Endothelium-Dependent Coronary Vasomotion Relates to the Susceptibility of LDL to Oxidation in Humans

Circulation

Volumn 93, Issue 9, 1996, Pages 1647-1650

  Anderson, Todd J ^a,c   Meredith, Ian T ^a   Charbonneau, François ^a   Yeung, Alan C ^a   Frei, Balz ^b   Selwyn, Andrew P ^a   Ganz, Peter ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c FOOTHILLS HOSPITAL   (Canada)

Author keywords

Acetylcholine; Antioxidants; Cholesterol; Endothelium; Endothelium derived factors

Indexed keywords

ACETYLCHOLINE; ANTIOXIDANT; CHOLESTEROL; COLESTYRAMINE; GLYCERYL TRINITRATE; HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN; MEVINOLIN; PROBUCOL;

ADULT; AGED; ARTICLE; BLOOD VESSEL REACTIVITY; CLINICAL ARTICLE; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY DILATATION; DIET THERAPY; DOSE RESPONSE; HUMAN; HYPERCHOLESTEROLEMIA; INTRAARTERIAL DRUG ADMINISTRATION; INTRACORONARY INFUSION; LIPOPROTEIN METABOLISM; OXIDATIVE STRESS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VASCULAR ENDOTHELIUM;

ACETYLCHOLINE; AGED; ANTICHOLESTEREMIC AGENTS; CORONARY VESSELS; ENDOTHELIUM, VASCULAR; HUMANS; HYPERCHOLESTEROLEMIA; LIPOPROTEINS, LDL; MIDDLE AGED; OXIDATION-REDUCTION; VASOCONSTRICTION; VASODILATION;

EID: 0029944767     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.93.9.1647     Document Type: Article

References (20)

1. Moncada S, Higgs A. The 1-arginine-nitric oxide pathway. N Engl J Med. 1993;329:2002-2012.
2. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980;288:373-376.
3. Ludmer PL, Selwyn AP, Shook TL, Wayne RR, Mudge GH, Alexander RW, Ganz P. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med. 1986;315:1046-1051.
4. Vita JA, Treasure CB, Nabel EG, McLenachan JM. Fish D, Yeung AC, Vekshtein VI, Selwyn AP, Ganz P. The coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation. 1990;81:491-497.
5. Steinberg D. Antioxidants and atherosclerosis: a current assessment. Circulation. 1991;84:1420-1425.
6. Simon BC, Cunningham LD, Cohen RA. Oxidized low density lipoproteins cause contraction and inhibit relaxation in the pig coronary artery. J Clin Invest. 1990;86:75-79.
7. Mangin EL Jr, Kugiyama K, Nguy JH, Kerns SA, Henry PD. Effects of lysolipids and oxidatively modified low density lipoprotein on endothelium-dependent relaxation of rabbit aorta. Circ Res. 1993; 72:161-166.
8. Ohara Y, Peterson TE, Harrison DG. Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest. 1993;92:2546-2551.
9. Rubanyi GM, Vanhouette PM. Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor. Am J Physiol. 1986; 250:H822-H827.
10. Anderson TJ, Meredith IT, Yeung AC, Frei B, Selwyn AP, Ganz P. The effect of cholesterol lowering and antioxidant therapy of endothelium-dependent coronary vasomotion. N Engl J Med. 1995; 332:488-493.
11. Frei B, Gaziano GM. Content of antioxidants, preformed lipid hydroperoxides, and cholesterol as predictors of the susceptibility of human LDL to metal ion-dependent and -independent oxidation. J Lipid Res. 1993;34:2135-2145.
12. Esterbauer H, Puhl H, Dieber-Rotheneder M, Waeg G, Rabl H. Effects of antioxidants on oxidative modification of LDL. Ann Med. 1991;23:573-581.
13. Reaven PD, Parthasarathy S, Beltz WF, Witztum JL. Effects of probucol dosage on plasma lipid and lipoprotein levels and on protection of low density lipoprotein against in vitro oxidation in humans. Arterioscl Thromb. 1992;12:318-324.
14. Andrews HE, Bruckdorfer KR, Dunn RC, Jacobs M. Low-density lipoproteins inhibit endothelium-dependent relaxation in rabbit aorta. Nature. 1987;327:237-239.
15. Tanner FC, Noll G, Boulanger CM, Lüscher TF. Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. Circulation. 1991;83:2012-2020.
16. Inoue N, Hirata K, Yamada M, Hamamori Y, Matsuda Y, Akita H, Yokoyama M. Lysophophatidylcholine inhibits bradykinin-induced phosphoinositide hydrolysis and calcium transients in cultured bovine aortic endothelial cells. Circ Res. 1992;71:1410-1412.
17. Plane F, Jacobs M, McManus D, Bruckdorfer KR. Probucol and other anti-oxidants prevent the inhibition of endothelium-dependent relaxation by low density lipoproteins. Atherosclerosis. 1993;103:73-79.
18. Simon BC, Haudenschild CC, Cohen RA. Preservation of endothelium-dependent relaxation in atherosclerotic rabbit aorta by probucol. J Cardiovasc Pharmacol. 1993;21:893-901.
19. Keaney JF, Gaziano M, Xu A, Frei B, Curran-Celentano J, Shwaery GT, Loscalzo J, Vita JA. Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits. Proc Natl Acad Sci U S A. 1993;90:11880-11884.
20. Parthasarathy S, Young SG, Witztum JL, Pittman RC, Steinberg D. Probucol inhibits oxidative modification of low density lipoprotein. J Clin Invest. 1986;77:641-644.