1998) Am J Cardiol , vol.81 , pp. 578-581
    • Schwartz, G.G.1    Oliver, M.F.2    Ezekowitz, M.D.3
  • 38
    • 0033552883 scopus 로고    scopus 로고
    • Mechanisms of disease - Atherosclerosis - An inflammatory disease
    • (1999) New Engl J Med , vol.340 , pp. 115-126
    • Ross, R.1
  • 44
    • 0032923669 scopus 로고    scopus 로고
    • C-reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men - Results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992
    • (1999) Circulation , vol.99 , pp. 237-242
    • Koenig, W.1    Sund, M.2    Frohlich, M.3
  • 52
    • 0034681953 scopus 로고    scopus 로고
    • Hydroxymethylglutaryl coenzyme A reductase inhibitors modify the inflammatory response of human macrophages and endothelial cells infected with Chlamydia pneumoniae
    • (2000) Circulation , vol.101 , pp. 1760-1763
    • Kothe, H.1    Dalhoff, K.2    Rupp, J.3
  • 55
    • 0032962809 scopus 로고    scopus 로고
    • Effect of cerivastatin sodium, a new inhibitor of HMG-CoA reductase, on plasma lipid levels, progression of atherosclerosis, and the lesional composition in the plaques of WHHL rabbits
    • (1999) Br J Pharmacol , vol.126 , pp. 961-968
    • Shiomi, M.1    Ito, T.2
  • 60
    • 0344589406 scopus 로고    scopus 로고
    • Methods and endpoint issues in clinical development of lipid-acting agents with pleiotropic effects
    • (1998) Am J Cardiol , vol.81
    • Davignon, J.1
  • 62
    • 0026607503 scopus 로고
    • Cholesterol inhibition, cancer, and chemotherapy
    • (1992) Lancet , vol.339 , pp. 1154-1156
    • Buchwald, H.1
  • 84
    • 0029670477 scopus 로고    scopus 로고
    • Translational control of p27Kip1 accumulation during the cell cycle
    • (1996) Science , vol.271 , pp. 1861-1864
    • Hengst, L.1    Reed, S.I.2
  • 85
    • 15644378138 scopus 로고    scopus 로고
    • Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells
    • (1997) J Biol Chem , vol.272 , pp. 13-16
    • Hirai, A.1    Nakamura, S.2    Noguchi, Y.3
  • 96
    • 0027370157 scopus 로고
    • Lovastatin inhibits platelet-derived growth factor (PDGF) stimulation of phosphatidylinositol 3-kinase activity as well as association of p85 subunit to tyrosine-phosphorylated PDGF receptor
    • (1993) J Biol Chem , vol.268 , pp. 22227-22230
    • McGuire, T.F.1    Corey, S.J.2    Sebti, S.M.3
  • 102
    • 0032487931 scopus 로고    scopus 로고
    • Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels
    • (1998) New Engl J Med , vol.339 , pp. 1349-1357
    • Tonkin, A.1    Aylward, P.2    Colquhoun, D.3
  • 103
    • 0032572086 scopus 로고    scopus 로고
    • Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels - Results of AFCAPS/TexCAPS
    • (1998) JAMA , vol.279 , pp. 1615-1622
    • Downs, J.R.1    Clearfield, M.2    Weis, S.3
  • 111
    • 0034647595 scopus 로고    scopus 로고
    • Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect : Reduction of MRNA levels for interleukin- 1beta, interleukin-6, cyclooxygenase-2, and p22phox by regulation of peroxisome proliferator- activated receptor alpha (PPARalpha) in primary endothelial cells
    • (2000) Life Sci , vol.67 , pp. 863-876
    • Inoue, I.1    Goto, S.2    Mizotani, K.3
  • 112
  • 117


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.