Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 14, 1999, Pages 7797-7802

  Rao, Sharmila ^a   Porter, Donald C ^a   Chen, Xiaomei ^a   Herliczek, Thaddeus ^a   Lowe, Michael ^a   Keyomarsi, Khandan ^a,b  

^a WADSWORTH CENTER   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LACTACYSTIN; MEVALONIC ACID; MEVINOLIN; PROTEASOME; PROTEIN P21; PROTEIN P27; CYCLIN DEPENDENT KINASE; CYSTEINE PROTEINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MULTIENZYME COMPLEX; PRODRUG; PROTEINASE INHIBITOR;

ARTICLE; BREAST CARCINOMA; CANCER CELL; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; PRIORITY JOURNAL; PROTEIN STABILITY; CELL CULTURE; CELL CYCLE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; KINETICS; METABOLISM; MICROSOME;

CELL CYCLE; CYCLIN-DEPENDENT KINASES; CYSTEINE ENDOPEPTIDASES; G1 PHASE; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; KINETICS; LOVASTATIN; MEVALONIC ACID; MICROSOMES; MULTIENZYME COMPLEXES; PRODRUGS; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; TUMOR CELLS, CULTURED;

EID: 0033529171     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.14.7797     Document Type: Article

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