Lovastatin augments sulindac-induced apoptosis in colon cancer cells and potentiates chemopreventive effects of sulindac

Gastroenterology

Volumn 117, Issue 4, 1999, Pages 838-847

  Agarwal, B ^a   Rao, C V ^a   Bhendwal, S ^a   Ramey, W R ^a   Shirin, H ^a   Reddy, B S ^a   Holt, P R ^a  

^a ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZOXYMETHANE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; NONSTEROID ANTIINFLAMMATORY AGENT; SULINDAC;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CHEMICAL CARCINOGENESIS; COLON CANCER; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENTIATION; HUMAN; HUMAN CELL; MALE; NONHUMAN; PRIORITY JOURNAL;

EID: 0032859782     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0016-5085(99)70342-2     Document Type: Article

References (52)

1. SJ Shiff L Qiao L-L Tsai B Rigas Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induced apoptosis in HT-29 colon adenocarcinoma cells J Clin Invest 96 1995 491 503
2. SJ Shiff MI Koutsos L Qiao B Rigas Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis Exp Cell Res 222 1996 178 188
3. U Metzger J Meier G Uhischmid H Weihe Influence of various prostaglandin synthesis inhibitors on DMH-induced rat colon cancer Dis Colon Rectum 27 1984 366 369
4. M Pollard PH Luckert Effect of piroxicam on primary intestinal tumors induced in rats by N-methylnitrosourea Cancer Lett 25 1984 117 121
5. BS Reddy H Maruyama G Kelloff Dose-related inhibition of colon carcinogenesis by dietar y piroxicam, a non-steroidal anti-inflammatory drug, during different stages of rat colon tumor development Cancer Res 47 1987 5340 5346
6. CV Rao A Rivenson B Simi E Zang G Kelloff V Steele BS Reddy Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent Cancer Res 55 1995 1464 1472
7. BS Reddy CV Rao A Rivenson GJ Kelloff Inhibitory effect of aspirin on azoxymethane-induced carcinogenesis in F344 rats Carcinogenesis 14 1993 1493 1497
8. F Tonelli R Valanzano P Dalora Sulindac therapy of colorectal polyps in familial adenomatous polyposis Dig Dis 12 1994 259 264
9. FM Giardiello SR Hamilton AJ Krush S Piantadosi LM Hylind P Celano SV Booker CR Robinson GJ Offerhaus Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis N Engl J Med 398 1993 1313 1316
10. Y Beazer-Barclay DB Levy AR Moser WF Dove SR Hamilton B Vogelstein KW Kinzler Sulindac suppresses tumorigenesis in the min mouse Carcinogenesis 17 1996 1757 1760
11. MJ Thun NM Namboodiri CW Heath Aspirin use and reduced risk of fatal colon cancer N Engl J Med 325 1991 1593 1596
12. KP Nugent AD Spigelman RKS Philips Tissue prostaglandin levels in familial adenomatous polyposis patients treated with sulindac Dis Colon Rectum 39 1996 659 662
13. G Winde KW Schmid W Schlegel R Fischer H Osswald H Bunte Complete reversion and prevention of rectal adenomas in colectomized patients with familial adenomatous polyposis by rectal low-dose sulindac maintenance treatment Dis Colon Rectum 38 1995 813 830
14. FM Giardiello EW Spannhake RN DuBois LM Hylind CR Robinson WC Hubbard SR Hamilton VW Yang Prostaglandin levels in human colorectal mucosa: effects of sulindac in patients with familial adenomatous polyposis Dig Dis Sci 43 1998 311 316
15. LJ Marnett Aspirin and potential role of prostaglandins in colon cancer Cancer Res 52 1992 5575 5589
16. WL Smith Prostanoid biosynthesis and mechanisms of action Am J Physiol 263 1992 F181 F191
17. R Hanif A Pittas Y Feng MI Koutsos L Qiao L Staiano-Coico SLl Shiff B Rigas Effect of non-steroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway Biochem Pharmacol 52 1996 237 245
18. GA Piazza ALK Rahm M Krutzsch G Sperl NS Paranka PH Gross K Brendel RW Burt DS Alberts R Pamukcu DJ Ahnen Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis Cancer Res 55 1995 3110 3116
19. GA Piazza DS Alberts LJ Hixson NS Paranka H Li T Finn C Bogert JM Guillen K Brendel PH Gross Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels Cancer Res 57 1997 2909 2915
20. GA Piazza AK Rahm TS Finn BH Fryer H Li AL Stoumen R Pamukou DJ Ahnen Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest and p53 induction Cancer Res 57 1997 2452 2459
21. JL Goldstein MS Brown Regulation of mevalonate pathway Nature 343 1990 425 430
22. JH Jackson CG Cochrane JR Bourne PA Solski JE Buss CJ Der Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation Proc Natl Acad Sci USA 87 1990 3042 3046
23. CM Newman AI Magee Post-translational processing of ras superfamily of small GTP-binding proteins Biochem Biophys Acta 1155 1993 79 96
24. E Porfiri T Evans P Chardin JF Hancock Prenylation of Ras proteins is required for efficient hsos-1 promoted guanine nucleotide exchange J Biol Chem 269 1994 22676 22677
25. KD Jones WT Couldwell DR Hinton Y Su S He L Anker RE Law Lovastatin induces growth inhibition and apoptosis in human malignant glioma cells Biochem Biophys Res Commun 205 1994 681 687
26. SJ Padayatty M Marcelli TC Shao GR Cunningham Lovastatin induced apoptosis in prostate stromal cells J Clin Endocrinol Metab 82 1997 1434 1439
27. KA Reedquist TK Pope DA Roess Lovastatin inhibits proliferation and differentiation and causes apoptosis in lipopolysaccha-ride-stimulated murine-B cells Biochem Biophys Res Commun 211 1995 665 670
28. D Perez-Sala F Mollinedo Inhibition of isoprenoid biosynthesis induces apoptosis in human promyelocytic HL-60 cells Biochem Biophys Res Commun 199 1994 1209 1215
29. S Satoh H Isobe K Ayukawa H Sakai H Nawata The effects of pravastatin, an HMG-CoA reductase inhibitor on cell viability and DNA production of rat hepatocytes Life Sci 59 1996 1103 1108
30. FM Sacks MA Pfeffer LA Moye JL Rouleau JD Rutherford TG Cole L Brown JW Warnica JMO Arnold C Wun BR Davis E Braunwald The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels N Engl J Med 335 1996 1001 1009
31. TR Pederson K Berge TJ Cook O Faergeman T Haghfelt J Kjekshus M Tatu T Mushner A Olsson K Pyoeraelae G Thorgeisson JA Tobert H Widel H Wilhelmson Safety and tolerability of cholesterol lowering agents with simvastatin during 5 years in Scandinavian simvastatin survival study Arch Intern Med 156 1996 2095 3085
32. T Narisawa M Morotomi Y Fukaura M Hasebe M Ito R Aizawa Chemoprevention by pravastatin, a 3-hydroxy-3-methylglutaryl–coenzyme A reductase inhibitor, of N -methyl- N -nitrosourea–induced colon carcinogenesis in F344 rats Jpn J Cancer Res 87 1996 798 804
33. T Narisawa Y Fukaura N Tanida M Hasebe M Ito R Aizawa Chemopreventive efficacy of low dose of pravastatin, an HMG-CoA reductase inhibitor, on 1,2-dimethylhydrazine–induced colon carcinogenesis in ICR mice Tohuku J Exp Med 180 1996 131 138
34. B Agarwal B Halmos SF Moss WG Ramey PR Holt Lovastatin sensitizes colon cancer HT-29 cells to apoptosis induced by chemotherapeutic agents Proc Am Assoc Cancer Res 39 1998 68
35. BS Reddy A Rivenson K El-Bayoumy P Upadhyaya B Pittman CV Rao Chemoprevention of colon cancer by organoselenium compounds and impact of high- or low-fat diets J Natl Cancer Inst 89 1997 506 512
36. MH Wargowich D-D Chen A Jiminez VE Steele M Velasco C Stephens R Price K Gray GJ Kelloff Aberrant crypt as a biomarker for colon cancer: evaluation of potential chemopreventive agents in a rat Cancer Epidemiol Biomarkers Prev 5 1996 355 360
37. X Li Z Darzynkiewicz Labelling DNA strand breaks with BrdUTP detection of apoptosis and cell proliferation Cell Prolif 28 1995 572 579
38. SF Moss B Agarwal N Arber RJ Guan M Krajewska S Krajewski JC Reed PR Holt Increased intestinal Bak expression results in apoptosis Biochem Biophys Res Commun 223 1996 199 203
39. CV Rao D Desai B Simi N Kulkarni S Amin BS Reddy Inhibitory effects of caffeic acid esters on azoxymethane-induced biochemical changes and aberrant crypt foci formation in rat colon Cancer Res 53 1993 4182 4188
40. H Sheng J Shao SC Kirkland P Isakson RJ Coffey J Morrow RD Beauchamp RN DuBois Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2 J Clin Invest 99 1997 2254 2259
41. J Parker MK Kaplon CJ Alvarez G Krishnaswamy Prostaglandin H synthetase expression is variable in human colorectal adenocarcinoma cell lines Exp Cell Res 236 1997 321 329
42. PJ Morin B Vogelstein KW Kinzler Apoptosis and APC in colorectal tumorigenesis Proc Natl Acad Sci USA 93 1996 7950 7954
43. M Ilyas IPM Tomlinson The interactions of APC, E-cadherin and b-catenin in tumor development and progression J Pathol 182 1997 128 137
44. M Marcelli GR Cunningham SJ Haidacher SJ Padayatty Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP Cancer Res 58 1998 76 83
45. EE Deschner Experimentally induced cancer of the colon Cancer (Phila) 34 1974 824 828
46. E McLellan A Medline RP Bird Sequential analysis of growth and morphological characteristics of aberrant crypt foci: putative preneoplastic lesions Cancer Res 51 1991 5270 5274
47. TP Pretlow MA O'Riordan TG Pretlow TA Stellato Aberrant crypts in human colonic mucosa: putative preneoplastic lesions J Cell Biochem 16G suppl 1992 55 62
48. T Takayama S Katsuki Y Takahashi M Ohi S Noijiri S Sakamaki J Kato K Koguwa H Miyaka Y Niitsu Aberrant crypt foci of the colon as precursors of adenoma and cancer N Engl J Med 339 1998 1277 1284
49. BS Reddy CV Rao K Seibert Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcino-genesis Cancer Res 56 1996 4566 4569
50. JR Downs DO Clearfield S Weis E Whitney DR Shapiro PA Beere A Langendorfer EA Stein W Kruyer AM Gotto Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels J Am Med Assoc 279 1998 1615 1622
51. CA Omer NJ Anthony CA Buser-Doepner AL Burkhardt SJ deSolms CJ Dinsmore JB Gibbs GD Hartman KS Koblan RB Lobell A Oliff TM Williams NE Kohl Farnesyl: protein transferase inhibitors as agents to inhibit tumor growth Biofactors 6 1997 359 366
52. PF Lebowitz JP Davide GC Prendergast Evidence that farnesyl-transferase inhibitors suppress ras transformation by interfering with rho activity Mol Cell Biology 15 1995 6613 6622