Importance of endothelial function in mediating the benefits of lipid- lowering therapy

American Journal of Cardiology

Volumn 82, Issue 10 B, 1998, Pages

  Brown, B Greg ^a   Zhao, Xue Qiao ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CELL ADHESION; CONFERENCE PAPER; HUMAN; MACROPHAGE; PRIORITY JOURNAL; THROMBOGENESIS; TISSUE REPAIR; TREATMENT OUTCOME; VASCULAR ENDOTHELIUM;

EID: 0032428190     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9149(98)00726-7     Document Type: Conference Paper

References (31)

1. Furchgott R.F., Zawadzki J.V. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 288:1980;373-376.
2. Clarkson P., Celermajer D.S., Donald A.E., Sampson M., Sorensen K.E., Adams M., Yue D.K., Betteridge D.J., Deanfield J.E. Impaired vascular reactivity in insulin-dependent diabetes mellitus is related to disease duration and low density lipoprotein cholesterol levels. J Am Coll Cardiol. 28:1996;573-579.
3. Sorensen K.E., Celermajer D.S., Georgakopoulos D., Hatcher G., Betteridge D.J., Deanfield J.E. Impairment of endothelium-dependent dilation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein (a) level. J Clin Invest. 93:1994;50-55.
4. Dyce M.C., Anderson T.J., Yeung A.C., Selwyn A.P., Gang P. Indices of LDL particle size closely relate to endothelial function. Circulation. 88:(suppl I):1993;I-466-I-471.
5. Harrison D.G., Armstrong M.L., Freiman P.C., Heistad D.D. Restoration of endothelium-dependent relaxation by dietary treatment of atherosclerosis. J Clin Invest. 80:1987;1808-1811.
6. Egashira K., Hirooka Y., Kai H., Sugimachi M., Suzuki S., Inou T., Takeshita A. Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia. Circulation. 89:1994;2519-2524.
7. Treasure C.B., Klein J.L., Weintraub W.S., Talley J.D., Stillabower M.E., Kosinski A.S., Zhang J., Boccuzzi S.J., Cedarholm J.C., Alexander R.W. Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease. N Engl J Med. 332:1995;481-487.
8. Anderson T.J., Meredith I.T., Yeung A.C., Frei B., Selwyn A.P., Ganz P. The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion. N Engl J Med. 332:1995;488-493.
9. Andrews T.C., Raby K., Barry J., Naimi C.L., Alfred E., Ganz P., Selwyn A.P. Effect of cholesterol reduction on myocardial ischemia in patients with coronary disease. Circulation. 95:1997;324-328.
10. Randomised trial of cholesterol lowering in 4,444 patients with coronary heart disease the Scandinavian Simvastatin Survival Study (4S) . Lancet. 344:1994;1383-1389.
11. Aengevaeren W.R., Uijen G.J., Jukema J.W., Bruschke A.V., van der Werf J. Functional evaluation of lipid-lowering therapy by pravastatin in the Regression Growth Evaluation Statin Study (REGRESS). Circulation. 96:1997;429-435.
12. Ridker P.M., Vaughan D.E., Stampfer M.J., Manson J.E., Hennekens C.H. Endogenous tissue-type plasminogen activator and risk of myocardial infarction. Lancet. 341:1993;1165-1168.
13. McLean J.W., Tomlinson J.E., Kuang W.J., Eaton D.L., Chen E.Y., Fless G.M., Scanu A.M., Lawn R.M. cDNA sequence of human apolipoprotein (a) is homologous to plasminogen. Nature. 330:1987;132-137.
14. Maher V.M., Brown B.G. Lipoprotein (a) and coronary heart disease. Curr Opin Lipidol. 6:1995;229-235.
15. Haider A.W., Andreotti F., Thompson G.R., Kluft C., Maseri A., Davies G.J. Serum lipoprotein (a) level is related to thrombin generation and spontaneous intermittent coronary occlusion in patients with acute myocardial infarction. Circulation. 94:1996;2072-2076.
16. Langille B.L., O'Donnell F. Reductions in arterial diameter produced by chronic decreases in blood flow are endothelium-dependent. Science. 231:1986;405-407.
17. Topper J.N., Cai J., Falb D., Gimbrone M.A. Jr. Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress . Proc Natl Acad Sci USA. 93:1996;10417-10422.
18. Glagov S., Weisenberg E., Zarins C.K., Stankunavicius R., Kolettis G.J. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med. 316:1987;1371-1375.
19. Gerrity R.G. The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. Am J Pathol. 103:1981;181-190.
20. Berliner J.A., Territo M.C., Sevanian A., Ramin S., Kim J.A., Bamshad B., Esterson M., Fogelman A.M. Minimally modified low-density lipoprotein stimulates monocyte endothelial interactions. J Clin Invest. 85:1990;1260-1266.
21. Stary H.C. Changes in the cells of atherosclerotic lesions as advanced lesions evolve in coronary arteries of children and young adults. Glagov S., Newman W.P., Schaffer S.A. Pathobiology of the Human Atherosclerotic Plaque. 1989;93-106 Springer-Verlag, New York.
22. Guyton J.R., Klemp K.F. The lipid-rich core region of human atherosclerotic fibrous plaques. Prevalence of small lipid droplets and vesicles by electron microscopy. Am J Pathol. 134:1989;705-717.
23. De Caterina R., Libby P., Peng H.B., Thannickal V.J., Rajavashisth T.B., Gimbrone M.A. Jr, Shin W.S., Liao J.K. Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Invest. 96:1995;60-68.
24. O'Brien K.D., McDonald T.O., Chait A., Allen M.D., Alpers C.E. Neovascular expression of E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in human atherosclerosis and their relation to intimal leukocyte content. Circulation. 93:1996;672-682.
25. Small D.M., Bond M.G., Waugh D., Prack M., Sawyer J.K. Physiochemical and histological changes in the arterial wall of nonhuman primates during progression and regression of atherosclerosis. J Clin Invest. 73:1984;1590-1605.
26. Gertz S.D., Malekzadeh S., Dollar A.L., Kragel A.H., Roberts W.C. Composition of atherosclerotic plaques in the four major epicardial coronary arteries in patients greater than or equal to 90 years of age. Am J Cardiol. 67:1991;1228-1233.
27. Brown B.G., Gallery C.A., Badger R.S., Kennedy J.W., Mathey D., Bolson E.L., Dodge H.T. Incomplete lysis of thrombus in the moderate underlying atherosclerotic lesion during intracoronary infusion of streptokinase for acute myocardial infarction quantitative angiographic observations . Circulation. 73:1986;653-661.
28. Constantinides P. Plaque hemorrhages, their genesis and their role in supra-plaque thrombosis and atherogenesis. Glagov S., Newman W.P., Schaffer S.A. Pathobiology of the Human Atherosclerotic Plaque. 1990;393-411 Springer-Verlag, New York.
29. Davies M.J. Stability and instability: two faces of coronary atherosclerosis. The Paul Dudley White Lecture 1995. Circulation. 94:1996;2013-2020.
30. Henney A.M., Wakeley P.R., Davies M.J., Foster K., Hembrey R., Murphy G., Humphries S. Localization of stromelysin gene expression in atherosclerotic plaques by in situ hybridization. Proc Natl Acad Sci USA. 88:1991;8154-8158.
31. Brown B.G., Zhao X.Q., Sacco D.E., Albers J.J. Lipid lowering and plaque regression. New insights into prevention of plaque disruption and clinical events in coronary disease. Circulation. 87:1993;1781-1791.