The effects of pravastatin, an HMG-CoA reductase inhibitor, on cell viability and DNA production of rat hepatocytes

Life Sciences

Volumn 59, Issue 14, 1996, Pages 1103-1108

  Satoh, Takeaki ^a   Isobe, Hidehiko ^a   Ayukawa, Kusuo ^a   Sakai, Hironori ^a   Nawata, Hajime ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

apoptosis; DNA production; hepatocytes; pravastatin

Indexed keywords

6 N (3,3 DIMETHYLALLYL)ADENINE; ADENINE DERIVATIVE; DNA; DYE; EPIDERMAL GROWTH FACTOR; FARNESOL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVALONIC ACID; PRAVASTATIN; RADIOISOTOPE; THYMIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; LIVER CELL CULTURE; LIVER MITOCHONDRION; MALE; NONHUMAN; RAT;

ANIMALIA;

EID: 0030606837     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/0024-3205(96)00427-4     Document Type: Article

References (24)

1. 1. J.L. GOLDSTEIN and M.S. BROWN,Nature 343 425-430(1990).
2. 2. K.P. FAIRBANKS, L.D. WITTE and D.S. GOODMAN,J.Biol.Chem. 259 1546-1551(1984).
3. 3. A.J.R. HABENICHT, J.A. GLOMSET and R. ROSS, J. Biol. Chem. 255 5134-5140 (1980).
4. 4. M.P. O'DONNELL, B.L. KASISKE, Y. KIM, D. ATLURU and W.F. KEANE, J. Clin. Invest.91 83-87(1993).
5. 5. K.P. FAIRBANKS, V.D. BARBU, L.D. WITTE, I.B. WEINSTEIN and D.S. GOODMAN, J.Cell.Physiol. 127 216-222(1986).
6. 6. W.A. MALTESE, R. DEFENDINI, R.A. GREEN, K.M. SHERIDAN and D.K. DONLEY, J.Clin.Invest. 76 1748-1754(1985).
7. 7. M.R. SOMA, P. PAGLIARIMI, G. BUTTI, R. PAOLETTI, P. PAOLETTI and R. FUMAGALLI, Cancer Res. 52 4348-4355(1992).
8. 8. S. SUMI, R.D. BEAUCHAMP, C.M. TOWENSEND, Jr. T. UCHIDA, M. MURAKAMI, S. RAJARAMAN, J. ISHIZUKA and J.C. THOMPSON, Gastroenterology 103 982-989(1992).
9. 9. V. QUESNEY-HUNEEUS, M.H. WILEY and M.D. SIPERSTEIN, Proc.Natl.Acad.Sci. USA. 76 5056-5060(1979).
10. 10. V. QUESNEY-HUNEEUS, H.A. GALICK, M.D. SIPERSTEIN, S.K. ERICKSON, T.A. SPENCER and J.A. NELSON, J. Biol. Chem. 258 378-385(1983).
11. 11. P.J. CASEY, P.A. SOLSKI, C.J. DER and J.E. BUSS, Proc.Natl.Acad.Sci.USA. 86 8323-8327(1989).
12. 12. C.C. FARNSWORTH, S.L. WOLDA, M.H. GELB and J.A. GLOMSET, J. Biol. Chem. 264,20422-20429(1989).
13. 13. J. INGLESE, W.J. KOCH, M.G. CARON and R.J. LEFKOWITZ, Nature 359, 147-150(1992).
14. 14. A. MASUMOTO, S. KOGA, E. UCHIDA and H. IBASYASI, Atherosclerosis 70 217-223(1988).
15. 15. F. DENISOT and R. LANG, J.Immunol.Methods 89 271-277(1986).
16. 16. J. WEJDE, M. CARLBERG, M HJERTMAN and O. LARSSON, J.Cell Physiol. 155 539-548(1993).
17. 17. G.GRANDALIANO, P. BISWAS, G.G. CHOUDHURY and H.E. ABBOUD, Kidney Int. 44 503-508(1993).
18. 18. A. MALLAT, A. PREAUX, S. BLAZEJEWSKI, D. DHUMEAUX, J. ROSENBAUM and P. MAVIER, Hepatology 20 1589-1594(1994).
19. 19. P.L. YEAGLE, Biochem.Biophys.Acta.822 267-287(1985).
20. 20. I.KANEKO, Y.HAZAMA-SHIMADA and A.ENDO, Eur.J.Bichem. 87 313-321(1978).
21. 21. M.S. BROWN and J.L. GOLDSTEIN, J. Lipid Res. 21 505-517(1980).
22. 22. S.L. PERKINS, S.F. LEDIN and J.D. STUBBS. Biochem.Biophys.Acta. 711 83-89(1982).
23. 23. A.D. COX, M.M. HISAKA, J.E. BUSS and C.J. DER, Mol.Cell.Biol. 12 2606-2615(1992).
24. 24. D. PÉREZ-SALA and F. MOLLINEDO, Biochem.Biophys.Res.Commun. 199 1209-1215 (1994).